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1.发明授权Halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors 失效用作一氧化氮合酶抑制剂的卤代2-氨基-5,6-庚烯酸衍生物公开(公告)号：US06465686B2
公开(公告)日：2002-10-15
申请号：US09835191
申请日：2001-04-13
申请人： Margaret L. Grapperhaus , James A. Sikorski , Alok K. Awasthi , Lijuan J. Wang , Barnett S. Pitzele , Donald W. Hansen, Jr. , Pamela T. Manning
发明人： Margaret L. Grapperhaus , James A. Sikorski , Alok K. Awasthi , Lijuan J. Wang , Barnett S. Pitzele , Donald W. Hansen, Jr. , Pamela T. Manning
IPC分类号： C07C24100
CPC分类号： C07D271/07 , C07B2200/07 , C07C257/14 , C07C259/14 , C07D257/06
摘要： The present invention discloses halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
摘要翻译： 本发明公开了用作一氧化氮合酶抑制剂的卤代2-氨基-5,6-庚烯酸衍生物。
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公开(公告)号：US06914158B2
公开(公告)日：2005-07-05
申请号：US10815375
申请日：2004-04-01
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
IPC分类号： A61P1/00 , A61K31/198 , A61K31/4166 , A61K31/4245 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/00 , A61P3/08 , A61P3/10 , A61P7/06 , A61P9/00 , A61P9/02 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P15/00 , A61P15/08 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/04 , A61P19/06 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/10 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P39/02 , A61P43/00 , C07C317/48 , C07C317/50 , C07C323/58 , C07C323/59 , C07D233/76 , C07D271/06 , C07D271/07 , C07D277/56 , C07C323/00
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.
摘要翻译： 本发明涉及脒基化合物及其盐和前药。 在另一个实施方案中，本发明还提供本发明化合物在治疗中的用途，特别是作为一氧化氮合酶抑制剂。 在另一个实施方案中，本发明提供了制备脒基化合物的方法。
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3.发明授权Halogenated 2-amino-3, 4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors 失效用作一氧化氮合酶抑制剂的卤化2-氨基-3,4-庚烯酸衍生物公开(公告)号：US06586471B1
公开(公告)日：2003-07-01
申请号：US09835193
申请日：2001-04-13
申请人： Donald W. Hansen, Jr. , Barnett S. Pitzele , Ronald Keith Webber , Mihaly V. Toth , Pamela T. Manning , Alok K. Awasthi , Mahima Trivedi
发明人： Donald W. Hansen, Jr. , Barnett S. Pitzele , Ronald Keith Webber , Mihaly V. Toth , Pamela T. Manning , Alok K. Awasthi , Mahima Trivedi
IPC分类号： A61K3122
CPC分类号： C07D209/48 , C07C257/14 , C07D263/04 , C07D263/06 , C07D413/06
摘要： The present invention contains halogenated 2-amino-3,4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
摘要翻译： 本发明包含可用作一氧化氮合酶抑制剂的卤代2-氨基-3,4-庚烯酸衍生物。
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4.发明授权Methods of making amidino compounds useful as nitric oxide synthase inhibitors 有权制备脒基化合物可用作一氧化氮合酶抑制剂的方法公开(公告)号：US07102013B2
公开(公告)日：2006-09-05
申请号：US10321969
申请日：2002-12-17
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
IPC分类号： C07D233/40 , C07C271/00 , C07C323/00
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： Method of making an alpha-amino acid compound having the structure of Formula 32: comprising treating under hydrolyzing conditions a hydantoin compound having the structure of Formula 33: where the substituents are described herein.
摘要翻译： 制备具有式32结构的α-氨基酸化合物的方法：包括在水解条件下处理具有结构式33的乙内酰脲化合物：其中取代基在本文中描述。
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公开(公告)号：US07196118B2
公开(公告)日：2007-03-27
申请号：US11032650
申请日：2005-01-10
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
IPC分类号： A61K31/195
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.
摘要翻译： 本发明涉及脒基化合物及其盐和前药。 在另一个实施方案中，本发明还提供本发明化合物在治疗中的用途，特别是作为一氧化氮合酶抑制剂。 在另一个实施方案中，本发明提供了制备脒基化合物的方法。
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公开(公告)号：US06586474B2
公开(公告)日：2003-07-01
申请号：US09816575
申请日：2001-03-23
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
IPC分类号： A61K31195
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.
