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1.发明授权Packaging of immunostimulatory substances into virus-like particles: method of preparation and use 有权将免疫刺激物质包装成病毒样颗粒：制备和使用方法公开(公告)号：US08691209B2
公开(公告)日：2014-04-08
申请号：US13294006
申请日：2011-11-10
申请人： Martin F. Bachmann , Tazio Storni , Patrik Maurer , Alain Tissot , Katrin Schwarz , Edwin Meijerink , Gerd Lipowsky , Paul Pumpens , Indulis Cielens , Regina Renhofa
发明人： Martin F. Bachmann , Tazio Storni , Patrik Maurer , Alain Tissot , Katrin Schwarz , Edwin Meijerink , Gerd Lipowsky , Paul Pumpens , Indulis Cielens , Regina Renhofa
CPC分类号： A61K39/12 , A61K39/00 , A61K39/0011 , A61K39/02 , A61K39/39 , A61K2039/52 , A61K2039/5258 , A61K2039/55555 , A61K2039/55561 , A61K2039/57 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2710/22022 , C12N2710/22023 , C12N2730/10122 , C12N2730/10123 , C12N2795/00034 , C12N2795/18122 , Y02A50/412 , Y02A50/467
摘要： The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.
摘要翻译： 本发明涉及病毒样颗粒（VLP）可以加载免疫刺激物质，特别是含有非甲基化C和G（CpG）的DNA寡核苷酸的发现。 这样的CpG-VLP比其不含CpG的对应物显着地更具免疫原性，并诱导增强的B和T细胞应答。 与抗VLP本身的免疫应答相似地，抗体任选偶联，融合或附着于VLP的抗原的免疫应答也被增强。 此外，针对VLP和抗原的T细胞应答特别针对Th1型。 因此，连接到CpG负载的VLP的抗原可能是针对过敏，肿瘤和其他自身分子和慢性病毒性疾病的预防性或治疗性接种疫苗的理想疫苗。
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2.发明授权公开(公告)号：US08574564B2
公开(公告)日：2013-11-05
申请号：US12576086
申请日：2009-10-08
申请人： Wolfgang A. Renner , Martin F. Bachmann , Indulis Cielens , Conrad Johannes Coester , Klaus Dietmeier , Sebastian Fuchs , Vania Manolova , Patrik Maurer , Paul Pumpens , Regina Renhofa , Alain Tissot , Yu Zou
发明人： Wolfgang A. Renner , Martin F. Bachmann , Indulis Cielens , Conrad Johannes Coester , Klaus Dietmeier , Sebastian Fuchs , Vania Manolova , Patrik Maurer , Paul Pumpens , Regina Renhofa , Alain Tissot , Yu Zou
CPC分类号： A61K39/12 , A61K39/39 , A61K47/6901 , A61K47/6931 , A61K49/0004 , A61K49/0093 , A61K49/0097 , A61K2039/5258 , A61K2039/55555 , A61K2039/55561 , B82Y5/00 , C12N2795/18123
摘要： The application is related to compositions and methods for the treatment of hypersensitivity, wherein the compositions comprise a particle packaged with immunostimulatory nucleic acids. The compositions of the invention are particularly useful in the treatment of atopic eczema, asthma and IgE-mediated allergy (type I allergy), especially pollen allergy and house dust allergy.
