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公开(公告)号：US08716281B2
公开(公告)日：2014-05-06
申请号：US13697730
申请日：2011-05-04
申请人： Marian C. Bryan , Alan C. Cheng , Elizabeth M. Doherty , James R. Falsey , Ingrid M. Fellows , Joseph L. Kim , Richard T. Lewis , Michele H. Potashman , Douglas A. Whittington
发明人： Marian C. Bryan , Alan C. Cheng , Elizabeth M. Doherty , James R. Falsey , Ingrid M. Fellows , Joseph L. Kim , Richard T. Lewis , Michele H. Potashman , Douglas A. Whittington
IPC分类号： A61K31/18
CPC分类号： C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention describes pyrimidine compounds of Formula I that are useful as anaplastic lymphoma kinase inhibitors, pharmaceutically acceptable compositions thereof, and methods of using the same.
摘要翻译： 本发明描述了可用作间变性淋巴瘤激酶抑制剂，其药学上可接受的组合物的式I的嘧啶化合物及其使用方法。
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2.发明申请公开(公告)号：US20130158019A1
公开(公告)日：2013-06-20
申请号：US13697730
申请日：2011-05-04
申请人： Marian C. Bryan , Alan C. Cheng , Elizabeth M. Doherty , James R. Falsey , Ingrid M. Fellows , Joseph L. Kim , Richard T. Lewis , Michele H. Potashman , Douglas A. Whittington
发明人： Marian C. Bryan , Alan C. Cheng , Elizabeth M. Doherty , James R. Falsey , Ingrid M. Fellows , Joseph L. Kim , Richard T. Lewis , Michele H. Potashman , Douglas A. Whittington
IPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D417/04 , C07D471/04 , C07D409/14 , C07D405/14 , C07D403/04
CPC分类号： C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds of Formula I are useful inhibitors of anaplastic lymphoma kinase. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
摘要翻译： 式I化合物是间变性淋巴瘤激酶的有用抑制剂。 式I的化合物具有以下结构：其中本文提供变量的定义。
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公开(公告)号：US08017601B2
公开(公告)日：2011-09-13
申请号：US11479187
申请日：2006-06-30
申请人： Tae-Seong Kim , Jean-Christophe Harmange , Steven Bellon , Shon Booker , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Timothy S. Harvey , Joseph L. Kim , Matthew Lee , Longbin Liu , Vinod F. Patel , Andrew Tasker
发明人： Tae-Seong Kim , Jean-Christophe Harmange , Steven Bellon , Shon Booker , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Timothy S. Harvey , Joseph L. Kim , Matthew Lee , Longbin Liu , Vinod F. Patel , Andrew Tasker
IPC分类号： C07D403/02 , A61K31/538
CPC分类号： C07D333/38 , C07D217/02 , C07D217/24 , C07D401/10 , C07D401/12 , C07D409/12 , C07D417/10 , C07D417/12
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：US20110251199A1
公开(公告)日：2011-10-13
申请号：US13163666
申请日：2011-06-17
申请人： Frenel F. De Morin , Jian J. Chen , Elizabeth M. Doherty , Stephen Hitchcock , Qi Huang , Joseph L. Kim , Gang Liu , Thomas Nixey , Nick A. Paras , Jeffrey Petkus , Daniel M. Retz , Adrian L. Smith , Jiawang Zhu
发明人： Frenel F. De Morin , Jian J. Chen , Elizabeth M. Doherty , Stephen Hitchcock , Qi Huang , Joseph L. Kim , Gang Liu , Thomas Nixey , Nick A. Paras , Jeffrey Petkus , Daniel M. Retz , Adrian L. Smith , Jiawang Zhu
IPC分类号： A61K31/502 , A61K31/517 , A61P35/00 , A61K31/506 , C07D403/10 , C07D413/14 , C07D417/10 , C07D401/14
CPC分类号： C07D401/14 , C07D239/84 , C07D239/95 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要： The present invention comprises a new class of compounds capable of modulating Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have a general Formula I and A1, A2, A3, A4, X, Z, Z′, R1, R2, R3, R4, R5 and R6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译： 本发明包括能够调节Raf激酶的新一类化合物，因此可用于治疗Raf激酶介导的疾病，包括黑素瘤，肿瘤和其它癌症相关病症。 该化合物具有通式Ⅰ和A1，A2，A3，A4，X，Z，Z'，R1，R2，R3，R4，R5和R6的定义。 本发明还包括药物组合物，用于治疗Raf激酶介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。
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5.发明授权公开(公告)号：US08440674B2
公开(公告)日：2013-05-14
申请号：US13163666
申请日：2011-06-17
申请人： Frenel F. De Morin , Jian J. Chen , Elizabeth M. Doherty , Stephen A. Hitchcock , Qi Huang , Joseph L. Kim , Gang Liu , Thomas Nixey , Nick A. Paras , Jeffrey Petkus , Daniel Martin Retz , Adrian Leonard Smith , Jiawang Zhu
