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    Methods and devices for the long-term culture of hematopoietic progenitor cells
    1.
    发明申请
    Methods and devices for the long-term culture of hematopoietic progenitor cells 审中-公开
    造血祖细胞长期培养的方法和装置

    公开(公告)号：US20070148769A1

    公开(公告)日：2007-06-28

    申请号：US11474931

    申请日：2006-06-26

    申请人： Mark Pykett ,  Michael Rosenzweig ,  Richard Kaplan

    发明人： Mark Pykett ,  Michael Rosenzweig ,  Richard Kaplan

    IPC分类号： C12N5/08 ,  C12N5/06 ,  C12M3/00

    CPC分类号： C12M23/20 ,  A61K2035/124 ,  C12M25/14 ,  C12M29/10 ,  C12N5/0647 ,  C12N2501/125 ,  C12N2501/23 ,  C12N2501/26 ,  C12N2510/00 ,  C12N2533/30 ,  C12N2533/52

    摘要： The invention pertains to methods and devices for the long term, in vitroculture of hematopoietic progenitor cells in the absence of exogenously added hematopoietic growth factors, improved methods for the introduction of foreign genetic material into cells of hematopoietic origin, and to apparatus for performing these methods. The hematopoietic progenitor cells are cultured on a three-dimensional porous biomaterial. The three-dimensional porous biomaterial enhances hematopoietic progenitor cell survival and leads to an expansion of progenitor cell numbers and/or functionality, while maintaining progenitor cell pluripotency in the absence of exogenous growth factors. In addition, the three-dimensional porous biomaterial supports high level transduction on cells cultured upon such environment.

    摘要翻译： 本发明涉及在没有外源性添加的造血生长因子的情况下在造血祖细胞的培养中长期的方法和装置，用于将外来遗传物质引入造血源的细胞的改进方法以及用于进行这些方法的装置 。 造血祖细胞在三维多孔生物材料上培养。 三维多孔生物材料增强造血祖细胞的存活并导致祖细胞数量和/或功能的扩大，同时在没有外源生长因子的情况下保持祖细胞多能性。 此外，三维多孔生物材料支持在这种环境下培养的细胞上的高水平转导。

    Methods and devices for the long-term culture of hematopoietic progenitor cells
    2.
    发明申请
    Methods and devices for the long-term culture of hematopoietic progenitor cells 失效
    造血祖细胞长期培养的方法和装置

    公开(公告)号：US20050079609A1

    公开(公告)日：2005-04-14

    申请号：US10705720

    申请日：2003-11-10

    申请人： Mark Pykett ,  Michael Rosenzweig ,  Richard Kaplan

    发明人： Mark Pykett ,  Michael Rosenzweig ,  Richard Kaplan

    IPC分类号： A61K35/12 ,  C12M3/00 ,  C12N5/02 ,  C12N5/0789 ,  C12N5/08 ,  A61F2/00

    CPC分类号： C12M23/20 ,  A61K2035/124 ,  C12M25/14 ,  C12M29/10 ,  C12N5/0647 ,  C12N2501/125 ,  C12N2501/23 ,  C12N2501/26 ,  C12N2510/00 ,  C12N2533/30 ,  C12N2533/52

    摘要： The invention pertains to methods and devices for the long term, in vitroculture of hematopoietic progenitor cells in the absence of exogenously added hematopoietic growth factors, improved methods for the introduction of foreign genetic material into cells of hematopoietic origin, and to apparatus for performing these methods. The hematopoietic progenitor cells are cultured on a three-dimensional porous biomaterial. The three-dimensional porous biomaterial enhances hematopoietic progenitor cell survival and leads to an expansion of progenitor cell numbers and/or functionality, while maintaining progenitor cell pluripotency in the absence of exogenous growth factors. In addition, the three-dimensional porous biomaterial supports high level transduction on cells cultured upon such environment.

    摘要翻译： 本发明涉及在没有外源性添加的造血生长因子的情况下在造血祖细胞的培养中长期的方法和装置，用于将外来遗传物质引入造血源的细胞的改进方法以及用于进行这些方法的装置 。 造血祖细胞在三维多孔生物材料上培养。 三维多孔生物材料增强造血祖细胞的存活并导致祖细胞数量和/或功能的扩大，同时在没有外源生长因子的情况下保持祖细胞多能性。 此外，三维多孔生物材料支持在这种环境下培养的细胞上的高水平转导。

    Deployable reflector structure
    5.
    发明授权
    Deployable reflector structure 失效
    可部署的反射器结构

    公开(公告)号：US4030102A

    公开(公告)日：1977-06-14

    申请号：US625210

    申请日：1975-10-23

    申请人： Richard Kaplan ,  Jack L. Schultz

    发明人： Richard Kaplan ,  Jack L. Schultz

    IPC分类号： H01Q15/16 ,  H01Q15/20

    CPC分类号： H01Q15/161 ,  F16C11/04 ,  Y10S136/292 ,  Y10S343/02

    摘要： A supporting structure that deployed resembles a spoked wheel which is retractable into a compact volume by virtue of hinged rim and reelable spokes that is an efficient and stable structure for storing, deploying and supporting surfaces such as radar and communications antennas, shielding, earth sensing, solar cell arrays and solar energy reflectors.