摘要翻译： 本申请涉及治疗超敏反应的组合物和方法，其中组合物包含用免疫刺激核酸包装的颗粒。 本发明的组合物特别可用于治疗特应性湿疹，哮喘和IgE介导的过敏（I型过敏），特别是花粉过敏和房屋尘埃过敏。
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公开(公告)号：US20100092508A1
公开(公告)日：2010-04-15
申请号：US12341763
申请日：2008-12-22
CPC分类号： C12N7/00 , A61K39/00 , A61K39/0005 , A61K39/35 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , C07K14/005 , C07K14/5409 , C07K16/24 , C07K16/40 , C07K2317/34 , C07K2319/00 , C07K2319/21 , C07K2319/50 , C12N2795/18122 , C12N2795/18123 , Y02A50/412
摘要： The present invention provides a composition comprising an AP205 virus like particle (VLP) and an antigen. The invention also provides a process for producing an antigen or antigenic determinant bound to AP205 VLP. AP205 VLP bound to an antigen is useful in the production of compositions for inducing immune responses that are useful for the prevention or treatment of diseases, disorders or conditions including infectious diseases, allergies, cancer, drug addiction, poisoning and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译： 本发明提供包含AP205病毒样颗粒（VLP）和抗原的组合物。 本发明还提供了一种制备与AP205 VLP结合的抗原或抗原决定簇的方法。 与抗原结合的AP205 VLP可用于产生用于诱导免疫应答的组合物，其可用于预防或治疗疾病，病症或病症，包括感染性疾病，过敏，癌症，药物成瘾，中毒，并有效诱导自身特异性 免疫应答，特别是抗体应答。
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4.发明申请Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity 审中-公开免疫刺激核酸包装颗粒治疗超敏反应公开(公告)号：US20070184068A1
公开(公告)日：2007-08-09
申请号：US11638664
申请日：2006-12-14
申请人： Wolfgang Renner , Martin Bachmann , Indulis Cielens , Conrad Coester , Klaus Dietmeier , Sebastian Fuchs , Vania Manolova , Patrik Maurer , Paul Pumpens , Regina Renhofa , Alain Tissot , Yu Zou
发明人： Wolfgang Renner , Martin Bachmann , Indulis Cielens , Conrad Coester , Klaus Dietmeier , Sebastian Fuchs , Vania Manolova , Patrik Maurer , Paul Pumpens , Regina Renhofa , Alain Tissot , Yu Zou
CPC分类号： A61K39/12 , A61K39/39 , A61K47/6901 , A61K47/6931 , A61K49/0004 , A61K49/0093 , A61K49/0097 , A61K2039/5258 , A61K2039/55555 , A61K2039/55561 , B82Y5/00 , C12N2795/18123
摘要： The application is related to compositions and methods for the treatment of hypersensitivity, wherein the compositions comprise a particle packaged with immunostimulatory nucleic acids. The compositions of the invention are particularly useful in the treatment of atopic eczema, asthma and IgE-mediated allergy (type I allergy), especially pollen allergy and house dust allergy.
摘要翻译： 本申请涉及治疗超敏反应的组合物和方法，其中组合物包含用免疫刺激核酸包装的颗粒。 本发明的组合物特别可用于治疗特应性湿疹，哮喘和IgE介导的过敏（I型过敏），特别是花粉过敏和房屋尘埃过敏。
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5.发明申请Virus-Like Particles Comprising a Fusion Protein of the Coat Protein of Ap205 and an Antigenic Polypeptide 审中-公开包含Ap205的外壳蛋白和抗原多肽的融合蛋白的病毒样颗粒公开(公告)号：US20080292652A1
公开(公告)日：2008-11-27
申请号：US11663350
申请日：2005-09-21
申请人： Martin F Bachmann , Alain Tissot , Gary Jennings , Regina Renhofa , Paul Pumpens , Indulis Cielens
发明人： Martin F Bachmann , Alain Tissot , Gary Jennings , Regina Renhofa , Paul Pumpens , Indulis Cielens
CPC分类号： C12N7/00 , A61K2039/5258 , A61K2039/6075 , C12N2795/18123
摘要： The present invention is in the fields of medicine, immunology, virology and molecular biology. The present invention provides a composition comprising a modified virus-like (VLP) particle derived from RNA bacteriophage AP205. The invention also provides a process for producing the aforementioned VLP. The modified VLP disclosed in the present invention is useful in the production of compositions for inducing immune responses for the prevention or treatment of diseases, disorders including infectious diseases, allergies, cancers and drug addiction. Moreover, the modified VLP disclosed in the present invention is, in particular, useful to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译： 本发明涉及医学，免疫学，病毒学和分子生物学领域。 本发明提供包含衍生自RNA噬菌体AP205的经修饰的病毒样（VLP）颗粒的组合物。 本发明还提供了制备上述VLP的方法。 本发明公开的经修饰的VLP可用于生产用于预防或治疗疾病，包括感染性疾病，过敏症，癌症和药物成瘾的疾病的免疫应答的组合物。 此外，本发明中公开的经修饰的VLP尤其可有效地诱导自身特异性免疫应答，特别是抗体应答。
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公开(公告)号：US07138252B2
公开(公告)日：2006-11-21
申请号：US10617876
申请日：2003-07-14
CPC分类号： C12N7/00 , A61K39/00 , A61K39/0005 , A61K39/35 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , C07K14/005 , C07K14/5409 , C07K16/24 , C07K16/40 , C07K2317/34 , C07K2319/00 , C07K2319/21 , C07K2319/50 , C12N2795/18122 , C12N2795/18123 , Y02A50/412
摘要： The present invention provides a composition comprising an AP205 virus like particle (VLP) and an antigen. The invention also provides a process for producing an antigen or antigenic determinant bound to AP205 VLP. AP205 VLP bound to an antigen is useful in the production of compositions for inducing immune responses that are useful for the prevention or treatment of diseases, disorders or conditions including infectious diseases, allergies, cancer, drug addiction, poisoning and to efficiently induce self-specific immune responses, in particular antibody responses.
