公开(公告)号：US20090176774A1

公开(公告)日：2009-07-09

申请号：US12157303

申请日：2008-06-09

申请人： Michele Potashman ,  Tae-Seong Kim ,  Steven Bellon ,  Shon Booker ,  Yuan Cheng ,  Joseph L. Kim ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Jean-Christophe Harmange ,  George Borg ,  Matthew Weiss ,  Brian L. Hodous ,  Russell Graceffa ,  William H. Buckner ,  Craig E. Masse ,  Deborah Choquette ,  Matthew W. Martin ,  Julie Germain ,  Lucian V. DiPietro ,  Stuart C. Chaffee ,  Joseph J. Nunes ,  John L. Buchanan ,  David C. McGowan ,  Douglas A. Whittington ,  Gregory J. Habgood ,  Vinod F. Patel ,  Daniel La

发明人： Michele Potashman ,  Tae-Seong Kim ,  Steven Bellon ,  Shon Booker ,  Yuan Cheng ,  Joseph L. Kim ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Jean-Christophe Harmange ,  George Borg ,  Matthew Weiss ,  Brian L. Hodous ,  Russell Graceffa ,  William H. Buckner ,  Craig E. Masse ,  Deborah Choquette ,  Matthew W. Martin ,  Julie Germain ,  Lucian V. DiPietro ,  Stuart C. Chaffee ,  Joseph J. Nunes ,  John L. Buchanan ,  David C. McGowan ,  Douglas A. Whittington ,  Gregory J. Habgood ,  Vinod F. Patel ,  Daniel La

IPC分类号： A61K31/536 ,  A61K31/517 ,  A61K31/502 ,  A61K31/498 ,  A61K31/4709

CPC分类号： C07D213/64 ,  C07D213/81 ,  C07D215/233 ,  C07D215/38 ,  C07D215/48 ,  C07D215/54 ,  C07D237/34 ,  C07D239/34 ,  C07D239/47 ,  C07D239/84 ,  C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：US07435823B2

公开(公告)日：2008-10-14

申请号：US11042634

申请日：2005-01-24

申请人： Michele Potashman ,  Tae-Seong Kim ,  Steven Bellon ,  Shon Booker ,  Yuan Cheng ,  Joseph L. Kim ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Jean-Christophe Harmange ,  George Borg ,  Matthew Weiss ,  Brian L. Hodous ,  Russell Graceffa ,  William H. Buckner ,  Craig E. Masse ,  Deborah Choquette ,  Matthew W. Martin ,  Julie Germain ,  Lucian V. DiPietro ,  Stuart C. Chaffee ,  Joseph J. Nunes ,  John L. Buchanan ,  Gregory J. Habgood ,  David C. McGowan ,  Douglas A. Whittington ,  Daniel La ,  Vinod F. Patel

发明人： Michele Potashman ,  Tae-Seong Kim ,  Steven Bellon ,  Shon Booker ,  Yuan Cheng ,  Joseph L. Kim ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Jean-Christophe Harmange ,  George Borg ,  Matthew Weiss ,  Brian L. Hodous ,  Russell Graceffa ,  William H. Buckner ,  Craig E. Masse ,  Deborah Choquette ,  Matthew W. Martin ,  Julie Germain ,  Lucian V. DiPietro ,  Stuart C. Chaffee ,  Joseph J. Nunes ,  John L. Buchanan ,  Gregory J. Habgood ,  David C. McGowan ,  Douglas A. Whittington ,  Daniel La ,  Vinod F. Patel

IPC分类号： C07D215/38 ,  C07D265/34

CPC分类号： C07D213/64 ,  C07D213/81 ,  C07D215/233 ,  C07D215/38 ,  C07D215/48 ,  C07D215/54 ,  C07D237/34 ,  C07D239/34 ,  C07D239/47 ,  C07D239/84 ,  C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：US08178557B2

公开(公告)日：2012-05-15

申请号：US12157303

申请日：2008-06-09

申请人： Michele Potashman ,  Tae-Seong Kim ,  Steven Bellon ,  Shon Booker ,  Yuan Cheng ,  Joseph L. Kim ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Jean-Christophe Harmange ,  George Borg ,  Matthew Weiss ,  Brian L. Hodous ,  Russell Graceffa ,  William H. Buckner ,  Craig E. Masse ,  Deborah Choquette ,  Matthew W. Martin ,  Julie Germain ,  Lucian V. DiPietro ,  Stuart C. Chaffee ,  Joseph J. Nunes ,  John L. Buchanan ,  David C. McGowan ,  Douglas A. Whittington ,  Gregory J. Habgood ,  Vinod F. Patel ,  Daniel La

发明人： Michele Potashman ,  Tae-Seong Kim ,  Steven Bellon ,  Shon Booker ,  Yuan Cheng ,  Joseph L. Kim ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Jean-Christophe Harmange ,  George Borg ,  Matthew Weiss ,  Brian L. Hodous ,  Russell Graceffa ,  William H. Buckner ,  Craig E. Masse ,  Deborah Choquette ,  Matthew W. Martin ,  Julie Germain ,  Lucian V. DiPietro ,  Stuart C. Chaffee ,  Joseph J. Nunes ,  John L. Buchanan ,  David C. McGowan ,  Douglas A. Whittington ,  Gregory J. Habgood ,  Vinod F. Patel ,  Daniel La

