公开(公告)号：US07200659B2

公开(公告)日：2007-04-03

申请号：US11031848

申请日：2005-01-07

申请人： Mark S. Bayus ,  James C. Chen ,  Steven E. Klein ,  Richard A. Ripberger

发明人： Mark S. Bayus ,  James C. Chen ,  Steven E. Klein ,  Richard A. Ripberger

IPC分类号： G06F15/173

CPC分类号： G06F3/0637 ,  G06F3/0622 ,  G06F3/0689

摘要： A log-in resource release system includes a set of lists for managing log-in requests to a processing cluster input/output port from host server input/output ports. Host servers that have been granted memory structures within a memory storage device (“configured hosts”) are granted priority access to a storage processing device's input/output port (“cluster port”). If the cluster port has exhausted its log-in resources, log-on requests from non-configured hosts will be not be accepted. New log-in requests from configured hosts will cause a host connected at a link or transport layer but not an upper layer to be logged off. If no hosts are connected only at the link or transport layer, a non-configured host connected at an upper layer will be logged off. If only configured hosts are connected and only at the upper layer, the log-on request by the configured host will be denied.

摘要翻译： 登录资源释放系统包括一组用于管理从主机服务器输入/输出端口到处理集群输入/输出端口的登录请求的列表。 被授予内存存储设备（“配置的主机”）内存结构的主机服务器被授予对存储处理设备的输入/输出端口（“群集端口”）的优先权访问权限。 如果群集端口已耗尽其登录资源，则不会接受未配置主机的登录请求。 配置主机的新登录请求将导致连接在链路或传输层但不是上层的主机被注销。 如果没有主机仅在链路或传输层连接，则在上层连接的未配置的主机将被注销。 如果仅配置的主机已连接，并且仅在上层，则配置的主机的登录请求将被拒绝。

公开(公告)号：US07523207B2

公开(公告)日：2009-04-21

申请号：US10719179

申请日：2003-11-20

申请人： James C. Chen ,  Patricia C. Lu ,  Chung M. Fung ,  Minh-Ngoc L. Huynh ,  Christopher M. Sansone ,  Dung N. Dang ,  Gail A. Spear ,  Richard A. Ripberger

发明人： James C. Chen ,  Patricia C. Lu ,  Chung M. Fung ,  Minh-Ngoc L. Huynh ,  Christopher M. Sansone ,  Dung N. Dang ,  Gail A. Spear ,  Richard A. Ripberger

IPC分类号： G06F15/16 ,  G06F15/173 ,  G06F15/177

CPC分类号： H04L67/1097 ,  H04L29/12801 ,  H04L61/6004

摘要： Methods, system and computer program product are provided to configure a path between nodes through a fabric in a fibre channel storage area network (SAN). A node name is provided for a target node on the SAN and a port name is provided for each port in the target node. A relationship is established in a data structure between each port name and a slot in which each port is physically located in the target node. Prior to configuring a path between a source node and a port in the target node, the ports which are physically connected and logged in to the fabric are identified by port address. The port names corresponding to the port addresses are then identified. The port names are used to generate interface_ids of the ports corresponding to the physical slots in which the ports are located. A data structure is created to maintain the relationship between interface_ids and port names. To establish a path connection between a port in the source node and a selected port in the target node, the node name of the target node and the interface_id of the selected port are input to the data structure and the port name of the selected port is output. The port name is then used to obtain the address of the selected port and an I/O session path opened between the source and target nodes.

