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    Method for predicting the response of a tumor in a patient suffering from or at risk of developing recurrent gynecologic cancer towards a chemotherapeutic agent
    3.
    发明申请
    Method for predicting the response of a tumor in a patient suffering from or at risk of developing recurrent gynecologic cancer towards a chemotherapeutic agent 审中-公开
    患有或有发生复发性妇科癌症危险的患者肿瘤对化疗药物的反应的方法

    公开(公告)号：US20110143946A1

    公开(公告)日：2011-06-16

    申请号：US12674782

    申请日：2008-08-25

    申请人： Mathias Gehrmann ,  Jan Christoph Brase ,  Marcus Schmidt

    发明人： Mathias Gehrmann ,  Jan Christoph Brase ,  Marcus Schmidt

    IPC分类号： C12Q1/68 ,  C40B30/00 ,  C12Q1/26 ,  C07H21/00 ,  C07K16/40

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158

    摘要： The present invention relates to a method for predicting a response of a tumor in a patient suffering from or at risk of developing recurrent gynecologic cancer towards a chemotherapeutic agent, said method comprising the steps of: a) obtaining a biological sample from said patient; b) determining the pattern of expression level of at least one gene of the group comprising AKR1C1, MLPH, ESR1, PGR, COMP, DCN, IGKC, CCL5, FBN1 and/or UBE2C, or of genes coregulated therewith, in said sample; c) comparing the pattern of expression levels determined in (b) with one or several reference pattern (s) of expression levels; d) identifying at least one marker gene; e) determining a molecular subtype for said sample on the basis of (d); and f) predicting from said molecular subtype response of a tumor for a chemotherapeutic agent, wherein the molecular subtype is selected from the group comprising the subtypes basal, stromal-high, stromal-low, luminal A, immune system-high, immune system-low, proliferation-high and/or proliferation-low.

    摘要翻译： 本发明涉及一种用于预测患有或具有针对化疗剂的复发性妇科癌的风险的患者中的肿瘤的反应的方法，所述方法包括以下步骤：a）从所述患者获得生物样品; b）确定所述样品中包含AKR1C1，MLPH，ESR1，PGR，COMP，DCN，IGKC，CCL5，FBN1和/或UBE2C或与其结合的基因的组的至少一个基因的表达水平的模式; c）比较（b）中确定的表达水平与一种或几种表达水平的参考模式的模式; d）鉴定至少一个标记基因; e）基于（d）确定所述样品的分子亚型; 以及f）从所述化学治疗剂的肿瘤的分子亚型应答预测其中所述分子亚型选自基础基质，基质高，基质低，管腔A，免疫系统高免疫系统的亚型， 低，增殖高和/或增殖低。

    TWO-LAYER-THREE-WAY CATALYST
    6.
    发明申请
    TWO-LAYER-THREE-WAY CATALYST 有权
    两层三层催化剂

    公开(公告)号：US20100135879A1

    公开(公告)日：2010-06-03

    申请号：US12530580

    申请日：2008-02-16

    申请人： Martin Roesch ,  Dieter Lindner ,  Raoul Klingmann ,  Patrizia Laura ,  Joerg-Michael Richter ,  Marcus Schmidt

    发明人： Martin Roesch ,  Dieter Lindner ,  Raoul Klingmann ,  Patrizia Laura ,  Joerg-Michael Richter ,  Marcus Schmidt

    IPC分类号： B01J23/10 ,  B01J21/06 ,  B01D53/94 ,  B01J23/44 ,  B01J21/04

    CPC分类号： B01J37/0244 ,  B01D53/945 ,  B01D2255/1021 ,  B01D2255/1023 ,  B01D2255/1025 ,  B01D2255/2042 ,  B01D2255/407 ,  B01D2255/9022 ,  B01J23/44 ,  B01J23/464 ,  B01J23/63 ,  Y02A50/2324 ,  Y02T10/22

    摘要： A double-layer three-way catalyst is presented, which is formed from a catalytic coating applied directly to an inert honeycomb and a catalytically active coating thereon, and is suitable especially for cleaning of exhaust gases of motor vehicles with gasoline-operated internal combustion engines. The catalyst contains, in each layer, an active aluminum oxide and a cerium/zirconium mixed oxide, both of which are catalytically activated by palladium. The second layer on the gas side contains not only palladium but also rhodium, which is applied to the active aluminum oxide and the cerium/zirconium mixed oxide of the second layer in addition to the palladium. The cerium/zirconium mixed oxide of the second layer has a higher zirconium oxide content than the cerium/zirconium mixed oxide of the first layer. The catalyst is notable for exceptional activity coupled with outstanding aging stability.

