公开(公告)号：US10391307B2

公开(公告)日：2019-08-27

申请号：US15352514

申请日：2016-11-15

Applicant: Boston Scientific Neuromodulation Corporation ,  MRI Interventions, Inc.

Inventor： Paul A. Bottomley ,  Parag V. Karmarkar ,  Justin M. Allen ,  William A. Edelstein

IPC: A61N1/05 ,  A61N1/08 ,  A61N1/37 ,  A61B5/055 ,  A61B90/00 ,  A61B18/14

Abstract: RF/MRI compatible leads include at least one conductor that turns back on itself at least twice in a lengthwise direction, and can turn back on itself at least twice at multiple locations along its length. The at least one electrical lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related devices and methods of fabricating leads are also described.

公开(公告)号：US20170113036A1

公开(公告)日：2017-04-27

申请号：US15352514

申请日：2016-11-15

Applicant: Boston Scientific Neuromodulation Corporation ,  MRI Interventions, Inc.

Inventor： Paul A. Bottomley ,  Parag V. Karmarkar ,  Justin M. Allen ,  William A. Edelstein

IPC: A61N1/08 ,  A61N1/37 ,  A61N1/05

CPC classification number: A61N1/08 ,  A61B5/055 ,  A61B18/1492 ,  A61B2090/374 ,  A61N1/05 ,  A61N1/0565 ,  A61N1/086 ,  A61N1/3718 ,  Y10T29/49117

Abstract: RF/MRI compatible leads include at least one conductor that turns back on itself at least twice in a lengthwise direction, and can turn back on itself at least twice at multiple locations along its length. The at least one electrical lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related devices and methods of fabricating leads are also described.

公开(公告)号：US20130131496A1

公开(公告)日：2013-05-23

申请号：US13749351

申请日：2013-01-24

Applicant: MRI Interventions, Inc.

Inventor： Kimble L. Jenkins ,  Peter Piferi ,  Kamal Vij ,  Daniele Ghidoli ,  Jesse Flores ,  Parag V. Karmarkar ,  Rajesh Pandey

IPC: A61B5/06 ,  A61B5/00 ,  A61B5/053 ,  A61B18/02 ,  A61M25/01 ,  A61M5/00 ,  A61B5/055 ,  A61B18/18

CPC classification number: A61B5/062 ,  A61B5/0044 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/053 ,  A61B5/055 ,  A61B5/065 ,  A61B5/415 ,  A61B5/418 ,  A61B18/02 ,  A61B18/18 ,  A61B34/10 ,  A61B34/20 ,  A61B2090/365 ,  A61B2090/374 ,  A61B2090/3954 ,  A61M5/00 ,  A61M25/01 ,  A61M25/0127 ,  A61M29/00 ,  A61M2025/0089 ,  A61M2025/0166 ,  A61M2025/0681 ,  A61M2025/09175 ,  G01R33/286 ,  G01R33/287

Abstract: An MRI-compatible catheter that reduces localized heating due to MR scanner-induced currents includes an elongated flexible shaft having a distal end portion and an opposite proximal end portion. A handle is attached to the proximal end portion and includes an electrical connector interface configured to be in electrical communication with an MRI scanner. One or more RF tracking coils are positioned adjacent the distal end portion of the shaft. Each RF tracking coil includes a conductive lead, such as a coaxial cable, that extends between the RF tracking coil and the electrical connector interface and electrically connects the RF tracking coil to an MRI scanner. In some embodiments of the present invention, the conductive lead has a length sufficient to define an odd harmonic/multiple of a quarter wavelength of the operational frequency of the MRI Scanner, and/or includes a series of pre-formed back and forth segments along its length.

