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公开(公告)号：US20130071463A1
公开(公告)日：2013-03-21
申请号：US13616386
申请日：2012-09-14
申请人： Maria Palasis , Upma Sharma , John Marini , Quynh Pham , Toby Freyman , Adam Rago
发明人： Maria Palasis , Upma Sharma , John Marini , Quynh Pham , Toby Freyman , Adam Rago
CPC分类号： A61K9/70 , A61K9/0024 , A61K9/0092 , A61K31/445 , A61K31/4468 , A61K31/4535 , A61K31/485 , A61K31/575 , A61K38/00 , A61K47/34
摘要： Medical implants and methods useful in treating postoperative pain are described. The implants comprise one or more electrospun drug-loaded fibers, which fibers comprise a drug useful in the treatment of pain. The implants are implanted at sites of interest including joint capsules, bones, and subcutaneous spaces, and are secured with tissue flaps or fasteners.
摘要翻译： 描述了可用于治疗术后疼痛的医疗植入物和方法。 植入物包含一种或多种电纺丝载药纤维，该纤维包含可用于治疗疼痛的药物。 将植入物植入感兴趣的部位，包括关节囊，骨骼和皮下空间，并用组织瓣或紧固件固定。
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公开(公告)号：US20160279302A1
公开(公告)日：2016-09-29
申请号：US14928857
申请日：2015-10-30
申请人： Upma Sharma , Irina Gitlin , Gregory T. Zugates , Adam Rago , Parisa Zamiri , Ray Busold , Robert J. Caulkins , Toby Freyman , Quynh Pham , Changchen You , Jeffrey Carbeck
发明人： Upma Sharma , Irina Gitlin , Gregory T. Zugates , Adam Rago , Parisa Zamiri , Ray Busold , Robert J. Caulkins , Toby Freyman , Quynh Pham , Changchen You , Jeffrey Carbeck
CPC分类号： A61L31/06 , A61B17/12031 , A61B17/12163 , A61B17/12186 , A61B2017/12004 , A61J1/2093 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/141 , A61L31/146 , A61L31/148 , A61L2400/04 , A61L2400/06 , A61L2400/18 , A61M37/00 , C08L63/00 , C08L67/04
摘要： Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
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公开(公告)号：US20130317418A1
公开(公告)日：2013-11-28
申请号：US13815910
申请日：2013-03-15
申请人： Toby Freyman , Joseph Lomakin , John Marini , Jennifer Mortensen , Adam Rago , Rany Busold , Upma Sharma , Gregory T. Zugates
发明人： Toby Freyman , Joseph Lomakin , John Marini , Jennifer Mortensen , Adam Rago , Rany Busold , Upma Sharma , Gregory T. Zugates
IPC分类号： A61M37/00
CPC分类号： A61B17/12181 , A61B17/12113 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/07 , A61F2002/065 , A61F2002/077 , A61F2210/0085 , A61J1/2093 , A61L24/0036 , A61L24/0089 , A61L24/046 , A61L31/06 , A61L31/128 , A61L31/146 , A61L2300/60 , A61L2400/06 , A61M37/00 , C08L67/04 , C08L83/04
摘要： Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms or fluid filled spaces are disclosed. The systems include an insertable medical device and an in-situ forming foam of lava like materials with a fast forming outer skin and a slower hardening interior that is formed from a one-, two- or multi-part formulation. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and/or the tissue surface of the aneurysm.
摘要翻译： 公开了与原位形成聚合物泡沫相关的用于治疗动脉瘤或填充液体的空间的系统，方法和试剂盒。 这些系统包括可插入的医疗装置和具有快速成形外皮的熔岩状材料的原位成形泡沫体，以及由一部分，两部分或多部分制剂形成的较慢的硬化内部。 当用于治疗动脉瘤时，将泡沫放置成与医疗装置的外表面的至少一部分和/或动脉瘤的组织表面接触。
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公开(公告)号：US20160051264A1
公开(公告)日：2016-02-25
申请号：US14728393
申请日：2015-06-02
申请人： Toby Freyman , Joseph Lomakin , John Marini , Jennifer Mortensen , Adam Rago , Rany Busold , Upma Sharma , Gregory T. Zugates
发明人： Toby Freyman , Joseph Lomakin , John Marini , Jennifer Mortensen , Adam Rago , Rany Busold , Upma Sharma , Gregory T. Zugates
CPC分类号： A61B17/12181 , A61B17/12113 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/07 , A61F2002/065 , A61F2002/077 , A61F2210/0085 , A61J1/2093 , A61L24/0036 , A61L24/0089 , A61L24/046 , A61L31/06 , A61L31/128 , A61L31/146 , A61L2300/60 , A61L2400/06 , A61M37/00 , C08L67/04 , C08L83/04
摘要： Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms or fluid filled spaces are disclosed. The systems include an insertable medical device and an in-situ forming foam of lava like materials with a fast forming outer skin and a slower hardening interior that is formed from a one-, two- or multi-part formulation. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and/or the tissue surface of the aneurysm.
