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    Method of Mass Spectrometry and Mass Spectrometer Using Peak Deconvolution
    3.
    发明申请
    Method of Mass Spectrometry and Mass Spectrometer Using Peak Deconvolution 有权
    使用峰值去卷积的质谱法和质谱仪的方法

    公开(公告)号：US20130168546A1

    公开(公告)日：2013-07-04

    申请号：US13576344

    申请日：2011-02-14

    申请人： Richard Denny ,  Keith Richardson ,  Martin Raymond Green ,  Steven Derek Pringle ,  Anthony James Gilbert ,  John Skilling ,  Jason Lee Wildgoose

    发明人： Richard Denny ,  Keith Richardson ,  Martin Raymond Green ,  Steven Derek Pringle ,  Anthony James Gilbert ,  John Skilling ,  Jason Lee Wildgoose

    IPC分类号： H01J49/00 ,  H01J49/40

    CPC分类号： H01J49/0036 ,  H01J49/40

    摘要： A method of mass spectrometry is disclosed wherein a signal output from an ion detector is digitised by an Analogue to Digital Converter and is then deconvoluted to determine one or more ion arrival times and one more ion arrival intensities. The process of deconvoluting the ion signal involves determining a point spread function characteristic of an ion arriving at and being detected by the ion detector. A distribution of ion arrival times which produces a best fit to the digitised signal is then determined given that each ion arrival is assumed to produce a response given by the point spread function. A plurality of ion arrival times are then combined to produce a composite ion arrival time-intensity spectrum.

    摘要翻译： 公开了一种质谱法，其中从离子检测器输出的信号被模拟数字转换器数字化，然后进行解卷积，以确定一个或多个离子到达时间和一个离子到达强度。 去卷积离子信号的过程涉及确定到达并被离子检测器检测的离子的点扩散函数特征。 因此，假设每个离子到达产生由点扩散函数给出的响应，则确定产生与数字化信号最佳拟合的离子到达时间的分布。 然后将多个离子到达时间组合以产生复合离子到达时间强度谱。

    Ion Population Control Device For A Mass Spectrometer
    4.
    发明申请
    Ion Population Control Device For A Mass Spectrometer 有权
    用于质谱仪的离子种群控制装置

    公开(公告)号：US20120119078A1

    公开(公告)日：2012-05-17

    申请号：US13145368

    申请日：2010-01-20

    申请人： Martin Raymond Green ,  Daniel James Kenny ,  Jason Lee Wildgoose

    发明人： Martin Raymond Green ,  Daniel James Kenny ,  Jason Lee Wildgoose

    IPC分类号： H01J49/42 ,  H01J49/00

    CPC分类号： H01J49/4265

    摘要： A mass spectrometer is disclosed wherein an ion beam attenuator is arranged upstream of an ion trap mass analyser. An ion tunnel ion trap comprising an upstream ion accumulation section and a downstream ion accumulation section is arranged upstream of the ion beam attenuator. Ions are released from the ion tunnel ion trap and the intensity of the ion beam which is transmitted to the ion trap analyser is controlled by the ion beam attenuator. The fill time during which ions are admitted into the ion trap mass analyser remains substantially constant and is substantially independent of the intensity of the ion beam.

    摘要翻译： 公开了一种质谱仪，其中离子束衰减器布置在离子阱质量分析器的上游。 包括上游离子聚集部分和下游离子聚集部分的离子隧道离子阱设置在离子束衰减器的上游。 离子离子离子阱释放离子，离子束分离器的离子束强度由离子束衰减器控制。 离子进入离子阱质量分析仪的填充时间保持基本恒定，并且基本上与离子束的强度无关。

    Linear Ion Trap
    5.
    发明申请
    Linear Ion Trap 有权
    线性离子阱

    公开(公告)号：US20110049358A1

    公开(公告)日：2011-03-03

    申请号：US12812342

    申请日：2009-01-12

    申请人： Martin Raymond Green ,  Daniel James Kenny ,  David Langridge ,  Jason Lee Wildgoose

    发明人： Martin Raymond Green ,  Daniel James Kenny ,  David Langridge ,  Jason Lee Wildgoose

    IPC分类号： H01J49/00

    CPC分类号： H01J49/4225 ,  H01J49/4285

    摘要： A linear ion trap (6,7,8)is disclosed comprising a central quadrupole rod set (6)and a post-filter quadrupole rod set (8). A 180° phase difference is maintained between axially adjacent rod electrodes of the central quadrupole rod set (6) and the post-filter quadrupole (8) so that an axial pseudo-potential barrier is created between the central quadrupole rod set (6) and the post-filter quadrupole (8). A supplementary AC voltage is applied to the rods of the central quadrupole (6) in order to radially excite ions which are desired to be ejected from the ion trap. The ions are ejected from the ion trap (6,7,8) non-adiabatically in an axial direction.