    摘要翻译： 提出了一种双层三元催化剂，其由直接施加到惰性蜂窝体上的催化涂层和其上的催化活性涂层形成，并且特别适用于用汽油操作的内燃机清洁机动车辆的废气 。 催化剂在每层中含有活性氧化铝和铈/锆混合氧化物，它们均由钯催化活化。 除了钯之外，气体侧的第二层不仅包含钯而且还包含铑，其施加到活性氧化铝和第二层的铈/锆混合氧化物。 第二层的铈/锆混合氧化物具有比第一层的铈/锆混合氧化物更高的氧化锆含量。 该催化剂值得注意的是出色的活性和突出的老化稳定性。

    Implantable medical devices with multiple transducers
    7.
    发明申请
    Implantable medical devices with multiple transducers 有权
    具有多个传感器的可植入医疗设备

    公开(公告)号：US20070282397A1

    公开(公告)日：2007-12-06

    申请号：US11654917

    申请日：2007-01-17

    申请人： Geoffrey Ball ,  Marcus Schmidt

    发明人： Geoffrey Ball ,  Marcus Schmidt

    IPC分类号： H04R25/00

    CPC分类号： A61N1/0541 ,  A61N1/36036 ,  H04R25/606

    摘要： The present invention relates to implantable medical devices for improving sound perception by individuals with severe to profound hearing loss or tinnitus. In particular, the present invention provides methods and devices for stimulating structures of the ear via multiple signal transducers.

    摘要翻译： 本发明涉及用于改善具有严重到严重听力损失或耳鸣的个体的声音感知的可植入医疗装置。 特别地，本发明提供了用于通过多个信号传感器刺激耳朵的结构的方法和装置。

    MOLECULAR MARKERS FOR CANCER PROGNOSIS
    8.
    发明申请
    MOLECULAR MARKERS FOR CANCER PROGNOSIS 审中-公开
    癌症预防分子标记

    公开(公告)号：US20110172928A1

    公开(公告)日：2011-07-14

    申请号：US12999406

    申请日：2009-06-16

    申请人： Mathias Gehrmann ,  Udo Stropp ,  Karsten Weber ,  Christian Von Törne ,  Marcus Schmidt

    发明人： Mathias Gehrmann ,  Udo Stropp ,  Karsten Weber ,  Christian Von Törne ,  Marcus Schmidt

    IPC分类号： G06F19/00

    CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  G16B20/00 ,  G16B25/00 ,  G16B40/00

    摘要： The present invention relates to methods for prediction of an outcome of neoplastic disease or cancer. More specifically, the present invention relates to a method for the prediction of breast cancer by determining in a biological sample from said patient an expression level of a plurality of genes selected from the group consisting of ACTG1, CA12, CALM2, CCND1, CHPT1, CLEC2B, CTSB, CXCL13, DCN, DHRS2, EIF4B, ERBB2, ESR1, FBXO28, GABRP, GAPDH, H2AFZ, IGFBP3, IGHG1, IGKC, KCTD3, KIAA0101, KRT17, MLPH, MMP1, NAT1, NEK2, NR2F2, OAZ1, PCNA, PDLIM5, PGR, PPIA, PRC1, RACGAP1, RPL37A, SOX4, TOP2A, UBE2C and VEGF.

    摘要翻译： 本发明涉及用于预测肿瘤性疾病或癌症的结果的方法。 更具体地，本发明涉及通过在来自所述患者的生物样品中测定多种选自ACTG1，CA12，CALM2，CCND1，CHPT1，CLEC2B的多种基因的表达水平来预测乳腺癌的方法 ，CTSB，CXCL13，DCN，DHRS2，EIF4B，ERBB2，ESR1，FBXO28，GABRP，GAPDH，H2AFZ，IGFBP3，IGHG1，IGKC，KCTD3，KIAA0101，KRT17，MLPH，MMP1，NAT1，NEK2，NR2F2，OAZ1，PCNA，PDLIM5 ，PGR，PPIA，PRC1，RACGAP1，RPL37A，SOX4，TOP2A，UBE2C和VEGF。

    Middle Ear Fixation Structure
    9.
    发明申请
    Middle Ear Fixation Structure 有权
    中耳固定结构

    公开(公告)号：US20100305677A1

    公开(公告)日：2010-12-02

    申请号：US12849123

    申请日：2010-08-03

    申请人： Marcus Schmidt ,  Claude Jolly ,  Stefan B. Nielsen ,  Joachim Müller ,  Daniel Schaudel

    发明人： Marcus Schmidt ,  Claude Jolly ,  Stefan B. Nielsen ,  Joachim Müller ,  Daniel Schaudel

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0541 ,  A61F2002/183 ,  A61N1/36036

    摘要： An implantable fixation structure includes a c-shape bone fixation clip adapted to fit over and attach to a bony bridge element in the middle ear of a patient. A c-shape electrode fixation clip is adapted to fit over and attach to an electrode array element in the middle ear of the patient. A connecting bar has a first end connected to the bone fixation clip and a second end connected to the electrode fixation clip. A coupling clip is connected to the connecting bar between the first end and the second end and adapted to fit over and attach to a cochlear implant element and hold the cochlear implant element in a desired position relative to the middle ear of the patient.

    摘要翻译： 可植入固定结构包括适于安装在患者的中耳中并附着到骨桥元件的c形骨固定夹。 c形电极固定夹适于装配在患者的中耳中并附着到患者​​的中耳中的电极阵列元件。 连接杆具有连接到骨固定夹的第一端和连接到电极固定夹的第二端。 耦合夹在第一端和第二端之间连接到连接杆，并且适于安装在耳蜗植入元件上并附接到耳蜗植入元件并将耳蜗植入物元件相对于患者的中耳保持在期望的位置。