Abstract translation: 减少由于MR扫描器感应电流引起的局部加热的MRI兼容导管包括具有远端部分和相对近端部分的细长柔性轴。 手柄附接到近端部分并且包括被配置为与MRI扫描仪电连通的电连接器接口。 一个或多个RF跟踪线圈定位在轴的远端部分附近。 每个RF跟踪线圈包括在RF跟踪线圈和电连接器接口之间延伸的导电引线，例如同轴电缆，并将RF跟踪线圈电连接到MRI扫描器。 在本发明的一些实施例中，导电引线具有足以限定MRI扫描器的工作频率的四分之一波长的奇次谐波/倍数的长度，和/或包括一系列预先形成的前后段 它的长度。

公开(公告)号：US09763745B2

公开(公告)日：2017-09-19

申请号：US14693456

申请日：2015-04-22

Applicant: MRI Interventions, Inc.

Inventor： Parag V. Karmarkar ,  Kimble Jenkins

IPC: A61B5/05 ,  A61B19/00 ,  A61B5/0476 ,  A61B5/055 ,  A61B5/00 ,  A61N1/05 ,  G01R33/28 ,  G01R33/34 ,  A61B34/20 ,  A61B90/11 ,  A61B17/00 ,  A61N1/37 ,  A61N1/08 ,  G01R33/48 ,  A61N1/372 ,  A61B90/00

CPC classification number: A61B90/11 ,  A61B5/0476 ,  A61B5/055 ,  A61B5/6847 ,  A61B5/6864 ,  A61B5/6865 ,  A61B5/7435 ,  A61B34/10 ,  A61B34/20 ,  A61B90/14 ,  A61B2017/00039 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2090/374 ,  A61B2090/3954 ,  A61M39/08 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/08 ,  A61N1/086 ,  A61N1/3718 ,  A61N1/372 ,  A61N2001/086 ,  G01R33/285 ,  G01R33/286 ,  G01R33/287 ,  G01R33/288 ,  G01R33/34084 ,  G01R33/4808

Abstract: MRI compatible localization and/or guidance systems for facilitating placement of an interventional therapy and/or device in vivo include: (a) a mount adapted for fixation to a patient; (b) a targeting cannula with a lumen configured to attach to the mount so as to be able to controllably translate in at least three dimensions; and (c) an elongate probe configured to snugly slidably advance and retract in the targeting cannula lumen, the elongate probe comprising at least one of a stimulation or recording electrode. In operation, the targeting cannula can be aligned with a first trajectory and positionally adjusted to provide a desired internal access path to a target location with a corresponding trajectory for the elongate probe. Automated systems for determining an MR scan plane associated with a trajectory and for determining mount adjustments are also described.

公开(公告)号：US20200078131A1

公开(公告)日：2020-03-12

申请号：US16675690

申请日：2019-11-06

Applicant: MRI Interventions, Inc.

Inventor： Parag V. Karmarkar ,  Kimble Jenkins

IPC: A61B90/11 ,  A61B5/0476 ,  G01R33/34 ,  G01R33/28 ,  A61N1/08 ,  A61N1/05 ,  A61M39/08 ,  A61B90/14 ,  A61B34/20 ,  A61B34/10 ,  A61B5/00 ,  A61B5/055

Abstract: MRI compatible localization and/or guidance systems for facilitating placement of an interventional therapy and/or device in vivo include: (a) a mount adapted for fixation to a patient; (b) a targeting cannula with a lumen configured to attach to the mount so as to be able to controllably translate in at least three dimensions; and (c) an elongate probe configured to snugly slidably advance and retract in the targeting cannula lumen, the elongate probe comprising at least one of a stimulation or recording electrode. In operation, the targeting cannula can be aligned with a first trajectory and positionally adjusted to provide a desired internal access path to a target location with a corresponding trajectory for the elongate probe. Automated systems for determining an MR scan plane associated with a trajectory and for determining mount adjustments are also described.

公开(公告)号：US20170215981A1

公开(公告)日：2017-08-03

申请号：US15492747

申请日：2017-04-20

Applicant: MRI Interventions, Inc.

