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公开(公告)号:US11530304B2
公开(公告)日:2022-12-20
申请号:US15433566
申请日:2017-02-15
申请人: MODERN MEADOW, INC.
发明人: Brendan Patrick Purcell , David Thomas Williamson , Lixin Dai , Darryl Miles Cassingham , Stephen M. Spinella , Katherine Amy Congdon
IPC分类号: B32B5/26 , D06N3/00 , D06N7/00 , C08J3/24 , D01F4/00 , D06M15/15 , B32B5/02 , B32B7/12 , B32B9/02 , B32B15/02 , B32B15/14 , B32B23/10 , B32B27/12 , B32B29/02 , B32B1/08 , B32B3/26 , D04H1/4382 , C14C13/00 , D04H13/00 , D06P3/32 , C07K14/78 , C14C9/00 , C14C9/02 , D01C3/00 , D04H1/00 , D06M15/05 , D06M23/16 , D06M101/06
摘要: A biofabricated material comprising a network of crosslinked collagen fibrils produced from recombinant collagen that contains substantially no 3-hydroxyproline residues is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g., distal surface) to the other (proximal inner layers).
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公开(公告)号:US10301440B2
公开(公告)日:2019-05-28
申请号:US15433777
申请日:2017-02-15
申请人: MODERN MEADOW, INC.
发明人: Brendan Patrick Purcell , David Thomas Williamson , Lixin Dai , Darryl Miles Cassingham , Stephen M. Spinella
IPC分类号: D06M15/15 , C08J3/24 , C14C13/00 , D04H13/00 , D06P3/32 , C07K14/78 , C14C9/00 , C14C9/02 , D04H1/4382 , D01C3/00 , D06N3/00 , D04H1/00 , D06M15/05 , D01F4/00 , B32B5/26 , D06N7/00 , B32B5/02 , B32B7/12 , B32B9/02 , B32B15/02 , B32B15/14 , B32B23/10 , B32B27/12 , B32B29/02 , B32B1/08 , B32B3/26 , D06M101/06 , D06M23/16
摘要: A biofabricated material containing a network of crosslinked collagen fibrils is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g., distal surface) to the other (proximal inner layers).
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公开(公告)号:US11001679B2
公开(公告)日:2021-05-11
申请号:US16358299
申请日:2019-03-19
申请人: MODERN MEADOW, INC.
发明人: Brendan Patrick Purcell , David Thomas Williamson , Lixin Dai , Darryl Miles Cassingham , Stephen M. Spinella
IPC分类号: D06M15/15 , C08J3/24 , D01F4/00 , B32B5/26 , D06N3/00 , D06N7/00 , B32B5/02 , B32B7/12 , B32B9/02 , B32B15/02 , B32B15/14 , B32B23/10 , B32B27/12 , B32B29/02 , B32B1/08 , B32B3/26 , C14C13/00 , D04H13/00 , D06P3/32 , C07K14/78 , C14C9/00 , C14C9/02 , D04H1/4382 , D01C3/00 , D04H1/00 , D06M15/05 , D06M23/16 , D06M101/06
摘要: A biofabricated material containing a network of crosslinked collagen fibrils is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g., distal surface) to the other (proximal inner layers).