IPC分类号： A61K31/04

CPC分类号： C07D213/64 ,  C07D213/81 ,  C07D215/233 ,  C07D215/38 ,  C07D215/48 ,  C07D215/54 ,  C07D237/34 ,  C07D239/34 ,  C07D239/47 ,  C07D239/84 ,  C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：US07101868B2

公开(公告)日：2006-09-05

申请号：US10823809

申请日：2004-04-12

申请人： Daniel Elbaum ,  Benny C. Askew, Jr. ,  Shon Booker ,  Julie Germain ,  Gregory J. Habgood ,  Michael Handley ,  Tae-Seong Kim ,  Aiwen Li ,  Nobuko Nishimura ,  Vinod F. Patel ,  Chester Chenguang Yuan ,  Joseph L. Kim ,  Guolin Cai ,  Guoqing Chen ,  Michael Croghan ,  Lucian V. Di Pietro ,  Celia Dominguez ,  Qi Huang ,  Leon M. Smith, II ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu

发明人： Daniel Elbaum ,  Benny C. Askew, Jr. ,  Shon Booker ,  Julie Germain ,  Gregory J. Habgood ,  Michael Handley ,  Tae-Seong Kim ,  Aiwen Li ,  Nobuko Nishimura ,  Vinod F. Patel ,  Chester Chenguang Yuan ,  Joseph L. Kim ,  Guolin Cai ,  Guoqing Chen ,  Michael Croghan ,  Lucian V. Di Pietro ,  Celia Dominguez ,  Qi Huang ,  Leon M. Smith, II ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu

IPC分类号： A61K31/33 ,  A61K31/44 ,  C07D211/62 ,  C07D213/72

CPC分类号： C07D213/81 ,  C04B35/632 ,  C07D213/82 ,  C07D237/04 ,  C07D237/24 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：US06878714B2

公开(公告)日：2005-04-12

申请号：US10197974

申请日：2002-07-17

申请人： Benny Askew ,  Jeffrey Adams ,  Shon Booker ,  Guoqing Chen ,  Lucian V. DiPietro ,  Daniel Elbaum ,  Julie Germain ,  Stephanie D. Geuns-Meyer ,  Gregory J. Habgood ,  Michael Handley ,  Qi Huang ,  Tae-Seong Kim ,  Aiwen Li ,  Nobuko Nishimura ,  Rana Nomak ,  Vinod F. Patel ,  Babak Riahi ,  Joseph L. Kim ,  Ning Xi ,  Kevin Yang ,  Chester Chenguang Yuan

发明人： Benny Askew ,  Jeffrey Adams ,  Shon Booker ,  Guoqing Chen ,  Lucian V. DiPietro ,  Daniel Elbaum ,  Julie Germain ,  Stephanie D. Geuns-Meyer ,  Gregory J. Habgood ,  Michael Handley ,  Qi Huang ,  Tae-Seong Kim ,  Aiwen Li ,  Nobuko Nishimura ,  Rana Nomak ,  Vinod F. Patel ,  Babak Riahi ,  Joseph L. Kim ,  Ning Xi ,  Kevin Yang ,  Chester Chenguang Yuan

IPC分类号： A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61P9/10 ,  A61P11/06 ,  A61P15/08 ,  A61P17/06 ,  A61P19/00 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D407/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/02 ,  C07D471/04 ,  C07D491/02 ,  A61K31/4427

CPC分类号： C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：US07102009B2

公开(公告)日：2006-09-05

申请号：US10197918

申请日：2002-07-17

申请人： Vinod F. Patel ,  Benny Askew ,  Shon Booker ,  Guoqing Chen ,  Lucian V. DiPietro ,  Julie Germain ,  Gregory J. Habgood ,  Qi Huang ,  Tae-Seong Kim ,  Aiwen Li ,  Nobuko Nishimura ,  Rana Nomak ,  Babak Riahi ,  Chester Chenguang Yuan ,  Daniel Elbaum

发明人： Vinod F. Patel ,  Benny Askew ,  Shon Booker ,  Guoqing Chen ,  Lucian V. DiPietro ,  Julie Germain ,  Gregory J. Habgood ,  Qi Huang ,  Tae-Seong Kim ,  Aiwen Li ,  Nobuko Nishimura ,  Rana Nomak ,  Babak Riahi ,  Chester Chenguang Yuan ,  Daniel Elbaum

IPC分类号： C07D401/02 ,  A61K31/44

CPC分类号： C07D471/04 ,  A61K31/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：US07531553B2

