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公开(公告)号：US20060051840A1
公开(公告)日：2006-03-09
申请号：US11067260
申请日：2005-02-25
申请人： Maria Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Guiliani , Mariagrazia Pizza
发明人： Maria Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Guiliani , Mariagrazia Pizza
CPC分类号： A61K39/095 , A61K38/00 , A61K2039/545 , A61K2039/55505 , A61K2039/572 , A61K2039/575 , C07K14/22 , C07K2319/00 , C12P21/00 , C12P21/02 , C12Q1/689 , C12Q2600/156
摘要： Two or more Neisserial proteins (e.g. A and B) are expressed as a single hybrid protein which can be represented simply by the formula NH2-A-B—COOH.
摘要翻译： 两个或更多个Neisserial蛋白（例如A和B）被表达为单独的杂合蛋白，其可以简单地用式NH 2 -A-B-COOH表示。
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公开(公告)号：US20110076300A1
公开(公告)日：2011-03-31
申请号：US12870718
申请日：2010-08-27
IPC分类号： A61K39/095 , C07K16/00 , C07H21/00 , A61K39/00 , A61P31/04 , A61P37/04 , C12N15/63 , C12N1/21 , C12N1/00
CPC分类号： C07K14/22 , A61K39/00 , C07K2319/00
摘要： fHBP is a protein in Neisseria meningitidis. Three families of fHBP are known. To increase the ability of a fHBP protein to elicit antibodies that are cross-reactive between the families, fHBP is selected or engineered to have a sequence which can elicit broad-spectrum bactericidal anti-meningococcal antibodies after administration to a host animal.
摘要翻译： fHBP是脑膜炎奈瑟菌中的蛋白质。 已知三个fHBP家族。 为了增加fHBP蛋白引起家族之间交叉反应的抗体的能力，选择或改造fHBP以具有在给予宿主动物后可引发广谱杀菌抗脑膜炎球菌抗体的序列。
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公开(公告)号：US09579372B2
公开(公告)日：2017-02-28
申请号：US12918729
申请日：2009-02-20
IPC分类号： A61K39/095 , A61K39/02 , A61K39/38 , A61K38/00 , C07K1/00 , C07H21/04 , C12N15/00 , C07K14/22 , A61K39/00
CPC分类号： A61K39/095 , A61K39/00 , C07K14/22
摘要： fHBP is a protein in Neisseria meningitidis. Three families of fHBP are known. To increase the ability of a fHBP protein to elicit antibodies that are cross-reactive between the families, fHBP is selected or engineered to have a sequence which can elicit broad-spectrum bactericidal anti-meningococcal antibodies after administration to a host animal.
摘要翻译： fHBP是脑膜炎奈瑟菌中的蛋白质。 已知三个fHBP家族。 为了增加fHBP蛋白引起家族之间交叉反应的抗体的能力，选择或改造fHBP以具有在给予宿主动物后可引发广谱杀菌抗脑膜炎球菌抗体的序列。
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公开(公告)号：US20110020390A1
公开(公告)日：2011-01-27
申请号：US12918729
申请日：2009-02-20
IPC分类号： A61K39/385 , C07K2/00 , C12N15/31 , C12N15/63 , C12N1/00 , C12N1/21 , A61K39/095 , A61P37/04
CPC分类号： A61K39/095 , A61K39/00 , C07K14/22
摘要： fHBP is a protein in Neisseria meningitidis. Three families of fHBP are known. To increase the ability of a fHBP protein to elicit antibodies that are cross-reactive between the families, fHBP is selected or engineered to have a sequence which can elicit broad-spectrum bactericidal anti-meningococcal antibodies after administration to a host animal.
