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公开(公告)号：US08858555B2
公开(公告)日：2014-10-14
申请号：US12573310
申请日：2009-10-05
CPC分类号： A61B17/62 , A61B17/6441 , A61B17/645 , A61B17/848 , A61B17/88 , A61B2017/564 , A61B2017/681
摘要： An external fixation system and method for realigning, compressing or distracting broken bones has a planar ring element with an adjustable device having a body releasably mounted on the ring element. The adjustable device includes a first member for movement in a direction generally perpendicular to the ring element. A second member is pivotally connected to the first member for angular movement with respect to the ring. A third member is mounted on the second member for movement in a direction parallel to the second member and with respect to a circumference of the planar ring element. The method includes inserting k-wires into bone and affixing the k-wires to the ring element and affixing the k-wires to an adjustable device. The pieces of bone are realigned, compressed or distracted by adjusting at least one of a first and second members forming the device.
摘要翻译： 用于重新排列，压缩或分散骨头的外部固定系统和方法具有平面环形元件，其具有可拆卸的装置，其具有可释放地安装在环形元件上的主体。 可调节装置包括用于沿大致垂直于环形元件的方向移动的第一构件。 第二构件枢转地连接到第一构件，用于相对于环角度运动。 第三构件安装在第二构件上，用于沿平行于第二构件的方向并相对于平面环形元件的圆周移动。 该方法包括将k线插入骨头并将k线固定到环形元件并将k线固定到可调节装置。 通过调节形成该装置的第一和第二构件中的至少一个来使骨块重新对准，压缩或分散。
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公开(公告)号：US09101398B2
公开(公告)日：2015-08-11
申请号：US13592832
申请日：2012-08-23
摘要： Disclosed herein are systems and methods for manipulating the orientation of a plurality of bone fragments with respect to one another. A bone transport frame including first and second rings, a plurality of elongate struts, and a plurality of ring transport assemblies for orienting a first bone segment with respect to a second bone segment is disclosed. A third ring may be included in the bone transport frame for orienting a third bone segment with respect to the first and second bone segments. Manipulation of an adjustable member of the bone transport frame can transport a ring in either a proximal or distal direction with respect to other rings of the frame. Manipulation of another adjustable member of the bone transport frame can translate a central axis of one of the rings either toward or away from the central axes of the plurality of elongate struts.
摘要翻译： 本文公开了用于操纵多个骨碎片相对于彼此的取向的系统和方法。 公开了一种骨运送框架，其包括第一和第二环，多个细长支柱以及用于使第一骨段相对于第二骨段定向的多个环输送组件。 骨运送框架中可以包括第三环，用于相对于第一和第二骨段定向第三骨段。 骨运送框架的可调节构件的操纵可以相对于框架的其它环在近端或远端方向上输送环。 骨运送框架的另一可调节构件的操纵可使一个环的中心轴线朝向或远离多个细长支柱的中心轴线转移。
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公开(公告)号：US08834467B2
公开(公告)日：2014-09-16
申请号：US13206058
申请日：2011-08-09
CPC分类号： A61B17/60 , A61B17/62 , A61B17/66 , A61B17/8875
摘要： An external fixator system comprising at least two fixation plates which are arranged at a distance to each another, at least one adjustable length having a first end region and a second end region which are in connection with the fixation plates and at least one actuation unit to adjust the length of the strut in order to adjust the distance and/or orientation between the fixation plates. The actuation unit is in a fixed connection with at least one of the fixation plates as well as with at least one of the end regions of the respective strut in order to connect the strut with the fixation plate. The actuation unit comprises a feedback unit which provides the user with a feedback concerning the degree of the actuation.
摘要翻译： 一种外部固定器系统，包括至少两个彼此间隔设置的固定板，至少一个可调节的长度，具有与固定板连接的第一端部区域和第二端部区域，以及至少一个致动单元， 调整支柱的长度以调节固定板之间的距离和/或方位。 致动单元与至少一个固定板以及相应支柱的至少一个端部区域固定连接，以将支柱与固定板连接。 致动单元包括反馈单元，其向使用者提供关于致动程度的反馈。
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公开(公告)号：US20140058389A1
公开(公告)日：2014-02-27
申请号：US13592832
申请日：2012-08-23
IPC分类号： A61B17/62
摘要： Disclosed herein are systems and methods for manipulating the orientation of a plurality of bone fragments with respect to one another. A bone transport frame including first and second rings, a plurality of elongate struts, and a plurality of ring transport assemblies for orienting a first bone segment with respect to a second bone segment is disclosed. A third ring may be included in the bone transport frame for orienting a third bone segment with respect to the first and second bone segments. Manipulation of an adjustable member of the bone transport frame can transport a ring in either a proximal or distal direction with respect to other rings of the frame. Manipulation of another adjustable member of the bone transport frame can translate a central axis of one of the rings either toward or away from the central axes of the plurality of elongate struts.