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公开(公告)号:US20170233834A1
公开(公告)日:2017-08-17
申请号:US15433650
申请日:2017-02-15
申请人: MODERN MEADOW, INC
发明人: Brendan Patrick PURCELL , David Thomas Williamson , Francoise Suzanne Marga , Susan J. Schofer , Darryl Miles Cassingham , Stephen M. Spinella , Amy Congdon
IPC分类号: C14C9/00 , D04H1/4382 , C07K14/78 , C14C9/02 , D06P3/32
CPC分类号: C08J3/24 , B32B1/08 , B32B3/266 , B32B5/022 , B32B5/024 , B32B5/026 , B32B5/26 , B32B7/12 , B32B9/025 , B32B15/02 , B32B15/14 , B32B23/10 , B32B27/12 , B32B29/02 , B32B2250/02 , B32B2250/03 , B32B2250/20 , B32B2250/40 , B32B2250/42 , B32B2255/02 , B32B2255/26 , B32B2262/0207 , B32B2262/0261 , B32B2262/0269 , B32B2262/0276 , B32B2262/0292 , B32B2262/04 , B32B2262/062 , B32B2262/065 , B32B2262/067 , B32B2262/08 , B32B2262/10 , B32B2262/101 , B32B2262/103 , B32B2262/106 , B32B2262/14 , B32B2264/105 , B32B2307/202 , B32B2307/208 , B32B2307/308 , B32B2307/4026 , B32B2307/422 , B32B2307/50 , B32B2307/51 , B32B2307/54 , B32B2307/5825 , B32B2307/708 , B32B2307/7265 , B32B2437/00 , B32B2437/02 , B32B2437/04 , B32B2439/46 , B32B2451/00 , B32B2457/00 , B32B2471/00 , B32B2479/00 , B32B2519/00 , B32B2571/00 , B32B2601/00 , B32B2605/003 , B32B2605/08 , B32B2605/12 , B32B2605/18 , C07K14/78 , C08J2389/06 , C14C9/00 , C14C9/02 , C14C13/00 , D01C3/00 , D01F4/00 , D04H1/00 , D04H1/4382 , D04H13/00 , D06M15/05 , D06M15/15 , D06M23/16 , D06M2101/06 , D06N3/00 , D06N3/0018 , D06N7/0097 , D06N2201/06 , D06N2203/02 , D06P3/32
摘要: Described herein is a method for producing a biofabricated material from collagen or collagen-like proteins which are recombinantly produced and which contain substantially no 3-hydroxyproline. The collagen or collagen-like proteins are isolated from animal sources, or produced by recombinant DNA techniques or by chemical synthesis. The collagen or collagen-like proteins are fibrillated, crosslinked, dehydrated and lubricated thus forming the biofabricated material having a substantially uniform network of collagen fibrils.
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公开(公告)号:US11214844B2
公开(公告)日:2022-01-04
申请号:US16189692
申请日:2018-11-13
申请人: MODERN MEADOW, INC.
发明人: Brendan Patrick Purcell , Suzanne Lee , Lixin Dai , Katherine Amy Congdon , Stephen M. Spinella , Chi Man Ng
摘要: The invention herein provides biofabricated materials having zonal properties and methods of making biofabricated materials having zonal properties.
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公开(公告)号:US10370504B2
公开(公告)日:2019-08-06
申请号:US15433650
申请日:2017-02-15
申请人: MODERN MEADOW, INC.
发明人: Brendan Patrick Purcell , David Thomas Williamson , Francoise Suzanne Marga , Susan J. Schofer , Darryl Miles Cassingham , Stephen M. Spinella , Amy Congdon
IPC分类号: C08J3/24 , C14C13/00 , D04H13/00 , D06P3/32 , C07K14/78 , C14C9/00 , C14C9/02 , D04H1/4382 , D01C3/00 , D06N3/00 , D04H1/00 , D06M15/05 , D01F4/00 , B32B5/26 , D06M15/15 , D06N7/00 , B32B5/02 , B32B7/12 , B32B9/02 , B32B15/02 , B32B15/14 , B32B23/10 , B32B27/12 , B32B29/02 , B32B1/08 , B32B3/26 , D06M101/06 , D06M23/16
摘要: Described herein is a method for producing a biofabricated material from collagen or collagen-like proteins which are recombinantly produced and which contain substantially no 3-hydroxyproline. The collagen or collagen-like proteins are isolated from animal sources, or produced by recombinant DNA techniques or by chemical synthesis. The collagen or collagen-like proteins are fibrillated, crosslinked, dehydrated and lubricated thus forming the biofabricated material having a substantially uniform network of collagen fibrils.
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