摘要翻译： 提供方法，系统和计算机程序产品，以通过光纤通道存储区域网络（SAN）中的结构来配置节点之间的路径。 为SAN上的目标节点提供节点名称，并为目标节点中的每个端口提供端口名称。 在每个端口名称和每个端口物理上位于目标节点的时隙之间的数据结构中建立关系。 在目标节点中的源节点和端口之间配置路径之前，物理连接并登录到结构的端口由端口地址标识。 然后识别与端口地址对应的端口名称。 端口名称用于生成与端口所在物理槽相对应的端口的接口ID。 创建数据结构以维护interface_ids和端口名称之间的关系。 要在源节点中的端口和目标节点的选定端口之间建立路径连接，将目标节点的节点名称和所选端口的interface_id输入到数据结构，所选端口的端口名称为 输出。 然后使用端口名称来获取所选端口的地址以及在源节点和目标节点之间打开的I / O会话路径。

公开(公告)号：US20080205299A1

公开(公告)日：2008-08-28

申请号：US12117112

申请日：2008-05-08

申请人： James C. Chen ,  Patricia C. Lu ,  Chung M. Fung ,  Minh-Ngoc L. Huynh ,  Christopher M. Sansone ,  Dung N. Dang ,  Gail A. Spear ,  Richard A. Ripberger

发明人： James C. Chen ,  Patricia C. Lu ,  Chung M. Fung ,  Minh-Ngoc L. Huynh ,  Christopher M. Sansone ,  Dung N. Dang ,  Gail A. Spear ,  Richard A. Ripberger

IPC分类号： H04L12/28

CPC分类号： H04L67/1097 ,  H04L29/12801 ,  H04L61/6004

摘要： System and computer program product are provided to configure a path between nodes through a fabric in a fibre channel storage area network (SAN). A node name is provided for a target node on the SAN and a port name is provided for each port in the target node. A relationship is established in a data structure between each port name and a slot in which each port is physically located in the target node. Prior to configuring a path between a source node and a port in the target node, the ports which are physically connected and logged in to the fabric are identified by port address. The port names corresponding to the port addresses are then identified. The port names are used to generate interface_ids of the ports corresponding to the physical slots in which the ports are located. A data structure is created to maintain the relationship between interface_ids and port names. To establish a path connection between a port in the source node and a selected port in the target node, the node name of the target node and the interface_id of the selected port are input to the data structure and the port name of the selected port is output. The port name is then used to obtain the address of the selected port and an I/O session path opened between the source and target nodes.

摘要翻译： 提供系统和计算机程序产品，以通过光纤通道存储区域网络（SAN）中的结构来配置节点之间的路径。 为SAN上的目标节点提供节点名称，并为目标节点中的每个端口提供端口名称。 在每个端口名称和每个端口物理上位于目标节点的时隙之间的数据结构中建立关系。 在目标节点中的源节点和端口之间配置路径之前，物理连接并登录到结构的端口由端口地址标识。 然后识别与端口地址对应的端口名称。 端口名称用于生成与端口所在物理槽相对应的端口的接口ID。 创建数据结构以维护interface_ids和端口名称之间的关系。 要在源节点中的端口和目标节点的选定端口之间建立路径连接，将目标节点的节点名称和所选端口的interface_id输入到数据结构，所选端口的端口名称为 输出。 然后使用端口名称来获取所选端口的地址以及在源节点和目标节点之间打开的I / O会话路径。

公开(公告)号：US07873744B2

公开(公告)日：2011-01-18

申请号：US12117112

申请日：2008-05-08

申请人： James C. Chen ,  Patricia C. Lu ,  Chung M. Fung ,  Minh-Ngoc L. Huynh ,  Christopher M. Sansone ,  Dung N. Dang ,  Gail A. Spear ,  Richard A. Ripberger

发明人： James C. Chen ,  Patricia C. Lu ,  Chung M. Fung ,  Minh-Ngoc L. Huynh ,  Christopher M. Sansone ,  Dung N. Dang ,  Gail A. Spear ,  Richard A. Ripberger