摘要翻译： 本文公开了用于操纵多个骨碎片相对于彼此的取向的系统和方法。 公开了一种骨运送框架，其包括第一和第二环，多个细长支柱以及用于使第一骨段相对于第二骨段定向的多个环输送组件。 骨运送框架中可以包括第三环，用于相对于第一和第二骨段定向第三骨段。 骨运送框架的可调节构件的操纵可以相对于框架的其它环在近端或远端方向上输送环。 骨运送框架的另一可调节构件的操纵可使一个环的中心轴线朝向或远离多个细长支柱的中心轴线转移。
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公开(公告)号：US20120041439A1
公开(公告)日：2012-02-16
申请号：US13206058
申请日：2011-08-09
IPC分类号： A61B17/00
CPC分类号： A61B17/60 , A61B17/62 , A61B17/66 , A61B17/8875
摘要： An external fixator system comprising at least two fixation plates which are arranged at a distance to each another, at least one adjustable length having a first end region and a second end region which are in connection with the fixation plates and at least one actuation unit to adjust the length of the strut in order to adjust the distance and/or orientation between the fixation plates. The actuation unit is in a fixed connection with at least one of the fixation plates as well as with at least one of the end regions of the respective strut in order to connect the strut with the fixation plate. The actuation unit comprises a feedback unit which provides the user with a feedback concerning the degree of the actuation.
摘要翻译： 一种外部固定器系统，包括至少两个彼此间隔设置的固定板，至少一个可调节的长度，具有与固定板连接的第一端部区域和第二端部区域，以及至少一个致动单元， 调整支柱的长度以调节固定板之间的距离和/或方位。 致动单元与至少一个固定板以及相应支柱的至少一个端部区域固定连接，以将支柱与固定板连接。 致动单元包括反馈单元，其向使用者提供关于致动程度的反馈。
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公开(公告)号：US20110082458A1
公开(公告)日：2011-04-07
申请号：US12573310
申请日：2009-10-05
IPC分类号： A61B17/00
CPC分类号： A61B17/62 , A61B17/6441 , A61B17/645 , A61B17/848 , A61B17/88 , A61B2017/564 , A61B2017/681
摘要： An external fixation system and method for realigning, compressing or distracting broken bones has a planar ring element with an adjustable device having a body releasably mounted on the ring element. The adjustable device includes a first member for movement in a direction generally perpendicular to the ring element. A second member is pivotally connected to the first member for angular movement with respect to the ring. A third member is mounted on the second member for movement in a direction parallel to the second member and with respect to a circumference of the planar ring element. The method includes providing an external fixation system and inserting a k-wire through a first piece of bone and affixing the k-wire or half pin to the ring element. Then inserting a second k-wire or half pin through a second piece of bone and affixing the k-wire or half pin to an adjustable device. The pieces of bone are realigned, compressed or distracted by adjusting at least one of a first and second adjustable member forming the device.
摘要翻译： 用于重新排列，压缩或分散骨头的外部固定系统和方法具有平面环形元件，其具有可拆卸的装置，其具有可释放地安装在环形元件上的主体。 可调节装置包括用于沿大致垂直于环形元件的方向移动的第一构件。 第二构件枢转地连接到第一构件，用于相对于环角度运动。 第三构件安装在第二构件上，用于沿平行于第二构件的方向并相对于平面环形元件的圆周移动。 该方法包括提供外部固定系统，并将k线穿过第一块骨头并将k线或半销固定在环形元件上。 然后将第二k线或半针插入第二块骨头，并将k线或半针固定到可调节装置。 通过调节形成装置的第一和第二可调节构件中的至少一个来使骨块重新对准，压缩或分散。
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7.发明申请BIOCOMPATIBLE, NON-BIODEGRADABLE, NON-TOXIC POLYMER USEFUL FOR NANOPARTICLE PHARMACEUTICAL COMPOSITIONS 有权生物易燃，非生物降解，非毒性聚合物用于纳米脂肪药物组合物公开(公告)号：US20130274211A1
公开(公告)日：2013-10-17
申请号：US13633638
申请日：2012-10-02
申请人： Anand C. Burman , Rama Mukherjee , Dhiraj Khattar , Sanjoy Mullick , Manu Jaggi , Manoj Kumar Singh , Mukesh Kumar , Deepak Prusthy , Pawan Kumar Gupta , Rajendran Praveen , Shobhit Singh
发明人： Anand C. Burman , Rama Mukherjee , Dhiraj Khattar , Sanjoy Mullick , Manu Jaggi , Manoj Kumar Singh , Mukesh Kumar , Deepak Prusthy , Pawan Kumar Gupta , Rajendran Praveen , Shobhit Singh
IPC分类号： A61K47/32
CPC分类号： A61K47/32 , C08F220/56 , C08F222/12 , C08F222/385 , C08F226/10
摘要： The invention relates to a biocompatible, non-biodegradable, and non-toxic polymer of formula (I), comprising of three monomeric units, selected from 1-Vinylpyrrolidne (VP), N-Isopropylactylamide (NIPAM), and ester of Maleic anhydride and Polyethylene glycol (MPEG), cross-linked with a bi-functional vinyl derivative, of high purity and substantially free of respective toxic monomeric contaminants, and a process for preparation thereof. The invention further relates to nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds comprising the polymer of the invention, which are safe, less-toxic and convenient for bedside administration to patients in need thereof. Furthermore, the invention relates to a highly selective method for preparation of nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds.
