-
公开(公告)号：US06331570B1
公开(公告)日：2001-12-18
申请号：US09401356
申请日：1999-09-21
IPC分类号： A61K31195
CPC分类号： A61K31/196 , C07C235/16 , C07C2602/10
摘要： Disclosed is the (R)-enantiomer of the formula which has unexpectedly been found to possess all of the biological activity of the racemic compound disclosed in the prior art as an RAR&ggr;-specific agonist.
摘要翻译： 公开了已公开发现具有现有技术中公开的外消旋化合物的所有生物活性的（R） - 对映体作为RARγ-特异性激动剂。
-
2.发明授权Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same 有权可用作抗炎剂的氨基取代的四环化合物和包含其的药物组合物公开(公告)号：US06960585B2
公开(公告)日：2005-11-01
申请号：US09965977
申请日：2001-09-27
申请人： Francis Beaulieu , Carl Quellet , Makonen Belema , Yuping Qiu , Xuejie Yang , Fred C. Zusi
发明人： Francis Beaulieu , Carl Quellet , Makonen Belema , Yuping Qiu , Xuejie Yang , Fred C. Zusi
IPC分类号： A61K31/4745 , A61K31/4985 , A61K31/519 , A61P1/04 , A61P11/00 , A61P11/06 , A61P17/06 , A61P29/00 , A61P31/18 , A61P31/22 , A61P35/00 , A61P37/00 , C07D471/04 , C07D487/04 , C07D513/04
CPC分类号： C07D471/04 , A61K31/519 , C07D487/04 , C07D513/04 , Y02A50/411
摘要： Compounds of formula (I), or pharmaceutically-acceptable salts thereof, are useful in treating inflammatory and immune diseases and disorders, wherein X, Y1, Y2, and R2-4 are as defined in the specification.
摘要翻译： 式（I）化合物或其药学上可接受的盐可用于治疗炎症和免疫疾病和病症，其中X，Y 1，Y 2和R 本说明书中所定义的。
-
公开(公告)号：US08329159B2
公开(公告)日：2012-12-11
申请号：US11835462
申请日：2007-08-08
申请人： Makonen Belema , Van N. Nguyen
发明人： Makonen Belema , Van N. Nguyen
IPC分类号： A61K38/20 , A61K31/4164 , A61K31/517 , A61K31/715 , A61K38/46 , A61P31/00 , C07D403/02 , C07D401/00
CPC分类号： C07D233/64 , A61K31/4178 , A61K45/06 , C07D207/16 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07F5/025 , C07F7/0812
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
-
公开(公告)号：US08143301B2
公开(公告)日：2012-03-27
申请号：US12754169
申请日：2010-04-05
申请人： Makonen Belema , John F. Kadow
发明人： Makonen Belema , John F. Kadow
IPC分类号： A61K31/4174 , C07D233/64
CPC分类号： C07D403/14 , C07D403/04 , C07D405/14
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
-
公开(公告)号：US08143288B2
公开(公告)日：2012-03-27
申请号：US11446788
申请日：2006-06-05
申请人： Michael Serrano-Wu , Makonen Belema , Lawrence B. Snyder , Nicholas A. Meanwell , Denis R. St. Laurent , Ramesh Kakarla , Van N. Nguyen , Yuping Qiu , Xuejie Yang , John E. Leet , Min Gao , Donald R. O'Boyle, II , Julie A. Lemm , Fukang Yang
发明人： Michael Serrano-Wu , Makonen Belema , Lawrence B. Snyder , Nicholas A. Meanwell , Denis R. St. Laurent , Ramesh Kakarla , Van N. Nguyen , Yuping Qiu , Xuejie Yang , John E. Leet , Min Gao , Donald R. O'Boyle, II , Julie A. Lemm , Fukang Yang
IPC分类号： A61K31/444 , A61K31/4439 , A61K31/42 , A61K31/416 , A61K31/4025 , C07D413/14 , C07D403/14 , C07D409/14
CPC分类号： C07D207/16 , C07D207/22 , C07D207/277 , C07D209/42 , C07D211/60 , C07D263/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Compounds having the structure of formula I are described. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular can inhibit the function of the HCV NS5A protein.