摘要翻译： 公开了与原位形成聚合物泡沫相关的用于治疗动脉瘤或填充液体的空间的系统，方法和试剂盒。 这些系统包括可插入的医疗装置和具有快速成形外皮的熔岩状材料的原位成形泡沫体，以及由一部分，两部分或多部分制剂形成的较慢的硬化内部。 当用于治疗动脉瘤时，将泡沫放置成与医疗装置的外表面的至少一部分和/或动脉瘤的组织表面接触。
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公开(公告)号：US09700656B2
公开(公告)日：2017-07-11
申请号：US14492393
申请日：2014-09-22
申请人： Upma Sharma , Irina Gitlin , Gregory T. Zugates , Adam Rago , Parisa Zamiri , Rany Busold , Toby Freyman , Robert J. Caulkins , Quynh P. Pham , Changchen You , Jeffrey D. Carbeck
发明人： Upma Sharma , Irina Gitlin , Gregory T. Zugates , Adam Rago , Parisa Zamiri , Rany Busold , Toby Freyman , Robert J. Caulkins , Quynh P. Pham , Changchen You , Jeffrey D. Carbeck
IPC分类号： A61F2/02 , A61L31/06 , A61J1/20 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/14 , A61M37/00 , A61B17/12
CPC分类号： A61L31/06 , A61B17/12031 , A61B17/12163 , A61B17/12186 , A61B2017/12004 , A61J1/2093 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/141 , A61L31/146 , A61L31/148 , A61L2400/04 , A61L2400/06 , A61L2400/18 , A61M37/00 , C08L63/00 , C08L67/04
摘要： Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
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公开(公告)号：US09623143B2
公开(公告)日：2017-04-18
申请号：US14215988
申请日：2014-03-17
申请人： Gregory T. Zugates , Adam Rago , Toby Freyman , Upma Sharma , Rany Busold , John Caulkins , Parisa Zamiri , Jennifer Mortensen , Meghan McGill , Daniel K. Bonner
发明人： Gregory T. Zugates , Adam Rago , Toby Freyman , Upma Sharma , Rany Busold , John Caulkins , Parisa Zamiri , Jennifer Mortensen , Meghan McGill , Daniel K. Bonner
CPC分类号： A61L24/0015 , A61L24/0036 , A61L24/046 , A61L27/14 , A61L27/56 , A61L31/04 , A61L31/146 , A61L2300/418 , A61L2400/04 , A61L2430/22 , C08L75/04
摘要： The present invention relates generally to systems and methods and systems for generating polymer foams within body cavities to locate and/or control bleeding. The present invention further relates to methods and systems for generating polymer foams within non-compressible wounds to control or stop bleeding. The present invention further relates to the use of foams and gels for medical and cosmetic purposes.
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7.发明授权公开(公告)号：US09579449B2
公开(公告)日：2017-02-28
申请号：US14211469
申请日：2014-03-14
申请人： Upma Sharma , Rany Busold , Adam Rago , Gregory T. Zugates , Toby Freyman , Lisette Manrique Miller
发明人： Upma Sharma , Rany Busold , Adam Rago , Gregory T. Zugates , Toby Freyman , Lisette Manrique Miller
IPC分类号： A61F2/02 , A61M5/14 , A61B17/00 , B01F5/06 , B01F7/00 , B01F13/00 , B01F15/00 , B01F15/02 , B01F3/04 , A61C9/00 , A61M5/145 , A61M5/19 , B05C17/005 , B65D81/32 , A61B17/88 , A61M13/00
CPC分类号： A61B17/00491 , A61B2017/00398 , A61B2017/00495 , A61B2017/00544 , A61B2017/00548 , A61B2017/8838 , A61C9/0026 , A61M5/1409 , A61M5/1452 , A61M5/16804 , A61M5/19 , A61M13/003 , A61M2205/103 , B01F3/04453 , B01F5/0602 , B01F5/0604 , B01F7/00558 , B01F7/00583 , B01F13/0023 , B01F15/00253 , B01F15/00525 , B01F15/0279 , B05B7/0037 , B05B7/2421 , B05B7/2472 , B05C17/00553 , B65D81/325
摘要： Delivery systems for in situ forming foam formulations are provided. The devices may include various actuation mechanisms and may entrain air into fluid formulation components in a variety of ways, including mixing with air and the addition of compressed gas.
