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公开(公告)号：US09267163B2
公开(公告)日：2016-02-23
申请号：US11067260
申请日：2005-02-25
申请人： Maria Aricò , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marzia Monica Giuliani , Mariagrazia Pizza
发明人： Maria Aricò , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marzia Monica Giuliani , Mariagrazia Pizza
CPC分类号： A61K39/095 , A61K38/00 , A61K2039/545 , A61K2039/55505 , A61K2039/572 , A61K2039/575 , C07K14/22 , C07K2319/00 , C12P21/00 , C12P21/02 , C12Q1/689 , C12Q2600/156
摘要： Two or more Neisserial proteins (e.g. A and B) are expressed as a single hybrid protein which can be represented simply by the formula NH2-A-B—COOH.
摘要翻译： 两个或更多个奈赛尔蛋白（例如A和B）被表达为可以简单地用式NH 2 -A-B-COOH表示的单一杂合蛋白。
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公开(公告)号：US20060051840A1
公开(公告)日：2006-03-09
申请号：US11067260
申请日：2005-02-25
申请人： Maria Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Guiliani , Mariagrazia Pizza
发明人： Maria Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Guiliani , Mariagrazia Pizza
CPC分类号： A61K39/095 , A61K38/00 , A61K2039/545 , A61K2039/55505 , A61K2039/572 , A61K2039/575 , C07K14/22 , C07K2319/00 , C12P21/00 , C12P21/02 , C12Q1/689 , C12Q2600/156
摘要： Two or more Neisserial proteins (e.g. A and B) are expressed as a single hybrid protein which can be represented simply by the formula NH2-A-B—COOH.
摘要翻译： 两个或更多个Neisserial蛋白（例如A和B）被表达为单独的杂合蛋白，其可以简单地用式NH 2 -A-B-COOH表示。
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公开(公告)号：US20130005667A1
公开(公告)日：2013-01-03
申请号：US13340549
申请日：2011-12-29
申请人： Maria Beatrice Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Monica Guiliani , Mariagrazia Pizza
发明人： Maria Beatrice Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Monica Guiliani , Mariagrazia Pizza
IPC分类号： A61K38/16
CPC分类号： A61K39/095 , A61K38/00 , A61K2039/545 , A61K2039/55505 , A61K2039/572 , A61K2039/575 , C07K14/22 , C07K2319/00 , C12P21/00 , C12P21/02 , C12Q1/689 , C12Q2600/156
摘要： Alternative and improved approaches to the heterologous expression of the proteins of Neisseria meningitidis and Neisseria gonorrhoeae. These approaches typically affect the level of expression, the ease of purification, the cellular localisation, and/or the immunological properties of the expressed protein.
摘要翻译： 脑膜炎奈瑟氏球菌和淋病奈瑟氏球菌的异源表达的替代和改进的方法。 这些方法通常影响表达水平，纯化的便利性，细胞定位和/或表达的蛋白质的免疫学性质。
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公开(公告)号：US20100267931A1
公开(公告)日：2010-10-21
申请号：US12825210
申请日：2010-06-28
申请人： Maria Beatrice ARICO , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Monica Guiliani , Mariagrazia Pizza
发明人： Maria Beatrice ARICO , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Monica Guiliani , Mariagrazia Pizza
CPC分类号： A61K39/095 , A61K38/00 , A61K2039/545 , A61K2039/55505 , A61K2039/572 , A61K2039/575 , C07K14/22 , C07K2319/00 , C12P21/00 , C12P21/02 , C12Q1/689 , C12Q2600/156
摘要： Alternative and improved approaches to the heterologous expression of the proteins of Neisseria meningitidis and Neisseria gonorrhoeae. These approaches typically affect the level of expression, the ease of purification, the cellular localisation, and/or the immunological properties of the expressed protein.
摘要翻译： 脑膜炎奈瑟氏球菌和淋病奈瑟氏球菌的异源表达的替代和改进的方法。 这些方法通常影响表达水平，纯化的便利性，细胞定位和/或表达的蛋白质的免疫学性质。
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公开(公告)号：US07803387B2
公开(公告)日：2010-09-28
申请号：US10220481
申请日：2001-02-28
申请人： Maria Beatrice Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Monica Guiliani , Mariagrazia Pizza
发明人： Maria Beatrice Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Monica Guiliani , Mariagrazia Pizza
IPC分类号： A61K39/095 , A61K39/38 , A61K38/00 , C12P1/00 , C12P39/00
CPC分类号： A61K39/095 , A61K38/00 , A61K2039/545 , A61K2039/55505 , A61K2039/572 , A61K2039/575 , C07K14/22 , C07K2319/00 , C12P21/00 , C12P21/02 , C12Q1/689 , C12Q2600/156
摘要： Alternative and improved approaches to the heterologous expression of the proteins of Neisseria meningitidis and Neisseria gonorrhoeae. These approaches typically affect the level of expression, the ease of purification, the cellular localization, and/or the immunological properties of the expressed protein.