摘要翻译： fHBP是脑膜炎奈瑟菌中的蛋白质。 已知三个fHBP家族。 为了增加fHBP蛋白引起家族之间交叉反应的抗体的能力，选择或改造fHBP以具有在给予宿主动物后可引发广谱杀菌抗脑膜炎球菌抗体的序列。
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公开(公告)号：US20100221256A1
公开(公告)日：2010-09-02
申请号：US12775457
申请日：2010-05-06
申请人： Maria Arico , Maurizio Comanducci
发明人： Maria Arico , Maurizio Comanducci
IPC分类号： A61K39/395 , C07K16/00 , C12N1/20 , A61P31/04
CPC分类号： C07K14/22 , A61K39/00 , A61K2039/53
摘要： NadA, App and ORF40 function as adhesins in N. meningitidis. Adhesion can be modulated by targeting these three proteins. NadA allelic variants are disclosed. Autoproteolytic cleavage of App is disclosed, as is removal of the activity by mutagenesis. App is processed and secreted into culture medium when expressed in E. coli. Mature App proteins are disclosed. Knockout mutants are disclosed. Vesicles from non-Neisserial hosts with heterologous adhesin expression are disclosed.
摘要翻译： NadA，App和ORF40作为脑膜炎奈瑟氏球菌中的粘附素起作用。 可以通过靶向这三种蛋白来调节粘附。 公开了NadA等位基因变体。 公开了App的自体蛋白水解切割，以及通过诱变去除活性。 当在大肠杆菌中表达时，将APP加工并分泌到培养基中。 公开了成熟的App蛋白质。 揭示突变突变体。 公开了具有异源粘附素表达的非奈及利主体的囊泡。
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公开(公告)号：US20050232936A1
公开(公告)日：2005-10-20
申请号：US10484703
申请日：2002-07-26
申请人： Maria Arico , Maurizio Comanducci
发明人： Maria Arico , Maurizio Comanducci
IPC分类号： C12N15/09 , A61K39/00 , A61K39/095 , A61P31/04 , C07K14/22 , C12N1/21 , C12P21/00 , C12Q1/02 , C12R1/36 , A61K39/02 , C07H21/04 , C12N15/74
CPC分类号： C07K14/22 , A61K39/00 , A61K2039/53
摘要： NadA, App and ORF40 function as adhesins in N. meningitidis. Adhesion can be modulated by targeting these three proteins. NadA allelic variants are disclosed. Autoproteolytic cleavage of App is disclosed, as is removal of the activity by mutagenesis. App is processed and secreted into culture medium when expressed in E. coli. Mature App proteins are disclosed. Knockout mutants are disclosed. Vesicles from non-Neisserial hosts with heterologous adhesin expression are disclosed.
摘要翻译： NadA，App和ORF40作为脑膜炎奈瑟氏球菌中的粘附素起作用。 可以通过靶向这三种蛋白来调节粘附。 公开了NadA等位基因变体。 公开了App的自体蛋白水解切割，以及通过诱变去除活性。 当在大肠杆菌中表达时，将APP加工并分泌到培养基中。 公开了成熟的App蛋白质。 揭示突变突变体。 公开了具有异源粘附素表达的非奈及利主体的囊泡。
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公开(公告)号：US20080193971A1
公开(公告)日：2008-08-14
申请号：US11587191
申请日：2005-04-28
申请人： Davide Serruto , Maria Arico
发明人： Davide Serruto , Maria Arico
CPC分类号： A61K39/095 , C07K14/22
摘要： Meningococcal antigens are cleaved by human lactoferrin. The invention is based on the identification of the cleavage products of this reaction, and provides a method for cleaving a neisserial polypeptide, comprising the step of mixing the polypeptide with a lactoferrin enzyme. The invention also provides polypeptides obtainable by this process (i.e. the cleavage products of the lactoferrin digestion) which might be useful in the preparation of anti-meningococcal vaccines. Proteins of particular interest are meningococcal proteins 287 and App.
摘要翻译： 脑膜炎球菌抗原被人乳铁蛋白切割。 本发明基于该反应的切割产物的鉴定，并提供了切割奈司多肽的方法，包括将多肽与乳铁蛋白酶混合的步骤。 本发明还提供可通过该方法获得的多肽（即乳铁蛋白消化的切割产物），其可用于制备抗脑膜炎球菌疫苗。 特别感兴趣的蛋白质是脑膜炎球菌蛋白质287和App。
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