IPC分类号： G06F15/00

CPC分类号： H04L67/1097 ,  H04L29/12801 ,  H04L61/6004

摘要： System and computer program product are provided to configure a path between nodes through a fabric in a fibre channel storage area network (SAN). A node name is provided for a target node on the SAN and a port name is provided for each port in the target node. A relationship is established in a data structure between each port name and a slot in which each port is physically located in the target node. Prior to configuring a path between a source node and a port in the target node, the ports which are physically connected and logged in to the fabric are identified by port address. The port names corresponding to the port addresses are then identified. The port names are used to generate interface_ids of the ports corresponding to the physical slots in which the ports are located. A data structure is created to maintain the relationship between interface_ids and port names. To establish a path connection between a port in the source node and a selected port in the target node, the node name of the target node and the interface_id of the selected port are input to the data structure and the port name of the selected port is output. The port name is then used to obtain the address of the selected port and an I/O session path opened between the source and target nodes.

摘要翻译： 提供系统和计算机程序产品，以通过光纤通道存储区域网络（SAN）中的结构来配置节点之间的路径。 为SAN上的目标节点提供节点名称，并为目标节点中的每个端口提供端口名称。 在每个端口名称和每个端口物理上位于目标节点的时隙之间的数据结构中建立关系。 在目标节点中的源节点和端口之间配置路径之前，物理连接并登录到结构的端口由端口地址标识。 然后识别与端口地址对应的端口名称。 端口名称用于生成与端口所在物理槽相对应的端口的接口ID。 创建数据结构以维护interface_ids和端口名称之间的关系。 要在源节点中的端口和目标节点的选定端口之间建立路径连接，将目标节点的节点名称和所选端口的interface_id输入到数据结构，所选端口的端口名称为 输出。 然后使用端口名称来获取所选端口的地址以及在源节点和目标节点之间打开的I / O会话路径。

公开(公告)号：US20120149091A1

公开(公告)日：2012-06-14

申请号：US11608527

申请日：2006-12-08

申请人： Brian D. Wilkerson ,  James C. Chen ,  John Pulse ,  Andrei Guschin ,  Michael Weaver

发明人： Brian D. Wilkerson ,  James C. Chen ,  John Pulse ,  Andrei Guschin ,  Michael Weaver

IPC分类号： C12N1/12 ,  C12N1/00 ,  C12M1/02 ,  C12M1/42

CPC分类号： C12P7/649 ,  C12M21/02 ,  C12M31/10 ,  C12M41/06 ,  C12M41/36 ,  C12N1/12 ,  C12N13/00 ,  C12P7/6463 ,  C12P39/00 ,  Y02E50/13 ,  Y02E50/343 ,  Y02P20/134

摘要： Systems, devices, and methods for cultivating biomasses. A bioreactor system is operable for growing photosynthetic organisms. The bioreactor system includes a bioreactor and a lighting system. The lighting system includes one more light-emitting substrates configured to light at least some of a plurality of photosynthetic organisms retained in the bioreactor.

摘要翻译： 用于培育生物质的系统，装置和方法。 生物反应器系统可用于生长光合生物。 生物反应器系统包括生物反应器和照明系统。 照明系统包括一个以上的发光基板，其被配置为点亮保留在生物反应器中的多个光合生物中的至少一些光合生物。

公开(公告)号：US08097028B2

公开(公告)日：2012-01-17

申请号：US11357358

申请日：2006-02-17

申请人： James C. Chen ,  Nicholas Yeo ,  Phillip Burwell ,  Thomas Wenger

发明人： James C. Chen ,  Nicholas Yeo ,  Phillip Burwell ,  Thomas Wenger

IPC分类号： A61N5/06

CPC分类号： A61K41/0071 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0651 ,  A61N2005/0661

摘要： The present invention provides a prophylactic light activated treatment method for subjects at risk of a plaque-mediated thrombotic event, such as acute coronary syndromes. In one embodiment, the subject receives a dose of photosensitizer sufficient to result in a concentration of photosensitizer in the neovascularization associated with atherosclerotic disease to permit effective photodynamic therapy. Light of a wavelength that excites the photosensitizer, but that does not to any significant extent penetrate to an adventitial layer of the blood vessel, is applied to the region of the blood vessel. The therapeutic light dose, which may be applied in sequential stages, is sufficient to cause closure of neovasculature leakage and lead to plaque stabilization and reduced adverse clinical outcomes. The present invention further provides light transmission devices and systems useful in carrying out the methods of the present invention.

