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37 条记录 (耗时 0.043 秒)

    Closing device, in particular for motor vehicles
    5.
    发明授权
    Closing device, in particular for motor vehicles 有权
    关闭装置，特别是机动车辆

    公开(公告)号：US06768413B1

    公开(公告)日：2004-07-27

    申请号：US09529498

    申请日：2000-04-13

    申请人： Harald Kemmann ,  Andreas van den Boom ,  Stefan Lange

    发明人： Harald Kemmann ,  Andreas van den Boom ,  Stefan Lange

    IPC分类号： G06F704

    CPC分类号： G07C9/00309 ,  E05B81/78 ,  G07C2009/00793 ,  Y10T70/5889

    摘要： A closing device for a vehicle door lock is actuated by a hand lever. The lock can be switched between a secured, inoperative position of the hand lever and an operative position in which the lock can be opened by the hand lever. An electric control device arranged within the vehicle effects via an antenna of a vehicle-correlated transmission and reception unit a data request directed to a data carrier external to the vehicle held by a vehicle user. The data carrier has a transmission and reception unit transmitting a data reply via the antenna of the vehicle-correlated transmission and reception unit to the control device which, for a positive identification of the data carrier, triggers securing, respectively, release of the lock. The antenna of the transmission and reception unit is arranged in the hand lever in addition to at least some further components of the transmission and reception unit.

    摘要翻译： 用于车门锁的关闭装置由手柄致动。 锁可以在手柄的固定的非操作位置和操作位置之间切换，在该位置中锁可以被手柄打开。 布置在车辆内的电气控制装置通过车辆相关发送和接收单元的天线对车辆用户持有的车辆外部的数据载体进行数据请求。 数据载体具有发送和接收单元，经由车辆相关发送和接收单元的天线向控制装置发送数据应答，对于数据载体的肯定识别，分别触发确保锁定的释放。 发送和接收单元的天线除了发送和接收单元的至少一些其它部件之外还布置在手持杆中。

    Antisecretory factor peptides regulating pathological permeability changes
    6.
    发明授权
    Antisecretory factor peptides regulating pathological permeability changes 失效
    调节病理渗透性变化的调节因子肽

    公开(公告)号：US06344440B1

    公开(公告)日：2002-02-05

    申请号：US09029333

    申请日：1998-03-13

    申请人： Ivar Lönnroth ,  Stefan Lange ,  Eva Johansson ,  Eva Jennische ,  Christina Lönnroth

    发明人： Ivar Lönnroth ,  Stefan Lange ,  Eva Johansson ,  Eva Jennische ,  Christina Lönnroth

    IPC分类号： C07K1400

    CPC分类号： C07K14/47 ,  A23K20/147 ,  A61K38/00 ,  C07K14/575 ,  Y02A50/471

    摘要： A new recombinant protein called Antisecretory Factor (rAF) and homologues and peptide fragments thereof are described. The protein and the homologues and fragments thereof are useful for normalizing pathological fluid transport and/or inflammatory reactions in animals including humans. Antibodics against AF or homologues or fragments thereof are described. Nucleic acids coding for the protein or for homologues or fragments thereof are also described as well as vectors and hosts comprising the nucleic acids. The rAF and homologues and fragments thereof could be used for immunodetection, as feed additive for growing animals and as antidiarrheal and drugs against diseases involving edema, dehydration and/or inflammation.

    摘要翻译： 描述了称为反义因子（rAF）的新的重组蛋白及其同源物和肽片段。 蛋白质及其同系物及其片段可用于使包括人在内的动物的病理性流体转运和/或炎性反应正常化。 描述了针对AF或其同系物或其片段的抗体。 还描述编码蛋白质或同源物或其片段的核酸以及包含核酸的载体和宿主。 rAF及其同系物及其片段可用于免疫检测，作为用于生长动物的饲料添加剂和用于抗腹泻和针对涉及水肿，脱水和/或炎症的疾病的药物。

    Approach to treat intraocular hypertension
    7.
    发明授权
    Approach to treat intraocular hypertension 有权

    公开(公告)号：US09000125B2

    公开(公告)日：2015-04-07

    申请号：US13469838

    申请日：2012-05-11

    申请人： Hans-Arne Hansson ,  Stefan Lange ,  Eva Jennische

    发明人： Hans-Arne Hansson ,  Stefan Lange ,  Eva Jennische

    IPC分类号： C07K7/06 ,  A61K38/17

    CPC分类号： A61K38/1709

    摘要： The present invention relates to the use of antisecretory factors, such as antisecretory proteins, homologues, derivatives and/or fragments thereof having antisecretory activity, for the manufacture of a pharmaceutical composition for use in the treatment and/or prevention of intraocular hypertension. The invention thus relates to the use of pharmaceutical compositions comprising antisecretory factors in the treatment and/or prevention of intraocular hypertension, which is preferably characterized by hampered outflow of body fluid resulting in elevated pressure in the eye. The invention provides for a novel approach for treating and/or preventing such a condition turning the intraocular pressure to an acceptable level, optionally 21 mm Hg, or less.