摘要翻译： 本发明涉及式（I）的生物相容性，不可生物降解的和无毒的聚合物，其包含三种单体单元，其选自1-乙烯基吡咯烷酮（VP），N-异丙基丙烯酰胺（NIPAM）和马来酸酐的酯和 与双官能乙烯基衍生物交联的聚乙二醇（MPEG），其纯度高，基本上不含有毒的单体污染物及其制备方法。 本发明还涉及难溶于水的药物或包含本发明聚合物的化合物的纳米颗粒药物组合物，其对于有需要的患者的床边给药是安全的，毒性较小且方便的。 此外，本发明涉及用于制备难溶于水的药物或化合物的纳米颗粒药物组合物的高选择性方法。
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公开(公告)号：US08058302B2
公开(公告)日：2011-11-15
申请号：US12303235
申请日：2006-09-04
申请人： Kirtipalsinh Sajjansinh Solanki , Manoj Kumar Singh , Jay Shantilal Kothari , Virendra Kumar Agarwal
发明人： Kirtipalsinh Sajjansinh Solanki , Manoj Kumar Singh , Jay Shantilal Kothari , Virendra Kumar Agarwal
IPC分类号： A61K31/41 , C07D249/00
CPC分类号： C07D249/08
摘要： The present invention discloses two new related substances (6) and (7) of Anastrozole synthesis from Q.A. Salt (5) as in Scheme—1 and purification procedures to get Anastrozole (1) free from (6) and (7).
摘要翻译： 本发明公开了两种新的相关物质（6）和（7）。 盐（5）如方案-1和纯化程序得到不含（6）和（7）的阿那曲唑（1）。
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公开(公告)号：US08022055B2
公开(公告)日：2011-09-20
申请号：US11883753
申请日：2005-12-29
申请人： Rama Mukherjee , Sanjay Kumar Srivastava , Mohammad Jamshed Ahmed Siddiqui , Manu Jaggi , Anu T. Singh , Anand Vardhan , Manoj Kumar Singh , Praveen Rajendran , Hemant Kumar Jajoo , Anand C. Burman , Vivek Kumar , Nidhi Rani , Shiv Kumar Agarwal
发明人： Rama Mukherjee , Sanjay Kumar Srivastava , Mohammad Jamshed Ahmed Siddiqui , Manu Jaggi , Anu T. Singh , Anand Vardhan , Manoj Kumar Singh , Praveen Rajendran , Hemant Kumar Jajoo , Anand C. Burman , Vivek Kumar , Nidhi Rani , Shiv Kumar Agarwal
CPC分类号： C07J71/0005 , C07J71/0047
摘要： The invention relates to novel betulinic acid derivatives of formula (I), wherein R is C(═CH2)CH3 or CH(CH3)2; R2 together with the adjacent carbonyl group forms a carboxylic acid, carboxylic acid ester or amide or substituted amide; R3 or R4 are hydrogen or aryl with the proviso that both are not independently hydrogen or alkyl or R3 and R4 are combined together to form an aryl ring optionally substituted with a group X, wherein X is selected from halogen, alkyl, cyano, nitro, alkoxy, amino or substituted amine; Y is N or O; and R1 is zero when Y is O, and R1 is hydrogen, alkyl or aryl alkyl when Y is N, useful for inhibition of tumor cancer cells.
摘要翻译： 本发明涉及式（I）的新颖的桦木酸衍生物，其中R是C（= CH 2）CH 3或CH（CH 3）2; R2与相邻的羰基一起形成羧酸，羧酸酯或酰胺或取代的酰胺; R 3或R 4是氢或芳基，条件是两者不是独立地是氢或烷基，或者R 3和R 4结合在一起形成任选地被基团X取代的芳基，其中X选自卤素，烷基，氰基，硝基， 烷氧基，氨基或取代的胺; Y是N或O; 当Y为O时，R1为零，当Y为N时，R1为氢，烷基或芳基烷基，可用于抑制肿瘤细胞。
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公开(公告)号：US20110065927A1
公开(公告)日：2011-03-17
申请号：US12952707
申请日：2010-11-23
申请人： Kirtipalsinh Sajjansinh Solanki , Manoj Kumar Singh , Jay Shantilal Kothari , Virendra Kumar Agarwal
发明人： Kirtipalsinh Sajjansinh Solanki , Manoj Kumar Singh , Jay Shantilal Kothari , Virendra Kumar Agarwal
IPC分类号： C07D249/08
CPC分类号： C07D249/08
摘要： The present invention discloses two new related substances (6) and (7) of Anastrozole synthesis from Q.A. Salt (5) as in Scheme-1 and purification procedures to get Anastrozole (1) free from (6) and (7).
摘要翻译： 本发明公开了两种新的相关物质（6）和（7）。 盐（5）如方案-1和纯化程序得到不含（6）和（7）的阿那曲唑（1）。
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