摘要翻译： 本发明为患有斑块介导的血栓形成事件风险的受试者，例如急性冠状动脉综合征提供预防性光活化治疗方法。 在一个实施方案中，受试者接受足以导致与动脉粥样硬化疾病相关的新血管形成中的光敏剂浓度以允许有效的光动力疗法的剂量的光敏剂。 激发光敏剂的波长的光被施加到血管的区域，而不是任何显着程度的透射到血管的外膜层。 可以按顺序施用的治疗光剂量足以引起新血管渗漏的闭合并导致斑块稳定化并减少不良临床结果。 本发明还提供了用于实施本发明的方法的光传输装置和系统。

公开(公告)号：US20110009464A1

公开(公告)日：2011-01-13

申请号：US12817068

申请日：2010-06-16

申请人： James C. Chen

发明人： James C. Chen

IPC分类号： A61K31/407 ,  A61P35/00

CPC分类号： A61K41/0057 ,  A61K9/0019 ,  A61K31/407

摘要： The efficacy of light activated therapy treatment is enhanced by stimulating the immune system of the patient substantially above the pre-therapy level. Abnormal tissue that is destroyed by the light activated therapy releases factors that stimulate the immune system, leading to systemic reductions in abnormal tissue (i.e., reduction beyond the area treated using light), so long as the light therapy conditions favor apoptosis over necrosis. The volume of abnormal tissue destroyed is maximized to the extent possible, reducing tumor load, which reduces an amount of immunosuppressive factors in the body, enabling stimulation of the immune system to be successful.

摘要翻译： 通过刺激患者的免疫系统显着高于治疗前水平，提高了光活化治疗的疗效。 被光激活治疗破坏的异常组织释放刺激免疫系统的因素，导致异常组织的系统性减少（即，除了使用光治疗的区域之外减少），只要光疗条件有利于凋亡超过坏死。 破坏的异常组织的体积尽可能地最大化，减少肿瘤负荷，这减少了身体中的免疫抑制因子的量，使得能够刺激免疫系统成功。

公开(公告)号：US20110008372A1

公开(公告)日：2011-01-13

申请号：US12832494

申请日：2010-07-08

申请人： James C. Chen

发明人： James C. Chen

IPC分类号： A61K39/395 ,  A61K31/58 ,  A61K31/395 ,  A61K31/69 ,  A61K31/165 ,  A61K31/704 ,  A61P35/00

CPC分类号： A61K31/165 ,  A61K31/395 ,  A61K31/58 ,  A61K31/69 ,  A61K31/704

摘要： The efficacy of light activated therapy treatment is enhanced by use of additional therapeutic agents. Abnormal tissue is destroyed by light activated therapy, and the associated administration of one or more additional therapeutic agents can synergistically enhance the therapy. For example, the concepts disclosed herein encompass the use of the following agents in combination with light activated drug therapy: (1) agents that selectively inhibit heat shock protein 90 (Hsp90); (2) agents that inhibit the Hedgehog pathway (which is believed to play a central role in allowing the proliferation and survival of certain cancer-causing cells, and which is implicated in many of the most deadly cancers); and, (3) agents for reducing the anti-apoptotic effects of Bcl-2 or Bcl-xL. These agents can be used with light activated drug therapy individually, or in various combinations and permutations.