    摘要翻译： 一种支撑结构，其部署类似于通过铰接边缘和可卷绕轮辐可缩回到紧凑体积中的轮辐，该轮辐是用于存储，部署和支撑诸如雷达和通信天线，屏蔽，地球感测等的表面的有效且稳定的结构， 太阳能电池阵列和太阳能反射器。

    Method and apparatus for an interactive tour-guide system
    6.
    发明申请
    Method and apparatus for an interactive tour-guide system 审中-公开
    交互式导游系统的方法和装置

    公开(公告)号：US20050192025A1

    公开(公告)日：2005-09-01

    申请号：US10973948

    申请日：2004-10-26

    申请人： Richard Kaplan

    发明人： Richard Kaplan

    IPC分类号： G06F17/30 ,  H04L29/08 ,  H04W4/02 ,  H04Q7/20

    CPC分类号： G06F16/9537 ,  H04L67/306 ,  H04W4/029

    摘要： An interactive tour guide system includes software downloaded from a tour-guide web site to a PDA (portable digital assistant) or tablet laptop computer. The user indicates his geographic location to the interactive tour-guide device by entry on a dynamic city map. Intelligent agent software responsive to a request from the user creates a customized tour program. The intelligent agent guides the user along the customized tour route by voice, video and/or graphics, and provides information about each exhibit on the tour. The downloaded interactive tour guide system provides interactive guided tours, theme guided tours and a self-guided “wander mode” tour. The virtual tour-guide system can personalize each directed tour by taking individual user expressed preferences into account, and can use collaborative filtering of experiences with prior users to suggest other exhibits which may be of interest to the present user. The interactive tour-guide system responds like a human tour-guide to the needs of the user.

    摘要翻译： 互动导游系统包括从导游网站下载到PDA（便携式数字助理）或平板电脑笔记本电脑的软件。 用户通过在动态城市地图上输入来指示他到交互式导游设备的地理位置。 响应于来自用户的请求的智能代理软件创建定制的旅游节目。 智能代理人通过语音，视频和/或图形沿着定制的旅游路线引导用户，并提供有关旅游中每个展览的信息。 下载的互动导览系统提供互动导览，主题导览及自导游“漫游模式”之旅。 虚拟导游系统可以通过考虑个人用户表达的偏好来个性化每个定向游览，并且可以使用与先前用户的经验的协作过滤来建议当前用户可能感兴趣的其他展览。 互动导游系统像用户的需求一样响应人类导游。

    BRITTLE BIOCOMPATIBLE COMPOSITES AND METHODS
    8.
    发明申请
    BRITTLE BIOCOMPATIBLE COMPOSITES AND METHODS 审中-公开
    脆性生物成分复合材料和方法

    公开(公告)号：US20140025179A1

    公开(公告)日：2014-01-23

    申请号：US13829858

    申请日：2013-03-14

    申请人： Arthur J. Fortini ,  Richard Kaplan ,  Gregory Borwick

    发明人： Arthur J. Fortini ,  Richard Kaplan ,  Gregory Borwick

    IPC分类号： A61F2/28 ,  B32B3/26

    CPC分类号： A61F2/28 ,  A61F2002/3092 ,  A61F2002/30981 ,  A61F2310/00161 ,  A61F2310/00544 ,  A61L27/00 ,  A61L27/08 ,  A61L27/306 ,  A61L27/56 ,  B32B3/26 ,  Y10T428/249953 ,  Y10T428/24997

    摘要： Reticulated composites are formed with a thin coating of a ductile biocompatible metal such as tantalum on a brittle biocompatible substrate such as vitreous carbon. Such composites exhibit physical properties that permit these monolithic composites to be morselized, or sized and shaped manually. Such composites exhibit surfaces with excellent ductile metal biocompatibility properties, but with strength and fracture physical properties that are more characteristic of the brittle substrate than of the ductile metal. Such composites fracture easily, and may be morselized or worked by manual sizing and shaping. Such morselization and working is accomplished by breaking or fracturing the composite, rather than plastically deforming it. Morselized or manually shaped reticulated composites exhibit excellent biocompatibility characteristics with micro- and nano-textured surfaces that promote rapid bone ingrowth and adhesion. When the composite is broken, the substrate is exposed. The presence of exposed substrate does not significantly impair the biocompatibility of these composites.

    摘要翻译： 网状复合材料在脆性生物相容性底物如玻璃碳上形成薄延展性生物相容性金属如钽的薄涂层。 这种复合材料表现出物理性能，其允许这些整体复合材料被单独化，或者尺寸和手工成型。 这种复合材料表现出具有优良的延展性金属生物相容性的表面，但具有强度和断裂物理性质，其脆性基材比延性金属更具特征。 这种复合材料容易断裂，并可通过手工施胶和成型进行微孔化或加工。 这样的碎片化和加工是通过破碎或压裂复合材料来实现的，而不是塑性变形。 手工成形的网状复合材料具有优异的生物相容性特征，具有促进快速骨向内生长和粘附的微观和纳米纹理表面。 当复合材料破裂时，衬底被暴露。 暴露的底物的存在不会显着损害这些复合材料的生物相容性。