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    Methods for producing low binding surfaces
    3.
    发明授权
    Methods for producing low binding surfaces 有权
    生产低粘结表面的方法

    公开(公告)号：US06565789B2

    公开(公告)日：2003-05-20

    申请号：US09507421

    申请日：2000-02-18

    申请人： Dana Craig Bookbinder ,  Edward John Fewkes, Jr. ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

    发明人： Dana Craig Bookbinder ,  Edward John Fewkes, Jr. ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

    IPC分类号： B28B722

    CPC分类号： C07H21/00 ,  B01L3/50 ,  B01L3/5082 ,  B01L2200/12 ,  B01L2300/16 ,  B05D7/02 ,  C07B2200/11 ,  C08J7/047 ,  C08J7/065 ,  C08J2471/00 ,  C09D5/00 ,  G01N33/54393

    摘要： Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 to the surface; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions. Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to the mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.

    摘要翻译： 蛋白质结合水平小于约50-80ng / cm 2的疏水性聚合物表面通过以下方式实现：（1）将由溶剂和HLB数小于5的非离子表面活性剂组成的涂布溶液施加到表面 ; 和（2）干燥表面以除去溶剂，从而使表面活性剂与疏水性聚合物直接接触。 已经发现低HLB值和干燥步骤的组合产生低结合表面，其可以经受多次用水和/或蛋白质溶液洗涤。 或者，低结合表面可以通过将非离子表面活性剂施加到与熔融聚合物接触的模具表面并将聚合物形成所需形状，例如多孔板，移液管尖端等来制备。 此外，低粘合表面可以通过将HLB数小于或等于10的非可溶性非离子表面活性剂在模制制品之前加入到聚合物共混物中来制备。

    Low protein-binding polymer product produced using low HLB number non-ionic surfactant
    4.
    发明授权
    Low protein-binding polymer product produced using low HLB number non-ionic surfactant 有权
    使用低HLB值非离子表面活性剂制备的低蛋白结合聚合物产物

    公开(公告)号：US06319664B1

    公开(公告)日：2001-11-20

    申请号：US09507422

    申请日：2000-02-18

    申请人： Dana Craig Bookbinder ,  Edward John Fewkes, Jr. ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

    发明人： Dana Craig Bookbinder ,  Edward John Fewkes, Jr. ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

    IPC分类号： C12Q100

    CPC分类号： C07H21/00 ,  B01L3/50 ,  B01L3/5082 ,  B01L2200/12 ,  B01L2300/16 ,  B05D7/02 ,  C07B2200/11 ,  C08J7/047 ,  C08J7/065 ,  C08J2471/00 ,  C09D5/00 ,  G01N33/54393

    摘要： Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying to a hydrophobic polymer surface a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 and at least one hydrophilic element which can extend into an aqueous solution; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions. Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article. Molding uses shear condition that cause the surfactant to move to the surface of a polymer product formed by the molding such that a hydrophilic part of the surfactant extends from the surface to provide a surface having low binding for proteins.

    摘要翻译： 蛋白质结合水平小于约50-80ng / cm 2的疏水性聚合物表面通过以下方式实现：（1）将疏水性聚合物表面施用由HLB值少的溶剂和非离子表面活性剂组成的涂布溶液 可以延伸至水溶液中的至少一种亲水性元素; 和（2）干燥表面以除去溶剂，从而使表面活性剂与疏水性聚合物直接接触。 已经发现低HLB值和干燥步骤的组合产生低结合表面，其可以经受多次用水和/或蛋白质溶液洗涤。 或者，低结合表面可以通过将非离子表面活性剂施加到与熔融聚合物接触的模具表面并将聚合物形成期望的形状，例如多孔板，移液管尖端等中来制备。 此外，低粘合表面可以通过将HLB数小于或等于10的非可溶性非离子表面活性剂在模制制品之前加入到聚合物共混物中来制备。 成型使用剪切条件，使得表面活性剂移动到通过模制形成的聚合物产品的表面，使得表面活性剂的亲水部分从表面延伸，以提供具有低蛋白质结合的表面。

    Sealing glass paste method
    5.
    发明授权
    Sealing glass paste method 有权
    密封玻璃糊法

    公开(公告)号：US6069099A

    公开(公告)日：2000-05-30

    申请号：US171015

    申请日：1998-10-08

    申请人： Edward J. Fewkes ,  Margaret E. Greene ,  Robert Morena ,  Frances M. Smith

    发明人： Edward J. Fewkes ,  Margaret E. Greene ,  Robert Morena ,  Frances M. Smith

    IPC分类号： C03C8/14 ,  C03C8/16 ,  C03C8/20 ,  C03C8/24

    CPC分类号： C03C8/20 ,  C03C8/14 ,  C03C8/16 ,  C03C8/24

    摘要： A method of controlling the rheology of a sealing glass paste which comprises incorporating a fine inorganic powder in the paste as a mill addition to impart a steep rheology curve to the paste so that the paste resists flow while at rest, but flows readily when shear stress is applied, the amount of inorganic powder incorporated being not over about 10% by weight.