Inventor： Parag V. Karmarkar ,  Kimble Jenkins

IPC: A61B90/11 ,  A61B90/14 ,  A61M39/08 ,  G01R33/28 ,  A61B5/055 ,  A61N1/05 ,  A61N1/08 ,  A61B34/20 ,  A61B34/10

CPC classification number: A61B90/11 ,  A61B5/0476 ,  A61B5/055 ,  A61B5/6847 ,  A61B5/6864 ,  A61B5/6865 ,  A61B5/7435 ,  A61B34/10 ,  A61B34/20 ,  A61B90/14 ,  A61B2017/00039 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2090/374 ,  A61B2090/3954 ,  A61M39/08 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/08 ,  A61N1/086 ,  A61N1/3718 ,  A61N1/372 ,  G01R33/285 ,  G01R33/286 ,  G01R33/287 ,  G01R33/288 ,  G01R33/34084 ,  G01R33/4808

Abstract: MRI compatible localization and/or guidance systems for facilitating placement of an interventional therapy and/or device in vivo include: (a) a mount adapted for fixation to a patient; (b) a targeting cannula with a lumen configured to attach to the mount so as to be able to controllably translate in at least three dimensions; and (c) an elongate probe configured to snugly slidably advance and retract in the targeting cannula lumen, the elongate probe comprising at least one of a stimulation or recording electrode. In operation, the targeting cannula can be aligned with a first trajectory and positionally adjusted to provide a desired internal access path to a target location with a corresponding trajectory for the elongate probe. Automated systems for determining an MR scan plane associated with a trajectory and for determining mount adjustments are also described.

公开(公告)号：US09630000B2

公开(公告)日：2017-04-25

申请号：US15012692

申请日：2016-02-01

Applicant: Boston Scientific Neuromodulation Corporation ,  MRI Interventions, Inc.

Inventor： Paul A. Bottomley ,  Parag V. Karmarkar ,  Justin M. Allen ,  William A. Edelstein ,  Peter Piferi ,  Brian Gore

IPC: A61N1/05 ,  A61N1/08 ,  A61N1/04 ,  B29C33/12 ,  G01N3/32 ,  B29L31/00

CPC classification number: A61N1/08 ,  A61N1/0488 ,  A61N1/05 ,  A61N1/086 ,  B29C33/126 ,  B29L2031/753 ,  G01N3/32 ,  Y10T29/49071

Abstract: MRI/RF compatible leads include at least one conductor, a respective conductor having at least one segment with a multi-layer stacked coil configuration. The lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related leads and methods of fabricating leads are also described.

公开(公告)号：US20160220812A1

公开(公告)日：2016-08-04

申请号：US15012692

申请日：2016-02-01

Applicant: Boston Scientific Neuromodulation Corporation ,  MRI Interventions, Inc.

Inventor： Paul A. Bottomley ,  Parag V. Karmarkar ,  Justin M. Allen ,  William A. Edelstein ,  Peter Piferi ,  Brian Gore

IPC: A61N1/08 ,  A61N1/05

CPC classification number: A61N1/08 ,  A61N1/0488 ,  A61N1/05 ,  A61N1/086 ,  B29C33/126 ,  B29L2031/753 ,  G01N3/32 ,  Y10T29/49071

Abstract: MRI/RF compatible leads include at least one conductor, a respective conductor having at least one segment with a multi-layer stacked coil configuration. The lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related leads and methods of fabricating leads are also described.

Abstract translation: MRI / RF兼容引线包括至少一个导体，具有至少一个具有多层堆叠线圈配置的段的相应导体。 引线可以被配置为使得铅在局部组织中加热小于约10摄氏度（通常约5摄氏度或更低），或者当患者暴露于至少峰值输入SAR的目标RF频率时不加热局部组织 约4W / kg和/或全身平均SAR至少约2W / kg。 还描述了制造引线的相关引线和方法。

公开(公告)号：US20150223905A1

公开(公告)日：2015-08-13

申请号：US14693456

申请日：2015-04-22

Applicant: MRI Interventions, Inc.