摘要翻译： 提供了用于原位形成泡沫配方的输送系统。 装置可以包括各种致动机构，并且可以以各种方式将空气夹带到流体配方部件中，包括与空气混合和加入压缩气体。
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公开(公告)号：US09173817B2
公开(公告)日：2015-11-03
申请号：US13209020
申请日：2011-08-12
申请人： Upma Sharma , Irina Gitlin , Gregory T. Zugates , Adam Rago , Parisa Zamiri , Rany Busold , Toby Freyman , Robert J. Caulkins , Quynh P. Pham , Changcheng You , Jeffrey D. Carbeck
发明人： Upma Sharma , Irina Gitlin , Gregory T. Zugates , Adam Rago , Parisa Zamiri , Rany Busold , Toby Freyman , Robert J. Caulkins , Quynh P. Pham , Changcheng You , Jeffrey D. Carbeck
CPC分类号： A61L31/06 , A61B17/12031 , A61B17/12163 , A61B17/12186 , A61B2017/12004 , A61J1/2093 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/141 , A61L31/146 , A61L31/148 , A61L2400/04 , A61L2400/06 , A61L2400/18 , A61M37/00 , C08L63/00 , C08L67/04
摘要： Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
摘要翻译： 通常描述与聚合物泡沫有关的系统和方法。 一些实施方案涉及用于制备聚合物泡沫的组合物和方法，以及使用聚合物泡沫体的方法。 聚合物泡沫可以施加到体腔并且与例如组织，损伤的组织，内部器官等接触。在一些实施方案中，聚合物泡沫可以在体腔内形成（即，原位泡沫形成 ）。 此外，发泡聚合物可能能够在体腔的内表面上施加压力，并且能够防止或限制体液（例如血液等）的移动。
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9.发明申请公开(公告)号：US20140228745A1
公开(公告)日：2014-08-14
申请号：US14211469
申请日：2014-03-14
申请人： Upma Sharma , Rany Busold , Adam Rago , Gregory T. Zugates , Toby Freyman , Lisette Manrique Miller
发明人： Upma Sharma , Rany Busold , Adam Rago , Gregory T. Zugates , Toby Freyman , Lisette Manrique Miller
CPC分类号： A61B17/00491 , A61B2017/00398 , A61B2017/00495 , A61B2017/00544 , A61B2017/00548 , A61B2017/8838 , A61C9/0026 , A61M5/1409 , A61M5/1452 , A61M5/16804 , A61M5/19 , A61M13/003 , A61M2205/103 , B01F3/04453 , B01F5/0602 , B01F5/0604 , B01F7/00558 , B01F7/00583 , B01F13/0023 , B01F15/00253 , B01F15/00525 , B01F15/0279 , B05B7/0037 , B05B7/2421 , B05B7/2472 , B05C17/00553 , B65D81/325
摘要： Delivery systems for in situ forming foam formulations are provided. The devices may include various actuation mechanisms and may entrain air into fluid formulation components in a variety of ways, including mixing with air and the addition of compressed gas.
摘要翻译： 提供了用于原位形成泡沫配方的输送系统。 装置可以包括各种致动机构，并且可以以各种方式将空气夹带到流体配方部件中，包括与空气混合和加入压缩气体。
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公开(公告)号：US20120107439A1
公开(公告)日：2012-05-03
申请号：US13209020
申请日：2011-08-12
申请人： Upma Sharma , Irina Gitlin , Gregory T. Zugates , Adam Rago , Parisa Zamiri , Rany Busold , Robert J. Caulkins , Toby Freyman , Quynh P. Pham , Changcheng You , Jeffrey D. Carbeck
发明人： Upma Sharma , Irina Gitlin , Gregory T. Zugates , Adam Rago , Parisa Zamiri , Rany Busold , Robert J. Caulkins , Toby Freyman , Quynh P. Pham , Changcheng You , Jeffrey D. Carbeck
IPC分类号： B29C44/04
CPC分类号： A61L31/06 , A61B17/12031 , A61B17/12163 , A61B17/12186 , A61B2017/12004 , A61J1/2093 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/141 , A61L31/146 , A61L31/148 , A61L2400/04 , A61L2400/06 , A61L2400/18 , A61M37/00 , C08L63/00 , C08L67/04
摘要： Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
摘要翻译： 通常描述与聚合物泡沫有关的系统和方法。 一些实施方案涉及用于制备聚合物泡沫的组合物和方法，以及使用聚合物泡沫体的方法。 聚合物泡沫可以施加到体腔并且与例如组织，损伤的组织，内部器官等接触。在一些实施方案中，聚合物泡沫可以在体腔内形成（即，原位泡沫形成 ）。 此外，发泡聚合物可能能够在体腔的内表面上施加压力，并且能够防止或限制体液（例如血液等）的移动。
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