摘要翻译： 通过使用额外的治疗剂来增强光活化治疗的疗效。 异常组织被光激活治疗破坏，并且相关的一种或多种另外的治疗剂的施用可以协同增强治疗。 例如，本文公开的概念包括以下试剂与光活化药物治疗的组合的用途：（1）选择性抑制热休克蛋白90（Hsp90）的药剂; （2）抑制Hedgehog途径的药物（被认为在允许某些致癌细胞的增殖和存活中发挥核心作用，并且涉及许多致命的癌症）; 和（3）降低Bcl-2或Bcl-xL的抗凋亡作用的药剂。 这些药物可以单独使用轻度活化药物治疗，或以各种组合和排列使用。

公开(公告)号：US06396443B1

公开(公告)日：2002-05-28

申请号：US08665755

申请日：1996-06-18

申请人： Kenneth F. Conklin ,  David B. Giguere ,  James C. Chen

发明人： Kenneth F. Conklin ,  David B. Giguere ,  James C. Chen

IPC分类号： H01Q124

CPC分类号： H01Q1/22 ,  H01Q13/28 ,  H01Q21/061 ,  H01Q23/00

摘要： A point-to-point radio frequency unit/antenna has a flat antenna, preferably a continuous transverse stub antenna, integrated into the housing of the microwave unit. The radio frequency unit/antenna includes a housing having an exterior wall, a microwave radio frequency transceiver electronics package within the housing and having an antenna connection, and a flat antenna affixed to one face of the exterior wall of the housing. A microwave radio frequency feed communicates between the flat antenna and the antenna connection of the microwave transceiver electronics package. There is preferably a bracket structure on another face of the housing to affix the housing to a support.

摘要翻译： 点对点射频单元/天线具有集成到微波单元的壳体中的平坦天线，优选地是连续的横向短截线天线。 射频单元/天线包括具有外壁的外壳，壳体内的微波射频收发器电子封装，并且具有天线连接，以及固定到外壳的外壁的一个面上的平坦天线。 微波射频馈送在平坦天线和微波收发器电子封装的天线连接之间进行通信。 在壳体的另一个表面上优选地具有支架结构，以将壳体固定到支撑件上。

公开(公告)号：US06344050B1

公开(公告)日：2002-02-05

申请号：US09218336

申请日：1998-12-21

申请人： James C. Chen

发明人： James C. Chen

IPC分类号： A61N700

CPC分类号： A61K41/0057 ,  A61K47/60 ,  A61K47/68 ,  A61K47/6927

摘要： A photosensitizer suitable for use in administering photodynamic therapy (PDT), conjugated with antibodies that are targeted to antigens on abnormal tissue and polyethylene glycol (PEG) or other polymer that extends the residence time of the conjugate within a patient's body. The resulting pegylated targeted conjugate is administered to a patient, and after the antibodies have had sufficient time to bind with the antigens, light from an external or internal source having a waveband corresponding to an absorption waveband of the photosensitizer is administered. Use of an external light source that emits relatively long wavelength light enables the light to pass through any intervening dermal layer and normal tissue between the external light source and the treatment site. Since the photosensitizer in the conjugate is bound to the abnormal tissue, the light therapy has minimal effect on the intervening normal tissue. Furthermore, the efficacy of the PDT is enhanced due to the increased concentration of the photosensitizer of the conjugate linked to the abnormal tissue.

摘要翻译： 适用于施用光动力疗法（PDT）的光敏剂，其与针对异常组织上的抗原的抗体和聚乙二醇（PEG）或其它聚合物结合，所述聚合物延长缀合物在患者体内的停留时间。 将所得的聚乙二醇化靶向缀合物施用于患者，并且在抗体具有足够的时间与抗原结合之后，施用来自具有对应于光敏剂的吸收波段的波段的外部或内部源的光。 使用发射相对较长波长的光的外部光源使得光能够通过外部光源和处理部位之间的任何中间真皮层和正常组织。 由于缀合物中的光敏剂与异常组织结合，光疗对中间正常组织的影响最小。 此外，由于与异常组织连接的缀合物的光敏剂的浓度增加，PDT的功效增强。