Sensor with Improved Signal-to Noise Ratio and Improved Accuracy
    2.
    发明申请
    Sensor with Improved Signal-to Noise Ratio and Improved Accuracy 审中-公开
    传感器具有改善的信噪比和改进的精度

    公开(公告)号:US20080302976A1

    公开(公告)日:2008-12-11

    申请号:US12096183

    申请日:2006-11-28

    IPC分类号: G01T1/10

    CPC分类号: G01N21/6456

    摘要: The present invention provides a sensor and a method for detecting an optically variable molecule (9) in a sample (3). The sensor comprises an excitation radiation source (1) for irradiating the sample (4) and exciting the optically variable molecule (9), thus generating a luminescence signal (7). The sensor furthermore comprises a modulation means (4) for modulating the excitation radiation beam (2) in a direction different from, preferably substantially perpendicular to, a scanning direction of the excitation radiation beam (2) over the sample (3). The method and sensor according to the invention lead to an improved signal-to-noise ratio by reducing and even minimising the background signal in the luminescence signal (7) and to an improved accuracy by minimising signals coming from false-positives.

    摘要翻译: 本发明提供一种用于检测样品(3)中的光学可变分子(9)的传感器和方法。 传感器包括用于照射样品(4)并激发光学可变分子(9)的激发辐射源(1),从而产生发光信号(7)。 传感器还包括调制装置(4),用于在与样品(3)上的激发辐射束(2)的扫描方向不同,优选地基本上垂直的方向上调制激发辐射束(2)。 根据本发明的方法和传感器通过减少甚至最小化发光信号(7)中的背景信号并通过最小化来自假阳性的信号来提高精度,从而提高了信噪比。

    METHODS AND SYSTEMS FOR DETECTION WITH FRONT IRRADIATION
    6.
    发明申请
    METHODS AND SYSTEMS FOR DETECTION WITH FRONT IRRADIATION 审中-公开
    用于检测前辐射的方法和系统

    公开(公告)号:US20100096561A1

    公开(公告)日:2010-04-22

    申请号:US12443863

    申请日:2007-10-03

    IPC分类号: G01N21/01 G01J1/58

    摘要: A radiation detection system (100) is described comprising a measurement region (104) in a measurement chamber adapted for receiving at least one sample (108) to be examined and adapted for receiving excitation radiation for impingement on the at least one sample (108) and for generating sample radiation. The radiation detection system (100) furthermore comprises at least one detector element (106) for detection of the generated sample radiation. The radiation detection system thereby is a front irradiation system, i.e. the excitation radiation is incident on a first side of the measurement region (104) in a measurement chamber and the at least one detector element (106) is positioned at a second side of the measurement region (104) in a measurement chamber, the second side being opposite to the first side with respect to the measurement region (104) in a measurement chamber, such that detection occurs at the side facing the first side. The detection system (100) also comprises optical means (112) adapted for guiding said excitation radiation aside the at least one detector element (106).

    摘要翻译: 描述了辐射检测系统(100),其包括在测量室中的测量区域(104),其适于接收待检查的至少一个样品(108)并适于接收用于冲击至少一个样品(108)的激发辐射, 并用于产生样品辐射。 辐射检测系统(100)还包括用于检测所产生的样品辐射的至少一个检测器元件(106)。 因此,辐射检测系统是前照射系统,即激发辐射入射在测量室中的测量区域(104)的第一侧上,并且所述至少一个检测器元件(106)位于第二侧 测量室中的测量区域(104),第二侧在测量室中相对于测量区域(104)与第一侧相对,使得在面向第一侧的一侧发生检测。 检测系统(100)还包括适于将所述激发辐射引导到所述至少一个检测器元件(106)旁边的光学装置(112)。

    RADIATION DETECTORS USING EVANESCENT FIELD EXCITATION
    7.
    发明申请
    RADIATION DETECTORS USING EVANESCENT FIELD EXCITATION 审中-公开
    使用现场激励的辐射探测器

