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    Retina implant for stimulating a retina as a function of incident light
    1.
    发明申请
    Retina implant for stimulating a retina as a function of incident light 审中-公开
    用于刺激视网膜作为入射光的函数的视网膜植入物

    公开(公告)号：US20060069416A1

    公开(公告)日：2006-03-30

    申请号：US11194017

    申请日：2005-07-29

    申请人： Wilfried Nisch ,  Martin Stelzle ,  Heinz-Gerhard Graf ,  Eberhart Zrenner ,  Markus Schubert ,  Hugo Haemmerle

    发明人： Wilfried Nisch ,  Martin Stelzle ,  Heinz-Gerhard Graf ,  Eberhart Zrenner ,  Markus Schubert ,  Hugo Haemmerle

    IPC分类号： A61N1/18

    CPC分类号： A61N1/36046

    摘要： The present invention relates to a retina implant for the functional electrostimulation of a retina as a function of incident light. The retina implant has a stimulation chip that is designed to be implanted in the area of the retina of an eye. It further includes a radiation receiver that provides energy for the stimulation chip as a function of invisible radiation that occurs. In accordance with one aspect of the present invention, the radiation receiver is designed so as to be implanted in the area of the eye in a fashion spatially separated from the stimulation chip. The stimulation chip also has decoupling means in order to separate invisible scattered radiation from impinging visible light.

    摘要翻译： 本发明涉及视网膜植入物，用于根据入射光的功能性电刺激视网膜。 视网膜植入物具有被设计成植入眼睛视网膜区域的刺激芯片。 它还包括辐射接收器，其作为发生的不可见辐射的函数为刺激芯片提供能量。 根据本发明的一个方面，辐射接收器设计成以与刺激芯片空间分离的方式植入眼睛区域。 刺激芯片还具有去耦装置，以便将不可见的散射辐射与入射的可见光分开。

    Active retina implant with a multiplicity of pixel elements
    4.
    发明申请
    Active retina implant with a multiplicity of pixel elements 有权
    活性视网膜植入物具有多个像素元素

    公开(公告)号：US20060184245A1

    公开(公告)日：2006-08-17

    申请号：US11305920

    申请日：2005-12-19

    申请人： Heinz-Gerhard Graf ,  Alexander Dollberg ,  Bernd Hoefflinger ,  Wilfried Nisch ,  Hugo Haemmerle ,  Alfred Stett ,  Martin Stelzle ,  Eberhart Zrenner

    发明人： Heinz-Gerhard Graf ,  Alexander Dollberg ,  Bernd Hoefflinger ,  Wilfried Nisch ,  Hugo Haemmerle ,  Alfred Stett ,  Martin Stelzle ,  Eberhart Zrenner

    IPC分类号： A61F2/14

    CPC分类号： A61N1/36046

    摘要： An active retina implant has a multiplicity of pixel elements that convert incident light into electric stimulation signals for cells of the retina with which stimulation electrodes are to make contact. Each pixel element is provided with at least one image cell that converts incident light into electric signals, there being provided at least one amplifier whose input is connected to the image cell and whose output is connected to at least one stimulation electrode to which it supplies a stimulation signal. Also provided is an energy supply which provides externally coupled external energy as supply voltage for the image cells and the amplifiers. The image cell has a logarithmic characteristic according to which incident light of specific intensity is converted into electric signals of specific amplitude. The stimulation signal is supplied in the form of analog voltage pulses of specific pulse length and pulse spacings, the pulse amplitude being a function of the intensity of the incident light.

