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    METHODS AND SYSTEMS FOR DETECTION WITH FRONT IRRADIATION
    3.
    发明申请
    METHODS AND SYSTEMS FOR DETECTION WITH FRONT IRRADIATION 审中-公开
    用于检测前辐射的方法和系统

    公开(公告)号：US20100096561A1

    公开(公告)日：2010-04-22

    申请号：US12443863

    申请日：2007-10-03

    申请人： Mark Thomas Johnson ,  Marc Wilhelmus Gijsbert Ponjee ,  Marcello Leonardo Mario Balistreri ,  Maarten Marinus Johannes Wilhelmus Van Herpen ,  Derk Jan Wilfred Klunder

    发明人： Mark Thomas Johnson ,  Marc Wilhelmus Gijsbert Ponjee ,  Marcello Leonardo Mario Balistreri ,  Maarten Marinus Johannes Wilhelmus Van Herpen ,  Derk Jan Wilfred Klunder

    IPC分类号： G01N21/01 ,  G01J1/58

    CPC分类号： G01N21/6428 ,  B01L3/5027 ,  G01N21/6454

    摘要： A radiation detection system (100) is described comprising a measurement region (104) in a measurement chamber adapted for receiving at least one sample (108) to be examined and adapted for receiving excitation radiation for impingement on the at least one sample (108) and for generating sample radiation. The radiation detection system (100) furthermore comprises at least one detector element (106) for detection of the generated sample radiation. The radiation detection system thereby is a front irradiation system, i.e. the excitation radiation is incident on a first side of the measurement region (104) in a measurement chamber and the at least one detector element (106) is positioned at a second side of the measurement region (104) in a measurement chamber, the second side being opposite to the first side with respect to the measurement region (104) in a measurement chamber, such that detection occurs at the side facing the first side. The detection system (100) also comprises optical means (112) adapted for guiding said excitation radiation aside the at least one detector element (106).

    摘要翻译： 描述了辐射检测系统（100），其包括在测量室中的测量区域（104），其适于接收待检查的至少一个样品（108）并适于接收用于冲击至少一个样品（108）的激发辐射， 并用于产生样品辐射。 辐射检测系统（100）还包括用于检测所产生的样品辐射的至少一个检测器元件（106）。 因此，辐射检测系统是前照射系统，即激发辐射入射在测量室中的测量区域（104）的第一侧上，并且所述至少一个检测器元件（106）位于第二侧 测量室中的测量区域（104），第二侧在测量室中相对于测量区域（104）与第一侧相对，使得在面向第一侧的一侧发生检测。 检测系统（100）还包括适于将所述激发辐射引导到所述至少一个检测器元件（106）旁边的光学装置（112）。

    RADIATION DETECTORS USING EVANESCENT FIELD EXCITATION
    4.
    发明申请
    RADIATION DETECTORS USING EVANESCENT FIELD EXCITATION 审中-公开
    使用现场激励的辐射探测器

    公开(公告)号：US20090284746A1

    公开(公告)日：2009-11-19

    申请号：US12373995

    申请日：2007-07-04

    申请人： Derk Jan Wilfred Klunder ,  Maarten Marinus Johannes Wilhelm Van Herpen ,  Marcello Leonardo Mario Balistreri ,  Marc Wilhelmus Gijsbert Ponjee ,  Mark Thomas Johnson

    发明人： Derk Jan Wilfred Klunder ,  Maarten Marinus Johannes Wilhelm Van Herpen ,  Marcello Leonardo Mario Balistreri ,  Marc Wilhelmus Gijsbert Ponjee ,  Mark Thomas Johnson

    IPC分类号： G01N21/55 ,  G01N21/62

    CPC分类号： G01N21/6454 ,  B01L3/5027 ,  G01N21/6428 ,  G01N21/648 ,  G01N2021/7786

    摘要： A detection system (100, 150, 180, 200, 220, 250) for detecting luminescence from at least one sample (108) when excited by incident excitation radiation. Detecting luminescence may allow to detect, for example, biological, chemical or bio-chemical particles. The detection system (100, 150, 180, 200, 220, 250) comprising at least one optical component (102) with at least a first surface (104). The first surface (104) of the at least one optical component (102) is located to internally reflect incident excitation radiation to create an evanescent field outside the at least one optical component (102) for exciting the at least one sample (108). The detection system also comprises at least one detector element (110) that is in direct contact with the at least one optical component (102) to detect the luminescence from at least one excited sample (108) through the at least one optical component (102).

