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公开(公告)号：US08398999B2
公开(公告)日：2013-03-19
申请号：US13556139
申请日：2012-07-23
IPC分类号： A61K39/095 , C07H21/04 , C12P21/04 , C07K14/00
CPC分类号： C07K14/22 , A61K38/164 , A61K39/095 , C07K2319/00
摘要： NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other.
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2.发明授权公开(公告)号：US08226960B2
公开(公告)日：2012-07-24
申请号：US12085413
申请日：2006-11-27
IPC分类号： A61K39/095 , C07H21/04 , C12P21/04 , C07K14/00
CPC分类号： C07K14/22 , A61K38/164 , A61K39/095 , C07K2319/00
摘要： NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other.
摘要翻译： NMB1870是脑膜炎奈瑟氏球菌中的蛋白质。 NMB1870的三个家族是已知的。 为了增加NMB1870蛋白质引起家族之间交叉反应的抗体的能力，NMB1870被设计。 序列可以从一个NMB1870家族代替到另一个家族的相应位置。 来自不同家族的NMB1870序列的蛋白质可以彼此连接。
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3.发明申请CHIMERIC, HYBRID AND TANDEM POLYPEPTIDES OF MENINGOCOCCAL NMB1870 有权70 IC 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70公开(公告)号：US20110166323A1
公开(公告)日：2011-07-07
申请号：US12085413
申请日：2006-11-27
CPC分类号： C07K14/22 , A61K38/164 , A61K39/095 , C07K2319/00
摘要： NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other.
摘要翻译： NMB1870是脑膜炎奈瑟氏球菌中的蛋白质。 NMB1870的三个家族是已知的。 为了增加NMB1870蛋白质引起家族之间交叉反应的抗体的能力，NMB1870被设计。 序列可以从一个NMB1870家族代替到另一个家族的相应位置。 来自不同家族的NMB1870序列的蛋白质可以彼此连接。
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公开(公告)号：US20110008279A1
公开(公告)日：2011-01-13
申请号：US12086226
申请日：2006-12-06
CPC分类号： A61K39/39 , A61K2039/55544
摘要： This invention is in the field of immunology and relates to the discovery that adhesins are potent activators of dendritic cells.
摘要翻译： 本发明在免疫学领域中，并且涉及粘附素是树突细胞的有效激活剂的发现。
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5.发明申请CHIMERIC, HYBRID AND TANDEM POLYPEPTIDES OF MENINGOCOCCAL NMB1870 有权70 IC 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70公开(公告)号：US20120283413A1
公开(公告)日：2012-11-08
申请号：US13556139
申请日：2012-07-23
IPC分类号： C07K14/22
CPC分类号： C07K14/22 , A61K38/164 , A61K39/095 , C07K2319/00
摘要： NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other.
摘要翻译： NMB1870是脑膜炎奈瑟氏球菌中的蛋白质。 NMB1870的三个家族是已知的。 为了增加NMB1870蛋白质引起家族之间交叉反应的抗体的能力，NMB1870被设计。 序列可以从一个NMB1870家族代替到另一个家族的相应位置。 来自不同家族的NMB1870序列的蛋白质可以彼此连接。
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公开(公告)号：US09579372B2
公开(公告)日：2017-02-28
申请号：US12918729
申请日：2009-02-20
IPC分类号： A61K39/095 , A61K39/02 , A61K39/38 , A61K38/00 , C07K1/00 , C07H21/04 , C12N15/00 , C07K14/22 , A61K39/00
CPC分类号： A61K39/095 , A61K39/00 , C07K14/22
摘要： fHBP is a protein in Neisseria meningitidis. Three families of fHBP are known. To increase the ability of a fHBP protein to elicit antibodies that are cross-reactive between the families, fHBP is selected or engineered to have a sequence which can elicit broad-spectrum bactericidal anti-meningococcal antibodies after administration to a host animal.
摘要翻译： fHBP是脑膜炎奈瑟菌中的蛋白质。 已知三个fHBP家族。 为了增加fHBP蛋白引起家族之间交叉反应的抗体的能力，选择或改造fHBP以具有在给予宿主动物后可引发广谱杀菌抗脑膜炎球菌抗体的序列。
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公开(公告)号：US20110076300A1
公开(公告)日：2011-03-31
申请号：US12870718
申请日：2010-08-27
IPC分类号： A61K39/095 , C07K16/00 , C07H21/00 , A61K39/00 , A61P31/04 , A61P37/04 , C12N15/63 , C12N1/21 , C12N1/00
CPC分类号： C07K14/22 , A61K39/00 , C07K2319/00
摘要： fHBP is a protein in Neisseria meningitidis. Three families of fHBP are known. To increase the ability of a fHBP protein to elicit antibodies that are cross-reactive between the families, fHBP is selected or engineered to have a sequence which can elicit broad-spectrum bactericidal anti-meningococcal antibodies after administration to a host animal.
摘要翻译： fHBP是脑膜炎奈瑟菌中的蛋白质。 已知三个fHBP家族。 为了增加fHBP蛋白引起家族之间交叉反应的抗体的能力，选择或改造fHBP以具有在给予宿主动物后可引发广谱杀菌抗脑膜炎球菌抗体的序列。
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公开(公告)号：US20110020390A1
公开(公告)日：2011-01-27
申请号：US12918729
申请日：2009-02-20
IPC分类号： A61K39/385 , C07K2/00 , C12N15/31 , C12N15/63 , C12N1/00 , C12N1/21 , A61K39/095 , A61P37/04
CPC分类号： A61K39/095 , A61K39/00 , C07K14/22
摘要： fHBP is a protein in Neisseria meningitidis. Three families of fHBP are known. To increase the ability of a fHBP protein to elicit antibodies that are cross-reactive between the families, fHBP is selected or engineered to have a sequence which can elicit broad-spectrum bactericidal anti-meningococcal antibodies after administration to a host animal.
摘要翻译： fHBP是脑膜炎奈瑟菌中的蛋白质。 已知三个fHBP家族。 为了增加fHBP蛋白引起家族之间交叉反应的抗体的能力，选择或改造fHBP以具有在给予宿主动物后可引发广谱杀菌抗脑膜炎球菌抗体的序列。
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公开(公告)号：US20120135024A1
公开(公告)日：2012-05-31
申请号：US13070448
申请日：2011-03-23
申请人： Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人： Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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公开(公告)号：US20090232820A1
公开(公告)日：2009-09-17
申请号：US12013047
申请日：2008-01-11
申请人： Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人： Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
IPC分类号： A61K39/395 , C07K7/06 , C07K7/08 , C07K14/00 , A61K38/08 , A61K38/10 , A61K38/16 , C07K16/00 , C07H21/04
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
摘要翻译： 本发明提供脑膜炎奈瑟氏球菌的蛋白质，包括氨基酸序列和相应的核苷酸序列。 蛋白质被预测为用于疫苗和/或诊断的有用的抗原。
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