Potent LNA oligonucleotides for the inhibition of HIF-1a expression
    1.
    发明申请
    Potent LNA oligonucleotides for the inhibition of HIF-1a expression 有权
    用于抑制HIF-1a表达的强大的LNA寡核苷酸

    公开(公告)号:US20060252721A1

    公开(公告)日:2006-11-09

    申请号:US11271686

    申请日:2005-11-09

    IPC分类号: A61K48/00 C07H21/02

    摘要: The present disclosure relates to an LNA oligonucleotide consisting of a sequence selected from the group consisting of 5′-(Tx)GxGxcsasasgscsastscscsTxGxT-3′ and 5′-(Gx)TxTxascstsgscscststscsTxTxA-3′, wherein capital letters designate a beta-D-oxy-LNA nucleotide analogue, small letters designate a 2-deoxynucleotide, underline designates either a beta-D-oxy-LNA nucleotide analogue or a 2-deoxynucleotide, subscript “s” designates a phosphorothioate link between neighbouring nucleotides/LNA nucleotide analogues, and subscript “x” designates either a phosphorothioate link or a phosphorodiester link between neighbouring nucleotides/LNA nucleotide analogues, and wherein the sequence is optionally extended by up to five 2-deoxynucleotide units. The LNA oligonucleotides are useful for modulating the expression of hypoxia-inducible factor-1a (HIF-1a), e.g. in the treatment of cancer diseases, inhibiting angiogenesis, inducing apoptosis, preventing cellular proliferation, or treating an angiogenic disease, e.g. diabetic retinopathy, macular degeneration (ARMD), psoriasis, rheumatoid arthritis and other inflammatory diseases.

    摘要翻译: 本公开内容涉及由选自下组的序列组成的LNA寡核苷酸:5' - (T x)X G x 例如,本发明的一个或多个实施方案,其中, x> T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T -3'和5' - (G x x)T x x T x 其中一个或多个第一个或更多个> 其中大写字母表示β-D-氧基,其中大写字母表示β-D-氧基, -LNA核苷酸类似物,小写字母表示2-脱氧核苷酸,下划线表示β-D-氧-LNA核苷酸类似物或2-脱氧核苷酸,下标“s”表示相邻核苷酸/ LNA核苷酸类似物之间的硫代磷酸酯连接,下标 “x”表示相邻核苷酸/ LNA核苷酸类似物之间的硫代磷酸酯连接或磷酸二酯连接,并且其中该序列是选择性的 最多延伸5个2-脱氧核苷酸单位。 LNA寡核苷酸可用于调节缺氧诱导因子-1a(HIF-1a)的表达,例如, 在治疗癌症疾病,抑制血管发生,诱导细胞凋亡,预防细胞增殖或治疗血管生成疾病,例如, 糖尿病性视网膜病变,黄斑变性(ARMD),牛皮癣,类风湿性关节炎等炎症性疾病。

    Center bottom mounted drawer slide
    2.
    发明授权
    Center bottom mounted drawer slide 失效
    中央底部安装的抽屉滑轨

    公开(公告)号:US5275483A

    公开(公告)日:1994-01-04

    申请号:US7393

    申请日:1993-01-21

    申请人: Frank Rasmussen

    发明人: Frank Rasmussen

    IPC分类号: A47B88/14 A47B88/00

    摘要: A bottom center mounted drawer slide mechanism for a drawer and cabinet. The mechanism is designed to be mounted along the bottom centerline of the drawer. The mechanism includes a cabinet track structure consisting essentially of a substantially C-shaped cross-section, rollers, and mounting tabs; a drawer track with retention dimples and rollers; a mounting plate onto which the drawer mounts; and a mounting unit which mounts onto the cabinet. The rollers of the cabinet track structure and the drawer track allow the drawer to move in and out smoothly and with little need for alignment adjustment.