    摘要翻译： 用于当由入射激发辐射激发时用于检测来自至少一个样品（108）的发光的检测系统（100,150,180,200,250,250）。 检测发光可以允许检测例如生物，化学或生物化学颗粒。 所述检测系统（100,150,180,200,250,250）包括具有至少第一表面（104）的至少一个光学部件（102）。 所述至少一个光学部件（102）的第一表面（104）位于内部反射入射的激发辐射，以在所述至少一个光学部件（102）外部产生消逝场，用于激发所述至少一个样品（108）。 检测系统还包括至少一个与至少一个光学部件（102）直接接触的检测器元件（110），以检测来自至少一个激发的样品（108）的至少一个光学部件（102）的发光 ）。

    Sensor with Improved Signal-to Noise Ratio and Improved Accuracy
    5.
    发明申请
    Sensor with Improved Signal-to Noise Ratio and Improved Accuracy 审中-公开
    传感器具有改善的信噪比和改进的精度

    公开(公告)号：US20080302976A1

    公开(公告)日：2008-12-11

    申请号：US12096183

    申请日：2006-11-28

    申请人： Maarten Marinus Johannes Wilhelmus Van Herpen ,  Marcello Leonardo Mario Balistreri ,  Derk Jan Wilfred Klunder ,  Coen Theodorus Hubertus Fransiscus Liedenbaum

    发明人： Maarten Marinus Johannes Wilhelmus Van Herpen ,  Marcello Leonardo Mario Balistreri ,  Derk Jan Wilfred Klunder ,  Coen Theodorus Hubertus Fransiscus Liedenbaum

    IPC分类号： G01T1/10

    CPC分类号： G01N21/6456

    摘要： The present invention provides a sensor and a method for detecting an optically variable molecule (9) in a sample (3). The sensor comprises an excitation radiation source (1) for irradiating the sample (4) and exciting the optically variable molecule (9), thus generating a luminescence signal (7). The sensor furthermore comprises a modulation means (4) for modulating the excitation radiation beam (2) in a direction different from, preferably substantially perpendicular to, a scanning direction of the excitation radiation beam (2) over the sample (3). The method and sensor according to the invention lead to an improved signal-to-noise ratio by reducing and even minimising the background signal in the luminescence signal (7) and to an improved accuracy by minimising signals coming from false-positives.

    摘要翻译： 本发明提供一种用于检测样品（3）中的光学可变分子（9）的传感器和方法。 传感器包括用于照射样品（4）并激发光学可变分子（9）的激发辐射源（1），从而产生发光信号（7）。 传感器还包括调制装置（4），用于在与样品（3）上的激发辐射束（2）的扫描方向不同，优选地基本上垂直的方向上调制激发辐射束（2）。 根据本发明的方法和传感器通过减少甚至最小化发光信号（7）中的背景信号并通过最小化来自假阳性的信号来提高精度，从而提高了信噪比。

    System for Non-Invasive Measurement of Bloold Glucose Concentration
    7.
    发明申请
    System for Non-Invasive Measurement of Bloold Glucose Concentration 审中-公开
    Bloold葡萄糖浓度无创测量系统

    公开(公告)号：US20080269580A1

    公开(公告)日：2008-10-30

    申请号：US12158469

    申请日：2006-12-12

    申请人： Marcello Leonardo Mario Balistreri ,  Maarten Marinus Johannes Wilhelmus Van Herpen ,  Antonius Theodorus Martinus Van Gogh

