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公开(公告)号：US20080267966A1
公开(公告)日：2008-10-30
申请号：US11596557
申请日：2005-05-16
CPC分类号： C07K14/285 , A61K39/00 , A61K39/102 , A61K2039/505 , A61K2039/53
摘要： Polypeptides comprising non-typeable Haemophilus influenzae (NTHi) amino acid sequences. Over 2500 specific NTHi proteins are disclosed. The invention also provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine for treating or preventing disease and/or infection caused by H. influenzae, such as otitis media.
摘要翻译： 包含不可分型流感嗜血杆菌（NTHi）氨基酸序列的多肽。 公开了超过2500种特异性NTHi蛋白。 本发明还提供了相关的多肽，核酸，抗体和方法。 这些都可以用于治疗或预防由流感嗜血杆菌引起的疾病和/或感染的药物，例如中耳炎。
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公开(公告)号：US10596246B2
公开(公告)日：2020-03-24
申请号：US14368957
申请日：2011-12-29
申请人： Beatrice Maria Arico , Brunella Brunelli , Maurizio Comanducci , Mariagrazia Pizza , Silvana Savino , Maria Scarselli
发明人： Beatrice Maria Arico , Brunella Brunelli , Maurizio Comanducci , Mariagrazia Pizza , Silvana Savino , Maria Scarselli
IPC分类号： A61K39/095 , A61K47/64 , A61K39/09 , A61K39/00 , A61K39/39
摘要： The M01573 sequence of meningococcal fHbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways. In a first aspect, a fHbp-based vaccine includes two family I fHbp sequences, one which is more closely related to MC58 than to M01573, and vice versa. In a second aspect, a multi-family fHbp-based vaccine uses a family I fHbp sequence which is more closely related to MC58 than to M01573, in combination with a family III fHbp sequence. The compositions are adjuvanted with an aluminium phosphate adjuvant.
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公开(公告)号：US20060051840A1
公开(公告)日：2006-03-09
申请号：US11067260
申请日：2005-02-25
申请人： Maria Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Guiliani , Mariagrazia Pizza
发明人： Maria Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Guiliani , Mariagrazia Pizza
CPC分类号： A61K39/095 , A61K38/00 , A61K2039/545 , A61K2039/55505 , A61K2039/572 , A61K2039/575 , C07K14/22 , C07K2319/00 , C12P21/00 , C12P21/02 , C12Q1/689 , C12Q2600/156
摘要： Two or more Neisserial proteins (e.g. A and B) are expressed as a single hybrid protein which can be represented simply by the formula NH2-A-B—COOH.
摘要翻译： 两个或更多个Neisserial蛋白（例如A和B）被表达为单独的杂合蛋白，其可以简单地用式NH 2 -A-B-COOH表示。
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公开(公告)号：US20120148615A1
公开(公告)日：2012-06-14
申请号：US13357394
申请日：2012-01-24
IPC分类号： A61K39/102 , C12N15/31 , A61P31/04 , C12N1/00 , A61P37/04 , C07K14/285 , C12N15/63
CPC分类号： C07K14/285 , A61K39/00 , A61K39/102 , A61K2039/505 , A61K2039/53
摘要： Polypeptides comprising non-typeable Haemophilus influenzae (NTHi) amino acid sequences. Over 2500 specific NTHi proteins are disclosed. The invention also provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine for treating or preventing disease and/or infection caused by H. influenzae, such as otitis media.
摘要翻译： 包含不可分型流感嗜血杆菌（NTHi）氨基酸序列的多肽。 公开了超过2500种特异性NTHi蛋白。 本发明还提供了相关的多肽，核酸，抗体和方法。 这些都可以用于治疗或预防由流感嗜血杆菌引起的疾病和/或感染的药物，例如中耳炎。
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公开(公告)号：US08124098B2
公开(公告)日：2012-02-28
申请号：US12800898
申请日：2010-05-25
CPC分类号： C07K14/285 , A61K39/00 , A61K39/102 , A61K2039/505 , A61K2039/53
摘要： Polypeptides comprising non-typeable Haemophilus influenzae (NTHi) amino acid sequences. Over 2500 specific NTHi proteins are disclosed. The invention also provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine for treating or preventing disease and/or infection caused by H. influenzae, such as otitis media.
摘要翻译： 包含不可分型流感嗜血杆菌（NTHi）氨基酸序列的多肽。 公开了超过2500种特异性NTHi蛋白。 本发明还提供了相关的多肽，核酸，抗体和方法。 这些都可以用于治疗或预防由流感嗜血杆菌引起的疾病和/或感染的药物，例如中耳炎。
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公开(公告)号：US20110020390A1
公开(公告)日：2011-01-27
申请号：US12918729
申请日：2009-02-20
IPC分类号： A61K39/385 , C07K2/00 , C12N15/31 , C12N15/63 , C12N1/00 , C12N1/21 , A61K39/095 , A61P37/04
CPC分类号： A61K39/095 , A61K39/00 , C07K14/22
摘要： fHBP is a protein in Neisseria meningitidis. Three families of fHBP are known. To increase the ability of a fHBP protein to elicit antibodies that are cross-reactive between the families, fHBP is selected or engineered to have a sequence which can elicit broad-spectrum bactericidal anti-meningococcal antibodies after administration to a host animal.