摘要翻译： 脑膜炎奈瑟氏球菌和淋病奈瑟氏球菌的异源表达的替代和改进的方法。 这些方法通常影响表达水平，纯化的便利性，细胞定位和/或表达的蛋白质的免疫学性质。
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公开(公告)号：US08703914B2
公开(公告)日：2014-04-22
申请号：US13340549
申请日：2011-12-29
申请人： Maria Beatrice Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Monica Guiliani , Mariagrazia Pizza
发明人： Maria Beatrice Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Monica Guiliani , Mariagrazia Pizza
IPC分类号： C07K1/00
CPC分类号： A61K39/095 , A61K38/00 , A61K2039/545 , A61K2039/55505 , A61K2039/572 , A61K2039/575 , C07K14/22 , C07K2319/00 , C12P21/00 , C12P21/02 , C12Q1/689 , C12Q2600/156
摘要： Alternative and improved approaches to the heterologous expression of the proteins of Neisseria meningitidis and Neisseria gonorrhoeae. These approaches typically affect the level of expression, the ease of purification, the cellular localization, and/or the immunological properties of the expressed protein.
摘要翻译： 脑膜炎奈瑟氏球菌和淋病奈瑟氏球菌的异源表达的替代和改进的方法。 这些方法通常影响表达水平，纯化的便利性，细胞定位和/或表达的蛋白质的免疫学性质。
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公开(公告)号：US08114960B2
公开(公告)日：2012-02-14
申请号：US12825210
申请日：2010-06-28
申请人： Maria Beatrice Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marzia Monica Guiliani , Mariagrazia Pizza
发明人： Maria Beatrice Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marzia Monica Guiliani , Mariagrazia Pizza
IPC分类号： A61K38/00 , A61K38/095
CPC分类号： A61K39/095 , A61K38/00 , A61K2039/545 , A61K2039/55505 , A61K2039/572 , A61K2039/575 , C07K14/22 , C07K2319/00 , C12P21/00 , C12P21/02 , C12Q1/689 , C12Q2600/156
摘要： Alternative and improved approaches to the heterologous expression of the proteins of Neisseria meningitidis and Neisseria gonorrhoeae. These approaches typically affect the level of expression, the ease of purification, the cellular localization, and/or the immunological properties of the expressed protein.
摘要翻译： 脑膜炎奈瑟氏球菌和淋病奈瑟氏球菌的异源表达的替代和改进的方法。 这些方法通常影响表达水平，纯化的便利性，细胞定位和/或表达的蛋白质的免疫学性质。
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公开(公告)号：US08398999B2
公开(公告)日：2013-03-19
申请号：US13556139
申请日：2012-07-23
IPC分类号： A61K39/095 , C07H21/04 , C12P21/04 , C07K14/00
CPC分类号： C07K14/22 , A61K38/164 , A61K39/095 , C07K2319/00
摘要： NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other.
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9.发明授权公开(公告)号：US08226960B2
公开(公告)日：2012-07-24
申请号：US12085413
申请日：2006-11-27
IPC分类号： A61K39/095 , C07H21/04 , C12P21/04 , C07K14/00
CPC分类号： C07K14/22 , A61K38/164 , A61K39/095 , C07K2319/00
摘要： NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other.
摘要翻译： NMB1870是脑膜炎奈瑟氏球菌中的蛋白质。 NMB1870的三个家族是已知的。 为了增加NMB1870蛋白质引起家族之间交叉反应的抗体的能力，NMB1870被设计。 序列可以从一个NMB1870家族代替到另一个家族的相应位置。 来自不同家族的NMB1870序列的蛋白质可以彼此连接。
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10.发明申请CHIMERIC, HYBRID AND TANDEM POLYPEPTIDES OF MENINGOCOCCAL NMB1870 有权70 IC 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70公开(公告)号：US20110166323A1
公开(公告)日：2011-07-07
申请号：US12085413
申请日：2006-11-27
CPC分类号： C07K14/22 , A61K38/164 , A61K39/095 , C07K2319/00
摘要： NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other.
摘要翻译： NMB1870是脑膜炎奈瑟氏球菌中的蛋白质。 NMB1870的三个家族是已知的。 为了增加NMB1870蛋白质引起家族之间交叉反应的抗体的能力，NMB1870被设计。 序列可以从一个NMB1870家族代替到另一个家族的相应位置。 来自不同家族的NMB1870序列的蛋白质可以彼此连接。
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