    摘要翻译： 公开了一种线性离子阱（6,7,8），其包括中心四极杆组（6）和后过滤四极杆组（8）。 在中心四极杆组（6）和后过滤器四极（8）的轴向相邻杆电极之间保持180°相位差，使得在中心四极杆组（6）和 后滤器四极杆（8）。 向中心四极杆（6）的杆施加补充的交流电压，以便径向地激发希望从离子阱排出的离子。 离子从离子阱（6,7,8）沿轴向非绝热地排出。

    Ion guide with orthogonal sampling
    6.
    发明授权
    Ion guide with orthogonal sampling 有权
    离子导向与正交采样

    公开(公告)号：US08716660B2

    公开(公告)日：2014-05-06

    申请号：US14004529

    申请日：2012-03-13

    申请人： Martin Raymond Green ,  David J. Langridge ,  Jason Lee Wildgoose

    发明人： Martin Raymond Green ,  David J. Langridge ,  Jason Lee Wildgoose

    IPC分类号： H01J49/06

    CPC分类号： H01J49/065 ,  G01N27/622 ,  H01J49/0031 ,  H01J49/022 ,  H01J49/062 ,  H01J49/063 ,  H01J49/36

    摘要： A mass spectrometer is disclosed comprising a RF ion guide wherein in a mode of operation a continuous, quasi-continuous or pulsed beam of ions is orthogonally sampled from the ion guide and wherein the continuous, quasi-continuous or pulsed beam of ions is not axially trapped or otherwise axially confined within the RF ion guide. The ion guide is maintained, in use, at a pressure selected from the group consisting of: (i) 0.0001-0.001 mbar; (ii) 0.001-0.01 mbar; (iii) 0.01-0.1 mbar; (iv) 0.1-1 mbar; (v) 1-10 mbar; (vi) 10-100 mbar; and (vii) >100 mbar.

    摘要翻译： 公开了一种质谱仪，其包括RF离子导向器，其中在操作模式中，连续的，准连续的或脉冲的离子束从离子导向器正交地采样，并且其中连续的，准连续的或脉冲的离子束不是轴向的 被捕获或以其它方式轴向限制在RF离子导向器内。 离子导向器在使用中保持在选自以下的压力：（i）0.0001-0.001毫巴; （ii）0.001-0.01毫巴; （iii）0.01-0.1毫巴; （iv）0.1-1毫巴; （v）1-10毫巴; （vi）10-100毫巴; 和（vii）> 100mbar。

    Ion Guide With Orthogonal Sampling
    7.
    发明申请
    Ion Guide With Orthogonal Sampling 有权
    离子指南与正交采样

    公开(公告)号：US20140048702A1

    公开(公告)日：2014-02-20

    申请号：US14004529

    申请日：2012-03-13

    申请人： Martin Raymond Green ,  David J. Langridge ,  Jason Lee Wildgoose

    发明人： Martin Raymond Green ,  David J. Langridge ,  Jason Lee Wildgoose

    IPC分类号： H01J49/02

    CPC分类号： H01J49/065 ,  G01N27/622 ,  H01J49/0031 ,  H01J49/022 ,  H01J49/062 ,  H01J49/063 ,  H01J49/36

    摘要： A mass spectrometer is disclosed comprising a RF ion guide wherein in a mode of operation a continuous, quasi-continuous or pulsed beam of ions is orthogonally sampled from the ion guide and wherein the continuous, quasi-continuous or pulsed beam of ions is not axially trapped or otherwise axially confined within the RF ion guide. The Ion guide is maintained, in use, at a pressure selected from the group consisting of: (i) 0.0001-0.001 mbar; (ii) 0.001-0.01 mbar; (iii) 0.01-0.1 mbar; (iv) 0.1-1 mbar; (v) 1-10 mbar; (vi) 10-100 mbar; and (vii) >100 mbar.