摘要翻译： fHBP是脑膜炎奈瑟菌中的蛋白质。 已知三个fHBP家族。 为了增加fHBP蛋白引起家族之间交叉反应的抗体的能力，选择或改造fHBP以具有在给予宿主动物后可引发广谱杀菌抗脑膜炎球菌抗体的序列。
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公开(公告)号：US20080193971A1
公开(公告)日：2008-08-14
申请号：US11587191
申请日：2005-04-28
申请人： Davide Serruto , Maria Arico
发明人： Davide Serruto , Maria Arico
CPC分类号： A61K39/095 , C07K14/22
摘要： Meningococcal antigens are cleaved by human lactoferrin. The invention is based on the identification of the cleavage products of this reaction, and provides a method for cleaving a neisserial polypeptide, comprising the step of mixing the polypeptide with a lactoferrin enzyme. The invention also provides polypeptides obtainable by this process (i.e. the cleavage products of the lactoferrin digestion) which might be useful in the preparation of anti-meningococcal vaccines. Proteins of particular interest are meningococcal proteins 287 and App.
摘要翻译： 脑膜炎球菌抗原被人乳铁蛋白切割。 本发明基于该反应的切割产物的鉴定，并提供了切割奈司多肽的方法，包括将多肽与乳铁蛋白酶混合的步骤。 本发明还提供可通过该方法获得的多肽（即乳铁蛋白消化的切割产物），其可用于制备抗脑膜炎球菌疫苗。 特别感兴趣的蛋白质是脑膜炎球菌蛋白质287和App。
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公开(公告)号：US09579372B2
公开(公告)日：2017-02-28
申请号：US12918729
申请日：2009-02-20
IPC分类号： A61K39/095 , A61K39/02 , A61K39/38 , A61K38/00 , C07K1/00 , C07H21/04 , C12N15/00 , C07K14/22 , A61K39/00
CPC分类号： A61K39/095 , A61K39/00 , C07K14/22
摘要： fHBP is a protein in Neisseria meningitidis. Three families of fHBP are known. To increase the ability of a fHBP protein to elicit antibodies that are cross-reactive between the families, fHBP is selected or engineered to have a sequence which can elicit broad-spectrum bactericidal anti-meningococcal antibodies after administration to a host animal.
摘要翻译： fHBP是脑膜炎奈瑟菌中的蛋白质。 已知三个fHBP家族。 为了增加fHBP蛋白引起家族之间交叉反应的抗体的能力，选择或改造fHBP以具有在给予宿主动物后可引发广谱杀菌抗脑膜炎球菌抗体的序列。
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公开(公告)号：US20150209419A1
公开(公告)日：2015-07-30
申请号：US14368957
申请日：2011-12-29
申请人： Beatrice Maria Arico , Brunella Brunelli , Maurizio Comanducci , Mariagrazia Pizza , Silvana Savino , Maria Scarselli
发明人： Beatrice Maria Arico , Brunella Brunelli , Maurizio Comanducci , Mariagrazia Pizza , Silvana Savino , Maria Scarselli
IPC分类号： A61K39/095 , A61K39/09 , A61K47/48 , A61K39/39
CPC分类号： A61K39/095 , A61K39/092 , A61K39/39 , A61K47/646 , A61K2039/55505
摘要： The M01573 sequence of meningococcal fHbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways. In a first aspect, a fHbp-based vaccine includes two family I fHbp sequences, one which is more closely related to MC58 than to M01573, and vice versa. In a second aspect, a multi-family fHbp-based vaccine uses a family I fHbp sequence which is more closely related to MC58 than to M01573, in combination with a family III fHbp sequence. The compositions are adjuvanted with an aluminium phosphate adjuvant.
摘要翻译： 脑膜炎球菌fHbp的M01573序列在疫苗中的覆盖范围较差。 本发明以两种方式解决了这种差的覆盖面。 在第一方面，基于fHbp的疫苗包括两个家族I fHbp序列，一个与MC58比M01573更密切相关的序列，反之亦然。 在第二方面，多家fHbp基疫苗使用与MC58比M01573更紧密相关的家族I fHbp序列，与III族fHbp序列组合。 用磷酸铝佐剂佐剂组合物。
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公开(公告)号：US20100221256A1
公开(公告)日：2010-09-02
申请号：US12775457
申请日：2010-05-06
申请人： Maria Arico , Maurizio Comanducci
发明人： Maria Arico , Maurizio Comanducci
IPC分类号： A61K39/395 , C07K16/00 , C12N1/20 , A61P31/04
CPC分类号： C07K14/22 , A61K39/00 , A61K2039/53
摘要： NadA, App and ORF40 function as adhesins in N. meningitidis. Adhesion can be modulated by targeting these three proteins. NadA allelic variants are disclosed. Autoproteolytic cleavage of App is disclosed, as is removal of the activity by mutagenesis. App is processed and secreted into culture medium when expressed in E. coli. Mature App proteins are disclosed. Knockout mutants are disclosed. Vesicles from non-Neisserial hosts with heterologous adhesin expression are disclosed.
摘要翻译： NadA，App和ORF40作为脑膜炎奈瑟氏球菌中的粘附素起作用。 可以通过靶向这三种蛋白来调节粘附。 公开了NadA等位基因变体。 公开了App的自体蛋白水解切割，以及通过诱变去除活性。 当在大肠杆菌中表达时，将APP加工并分泌到培养基中。 公开了成熟的App蛋白质。 揭示突变突变体。 公开了具有异源粘附素表达的非奈及利主体的囊泡。
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