摘要翻译： 描述具有式I结构的化合物。 该化合物可以抑制丙型肝炎病毒（HCV）复制，特别是可以抑制HCV NS5A蛋白的功能。
-
公开(公告)号：US20110077280A1
公开(公告)日：2011-03-31
申请号：US12729940
申请日：2010-03-23
申请人： John A. Bender , Piyasena Hewawasam , John F. Kadow , Omar D. Lopez , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Lawrence B. Snyder , Denis R. St. Laurent , Gan Wang , Ningning Xu , Makonen Belema
发明人： John A. Bender , Piyasena Hewawasam , John F. Kadow , Omar D. Lopez , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Lawrence B. Snyder , Denis R. St. Laurent , Gan Wang , Ningning Xu , Makonen Belema
IPC分类号： A61K31/4178 , C07D403/14 , A61K31/4184 , C07D405/14 , A61P31/14
CPC分类号： C07D403/04 , C07D403/14 , C07D405/14
摘要： This disclosure concerns novel compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.
-
公开(公告)号：US20100303755A1
公开(公告)日：2010-12-02
申请号：US12780415
申请日：2010-05-14
申请人： Omar D. Lopez , Qi Chen , Makonen Belema
发明人： Omar D. Lopez , Qi Chen , Makonen Belema
IPC分类号： A61K38/20 , A61K38/21 , A61K38/43 , A61K38/48 , A61K38/00 , A61K31/708 , A61K31/7088 , A61K31/4178 , C07D403/14 , A61P31/14
CPC分类号： C07D403/14
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
-
公开(公告)号：US20080299075A1
公开(公告)日：2008-12-04
申请号：US12029680
申请日：2008-02-12
申请人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
发明人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
IPC分类号： C07D403/14 , A61K31/4178 , A61K38/20 , A61K38/21 , A61K38/43 , A61K38/48 , A61K31/7088 , A61K38/16 , A61P31/12
CPC分类号： C07D403/14
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译： 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。
-
公开(公告)号：US20080044379A1
公开(公告)日：2008-02-21
申请号：US11835485
申请日：2007-08-08
申请人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
发明人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
IPC分类号： A61K38/20 , A61K31/4178 , A61K31/4196 , A61K31/4245 , A61K31/426 , A61K31/4353 , A61K31/4427 , A61K38/21 , C07D213/02 , C07D295/00 , C07D277/02 , C07D249/08 , C07D241/02 , C07D239/02 , C07D237/02 , C07D233/54 , C07D221/00 , A61P31/12 , A61K31/4523 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/7052
CPC分类号： C07D401/14 , C07D403/14
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
-
公开(公告)号：US09546160B2
公开(公告)日：2017-01-17
申请号：US13465298
申请日：2012-05-07
申请人： Qi Chen , Omar D. Lopez , John A. Bender , Gan Wang , Van N. Nguyen , John F. Kadow , Nicholas A. Meanwell , Makonen Belema
发明人： Qi Chen , Omar D. Lopez , John A. Bender , Gan Wang , Van N. Nguyen , John F. Kadow , Nicholas A. Meanwell , Makonen Belema
IPC分类号： A01N43/50 , A61K31/415 , C07D403/14 , C07D405/14 , C07D413/14 , A61K31/4178 , A61K31/4184 , A61K31/5377 , A61K45/06
CPC分类号： C07D403/14 , A61K31/4178 , A61K31/4184 , A61K31/5377 , A61K45/06 , C07D405/14 , C07D413/14
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译： 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。
-
-
-
-
-
-
-
-
-
搜索结果
63 条记录 (耗时 0.069 秒)
