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    Transcranial stimulation with real-time monitoring
    2.
    发明授权
    Transcranial stimulation with real-time monitoring 有权

    公开(公告)号：US11065445B2

    公开(公告)日：2021-07-20

    申请号：US16092989

    申请日：2017-04-10

    Applicant: MONASH UNIVERSITY

    Inventor： Paul B Fitzgerald ,  Caley M. Sullivan ,  Richard H. Thomson

    IPC: A61N1/36 ,  A61B5/00 ,  A61B5/369 ,  A61B5/375 ,  A61N1/04 ,  A61B5/318 ,  A61B5/389

    Abstract: Closed-loop transcranial stimulation and monitoring is disclosed that includes generating a stimulation signal having a set of first oscillation parameters; applying the stimulation signal transcranially to a patient; monitoring the stimulation signal as applied to the patient; receiving a brain activity signal from the patient; generating a feedback signal based on the monitored stimulation signal as applied to the patient; and generating a modified activity signal by subtracting the feedback signal from the brain activity signal; determining one or more second oscillation parameters of the modified activity signal; and adjusting the set of first oscillation parameters of the stimulation signal based on the one or more second oscillation parameters of the modified activity signal. Closed-loop transcranial stimulation and monitoring is also disclosed in which the patient is engaged in a cognitive task.

    OPTIMISING CURRENT DIRECTION AND INTENSITY OF TRANSCRANIAL MAGNETIC STIMULATION
    3.
    发明申请
    OPTIMISING CURRENT DIRECTION AND INTENSITY OF TRANSCRANIAL MAGNETIC STIMULATION 审中-公开
    优化传统磁性刺激的电流方向和强度

    公开(公告)号：US20150174423A1

    公开(公告)日：2015-06-25

    申请号：US14402925

    申请日：2013-05-22

    Applicant: Monash University

    Inventor： Paul B. Fitzgerald ,  Richard H. Thomson

    IPC: A61N2/02 ,  A61B5/055 ,  A61B5/145 ,  A61B5/0484 ,  A61B5/0488 ,  A61B5/00 ,  A61N2/00 ,  A61B5/026

    CPC classification number: A61N2/02 ,  A61B5/0075 ,  A61B5/026 ,  A61B5/0484 ,  A61B5/0488 ,  A61B5/055 ,  A61B5/14542 ,  A61N2/006

    Abstract: A method of optimising transcranial magnetic stimulation is described. An electrical signal is applied to a coil to generate one or more magnetic field pulses for transcranial magnetic stimulation of a target cortical region of a patient. The transcranial magnetic stimulation has stimulation parameters including orientation of the coil relative to the patient and intensity of the magnetic stimulation. At least the orientation of the coil relative to the patient is varied. At different orientations of the coil relative to the patient, neuron activation at the target cortical region is determined by monitoring changes in blood flow and/or blood oxygenation, e.g. using near infra-red spectroscopy. Based on information obtained during the monitoring, one or more optimal coil orientations for the transcranial magnetic stimulation are determined. Apparatus for carrying out the method is also described.

    Abstract translation: 描述了一种优化经颅磁刺激的方法。 电信号被施加到线圈以产生用于患者的目标皮质区域的经颅磁刺激的一个或多个磁场脉冲。 经颅磁刺激具有刺激参数，包括线圈相对于患者的取向和磁刺激的强度。 至少线圈相对于患者的取向是不同的。 在线圈相对于患者的不同取向下，通过监测血流和/或血氧的变化来确定目标皮层区域的神经元活化，例如， 使用近红外光谱。 基于在监测期间获得的信息，确定经颅磁刺激的一个或多个最优线圈取向。 还描述了用于执行该方法的装置。

    Systems and methods for monitoring neural activity
    4.
    发明授权
    Systems and methods for monitoring neural activity 有权

    公开(公告)号：US12097366B2

    公开(公告)日：2024-09-24

    申请号：US17288125

    申请日：2019-10-25

    Applicant: MONASH UNIVERSITY

    Inventor： Richard H. Thomson ,  Paul B. Fitzgerald ,  Caley Sullivan ,  Mark Harrison

    IPC: A61N1/08 ,  A61N1/05 ,  A61N1/20

    CPC classification number: A61N1/08 ,  A61N1/0534 ,  A61N1/20

    Abstract: An apparatus for performing bioelectric stimulation, the apparatus comprising: a stimulation unit; a measurement unit comprising an amplifier; first and second stimulation electrodes operable to apply electrical signals to tissue of a patient; first and second measurement electrodes operable to receive first and second measurement signals from the tissue of the patient; wherein the stimulation unit is configured to deliver a first stimulation signal to the first stimulation electrode and a second stimulation signal to the second stimulation electrode; wherein the first signal and the second signal are mirrored about a biasing voltage, the biasing voltage set in dependence of the dynamic range of the amplifier.

    Optimising current direction and intensity of transcranial magnetic stimulation
    5.
    发明授权
    Optimising current direction and intensity of transcranial magnetic stimulation 有权

    公开(公告)号：US10112056B2

    公开(公告)日：2018-10-30

    申请号：US14402925

    申请日：2013-05-22

    Applicant: Monash University

    Inventor： Paul B. Fitzgerald ,  Richard H. Thomson

    IPC: A61N2/12 ,  A61N2/02 ,  A61B5/00 ,  A61B5/026 ,  A61B5/0484 ,  A61B5/0488 ,  A61B5/055 ,  A61B5/145 ,  A61N2/00

    Abstract: A method of optimizing transcranial magnetic stimulation is described. An electrical signal is applied to a coil to generate one or more magnetic field pulses for transcranial magnetic stimulation of a target cortical region of a patient. The transcranial magnetic stimulation has stimulation parameters including orientation of the coil relative to the patient and intensity of the magnetic stimulation. At least the orientation of the coil relative to the patient is varied. At different orientations of the coil relative to the patient, neuron activation at the target cortical region is determined by monitoring changes in blood flow and/or blood oxygenation, e.g. using near infra-red spectroscopy. Based on information obtained during the monitoring, one or more optimal coil orientations for the transcranial magnetic stimulation are determined. Apparatus for carrying out the method is also described.

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