    摘要翻译： PCT No.PCT / US97 / 06926 Sec。 371日期：1998年10月8日 102（e）日期1998年10月8日PCT 1997年4月21日PCT PCT。 出版物WO97 / 41078 日期1997年11月6日一种控制密封玻璃浆料的流变学的方法，其包括在糊料中加入细无机粉末作为研磨添加剂，以赋予浆料陡峭的流变曲线，使得糊料在静止时抵抗流动，但是 施加剪切应力时容易流动，掺入的无机粉末的量不超过约10重量％。

    Rapid-setting formable mixtures and method of making and using same
    6.
    发明授权
    Rapid-setting formable mixtures and method of making and using same 失效
    快速凝固成型混合物及其制备和使用方法

    公开(公告)号：US5925308A

    公开(公告)日：1999-07-20

    申请号：US900163

    申请日：1997-07-28

    申请人： Edward J. Fewkes ,  Frances M. Smith ,  Lung-Ming Wu

    发明人： Edward J. Fewkes ,  Frances M. Smith ,  Lung-Ming Wu

    IPC分类号： B22F1/00 ,  B22F3/22 ,  C04B35/634 ,  C04B38/06 ,  C08K3/00

    CPC分类号： B22F3/225 ,  B22F1/0059 ,  C04B35/634 ,  C04B35/63404 ,  C04B35/63416 ,  C04B35/63424 ,  C04B35/63488 ,  B22F2998/00 ,  C04B2111/00129

    摘要： A method of producing a formable mixture involves combining a powder material, and a plurality of gel-forming polymers, wherein at least one gel-forming polymer is a proton donor, and at least one gel forming polymer is a proton acceptor. A method of making a monolithic structure involves producing a formable mixture of powder material which can be ceramic, metal, glass, glass ceramic, molecular sieve and combinations thereof, a plurality of gel-forming polymers as described above, extruding the mixture to form a green monolithic structure, and drying and firing the green structure.

    摘要翻译： 制备可成形混合物的方法包括将粉末材料和多种凝胶形成聚合物组合，其中至少一种凝胶形成聚合物是质子供体，并且至少一种形成凝胶的聚合物是质子受体。 制造整体结构的方法包括制备可形成陶瓷，金属，玻璃，玻璃陶瓷，分子筛及其组合的粉末材料的混合物，多个如上所述的凝胶形成聚合物，挤出混合物以形成 绿色整体结构，干燥和烧结绿色结构。

    Methods for producing low binding surfaces
    7.
    发明申请
    Methods for producing low binding surfaces 审中-公开
    生产低粘结表面的方法

    公开(公告)号：US20080145280A1

    公开(公告)日：2008-06-19

    申请号：US11978863

    申请日：2007-10-30

    申请人： Dana Craig Bookbinder ,  Edward John Fewkes ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

    发明人： Dana Craig Bookbinder ,  Edward John Fewkes ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

    IPC分类号： B01L3/00 ,  B01L11/00 ,  B01L3/02 ,  B05D3/12

    CPC分类号： C07H21/00 ,  B01L3/50 ,  B01L3/5082 ,  B01L2200/12 ,  B01L2300/16 ,  B05D7/02 ,  C07B2200/11 ,  C08J7/047 ,  C08J7/065 ,  C08J2471/00 ,  C09D5/00 ,  G01N33/54393

    摘要： Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 to the surface; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions. Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to the mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.

    摘要翻译： 蛋白质结合水平小于约50-80ng / cm 2的疏水性聚合物表面通过以下方式实现：（1）施加由溶剂和具有HLB的非离子表面活性剂组成的涂布溶液 数量小于5的表面; 和（2）干燥表面以除去溶剂，从而使表面活性剂与疏水性聚合物直接接触。 已经发现低HLB值和干燥步骤的组合产生低结合表面，其可以经受多次用水和/或蛋白质溶液洗涤。 或者，低结合表面可以通过将非离子表面活性剂施加到与熔融聚合物接触的模具表面并将聚合物形成所需形状，例如多孔板，移液管尖端等来制备。 此外，低粘合表面可以通过将HLB数小于或等于10的非可溶性非离子表面活性剂在模制制品之前加入到聚合物共混物中来制备。