    发明人： Marcello Leonardo Mario Balistreri ,  Maarten Marinus Johannes Wilhelmus Van Herpen ,  Antonius Theodorus Martinus Van Gogh

    IPC分类号： A61B5/01 ,  A61B5/1468 ,  A61B8/06

    CPC分类号： A61B5/0066 ,  A61B5/015 ,  A61B5/14532 ,  A61B5/1455

    摘要： A system and method for non-invasive measurement of glucose concentration in a live subject including a thermal emission spectroscopy (TES) device 10, an optical coherence tomography (OCT) device 20 or near infrared diffuse reflectance (NIDR) device. The TES 10 generates a signal indicative of the absorbtion of glucose, from which the blood glucose concentration is determined and the OCT device 20 generates a signal indicative of the scattering coefficient of a portion of the live subject, from which the blood glucose concentration is determined. The signals generated by the TES and OCT devices along with signals generated by sensors for measuring the body heat and surface temperature of the subject are used in the metabolic heat conformation (MHC) method of determining blood glucose concentration. The system may include a photoacoustic sensor for generating a signal indicative of thermo-elastic skin properties from which the blood glucose concentration is also determined.

    摘要翻译： 包括热发射光谱（TES）装置10，光学相干断层摄影（OCT）装置20或近红外漫反射（NIDR）装置的活体内的葡萄糖浓度无创测量的系统和方法。 TES10产生指示葡萄糖吸收的信号，从该葡萄糖中测定血糖浓度，并且OCT装置20产生指示活体受试者的一部分的散射系数的信号，从该血糖浓度确定血葡萄糖浓度 。 在测定血糖浓度的代谢热构象（MHC）方法中使用由TES和OCT装置产生的信号以及由传感器产生的用于测量受试者体温和表面温度的信号。 该系统可以包括光声传感器，用于产生指示也确定血糖浓度的热弹性皮肤特性的信号。

    Glucose Sensor
    8.
    发明申请
    Glucose Sensor 审中-公开
    葡萄糖传感器

    公开(公告)号：US20080200781A1

    公开(公告)日：2008-08-21

    申请号：US11914976

    申请日：2006-05-19

    申请人： Maarten Marinus Johannes Wilhelmus Van Herpen ,  Marcello Leonardo Mario Balistreri ,  Cristian Presura

    发明人： Maarten Marinus Johannes Wilhelmus Van Herpen ,  Marcello Leonardo Mario Balistreri ,  Cristian Presura

    IPC分类号： A61B5/00

    CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/6826 ,  A61B5/6838

    摘要： A system for the non-invasive measurement of glucose concentration in a live subject is disclosed. The system exploits the metabolic heat conformation method, and comprises temperature sensing means for measuring the body heat in respect of the subject and means for measuring the concentration of haemoglobin and oxygenated haemoglobin in the blood of the subject. The system further comprises irradiating means for irradiating a portion of the live subject, a detector for collecting the measuring beam reflected by the live subject, means for determining from the reflected measuring beam, the blood flow velocity in respect of the live subject, and means for determining glucose concentration in the live subject as a function of the body heat, the haemoglobin and oxygenated haemoglobin concentrations and the blood flow velocity.

    摘要翻译： 公开了一种在活体受试者中非侵入性地测量葡萄糖浓度的系统。 该系统利用代谢热构象方法，并且包括用于测量对象的身体热量的温度感测装置和用于测量受试者血液中血红蛋白和氧合血红蛋白浓度的装置。 该系统还包括用于照射活体的一部分的照射装置，用于收集由活体受体反射的测量光束的检测器，用于根据反射的测量光束确定关于活体的血流速度的装置，以及装置 用于测定活体受试者中的葡萄糖浓度作为体热，血红蛋白和氧合血红蛋白浓度和血流速度的函数。