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公开(公告)号：US08906653B2
公开(公告)日：2014-12-09
申请号：US12864176
申请日：2009-01-23
申请人： Martin Völkert , Oskar Zelder , Burkhard Ernst , Weol Kyu Jeong
发明人： Martin Völkert , Oskar Zelder , Burkhard Ernst , Weol Kyu Jeong
IPC分类号： C12P13/00 , C08G73/00 , C02F3/00 , C07C209/84
CPC分类号： C12P13/001 , C07C209/84 , C07C211/09
摘要： The invention relates to a method for isolating 1,5-diaminopentane (DAP) from DAP-containing fermentation broths, to a method for the fermentative production of DAP using said isolating method and to a method for producing DAP-comprising polymers by using the DAP isolated or fermatively produced DAPs according to said methods.
摘要翻译： 本发明涉及从含DAP的发酵液中分离1,5-二氨基戊烷（DAP）的方法，使用所述分离方法发酵生产DAP的方法以及通过使用DAP生产含DAP的聚合物的方法 根据所述方法分离或人造产生的DAP。
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公开(公告)号：US20100292429A1
公开(公告)日：2010-11-18
申请号：US12864176
申请日：2009-01-23
申请人： Martin Völkert , Oskar Zelder , Burkhard Ernst , Weol Kyu Jeong
发明人： Martin Völkert , Oskar Zelder , Burkhard Ernst , Weol Kyu Jeong
IPC分类号： C07C209/84 , C12P13/00 , C08G73/02 , C08G18/72 , C08G63/685
CPC分类号： C12P13/001 , C07C209/84 , C07C211/09
摘要： The invention relates to a method for isolating 1,5-diaminopentane (DAP) from DAP-containing fermentation broths, to a method for the fermentative production of DAP using said isolating method and to a method for producing DAP-comprising polymers by using the DAP isolated or fermatively produced DAPs according to said methods.
摘要翻译： 本发明涉及从含DAP的发酵液中分离1,5-二氨基戊烷（DAP）的方法，使用所述分离方法发酵生产DAP的方法以及通过使用DAP生产含DAP的聚合物的方法 根据所述方法分离或人造产生的DAP。
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公开(公告)号：US08771998B2
公开(公告)日：2014-07-08
申请号：US12918241
申请日：2009-02-20
CPC分类号： C12P13/005 , C12N9/88 , C12P13/02
摘要： The present invention relates to a novel method for the fermentative production of gamma-aminobutyric acid (GABA) by cultivating a recombinant microorganism expressing an enzyme having a glutamate decarboxylase activity. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such hosts as well as to a method for preparing polyamides making use of GABA as obtained fermentative production.
摘要翻译： 本发明涉及通过培养表达具有谷氨酸脱羧酶活性的酶的重组微生物来发酵γ-氨基丁酸（GABA）的新方法。 本发明还涉及适用于制备这种宿主的相应的重组宿主，重组载体，表达盒和核酸以及使用GABA制备聚酰胺作为获得的发酵生产的方法。
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公开(公告)号：US08741623B2
公开(公告)日：2014-06-03
申请号：US12295348
申请日：2007-03-23
CPC分类号： C12P13/02 , C12N9/88 , C12P13/001
摘要： Process for the production of cadaverine by constructing a recombinant microorganism which has a deregulated lysine decarboxylase gene and at least one deregulated gene selected from the group (i) which consists of aspartokinase, aspartatesemialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, tetrahydrodipicolinate succinylase, succinyl-amino-ketopimelate transaminase, succinyl-diamino-pimelate desuccinylase, diaminopimelate epimerase, diaminopimelate dehydrogenase, arginyl-tRNA synthetase, diaminopimelate decarboxylase, pyruvate carboxylase, phosphoenolpyruvate carboxylase, glucose-6-phosphate dehydrogenase, transketolase, transaldolase, 6-phosphogluconolactonase, fructose 1,6-biphosphatase, homoserine dehydrogenase, phophoenolpyruvate carboxykinase, succinyl-CoA synthetase, methylmalonyl-CoA mutase, provided that if aspartokinase is deregulated as gene (i) at least a second gene (i) other than aspartokinase has to be deregulated, and cultivating said microorganism.