    摘要翻译： 活性视网膜植入物具有多个像素元件，其将入射光转换成用于刺激电极与之接触的视网膜细胞的电刺激信号。 每个像素元件设置有将入射光转换成电信号的至少一个图像单元，其中提供至少一个放大器，其输入端连接到图像单元，其输出端连接至至少一个刺激电极， 刺激信号。 还提供了一种将外部耦合的外部能量作为图像单元和放大器的电源电压的能量供给。 图像单元具有对数特性，根据该特性，将特定强度的入射光转换成特定幅度的电信号。 刺激信号以特定脉冲长度和脉冲间隔的模拟电压脉冲的形式提供，脉冲幅度是入射光强度的函数。

    Retina implant assembly and methods for manufacturing the same
    5.
    发明授权
    Retina implant assembly and methods for manufacturing the same 有权
    视网膜植入组件及其制造方法

    公开(公告)号：US06847847B2

    公开(公告)日：2005-01-25

    申请号：US10011641

    申请日：2001-11-07

    申请人： Wilfried Nisch ,  Alfred Stett ,  Markus Schubert ,  Michael Graf ,  Heinz Gerhard Graf ,  Hugo Hämmerle ,  Eberhart Zrenner ,  Martin Stelzle ,  Helmut Sachs

    发明人： Wilfried Nisch ,  Alfred Stett ,  Markus Schubert ,  Michael Graf ,  Heinz Gerhard Graf ,  Hugo Hämmerle ,  Eberhart Zrenner ,  Martin Stelzle ,  Helmut Sachs

    IPC分类号： A61F2/14 ,  A61F9/08 ,  A61N1/36

    CPC分类号： A61N1/0543 ,  A61F2/14 ,  A61F9/08 ,  A61N1/3787

    摘要： A retina implant including a chip adapted to be implanted into the interior of eye in subretinal contact with the retina. The chip has a plurality of pixel elements on a side thereof facing the lens for receiving an image projected into the retina and a plurality of electrodes for stimulating retina cells. The implants further includes a receiver coil for inductively coupling thereinto electromagnetic energy. The receiver coil coupled to a means for converting an alternating voltage induced into the receiver coil in a direct voltage suited for supplying the chip. The receiver coil is configured as a component separate from the chip, and for being positioned on the eye ball outside the sclera. The chip is connected to the receiver coil via a connecting lead which, in the implanted condition interconnects the interior and the exterior of the eye ball.

    摘要翻译： 一种视网膜植入物，包括适于植入眼睛内部的芯片，视网膜视网膜与视网膜接触。 该芯片在面向透镜的一侧具有多个像素元件，用于接收投影到视网膜中的图像，以及多个用于刺激视网膜细胞的电极。 植入物还包括用于感应地耦合到其中的电磁能的接收器线圈。 接收器线圈耦合到用于将感应到接收器线圈的交流电压以适于供应芯片的直流电压的装置。 接收器线圈被配置为与芯片分离的部件，并且用于定位在巩膜外的眼球上。 芯片通过连接引线连接到接收器线圈，该连接引线在植入条件下将眼球的内部和外部互连。

    Microelement device
    6.
    发明授权
    Microelement device 失效
    微量元件

    公开(公告)号：US06315940B1

    公开(公告)日：2001-11-13

    申请号：US09311780

    申请日：1999-05-13

    申请人： Wilfried Nisch ,  Alfred Stett ,  Ulrich Egert ,  Martin Stelzle

    发明人： Wilfried Nisch ,  Alfred Stett ,  Ulrich Egert ,  Martin Stelzle

    IPC分类号： G01N2726

    CPC分类号： G01N33/48728 ,  C12M23/12 ,  C12M35/02 ,  C12M41/46 ,  G01N21/763

    摘要： A microelement device has a plurality of microelements, which may be configured as microelectrodes, arranged on a substrate and adapted for making contact to cells present in a liquid environment. The cells are guided onto the microelectrodes, are isolated or are mechanically attracted to the microelectrodes. A negative-pressure force or a hydrodynamic force may be applied on the cells. Also described are a method for making contact to the cells, and a method for manufacturing the microelement device is disclosed.