Inventor： Parag V. Karmarkar ,  Kimble Jenkins

IPC: A61B19/00 ,  A61N1/05 ,  A61B5/00 ,  A61B5/0476 ,  A61B5/055

CPC classification number: A61B90/11 ,  A61B5/0476 ,  A61B5/055 ,  A61B5/6847 ,  A61B5/6864 ,  A61B5/6865 ,  A61B5/7435 ,  A61B34/10 ,  A61B34/20 ,  A61B90/14 ,  A61B2017/00039 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2090/374 ,  A61B2090/3954 ,  A61M39/08 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/08 ,  A61N1/086 ,  A61N1/3718 ,  A61N1/372 ,  A61N2001/086 ,  G01R33/285 ,  G01R33/286 ,  G01R33/287 ,  G01R33/288 ,  G01R33/34084 ,  G01R33/4808

Abstract: MRI compatible localization and/or guidance systems for facilitating placement of an interventional therapy and/or device in vivo include: (a) a mount adapted for fixation to a patient; (b) a targeting cannula with a lumen configured to attach to the mount so as to be able to controllably translate in at least three dimensions; and (c) an elongate probe configured to snugly slidably advance and retract in the targeting cannula lumen, the elongate probe comprising at least one of a stimulation or recording electrode. In operation, the targeting cannula can be aligned with a first trajectory and positionally adjusted to provide a desired internal access path to a target location with a corresponding trajectory for the elongate probe. Automated systems for determining an MR scan plane associated with a trajectory and for determining mount adjustments are also described.

Abstract translation: 用于促进介入治疗和/或装置体内放置的MRI兼容的定位和/或引导系统包括：（a）适于固定于患者的安装座; （b）具有被配置为附接到所述安装件以便能够可控地平移至少三个维度的内腔的靶向插管; 以及（c）细长探针，其被配置为在所述靶向插管腔中紧密地滑动地前进和后退，所述细长探针包括刺激或记录电极中的至少一个。 在操作中，瞄准套管可以与第一轨迹对准，并且被位置调节以便为具有针对细长探针的对应轨迹的目标位置提供期望的内部通路。 还描述了用于确定与轨迹相关联并用于确定安装调整的MR扫描平面的自动化系统。

公开(公告)号：US08688226B2

公开(公告)日：2014-04-01

申请号：US13872726

申请日：2013-04-29

Applicant: Boston Scientific Neuromodulation Corporation ,  MRI Interventions, Inc.

Inventor： Ergin Atalar ,  Justin Allen ,  Paul Bottomley ,  William Edelstein ,  Parag V. Karmarkar

IPC: A61N1/00

CPC classification number: A61N1/06 ,  A61N1/056 ,  A61N1/086

Abstract: Some embodiments are directed to MRI/RF compatible medical interventional devices. A plurality of spaced apart high impedance circuit segments are configured to have a high impedance at a high range of radiofrequencies and a low impedance at a low range of frequencies. The high impedance circuit segments may comprise co-wound coiled inductors and can reduce, block or inhibit RJ-transmission along the lead system (20) during exposure to RF associated with a high-Held magnet MRI systems, while permuting passage of low frequency physiologic signals, treatments and/or stimuli. The devices can include at least one electrode.

Abstract translation: 一些实施例涉及MRI / RF兼容医疗介入装置。 多个间隔开的高阻抗电路段被配置为在高频范围内具有高阻抗，并且在低频率范围内具有低阻抗。 高阻抗电路段可以包括共绕线圈电感器，并且可以在暴露于与高磁铁磁共振系统相关联的RF期间沿着引导系统（20）减少，阻止或抑制RJ-传输，同时置换低频生理 信号，治疗和/或刺激。 该装置可以包括至少一个电极。