公开(公告)日：2009-05-12

申请号：US10804915

申请日：2004-03-19

申请人： Lucian V. Di Pietro ,  Jean-Christophe Harmange ,  Benny C. Askew, Jr. ,  Daniel Elbaum ,  Julie Germain ,  Gregory J. Habgood ,  Joseph L. Kim ,  Vinod F. Patel ,  Michele Potashman ,  Simon van der Plas

发明人： Lucian V. Di Pietro ,  Jean-Christophe Harmange ,  Benny C. Askew, Jr. ,  Daniel Elbaum ,  Julie Germain ,  Gregory J. Habgood ,  Joseph L. Kim ,  Vinod F. Patel ,  Michele Potashman ,  Simon van der Plas

IPC分类号： A61K31/47 ,  C07D215/00

CPC分类号： C07D401/12 ,  C07D235/30 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：US07074789B2

公开(公告)日：2006-07-11

申请号：US10699518

申请日：2003-10-31

申请人： David M. Armistead ,  Jean E. Bemis ,  John L. Buchanan ,  Lucian V. DiPietro ,  Daniel Elbaum ,  Stephanie D. Geuns-Meyer ,  Gregory J. Habgood ,  Joseph L. Kim ,  Teresa L. Marshall ,  Perry M. Novak ,  Joseph J. Nunes ,  Vinod F. Patel ,  Leticia M. Toledo-Sherman ,  Xiaotian Zhu

发明人： David M. Armistead ,  Jean E. Bemis ,  John L. Buchanan ,  Lucian V. DiPietro ,  Daniel Elbaum ,  Stephanie D. Geuns-Meyer ,  Gregory J. Habgood ,  Joseph L. Kim ,  Teresa L. Marshall ,  Perry M. Novak ,  Joseph J. Nunes ,  Vinod F. Patel ,  Leticia M. Toledo-Sherman ,  Xiaotian Zhu

IPC分类号： C07D403/12 ,  C07D403/14 ,  A61K31/4155 ,  A61P35/04

CPC分类号： C07D401/04 ,  C07D251/18 ,  C07D251/22 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

摘要： The invention relates to inhibitors of enzymes that bind to ATP or GTP and/or catalyze phosphoryl transfer, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making phosphoryl transferase inhibitor compounds, methods of inhibiting phosphoryl transferase activity, and methods for treating disease or disease symptoms.

摘要翻译： 本发明涉及结合ATP或GTP和/或催化磷酸转移的酶抑制剂，包含抑制剂的组合物，以及使用抑制剂和抑制剂组合物的方法。 包含它们的抑制剂和组合物可用于治疗疾病或疾病症状。 本发明还提供了制备磷酸转移酶抑制剂化合物的方法，抑制磷酸转移酶活性的方法，以及治疗疾病或疾病症状的方法。

公开(公告)号：US07282504B2

公开(公告)日：2007-10-16

申请号：US11125614

申请日：2005-05-09

申请人： David M. Armistead ,  Jean E Bemis ,  Lucian V DiPietro ,  Stephanie D. Geuns-Meyer ,  Gregory J. Habgood ,  Joseph L. Kim ,  Joseph J. Nunes ,  Vinod F. Patel ,  Leticia M. Toledo-Sherman

发明人： David M. Armistead ,  Jean E Bemis ,  Lucian V DiPietro ,  Stephanie D. Geuns-Meyer ,  Gregory J. Habgood ,  Joseph L. Kim ,  Joseph J. Nunes ,  Vinod F. Patel ,  Leticia M. Toledo-Sherman

IPC分类号： C07D403/04 ,  A61K31/404

CPC分类号： C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14

摘要： The invention relates to inhibitors of kinases, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making kinase inhibitor compounds, methods of inhibiting kinase activity, and methods for treating disease or disease symptoms.

摘要翻译： 本发明涉及激酶抑制剂，包含抑制剂的组合物，以及使用抑制剂和抑制剂组合物的方法。 包含它们的抑制剂和组合物可用于治疗疾病或疾病症状。 本发明还提供了制备激酶抑制剂化合物的方法，抑制激酶活性的方法，以及治疗疾病或疾病症状的方法。

公开(公告)号：US07320992B2

公开(公告)日：2008-01-22

申请号：US10926238

申请日：2004-08-24

申请人： Christopher Tegley ,  Jeffrey A. Adams ,  Benny C. Askew, Jr. ,  Michael Croghan ,  Daniel Elbaum ,  Julie Germain ,  Gregory J. Habgood ,  Scott Harried ,  Aiwen Li ,  Nobuko Nishimura ,  Rana Nomak ,  Andrew Tasker ,  Kevin Yang

发明人： Christopher Tegley ,  Jeffrey A. Adams ,  Benny C. Askew, Jr. ,  Michael Croghan ,  Daniel Elbaum ,  Julie Germain ,  Gregory J. Habgood ,  Scott Harried ,  Aiwen Li ,  Nobuko Nishimura ,  Rana Nomak ,  Andrew Tasker ,  Kevin Yang

IPC分类号： A61K31/4439 ,  C07D401/12

CPC分类号： C04B35/632 ,  C07D401/12 ,  C07D401/14

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。