    摘要翻译： 微元件具有多个微元件，其可以被配置为微电极，布置在基板上并且适于与存在于液体环境中的电池接触。 细胞被引导到微电极上，被隔离或机械地吸引到微电极。 可以在电池上施加负压力或流体动力。 还描述了与细胞接触的方法，并且公开了一种用于制造微量元件的方法。

    Pair of measuring electrodes, biosensor comprising a pair of measuring electrodes of this type, and production process
    7.
    发明授权
    Pair of measuring electrodes, biosensor comprising a pair of measuring electrodes of this type, and production process 失效
    一对测量电极，包括一对这种测量电极的生物传感器和制造过程

    公开(公告)号：US07481912B2

    公开(公告)日：2009-01-27

    申请号：US10688771

    申请日：2003-10-16

    申请人： Martin Stelzle ,  Wilfried Nisch

    发明人： Martin Stelzle ,  Wilfried Nisch

    IPC分类号： G01N27/327 ,  G01N27/403

    CPC分类号： G01N27/3278 ,  Y10S977/957 ,  Y10T29/49002

    摘要： A pair of measuring electrodes comprising a first and a second, preferably in each case sheet-like electrode comprises an insulation layer arranged between said electrodes. One or more nanopores, which extend through said insulation layer as far as said first electrode, the surface of which is at least partially uncovered by said nanopores, are provided in each second electrode. The invention also describes a biosensor comprising a pair of measuring electrodes of this type, an electrochemical cell comprising a biosensor of this type and a process for producing said pair of measuring electrodes.

    摘要翻译： 包括第一和第二测量电极的一对测量电极，优选地在每种情况下都是片状电极，包括布置在所述电极之间的绝缘层。 在每个第二电极中设置有一个或多个纳米孔，其延伸穿过所述绝缘层，直到所述第一电极的表面至少部分地不被所述纳米孔覆盖。 本发明还描述了一种生物传感器，其包括一对这种测量电极，包括这种类型的生物传感器的电化学电池和用于产生所述一对测量电极的工艺。

    Active retina implant with a multiplicity of pixel elements
    10.
    发明授权
    Active retina implant with a multiplicity of pixel elements 有权
    活性视网膜植入物具有多个像素元素

    公开(公告)号：US07751896B2

    公开(公告)日：2010-07-06

    申请号：US11305920

    申请日：2005-12-19

    申请人： Heinz-Gerhard Graf ,  Alexander Dollberg ,  Bernd Hoefflinger ,  Wilfried Nisch ,  Hugo Haemmerle ,  Alfred Stett ,  Martin Stelzle ,  Eberhart Zrenner

    发明人： Heinz-Gerhard Graf ,  Alexander Dollberg ,  Bernd Hoefflinger ,  Wilfried Nisch ,  Hugo Haemmerle ,  Alfred Stett ,  Martin Stelzle ,  Eberhart Zrenner

    IPC分类号： A61F2/14

    CPC分类号： A61N1/36046

    摘要： An active retina implant has a multiplicity of pixel elements that convert incident light into electric stimulation signals for cells of the retina with which stimulation electrodes are to make contact. Each pixel element is provided with at least one image cell that converts incident light into electric signals, there being provided at least one amplifier whose input is connected to the image cell and whose output is connected to at least one stimulation electrode to which it supplies a stimulation signal. Also provided is an energy supply which provides externally coupled external energy as supply voltage for the image cells and the amplifiers. The image cell has a logarithmic characteristic according to which incident light of specific intensity is converted into electric signals of specific amplitude. The stimulation signal is supplied in the form of analog voltage pulses of specific pulse length and pulse spacings, the pulse amplitude being a function of the intensity of the incident light.

    摘要翻译： 活性视网膜植入物具有多个像素元件，其将入射光转换成用于刺激电极与之接触的视网膜细胞的电刺激信号。 每个像素元件设置有将入射光转换成电信号的至少一个图像单元，其中提供至少一个放大器，其输入端连接到图像单元，其输出端连接至至少一个刺激电极， 刺激信号。 还提供了一种将外部耦合的外部能量作为图像单元和放大器的电源电压的能量供给。 图像单元具有对数特性，根据该特性，将特定强度的入射光转换成特定幅度的电信号。 刺激信号以特定脉冲长度和脉冲间隔的模拟电压脉冲的形式提供，脉冲幅度是入射光强度的函数。