摘要翻译： 通过构建具有失调的赖氨酸脱羧酶基因的重组微生物和选自由天冬氨酸激酶，天冬氨酸二甲醛脱氢酶，二氢吡啶二羧酸合成酶，二氢吡啶二羧酸还原酶，四氢吡啶二羧酸盐琥珀酰基酶，琥珀酰 - 氨基酮基庚酸酯转氨酶，琥珀酰 - 二氨基 - 庚二酸二琥珀酰酶，二氨基庚二酸差向异构酶，二氨基庚二酸脱氢酶，精氨酰-tRNA合成酶，二氨基庚二酸脱羧酶，丙酮酸羧化酶，磷酸烯醇丙酮酸羧化酶，葡萄糖-6-磷酸脱氢酶，转酮酶，转醛醇酶，6-磷酸葡萄糖醛酸酶，果糖1， 6-二磷酸酶，高丝氨酸脱氢酶，磷酸烯醇丙酮酸羧激酶，琥珀酰辅酶A合成酶，甲基丙二酰-CoA变位酶，条件是如果天冬氨酸激酶被释放为基因（i）至少第二个基因（i），除了天冬氨酸激酶外必须解除调节，并培养所述 微生物。
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5.发明申请Production Process for Fine Chemicals Using Microorganisms with Reduced Isocitrate Dehydrogenase Activity 审中-公开使用具有降低的异柠檬酸脱氢酶活性的微生物的精细化学品的生产方法公开(公告)号：US20110207183A1
公开(公告)日：2011-08-25
申请号：US12990240
申请日：2009-04-28
申请人： Andrea Herold , Hartwig Schröder , Weol Kyu Jeong , Corinna Klopprogge , Oskar Zelder , Stefan Haefner , Ulrike Richter , Judith Becker , Christoph Wittmann
发明人： Andrea Herold , Hartwig Schröder , Weol Kyu Jeong , Corinna Klopprogge , Oskar Zelder , Stefan Haefner , Ulrike Richter , Judith Becker , Christoph Wittmann
IPC分类号： C12P13/20 , C12P1/00 , C12P1/04 , C12P13/04 , C12P13/00 , C12P13/08 , C12N1/00 , C12N1/21 , C12P13/02 , C12P17/12 , C12P17/10 , C12P13/12 , C12P7/40
CPC分类号： C12P13/001 , C12N9/0006 , C12P13/04 , C12P13/08 , C12P17/12 , C12Y101/01041
摘要： The present invention is directed to a method utilizing a microorganism with reduced isocitrate dehydrogenase activity for the production of fine chemicals. Said fine chemicals may be amino acids, monomers for polymer synthesis, sugars, lipids, oils, fatty acids or vitamins and are preferably amino acids of the aspartate family, especially methionine or lysine, or derivatives of said amino acids, especially cadaverine. Furthermore, the present invention relates to a recombinant microorganism having a reduced isocitrate dehydrogenase activity in comparison to the initial microorganism and the use of such microorganisms in producing fine chemicals such as aspartate family amino acids and their derivatives.
摘要翻译： 本发明涉及利用具有降低的异柠檬酸脱氢酶活性的微生物来生产精细化学品的方法。 所述精细化学品可以是氨基酸，用于聚合物合成的单体，糖，脂质，油，脂肪酸或维生素，并且优选天冬氨酸家族的氨基酸，特别是甲硫氨酸或赖氨酸，或所述氨基酸的衍生物，特别是尸胺。 此外，本发明涉及与初始微生物相比具有降低的异柠檬酸脱氢酶活性的重组微生物，以及这些微生物在生产精细化学品如天冬氨酸家族氨基酸及其衍生物中的用途。
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公开(公告)号：US20090246838A1
公开(公告)日：2009-10-01
申请号：US12295348
申请日：2007-03-23
CPC分类号： C12P13/02 , C12N9/88 , C12P13/001
摘要： Process for the production of cadaverine by constructing a recombinant microorganism which has a deregulated lysine decarboxylase gene and at least one deregulated gene selected from the group (i) which consists of aspartokinase, aspartatesemialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, tetrahydrodipicolinate succinylase, succinyl-amino-ketopimelate transaminase, succinyl-diamino-pimelate desuccinylase, diaminopimelate epimerase, diaminopimelate dehydrogenase, arginyl-tRNA synthetase, diaminopimelate decarboxylase, pyruvate carboxylase, phosphoenolpyruvate carboxylase, glucose-6-phosphate dehydrogenase, transketolase, transaldolase, 6-phosphogluconolactonase, fructose 1,6-biphosphatase, homoserine dehydrogenase, phophoenolpyruvate carboxykinase, succinyl-CoA synthetase, methylmalonyl-CoA mutase, provided that if aspartokinase is deregulated as gene (i) at least a second gene (i) other than aspartokinase has to be deregulated, and cultivating said microorganism.
