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公开(公告)号:US07435823B2
公开(公告)日:2008-10-14
申请号:US11042634
申请日:2005-01-24
申请人: Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , Gregory J. Habgood , David C. McGowan , Douglas A. Whittington , Daniel La , Vinod F. Patel
发明人: Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , Gregory J. Habgood , David C. McGowan , Douglas A. Whittington , Daniel La , Vinod F. Patel
IPC分类号: C07D215/38 , C07D265/34
CPC分类号: C07D213/64 , C07D213/81 , C07D215/233 , C07D215/38 , C07D215/48 , C07D215/54 , C07D237/34 , C07D239/34 , C07D239/47 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物,类似物,前药和药学上可接受的盐,用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号:US20090176774A1
公开(公告)日:2009-07-09
申请号:US12157303
申请日:2008-06-09
申请人: Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , David C. McGowan , Douglas A. Whittington , Gregory J. Habgood , Vinod F. Patel , Daniel La
发明人: Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , David C. McGowan , Douglas A. Whittington , Gregory J. Habgood , Vinod F. Patel , Daniel La
IPC分类号: A61K31/536 , A61K31/517 , A61K31/502 , A61K31/498 , A61K31/4709
CPC分类号: C07D213/64 , C07D213/81 , C07D215/233 , C07D215/38 , C07D215/48 , C07D215/54 , C07D237/34 , C07D239/34 , C07D239/47 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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公开(公告)号:US08178557B2
公开(公告)日:2012-05-15
申请号:US12157303
申请日:2008-06-09
申请人: Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , David C. McGowan , Douglas A. Whittington , Gregory J. Habgood , Vinod F. Patel , Daniel La
发明人: Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , David C. McGowan , Douglas A. Whittington , Gregory J. Habgood , Vinod F. Patel , Daniel La
IPC分类号: A61K31/04
CPC分类号: C07D213/64 , C07D213/81 , C07D215/233 , C07D215/38 , C07D215/48 , C07D215/54 , C07D237/34 , C07D239/34 , C07D239/47 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物,类似物,前药和药学上可接受的盐,用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号:US08476434B2
公开(公告)日:2013-07-02
申请号:US12952156
申请日:2010-11-22
申请人: Stephanie D. Geuns-Meyer , Brian L. Hodous , Stuart C. Chaffee , Paul Tempest , Ning Xi , Phillip R. Olivieri , Joseph L. Kim , Steven Bellon , Xiaotian Zhu , Yuan Cheng , Brian K. Albrecht , Vinod F. Patel , Victor J. Cee , Karina Romero , Hanh Nho Nguyen , Holly L. Deak , Rebecca E. Johnson
发明人: Stephanie D. Geuns-Meyer , Brian L. Hodous , Stuart C. Chaffee , Paul Tempest , Ning Xi , Phillip R. Olivieri , Joseph L. Kim , Steven Bellon , Xiaotian Zhu , Yuan Cheng , Brian K. Albrecht , Vinod F. Patel , Victor J. Cee , Karina Romero , Hanh Nho Nguyen , Holly L. Deak , Rebecca E. Johnson
IPC分类号: C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , A61K31/4427 , A61K31/506 , A61K31/54 , A61P19/02 , A61P35/00
CPC分类号: C07D213/73 , C07D239/42 , C07D401/04 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D471/04
摘要: The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other proliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.
摘要翻译: 本发明涉及具有通式I的化合物,其中A,B,D,E,G,H1-5和R1-4在本文中定义,以及能够调节各种蛋白激酶受体酶的合成中间体, 从而影响与这些激酶的活性相关的各种疾病状态和状况。 例如,化合物能够调节激酶,从而影响血管发生过程并治疗血管生成相关疾病和其它增殖性疾病,包括癌症和炎症。 本发明还包括药物组合物,包括该化合物,以及治疗与蛋白激酶活性有关的疾病状态的方法。
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公开(公告)号:US07880000B2
公开(公告)日:2011-02-01
申请号:US11126000
申请日:2005-05-09
申请人: Stephanie D. Geuns-Meyer , Brian L. Hodous , Stuart C. Chaffee , Paul A. Tempest , Philip R. Olivieri , Rebecca E. Johnson , Brian K. Albrecht , Vinod F. Patel , Victor J. Cee , Joseph L. Kim , Steven Bellon , Xiaotian Zhu , Yuan Cheng , Ning Xi , Karina Romero , Hanh Nho Nguyen , Holly L. Deak
发明人: Stephanie D. Geuns-Meyer , Brian L. Hodous , Stuart C. Chaffee , Paul A. Tempest , Philip R. Olivieri , Rebecca E. Johnson , Brian K. Albrecht , Vinod F. Patel , Victor J. Cee , Joseph L. Kim , Steven Bellon , Xiaotian Zhu , Yuan Cheng , Ning Xi , Karina Romero , Hanh Nho Nguyen , Holly L. Deak
IPC分类号: C07D401/14 , C07D403/14 , A61K31/53 , A61K31/4427 , A61K31/506 , A61P19/02 , A61P35/00
CPC分类号: C07D213/73 , C07D239/42 , C07D401/04 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D471/04
摘要: The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other poliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.