    摘要翻译： 公开了一种质谱仪，其包括RF离子导向器，其中在操作模式中，连续的，准连续的或脉冲的离子束从离子导向器正交地采样，并且其中连续的，准连续的或脉冲的离子束不是轴向的 被捕获或以其它方式轴向限制在RF离子导向器内。 离子导向器在使用中以选自以下的压力保持：（i）0.0001-0.001毫巴; （ii）0.001-0.01毫巴; （iii）0.01-0.1毫巴; （iv）0.1-1毫巴; （v）1-10毫巴; （vi）10-100毫巴; 和（vii）> 100mbar。

    Fast pushing time of flight mass spectrometer combined with restricted mass to charge ratio range delivery
    9.
    发明授权
    Fast pushing time of flight mass spectrometer combined with restricted mass to charge ratio range delivery 有权
    快速推进飞行时间质谱仪结合限制质量与电荷比范围传送

    公开(公告)号：US09048081B2

    公开(公告)日：2015-06-02

    申请号：US13997556

    申请日：2011-12-22

    申请人： Martin Raymond Green ,  Daniel James Kenny ,  Jason Lee Wildgoose

    发明人： Martin Raymond Green ,  Daniel James Kenny ,  Jason Lee Wildgoose

    IPC分类号： H01J49/40 ,  H01J49/02 ,  H01J49/00

    CPC分类号： H01J49/401 ,  H01J49/0031 ,  H01J49/0086

    摘要： Ions having a restricted range of mass to charge ratios are transmitted to the acceleration region of a Time of Flight mass analyzer. A control system applies a first extraction pulse to an acceleration electrode in order to accelerate a first group of ions into the time of flight region at a first time T1, wherein ions having the lowest mass to charge ratio in the first group of ions have a time of flight ΔT1min through the time of flight region and ions having the highest mass to charge ratio in the first group of ions have a time of flight ΔT1max through the time of flight region. The control system applies a second extraction pulse to the acceleration electrode at a subsequent second time T2, wherein ΔT1max−ΔT1min≦T2−T1

    摘要翻译： 具有有限范围的质荷比的离子被传送到飞行时间质量分析器的加速区域。 控制系统将第一提取脉冲施加到加速电极，以便在第一时间T1将第一组离子加速到飞行时间区域，其中在第一组离子中具有最低质荷比的离子具有 飞行时间Dgr;飞行时间T1min，第一组离子具有最高质荷比的离子在飞行时间段内具有飞行时间Dgr; T1max。 控制系统在随后的第二时间T2向加速电极施加第二提取脉冲，其中＆Dgr; T1max-＆Dgr; T1min＆N1; T2-T1 <＆Dgr; T1max。

    Ion mobility separator with variable effective length
    10.
    发明授权
    Ion mobility separator with variable effective length 有权
    具有可变有效长度的离子迁移分离器

    公开(公告)号：US08829433B2

    公开(公告)日：2014-09-09

    申请号：US14004486

    申请日：2012-03-13

    申请人： Martin Raymond Green ,  David J. Langridge ,  Jason Lee Wildgoose

    发明人： Martin Raymond Green ,  David J. Langridge ,  Jason Lee Wildgoose

    IPC分类号： B01D59/44 ,  H01J49/36

    CPC分类号： H01J49/36 ,  G01N27/624 ,  H01J49/06 ,  H01J49/42 ,  H01J49/426

    摘要： An ion mobility separator or spectrometer is disclosed comprising an inner cylinder and an outer cylinder defining an annular volume through which ions are transmitted. Spiral electrodes a-f are arranged on a surface of the inner cylinder and/or on a surface of the outer cylinder. A first device is arranged and adapted to maintain a DC electric field or a pseudo-potential force which acts to urge ions from a first end of the ion mobility separator or spectrometer to a second end of the ion mobility separator or spectrometer. A second device is arranged and adapted to apply one or more transient DC voltages to the spiral electrodes in order to urge ions towards the first end of the ion mobility separator or spectrometer. The net effect is to extend the effective path length of the ion mobility separator.

    摘要翻译： 公开了一种离子迁移率分离器或光谱仪，其包括限定通过离子传播的环形体积的内圆筒和外圆筒。 螺旋电极a-f布置在内筒的表面上和/或外筒的表面上。 第一装置被布置并适于维持DC电场或伪电势力，其作用是将离子从离子迁移率分离器或光谱仪的第一端推到离子迁移率分离器或光谱仪的第二端。 第二装置被布置并适于将一个或多个瞬态DC电压施加到螺旋电极，以促使离子朝向离子迁移分离器或光谱仪的第一端。 净效应是延长离子迁移率分离器的有效路径长度。