    High absorption erbium doped amplifying optical fiber
    8.
    发明授权
    High absorption erbium doped amplifying optical fiber 有权
    高吸收铒掺杂放大光纤

    公开(公告)号：US06819846B2

    公开(公告)日：2004-11-16

    申请号：US10206663

    申请日：2002-07-26

    申请人： Rachel S. Mozdy ,  Atul D. Pradhan ,  Frances M. Smith ,  William A. Wood

    发明人： Rachel S. Mozdy ,  Atul D. Pradhan ,  Frances M. Smith ,  William A. Wood

    IPC分类号： G02B616

    CPC分类号： H01S3/06716 ,  C03C13/04 ,  C03C13/046 ,  G02B6/02004 ,  G02B6/02285 ,  G02B6/0285 ,  H01S3/067 ,  H01S3/06729 ,  H01S3/1608

    摘要： An optical waveguide fiber amplifier comprising a core region comprises at least in part between 1300 wt.ppm and 3600 wt.ppm Er2O3, between 6.0 wt. % to 10.0 wt. % Al2O3 and between 9.0 wt. % and 20.0 wt. % GeO2. The amplifier also comprising an inner clad surrounding the core region and an outer clad surrounding the inner clad. The relative refractive index percentages and radii of the core region, inner clad and outer clad are chosen from the following ranges: the relative refractive index percent of the core segment within the range of from about 0.5% to about 2.0%; the relative refractive index percent of the inner clad within the range of from about 0.0% to about 0.4%; the outer radius of the core region within the range of from about 0.7 &mgr;m to about 1.5 &mgr;m; and, the outer radius of the inner clad within the range of from about 4.3 &mgr;m to about 18.8 &mgr;m.

    摘要翻译： 包括芯区域的光波导光纤放大器至少部分地包括在1300重量ppm和3600重量ppm Er 2 O 3之间，6.0重量％ ％〜10.0重量％ ％Al 2 O 3和9.0重量％ ％和20.0重量％ ％GeO2。 放大器还包括围绕芯区的内包层和围绕内包层的外包层。 芯区域，内包层和外包层的相对折射率百分比和半径选自以下范围：核心片段的相对折射率百分比在约0.5％至约2.0％的范围内; 内包层的相对折射率百分比在约0.0％至约0.4％的范围内; 芯区域的外半径在约0.7μm至约1.5μm的范围内; 并且内包层的外半径在约4.3μm至约18.8μm的范围内。

    Producing low binding hydrophobic surfaces by treating with a low HLB number non-ionic surfactant
    9.
    发明授权
    Producing low binding hydrophobic surfaces by treating with a low HLB number non-ionic surfactant 失效
    通过用低HLB值非离子表面活性剂处理生产低结合疏水性表面

    公开(公告)号：US6093559A

    公开(公告)日：2000-07-25

    申请号：US918354

    申请日：1997-08-26

    申请人： Dana Craig Bookbinder ,  Edward John Fewkes, Jr. ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

    发明人： Dana Craig Bookbinder ,  Edward John Fewkes, Jr. ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

    IPC分类号： B05D5/08 ,  B01L99/00 ,  B05D3/02 ,  C07H21/00 ,  C08J7/04 ,  C08J7/06 ,  G01N33/543 ,  C12N9/00 ,  C07K17/00 ,  G01N33/53

    CPC分类号： C07H21/00 ,  C08J7/047 ,  C08J7/065 ,  C09D5/00 ,  G01N33/54393 ,  B01L2200/12 ,  B01L2300/16 ,  B01L3/50 ,  B01L3/5082 ,  B05D7/02 ,  C07B2200/11 ,  C08J2471/00

    摘要： Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm.sup.2 are achieved by: (1) applying to a hydrophobic polymer surface a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 and at least one hydrophilic element which can extend into an aqueous solution; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions. Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.

    摘要翻译： 蛋白质结合水平小于约50-80ng / cm 2的疏水性聚合物表面通过以下方式实现：（1）将疏水性聚合物表面施用由HLB值少的溶剂和非离子表面活性剂组成的涂布溶液 可以延伸至水溶液中的至少一种亲水性元素; 和（2）干燥表面以除去溶剂，从而使表面活性剂与疏水性聚合物直接接触。 已经发现低HLB值和干燥步骤的组合产生低结合表面，其可以经受多次用水和/或蛋白质溶液洗涤。 或者，低结合表面可以通过将非离子表面活性剂施加到与熔融聚合物接触的模具表面并将聚合物形成期望的形状，例如多孔板，移液管尖端等来制备。 此外，低粘合表面可以通过将HLB数小于或等于10的非可溶性非离子表面活性剂在模制制品之前加入到聚合物共混物中来制备。