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公开(公告)号：US20070128219A1
公开(公告)日：2007-06-07
申请号：US11601687
申请日：2006-11-20
申请人： Martin Bachmann , Alain Tissot , Paul Pumpens , Indulis Cielens , Regina Renhofa
发明人： Martin Bachmann , Alain Tissot , Paul Pumpens , Indulis Cielens , Regina Renhofa
IPC分类号： A61K39/395 , A61K39/12
CPC分类号： C12N7/00 , A61K39/00 , A61K39/0005 , A61K39/35 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , C07K14/005 , C07K14/5409 , C07K16/24 , C07K16/40 , C07K2317/34 , C07K2319/00 , C07K2319/21 , C07K2319/50 , C12N2795/18122 , C12N2795/18123 , Y02A50/412
摘要： The present invention provides a composition comprising an AP205 virus like particle (VLP) and an antigen. The invention also provides a process for producing an antigen or antigenic determinant bound to AP205 VLP. AP205 VLP bound to an antigen is useful in the production of compositions for inducing immune responses that are useful for the prevention or treatment of diseases, disorders or conditions including infectious diseases, allergies, cancer, drug addiction, poisoning and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译： 本发明提供包含AP205病毒样颗粒（VLP）和抗原的组合物。 本发明还提供了一种制备与AP205 VLP结合的抗原或抗原决定簇的方法。 与抗原结合的AP205 VLP可用于产生用于诱导免疫应答的组合物，其可用于预防或治疗疾病，病症或病症，包括感染性疾病，过敏，癌症，药物成瘾，中毒，并有效诱导自身特异性 免疫应答，特别是抗体应答。
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公开(公告)号：US07494656B2
公开(公告)日：2009-02-24
申请号：US11601687
申请日：2006-11-20
申请人： Martin Bachmann , Alain Tissot , Paul Pumpens , Indulis Cielens , Regina Renhofa
发明人： Martin Bachmann , Alain Tissot , Paul Pumpens , Indulis Cielens , Regina Renhofa
IPC分类号： A61K39/145 , A61K39/385 , C12N7/00 , C12N15/09
CPC分类号： C12N7/00 , A61K39/00 , A61K39/0005 , A61K39/35 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , C07K14/005 , C07K14/5409 , C07K16/24 , C07K16/40 , C07K2317/34 , C07K2319/00 , C07K2319/21 , C07K2319/50 , C12N2795/18122 , C12N2795/18123 , Y02A50/412
摘要： The present invention provides a composition comprising an AP205 virus like particle (VLP) and an antigen. The invention also provides a process for producing an antigen or antigenic determinant bound to AP205 VLP. AP205 VLP bound to an antigen is useful in the production of compositions for inducing immune responses that are useful for the prevention or treatment of diseases, disorders or conditions including infectious diseases, allergies, cancer, drug addiction, poisoning and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译： 本发明提供包含AP205病毒样颗粒（VLP）和抗原的组合物。 本发明还提供了一种制备与AP205 VLP结合的抗原或抗原决定簇的方法。 与抗原结合的AP205 VLP可用于产生用于诱导免疫应答的组合物，其可用于预防或治疗疾病，病症或病症，包括感染性疾病，过敏，癌症，药物成瘾，中毒，并有效诱导自身特异性 免疫应答，特别是抗体应答。
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公开(公告)号：US5990085A
公开(公告)日：1999-11-23
申请号：US72323
申请日：1998-05-04
申请人： James J. Ireland , Paul Pumpens , Galina Borisova , Dace Skrastina , Guna Mezule
发明人： James J. Ireland , Paul Pumpens , Galina Borisova , Dace Skrastina , Guna Mezule
CPC分类号： C07K14/005 , A61K39/0005 , C07K14/575 , A61K2039/6075 , A61K38/00 , C07K2319/00 , C12N2730/10122 , Y10S977/803 , Y10S977/914 , Y10S977/918 , Y10S977/92
摘要： A fusion protein formed of an antigenic inhibin peptide inserted into hepatitis B capsid protein is expressed from a chimeric gene forming an effective immunogen which induces anti-inhibin antibodies when administered to a host animal.
摘要翻译： 由插入乙型肝炎衣壳蛋白的抗原性抑制素肽形成的融合蛋白由形成有效免疫原的嵌合基因表达，当施用于宿主动物时诱导抗抑制素抗体。
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