    公开(公告)号:US20090284746A1

    公开(公告)日:2009-11-19

    申请号:US12373995

    申请日:2007-07-04

    IPC分类号: G01N21/55 G01N21/62

    摘要: A detection system (100, 150, 180, 200, 220, 250) for detecting luminescence from at least one sample (108) when excited by incident excitation radiation. Detecting luminescence may allow to detect, for example, biological, chemical or bio-chemical particles. The detection system (100, 150, 180, 200, 220, 250) comprising at least one optical component (102) with at least a first surface (104). The first surface (104) of the at least one optical component (102) is located to internally reflect incident excitation radiation to create an evanescent field outside the at least one optical component (102) for exciting the at least one sample (108). The detection system also comprises at least one detector element (110) that is in direct contact with the at least one optical component (102) to detect the luminescence from at least one excited sample (108) through the at least one optical component (102).

    摘要翻译: 用于当由入射激发辐射激发时用于检测来自至少一个样品(108)的发光的检测系统(100,150,180,200,250,250)。 检测发光可以允许检测例如生物,化学或生物化学颗粒。 所述检测系统(100,150,180,200,250,250)包括具有至少第一表面(104)的至少一个光学部件(102)。 所述至少一个光学部件(102)的第一表面(104)位于内部反射入射的激发辐射,以在所述至少一个光学部件(102)外部产生消逝场,用于激发所述至少一个样品(108)。 检测系统还包括至少一个与至少一个光学部件(102)直接接触的检测器元件(110),以检测来自至少一个激发的样品(108)的至少一个光学部件(102)的发光 )。

    Multi Layer Variable Refractive Index Unit
    8.
    发明申请
    Multi Layer Variable Refractive Index Unit 审中-公开
    多层可变折射率单位

    公开(公告)号:US20080253262A1

    公开(公告)日:2008-10-16

    申请号:US10598991

    申请日:2005-03-08

    IPC分类号: G11B7/135

    摘要: A variable refractive index unit (140) includes an optical axis and a first layer (144a, 146a, 146a′ of controllably variable refractive index extending in a first predetermined configuration in a first plane transverse the optical axis. A second, different layer (144b, 146b, 146b′ of controllably variable refractive index extends in a second predetermined configuration in a second, different plane transverse the optical axis. The second layer (144b, 146b, 146b′) overlaps the first layer (144a, 146a, 146a′).

    摘要翻译: 可变折射率单元(140)包括光轴和在第一平面中沿第一预定结构延伸的可控地可变的折射率的第一层(144a,146a,146a'),横向于光轴;第二,不同的 第二层(144b,146b,146b')与第一层(144b,146b,146b')重叠在第一层 层(144a,146a,146a')。

    Optical Device for Recording and Reproducing Holographic Data
    10.
    发明申请
    Optical Device for Recording and Reproducing Holographic Data 审中-公开
    用于记录和再现全息数据的光学装置

    公开(公告)号:US20080291806A1

    公开(公告)日:2008-11-27

    申请号:US11568717

    申请日:2005-05-09

    IPC分类号: G11B7/00

    摘要: The invention relates to an optical recording and reproducing device. This device comprises means for receiving a recording medium (204), a radiation source (200) for producing a radiation beam, means (206) for detecting light corresponding to a holographic signal recorded in the recording medium, means (202) for directing the radiation beam towards the receiving means, and a reflective spatial light modulator (205) placed on the other side of the receiving means with respect to the detecting means.

    摘要翻译: 本发明涉及一种光学记录和再现装置。 该装置包括用于接收记录介质(204),用于产生辐射束的辐射源(200)的装置,用于检测对应于记录在记录介质中的全息信号的光的装置(206),用于引导 朝向接收装置的辐射束,以及相对于检测装置放置在接收装置的另一侧的反射空间光调制器(205)。