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公开(公告)号：US06489323B1
公开(公告)日：2002-12-03
申请号：US09329583
申请日：1999-06-10
申请人： Donald W. Hansen, Jr. , R. Keith Webber , E. Ann Hallinan , Mihaly V. Toth , Barnett S. Pitzele , Alok K. Awasthi , Alan E. Moormann , Suzanne Metz , Jeffery S. Snyder , William M. Moore , Jeffrey A. Scholten
发明人： Donald W. Hansen, Jr. , R. Keith Webber , E. Ann Hallinan , Mihaly V. Toth , Barnett S. Pitzele , Alok K. Awasthi , Alan E. Moormann , Suzanne Metz , Jeffery S. Snyder , William M. Moore , Jeffrey A. Scholten
IPC分类号： C07D49804
CPC分类号： C07D487/04 , C07D513/04 , C07D515/04 , C07F9/6561
摘要： The current invention relates to compounds of Formula I pharmaceutical compositions and methods of use as nitric oxide synthase inhibitors, wherein the substituents are defined in the application.
摘要翻译： 本发明涉及式I药物组合物的化合物和用作一氧化氮合酶抑制剂的方法，其中取代基在本申请中定义。
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8.发明授权2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors 失效可用作一氧化氮合酶抑制剂的2-氨基-2-烷基-4-己烯酸和己炔酸衍生物公开(公告)号：US07005450B2
公开(公告)日：2006-02-28
申请号：US10819853
申请日：2004-04-07
申请人： Richard C. Durley , James Sikorski , Donald W. Hansen, Jr. , Michelle A. Promo , Ronald Keith Webber , Barnett S. Pitzele , Alok K. Awasthi , Alan Moormann
发明人： Richard C. Durley , James Sikorski , Donald W. Hansen, Jr. , Michelle A. Promo , Ronald Keith Webber , Barnett S. Pitzele , Alok K. Awasthi , Alan Moormann
IPC分类号： A61K31/195
CPC分类号： C07D209/48 , A61K31/198 , C07C229/30 , C07C251/08 , C07C251/16 , C07C255/30 , C07C257/14 , C07C271/22 , C07D271/07 , C07D413/06
摘要： The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
摘要翻译： 本发明涉及2-氨基-2-烷基-4-己烯酸和己酸衍生物及其在治疗中的用途，特别是其用作一氧化氮合酶抑制剂。
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9.发明授权2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors 失效可用作一氧化氮合酶抑制剂的2-氨基-2-烷基-4-己烯酸和己炔酸衍生物公开(公告)号：US06756406B2
公开(公告)日：2004-06-29
申请号：US09952906
申请日：2001-09-15
申请人： Richard C. Durley , James Sikorski , Donald W. Hansen, Jr. , Michelle A. Promo , Ronald Keith Webber , Barnett S. Pitzele , Alok K. Awasthi , Alan Moorman
发明人： Richard C. Durley , James Sikorski , Donald W. Hansen, Jr. , Michelle A. Promo , Ronald Keith Webber , Barnett S. Pitzele , Alok K. Awasthi , Alan Moorman
IPC分类号： C07D27106
CPC分类号： C07D209/48 , A61K31/198 , C07C229/30 , C07C251/08 , C07C251/16 , C07C255/30 , C07C257/14 , C07C271/22 , C07D271/07 , C07D413/06
摘要： The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
摘要翻译： 本发明涉及2-氨基-2-烷基-4-己烯酸和己酸衍生物及其在治疗中的用途，特别是其用作一氧化氮合酶抑制剂。
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公开(公告)号：US06403830B2
公开(公告)日：2002-06-11
申请号：US09816577
申请日：2001-03-23
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey S. Snyder , Mahima Trivedi , Sofya Tsymbalov
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey S. Snyder , Mahima Trivedi , Sofya Tsymbalov
IPC分类号： C07C32358
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： The present invention relates to S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine, or a pharmaceutically acceptable salt thereof.
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