    摘要翻译: 用于抽屉和机柜的底部中心安装的抽屉滑动机构。 该机构被设计成沿着抽屉的底部中心线安装。 该机构包括主要由基本上C形的横截面,滚子和安装凸片组成的橱柜轨道结构; 带保留凹坑和滚筒的抽屉轨道; 安装板,抽屉安装在该安装板上; 以及安装在机柜上的安装单元。 橱柜轨道结构和抽屉轨道的滚轮允许抽屉平稳地进出,几乎不需要对准调整。

    Absorbing Article with Zones of Different Surface Properties
    3.
    发明申请
    Absorbing Article with Zones of Different Surface Properties 有权
    吸收物品与不同表面性质的区域

    公开(公告)号:US20080038536A1

    公开(公告)日:2008-02-14

    申请号:US10587265

    申请日:2005-01-26

    IPC分类号: B32B3/00 B05D5/10

    摘要: It is an object of the invention to provide an adhesive element having an adhesive surface showing adhesive properties for adhering to a substrate wherein at least a part of the surface has been treated, resulting in alteration of the surface properties of the heat treated part of the surface. By heat treatment it is possible to provide an adhesive surface having parts showing different colour, water absorption properties, and/or adhesive properties.

    摘要翻译: 本发明的目的是提供一种具有粘合表面的粘合剂表面的粘合剂表面,其表现出粘合到基材上的粘合性能,其中表面的至少一部分已经被处理,导致热处理部分的表面性质的改变 表面。 通过热处理,可以提供具有不同颜色,吸水性和/或粘合性能的部件的粘合剂表面。

    Microphone with adjustable properties
    5.
    发明申请
    Microphone with adjustable properties 失效
    麦克风具有可调性能

    公开(公告)号:US20070007858A1

    公开(公告)日:2007-01-11

    申请号:US10555763

    申请日:2004-05-06

    IPC分类号: H01L41/00

    摘要: The invention concerns a microphone with a membrane. The membrane has a first side which is in fluid contact with the surroundings and a second side which is facing a back chamber, where a barometric relief opening or vent opening is provided between the back chamber and the surroundings. According to the invention control means are provided for controlling the barometric relief opening.

    摘要翻译: 本发明涉及具有膜的麦克风。 膜具有与周围液体接触的第一侧和面向后室的第二侧,其中在后室和周围环境之间设置有气压释放开口或通气口。 根据本发明,提供控制装置用于控制气压释放口。

    Feed-through process and amplifier with feed-through
    6.
    发明申请
    Feed-through process and amplifier with feed-through 审中-公开
    直通过程和放大器与馈通

    公开(公告)号:US20050215054A1

    公开(公告)日:2005-09-29

    申请号:US10516886

    申请日:2003-05-22

    CPC分类号: H01L21/30608 H01L21/76898

    摘要: The invention concerns a process for generating a feed-through in a semiconductor wafer, which has electric circuitry embedded in a front surface whereby the hole for the feed-through is generated by the combined use of a front side protection layer and a wet KOH etch process etching the hole from the back side of the wafer, where a photomasking process is subsequently used do define the via followed by deposition of the via material.

    摘要翻译: 本发明涉及一种用于在半导体晶片中产生馈通的方法,该半导体晶片具有嵌入在前表面中的电路,由此通过组合使用前侧保护层和湿KOH蚀刻来产生馈通孔 从晶片的背面对孔进行蚀刻,随后使用光掩模工艺来确定通孔,然后沉积通孔材料。

    Audio Processing Device with Encapsulated Electronic Component
    7.
    发明申请
    Audio Processing Device with Encapsulated Electronic Component 审中-公开
    具有封装电子元件的音频处理装置

    公开(公告)号:US20080093692A1

    公开(公告)日:2008-04-24

    申请号:US11661935

    申请日:2005-09-05

    IPC分类号: H01L29/84 H01L21/56

    摘要: The invention regards an audio processing device with at least one encapsulated electronic component mounted and electrically connected to electric leads in a mounting substrate. Further electric components are mounted for connection with the encapsulated electronic component through the substrate and the encapsulation material is moulded onto the substrate. According to the invention at least one metal layer is deposited on a surface part of the encapsulation material. The invention further regards a method for producing an amplifier for an audio device whereby at least one encapsulated electronic component is mounted on, and electrically connected to a PCB and where the encapsulation material is provided to protect the electronic component wherein further a metal layer is generated at least on a surface area of the encapsulation material.