摘要翻译： 通过构建具有失调的赖氨酸脱羧酶基因的重组微生物和选自由天冬氨酸激酶，天冬氨酸二甲醛脱氢酶，二氢吡啶二羧酸合成酶，二氢吡啶二羧酸还原酶，四氢吡啶二羧酸盐琥珀酰基酶，琥珀酰 - 氨基酮基庚酸酯转氨酶，琥珀酰 - 二氨基 - 庚二酸二琥珀酰酶，二氨基庚二酸差向异构酶，二氨基庚二酸脱氢酶，精氨酰-tRNA合成酶，二氨基庚二酸脱羧酶，丙酮酸羧化酶，磷酸烯醇丙酮酸羧化酶，葡萄糖-6-磷酸脱氢酶，转酮酶，转醛醇酶，6-磷酸葡萄糖醛酸酶，果糖1， 6-二磷酸酶，高丝氨酸脱氢酶，磷酸烯醇丙酮酸羧激酶，琥珀酰辅酶A合成酶，甲基丙二酰-CoA变位酶，条件是如果天冬氨酸激酶被释放为基因（i）至少第二个基因（i），除了天冬氨酸激酶外必须解除调节，并培养所述 微生物。
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公开(公告)号：US20140256005A1
公开(公告)日：2014-09-11
申请号：US14289731
申请日：2014-05-29
CPC分类号： C12P13/005 , C12N9/88 , C12P13/02
摘要： The present invention relates to a novel method for the fermentative production of gamma-aminobutyric acid (GABA) by cultivating a recombinant microorganism expressing an enzyme having a glutamate decarboxylase activity. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such hosts as well as to a method for preparing polyamides making use of GABA as obtained fermentative production.
摘要翻译： 本发明涉及通过培养表达具有谷氨酸脱羧酶活性的酶的重组微生物来发酵γ-氨基丁酸（GABA）的新方法。 本发明还涉及适用于制备这种宿主的相应的重组宿主，重组载体，表达盒和核酸以及使用GABA制备聚酰胺作为获得的发酵生产的方法。
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公开(公告)号：US20100324258A1
公开(公告)日：2010-12-23
申请号：US12918241
申请日：2009-02-20
CPC分类号： C12P13/005 , C12N9/88 , C12P13/02
摘要： The present invention relates to a novel method for the fermentative production of gamma-aminobutyric acid (GABA) by cultivating a recombinant micro-organism expressing an enzyme having a glutamate decarboxylase activity. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such hosts as well as to a method for preparing polyamides making use of GABA as obtained fermentative production.
摘要翻译： 本发明涉及通过培养表达具有谷氨酸脱羧酶活性的酶的重组微生物来发酵γ-氨基丁酸（GABA）的新方法。 本发明还涉及适用于制备这种宿主的相应的重组宿主，重组载体，表达盒和核酸以及使用GABA制备聚酰胺作为获得的发酵生产的方法。
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9.发明申请公开(公告)号：US20120295317A1
公开(公告)日：2012-11-22
申请号：US13516034
申请日：2010-12-15
申请人： Hartwig Schröder , Weol Kyu Jeong , Annegret Serwe , Oskar Zelder
发明人： Hartwig Schröder , Weol Kyu Jeong , Annegret Serwe , Oskar Zelder
IPC分类号： C12P13/00 , C07C209/86 , C12N1/21
CPC分类号： C12N9/88 , C12P13/001
摘要： The present invention relates to the use of recombinant microorganisms comprising DNA molecules in a deregulated form which improve the production of cadaverine, as well as to recombinant DNA molecules and polypeptides used to produce the microorganism, said microorganism comprising an intracellular lysine decarboxylase activity and an enhanced lysine import activity or comprising an intracellular and an extracellular lysine decarboxylase activity or comprising an intracellular and extracellular lysine decarboxylase activity and an enhanced lysine import activity. The present invention also relates to a processes for the production of cadaverine using recombinant microorganisms.
摘要翻译： 本发明涉及包含DNA分子的重组微生物在去调节形式中的用途，其改善了尸胺的产生，以及用于产生微生物的重组DNA分子和多肽，所述微生物包含细胞内赖氨酸脱羧酶活性和增强的 赖氨酸进入活性或包含细胞内和细胞外赖氨酸脱羧酶活性或包含细胞内和细胞外赖氨酸脱羧酶活性和增强的赖氨酸进口活性。 本发明还涉及使用重组微生物生产尸胺的方法。
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公开(公告)号：US20110003963A1
公开(公告)日：2011-01-06
申请号：US12865895
申请日：2009-02-04
摘要： The present invention relates to a novel method for the fermentative production of dipicolinate by cultivating a recombinant microorganism expressing an enzyme having dipicolinate synthetase activity. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such hosts as well as a method of preparing polyester or polyamide copolymers making use of dipicolinate as obtained by fermentative production.
摘要翻译： 本发明涉及通过培养表达具有吡啶二羧酸合成酶活性的酶的重组微生物来发酵吡啶硫酸盐的新方法。 本发明还涉及适用于制备这种宿主的相应的重组宿主，重组载体，表达盒和核酸以及使用通过发酵生产得到的吡啶二酸盐制备聚酯或聚酰胺共聚物的方法。
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