摘要翻译: 本发明涉及具有通式I的化合物,其中A,B,D,E,G,H1-5和R1-4在本文中定义,以及能够调节各种蛋白激酶受体酶的合成中间体, 从而影响与这些激酶的活性相关的各种疾病状态和状况。 例如,这些化合物能够调节激酶,从而影响血管生成过程并治疗血管生成相关疾病和其它包括癌症和炎症的复发性疾病。 本发明还包括药物组合物,包括该化合物,以及治疗与蛋白激酶活性有关的疾病状态的方法。
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公开(公告)号:US07776869B2
公开(公告)日:2010-08-17
申请号:US11251490
申请日:2005-10-14
申请人: Stuart C. Chaffee , Brian K. Albrecht , Brian L. Hodous , Matthew W. Martin , David C. McGowan , Erin F. DiMauro , Gade Reddy , Victor J. Cee , Philip R. Olivieri , Anthony Reed , Karina Romero
发明人: Stuart C. Chaffee , Brian K. Albrecht , Brian L. Hodous , Matthew W. Martin , David C. McGowan , Erin F. DiMauro , Gade Reddy , Victor J. Cee , Philip R. Olivieri , Anthony Reed , Karina Romero
IPC分类号: C07D239/38 , C07D239/42 , A61K31/505 , A61K31/506 , A61P35/00
CPC分类号: C07D213/74 , C07D213/81 , C07D215/14 , C07D239/42 , C07D241/42 , C07D401/06 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/06 , C07D409/06 , C07D413/12 , C07D417/12 , C07D471/04
摘要: The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I wherein A1, A2, A3, A4, R1 and R2 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译: 本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病,包括炎症,癌症和相关病症的化合物。 化合物具有通式I,其中A1,A2,A3,A4,R1和R2如本文所定义。 因此,本发明还包括含有本发明化合物的药物组合物,使用本发明化合物和组合物预防和治疗激酶介导的疾病的方法,以及可用于制备本发明化合物的中间体和方法。
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公开(公告)号:US20100160283A1
公开(公告)日:2010-06-24
申请号:US12716187
申请日:2010-03-02
申请人: Stuart C. Chaffee , Brian K. Albrecht , Brian L. Hodous , Matthew W. Martin , David C. McGowan , Erin F. DiMauro , Gade Reddy , Victor J. Cee , Philip R. Olivieri , Anthony Reed , Karina Romero
发明人: Stuart C. Chaffee , Brian K. Albrecht , Brian L. Hodous , Matthew W. Martin , David C. McGowan , Erin F. DiMauro , Gade Reddy , Victor J. Cee , Philip R. Olivieri , Anthony Reed , Karina Romero
IPC分类号: A61K31/397 , A61P35/00 , C07D239/28 , A61K31/505 , C07D403/12 , A61K31/496 , C07D413/12 , A61K31/5377 , C07D417/12 , A61K31/541
CPC分类号: C07D213/74 , C07D213/81 , C07D215/14 , C07D239/42 , C07D241/42 , C07D401/06 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/06 , C07D409/06 , C07D413/12 , C07D417/12 , C07D471/04
摘要: The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I wherein A1, A2, A3, A4, R1 and R2 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译: 本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病,包括炎症,癌症和相关病症的化合物。 化合物具有通式I,其中A1,A2,A3,A4,R1和R2如本文所定义。 因此,本发明还包括含有本发明化合物的药物组合物,使用本发明化合物和组合物预防和治疗激酶介导的疾病的方法,以及可用于制备本发明化合物的中间体和方法。
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公开(公告)号:US09499522B2
公开(公告)日:2016-11-22
申请号:US14210526
申请日:2014-03-14
申请人: Lucian V. DiPietro , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu , Steven Mark Wenglowsky , Douglas Wilson , Yulian Zhang
发明人: Lucian V. DiPietro , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu , Steven Mark Wenglowsky , Douglas Wilson , Yulian Zhang
IPC分类号: C07D403/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D487/04 , C07D487/08 , C07D401/12 , C07D403/04 , C07D403/14 , C07D239/94 , C07D487/22
CPC分类号: C07D403/14 , C07D239/94 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D473/34 , C07D487/04 , C07D487/08 , C07D487/22
摘要: Compounds and compositions useful for treating disorders related to Kit are described herein.
摘要翻译: 本文描述了可用于治疗与Kit相关的疾病的化合物和组合物。
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公开(公告)号:US20140296206A1
公开(公告)日:2014-10-02
申请号:US14210526
申请日:2014-03-14
申请人: Lucian V. DiPietro , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu , Steven Mark Wenglowsky , Douglas Wilson , Yulian Zhang
发明人: Lucian V. DiPietro , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu , Steven Mark Wenglowsky , Douglas Wilson , Yulian Zhang
IPC分类号: C07D403/12 , C07D487/08 , C07D413/14 , C07D409/14 , C07D405/14 , C07D487/04 , C07D401/14
CPC分类号: C07D403/14 , C07D239/94 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D473/34 , C07D487/04 , C07D487/08 , C07D487/22
摘要: Compounds and compositions useful for treating disorders related to Kit are described herein.
摘要翻译: 本文描述了可用于治疗与Kit相关的疾病的化合物和组合物。
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公开(公告)号:US09434700B2
公开(公告)日:2016-09-06
申请号:US14521909
申请日:2014-10-23
IPC分类号: C07D405/12 , A61K31/517 , C07D239/84 , C07D401/12 , C07D403/12 , C07D403/14 , C07D471/04 , C07D401/04 , C07D475/00 , C07D235/30 , C07D409/12 , C07D475/08
CPC分类号: C07D401/04 , C07D235/30 , C07D239/84 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D471/04 , C07D475/00
摘要: Described herein are inhibitors of FGFR-4, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
摘要翻译: 本文描述的是FGFR-4的抑制剂,包括这些化合物的药物组合物,以及使用这些化合物和组合物的方法。
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