发明人： Frenel F. De Morin , Jian J. Chen , Elizabeth M. Doherty , Stephen A. Hitchcock , Qi Huang , Joseph L. Kim , Gang Liu , Thomas Nixey , Nick A. Paras , Jeffrey Petkus , Daniel Martin Retz , Adrian Leonard Smith , Jiawang Zhu
IPC分类号： A01N43/54
CPC分类号： C07D401/14 , C07D239/84 , C07D239/95 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要： The present invention comprises a new class of compounds capable of modulating Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have a general Formula I wherein R1 is and A1, A2, A3, A4, X, Z, Z′, R1, R2, R3, R4, R5 and R6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译： 本发明包括能够调节Raf激酶的新一类化合物，因此可用于治疗Raf激酶介导的疾病，包括黑素瘤，肿瘤和其它癌症相关病症。 该化合物具有通式I，其中R1为和A1，A2，A3，A4，X，Z，Z'，R1，R2，R3，R4，R5和R6如本文所定义。 本发明还包括药物组合物，用于治疗Raf激酶介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。
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公开(公告)号：US07435823B2
公开(公告)日：2008-10-14
申请号：US11042634
申请日：2005-01-24
申请人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , Gregory J. Habgood , David C. McGowan , Douglas A. Whittington , Daniel La , Vinod F. Patel
发明人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , Gregory J. Habgood , David C. McGowan , Douglas A. Whittington , Daniel La , Vinod F. Patel
IPC分类号： C07D215/38 , C07D265/34
CPC分类号： C07D213/64 , C07D213/81 , C07D215/233 , C07D215/38 , C07D215/48 , C07D215/54 , C07D237/34 , C07D239/34 , C07D239/47 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：US20090176774A1
公开(公告)日：2009-07-09
申请号：US12157303
申请日：2008-06-09
申请人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , David C. McGowan , Douglas A. Whittington , Gregory J. Habgood , Vinod F. Patel , Daniel La
发明人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , David C. McGowan , Douglas A. Whittington , Gregory J. Habgood , Vinod F. Patel , Daniel La
IPC分类号： A61K31/536 , A61K31/517 , A61K31/502 , A61K31/498 , A61K31/4709
CPC分类号： C07D213/64 , C07D213/81 , C07D215/233 , C07D215/38 , C07D215/48 , C07D215/54 , C07D237/34 , C07D239/34 , C07D239/47 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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公开(公告)号：US08178557B2
公开(公告)日：2012-05-15
申请号：US12157303
申请日：2008-06-09
申请人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , David C. McGowan , Douglas A. Whittington , Gregory J. Habgood , Vinod F. Patel , Daniel La
发明人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , David C. McGowan , Douglas A. Whittington , Gregory J. Habgood , Vinod F. Patel , Daniel La
IPC分类号： A61K31/04
CPC分类号： C07D213/64 , C07D213/81 , C07D215/233 , C07D215/38 , C07D215/48 , C07D215/54 , C07D237/34 , C07D239/34 , C07D239/47 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：US09499522B2
公开(公告)日：2016-11-22
申请号：US14210526
申请日：2014-03-14
申请人： Lucian V. DiPietro , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu , Steven Mark Wenglowsky , Douglas Wilson , Yulian Zhang
发明人： Lucian V. DiPietro , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu , Steven Mark Wenglowsky , Douglas Wilson , Yulian Zhang
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D487/04 , C07D487/08 , C07D401/12 , C07D403/04 , C07D403/14 , C07D239/94 , C07D487/22
CPC分类号： C07D403/14 , C07D239/94 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D473/34 , C07D487/04 , C07D487/08 , C07D487/22
摘要： Compounds and compositions useful for treating disorders related to Kit are described herein.
摘要翻译： 本文描述了可用于治疗与Kit相关的疾病的化合物和组合物。
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公开(公告)号：US20150111887A1
公开(公告)日：2015-04-23
申请号：US14515327
申请日：2014-10-15
IPC分类号： C07D487/04 , A61K45/06 , A61K31/5377 , A61K31/53
CPC分类号： C07D487/04 , A61K31/496 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14
摘要： Compounds and compositions useful for treating disorders related to mutant KIT are described herein.
摘要翻译： 本文描述了可用于治疗与突变型KIT相关的病症的化合物和组合物。
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