    摘要翻译: 本发明涉及一种具有至少一个封装的电子部件的音频处理装置,其在安装基板中安装并电连接到电引线。 另外的电气部件被安装用于通过衬底与封装的电子部件连接,并且封装材料被模制到衬底上。 根据本发明,至少一个金属层沉积在封装材料的表面部分上。 本发明还涉及一种用于制造用于音频装置的放大器的方法,其中至少一个封装的电子部件安装在PCB上并电连接到PCB,并且其中提供封装材料以保护电子部件,其中还产生金属层 至少在封装材料的表面积上。

    Product and a method of providing a product, such as a laser welded product
    8.
    发明申请
    Product and a method of providing a product, such as a laser welded product 审中-公开
    产品和提供产品的方法,例如激光焊接产品

    公开(公告)号:US20050224472A1

    公开(公告)日:2005-10-13

    申请号:US10822861

    申请日:2004-04-13

    摘要: A method of decreasing the penetration depth of radiation provided to an interface, such as a surface, or a predetermined volume in a means, where the means has a scattering coefficient larger than one tenth of an absorption coefficient thereof so that the radiation not absorbed at the interface or in the volume but transmitted further into the means is at least partly reflected toward the interface/volume. The radiation intensity is higher in the volume and the absorption coefficient may be reduced while retaining the total absorption in the volume. This may be used for all known techniques where radiation is desired absorbed, such as in welding, surface preparation, polymer chemistry, the activation of photo activatable substances etc.

    摘要翻译: 一种减少提供给界面的辐射穿透深度的方法,例如在装置中具有大于其吸收系数的十分之一的散射系数的装置中的预定体积,使得辐射不被吸收在 接口或体积中但进一步传递到装置中至少部分地朝向接口/体积反射。 体积中的辐射强度较高,并且可以减小吸收系数,同时保持体积中的总吸收。 这可以用于需要吸收辐射的所有已知技术,例如在焊接,表面处理,聚合物化学,活化可激活活性物质等方面。

    Wind noise insensitive hearing aid
    9.
    发明申请
    Wind noise insensitive hearing aid 有权
    风噪声不敏感助听器

    公开(公告)号:US20050041825A1

    公开(公告)日:2005-02-24

    申请号:US10501231

    申请日:2003-01-07

    IPC分类号: H04R25/00

    摘要: The invention concerns a hearing aid with at least one primary sound to electric converting transducer converting sounds in the environment into electrical signals and a signal processing unit for amplifying the electrical signal according to the needs of the user and an electrical to sound transducer for receiving the amplified electrical signal and delivering a sound signal to the ear wherein at least one further sound to electrical transducer is provided. The said further transducer has a sensitivity to wind noise which is smaller than the sensitivity to wind noise of the primary transducer and further the signal processing unit has means for detecting the level of wind noise in the signal from the primary sound to electric converting transducer. According to the invention also selecting means are provided for selecting the signal to be amplified from either the primary—or the at least one further sound to electrical transducer.

    摘要翻译: 本发明涉及一种助听器,其具有至少一个主要声音以电转换换能器将环境中的声音转换为电信号;以及信号处理单元,用于根据用户的需要放大电信号,以及电 - 声换能器,用于接收 放大的电信号并将声音信号传送到耳朵,其中提供至少一个另外的声音至电变换器。 所述另外的传感器对风噪声的灵敏度小于主要传感器的风噪声的灵敏度,此外,信号处理单元具有用于检测从主声音到电转换换能器的信号中的风噪声水平的装置。 根据本发明,还提供了选择装置,用于从主要或至少一个另外的声音到电变换器中选择要被放大的信号。