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公开(公告)号：US06420384B2
公开(公告)日：2002-07-16
申请号：US09740619
申请日：2000-12-18
IPC分类号： C07D40101
CPC分类号： C07D471/04 , A61K47/54 , A61K47/548 , C07D487/04 , C07F9/4012 , C07F9/405 , C07F9/58 , C07F9/65583 , C07F9/6561 , C07F9/65616
摘要： Compounds and methods of treating or preventing bone disorders including osteoporosis, rheumatoid arthritis, and metastatic bone disease are provided. The inventive compounds comprise a bone targeting moiety and a payload. The payload portion of these inventive compounds inhibit the proton pump of osteoclasts, thereby, reducing bone resorption. Compounds of the present invention include compounds of the following formula:
摘要翻译： 提供了治疗或预防包括骨质疏松症，类风湿性关节炎和转移性骨病在内的骨疾病的化合物和方法。 本发明化合物包括骨靶向部分和有效载荷。 这些本发明化合物的有效载荷部分抑制破骨细胞的质子泵，从而减少骨吸收。 本发明的化合物包括下式的化合物：
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公开(公告)号：US07115589B2
公开(公告)日：2006-10-03
申请号：US09740393
申请日：2000-12-18
申请人： Manfred Weigele , Tomi K. Sawyer , Regine Bohacek , William C. Shakespeare , Rajeswari Sundaramoorthi , Yihan Wang , David C. Dalgarno , Chester A. Metcalf, III
发明人： Manfred Weigele , Tomi K. Sawyer , Regine Bohacek , William C. Shakespeare , Rajeswari Sundaramoorthi , Yihan Wang , David C. Dalgarno , Chester A. Metcalf, III
IPC分类号： C07F9/6561 , A61K31/675 , A61P19/10 , A61P19/08 , A61P35/00
CPC分类号： C07D471/04 , A61K47/548 , C07D487/04 , C07F9/4012 , C07F9/405 , C07F9/58 , C07F9/65583 , C07F9/6561 , C07F9/65616
摘要： This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use. In these compounds, RB is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety which comprises one or more phosphorus-containing moieties.
摘要翻译： 本发明涉及以下通式的化合物：其中R A，R B，R C和R D D均为 >如本文所定义，以及其制备和使用。 在这些化合物中，R B是包含一个或多个含磷部分的脂族，杂脂族，芳基或杂芳基部分。
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公开(公告)号：US09090561B2
公开(公告)日：2015-07-28
申请号：US13614838
申请日：2012-09-13
申请人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
发明人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
IPC分类号： C07D471/04 , A61K31/4375 , C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12
CPC分类号： C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D471/04
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。
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公开(公告)号：US20130018046A1
公开(公告)日：2013-01-17
申请号：US13614838
申请日：2012-09-13
申请人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
发明人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
IPC分类号： A61K31/4439 , C07D403/12 , A61K31/506 , C07D401/12 , A61K31/496 , C07D471/04 , A61K31/4375 , C07D413/12 , A61K31/4725 , A61K31/502 , A61K31/497 , C07D498/04 , A61K31/5383 , A61K31/551 , A61K31/5377 , A61K31/53 , A61P35/00 , C07D401/14
CPC分类号： C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D471/04
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
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公开(公告)号：US08278307B2
公开(公告)日：2012-10-02
申请号：US12227130
申请日：2007-05-08
申请人： William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Mathew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi K. Sawyer , Jan Antoinette C. Romero
发明人： William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Mathew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi K. Sawyer , Jan Antoinette C. Romero
IPC分类号： A61K31/496 , A61K31/4178 , C07D403/12
CPC分类号： C07D231/12 , C07D233/64 , C07D233/90 , C07D277/40 , C07D403/12 , C07D403/14 , C07D417/12 , C07D417/14
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，以及其制备和用途。
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公开(公告)号：US20090156596A1
公开(公告)日：2009-06-18
申请号：US11990299
申请日：2006-08-11
申请人： Yihan Wang , Wei-Sheng Huang , Rajeswari Sundaramoorthi , Xiaotian Zhu , R. Mathew Thomas , William C. Shakespeare , David C. Dalgarno , Tomi K. Sawyer
发明人： Yihan Wang , Wei-Sheng Huang , Rajeswari Sundaramoorthi , Xiaotian Zhu , R. Mathew Thomas , William C. Shakespeare , David C. Dalgarno , Tomi K. Sawyer
IPC分类号： A61K31/5355 , C07D473/00 , C07D413/14 , A61P35/00 , A61K31/52
CPC分类号： C07F9/65616
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。
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公开(公告)号：US20120135986A1
公开(公告)日：2012-05-31
申请号：US13357745
申请日：2012-01-25
申请人： Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antionette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
发明人： Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antionette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
IPC分类号： A61K31/5377 , A61K31/4985 , C07D471/04 , A61K31/437 , A61P35/00 , A61K31/5025 , A61K31/53 , A61K31/519 , C07D473/34 , A61K31/52 , C07D487/04 , A61K31/496
CPC分类号： C07D471/04 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，以及其制备和用途。
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公开(公告)号：US20090176781A1
公开(公告)日：2009-07-09
申请号：US12227002
申请日：2007-05-08
申请人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zhu , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
发明人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zhu , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
IPC分类号： A61K31/5377 , C07D401/14 , A61K31/4439 , A61K31/506 , C07D403/12 , C07D413/12 , A61P35/00
CPC分类号： C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D471/04
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。
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公开(公告)号：US08461167B2
公开(公告)日：2013-06-11
申请号：US12227002
申请日：2007-05-08
申请人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
发明人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
IPC分类号： A01N43/54 , A61K31/505 , C07D239/02
CPC分类号： C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D471/04
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
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公开(公告)号：US20130005738A1
公开(公告)日：2013-01-03
申请号：US13612067
申请日：2012-09-12
申请人： William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Mathew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi K. Sawyer , Jan Antoinette C. Romero
发明人： William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Mathew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi K. Sawyer , Jan Antoinette C. Romero
IPC分类号： C07D403/12 , A61P35/00 , C07D417/12 , A61K31/427 , A61K31/496 , A61K31/4178
CPC分类号： C07D231/12 , C07D233/64 , C07D233/90 , C07D277/40 , C07D403/12 , C07D403/14 , C07D417/12 , C07D417/14
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。
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