    Modulation of lipid rafts
    8.
    发明授权
    Modulation of lipid rafts 有权

    公开(公告)号：US08487074B2

    公开(公告)日：2013-07-16

    申请号：US12289390

    申请日：2008-10-27

    申请人： Hans-Arne Hansson ,  Stefan Lange

    发明人： Hans-Arne Hansson ,  Stefan Lange

    IPC分类号： C07K14/00

    CPC分类号： A61K38/1709 ,  A61K38/08

    摘要： The present invention relates to the use of an antisecretory protein, derivative, homologue, and/or fragment thereof, having equivalent activity, and/or a pharmaceutically active salt thereof, for the manufacture of a pharmaceutical composition and/or a medical food for the treatment and/or prevention of dysfunction, e.g. abnormal function, hypo- or hyper-function of lipid rafts, receptors and/or caveolae. A dysfunction of lipid rafts, receptors and/or caveolae may be caused by or be a cause of a variety of other conditions, which are also encompassed by the present invention, such as vascular, and lung dysfunctions, and/or endocrine disorders, e.g. diabetes and related disorders. Furthermore, the invention relates to a method for the treatment and/or prevention of dysfunction of lipid rafts and/or caveolae in a mammal in need thereof.

    Approach to treat intraocular hypertension
    9.
    发明授权
    Approach to treat intraocular hypertension 有权
    治疗眼内高血压的方法

    公开(公告)号：US08207296B2

    公开(公告)日：2012-06-26

    申请号：US12289388

    申请日：2008-10-27

    申请人： Hans-Arne Hansson ,  Stefan Lange ,  Eva Jennische

    发明人： Hans-Arne Hansson ,  Stefan Lange ,  Eva Jennische

    IPC分类号： C07K7/06

    CPC分类号： A61K38/1709

    摘要： The present invention relates to the use of antisecretory factors, such as antisecretory proteins, homologues, derivatives and/or fragments thereof having antisecretory activity, for the manufacture of a pharmaceutical composition for use in the treatment and/or prevention of intraocular hypertension. The invention thus relates to the use of pharmaceutical compositions comprising antisecretory factors in the treatment and/or prevention of intraocular hypertension, which is preferably characterized by hampered outflow of body fluid resulting in elevated pressure in the eye. The invention provides for a novel approach for treating and/or preventing such a condition turning the intraocular pressure to an acceptable level, optionally 21 mm Hg, or less.

    摘要翻译： 本发明涉及具有抗分泌活性的抗分泌蛋白，同系物，衍生物和/或片段等抗分泌因子在制备用于治疗和/或预防眼内高血压的药物组合物中的应用。 因此，本发明涉及包含抗分泌因子的药物组合物在治疗和/或预防眼内高血压中的用途，其优点在于体内流体受阻的流出，导致眼压升高。 本发明提供了一种用于治疗和/或预防这种将眼内压转换成可接受水平（可选地为21mm Hg或更小）的病症的新方法。

    High Efficiency Conversion LED
    10.
    发明申请
    High Efficiency Conversion LED 审中-公开
    高效率转换LED

    公开(公告)号：US20120146078A1

    公开(公告)日：2012-06-14

    申请号：US13391180

    申请日：2010-08-11

    申请人： Frank Baumann ,  Norbert Boenisch ,  Tim Fiedler ,  Frank Jermann ,  Stefan Lange ,  Reiner Windisch

    发明人： Frank Baumann ,  Norbert Boenisch ,  Tim Fiedler ,  Frank Jermann ,  Stefan Lange ,  Reiner Windisch

    IPC分类号： H01L33/50

    摘要： A conversion LED with a chip which emits primary blue radiation, and a layer containing luminescent substance upstream of the chip which converts at least part of the primary radiation of the chip into secondary radiation, wherein a first garnet A3B5O12:Ce yellow-green emitting luminescent substance and a second nitride silicate M2X5Y8:D orange-red emitting luminescent substance is used, wherein the peak wavelength of the primary radiation is in the range of 430 to 450 nm, in particular of up to 445 nm, while the first luminescent substance is a garnet with the cation A=Lu or a mixture of Lu, Y with up a Y fraction of up to 30%, and wherein B has fractions of both Al and Ga, while the second luminescent substance is a nitride silicate which contains both Ba and Sr as cation M, and in which the doping consists of Eu, wherein the second luminescent substance contains 35 to 75 mol.-% Ba for the component M, remainder is Sr, where X=Si and Y=N.

    摘要翻译： 具有发射初级蓝色辐射的芯片的转换LED和在芯片上游含有发光物质的层，其将芯片的至少一部分辐射转换成次级辐射，其中第一石榴石A3B5O12：Ce黄绿色发光发光 物质和第二氮化硅玻璃M2X5Y8：D橙红色发光发光物质，其中初级辐射的峰值波长在430至450nm的范围内，特别是高达445nm，而第一发光物质为 具有阳离子A = Lu或Lu，Y的混合物的石榴石，其Y含量高达30％，其中B具有Al和Ga两者的分数，而第二发光物质是含有Ba 和Sr作为阳离子M，其中掺杂由Eu组成，其中第二发光物质对于组分M含有35至75mol％的Ba，余量为Sr，其中X = Si且Y = N。