公开(公告)号：US08071558B2

公开(公告)日：2011-12-06

申请号：US11909493

申请日：2006-03-22

申请人： Masaaki Tokuda ,  Ken Izumori ,  Tatsuhiro Matsuo ,  Kenji Morimoto ,  Kaoru Takekawa

发明人： Masaaki Tokuda ,  Ken Izumori ,  Tatsuhiro Matsuo ,  Kenji Morimoto ,  Kaoru Takekawa

IPC分类号： A61K31/7004 ,  A61P3/08

CPC分类号： A23K50/40 ,  A23K20/163 ,  A23L27/30 ,  A23L33/10 ,  A61K31/7004

摘要： A novel use of D-psicose (for suppressing the abnormal intra-day increase of blood glucose level) is provided. A composition containing D-psicose as the active component and for use in suppressing the abnormal intra-day increase of plasma glucose concentration. The composition is a composition in blend with D-psicose and/or a derivative thereof. The composition is in a form selected from sweeteners, seasonings, food additives, food materials, food and drink products, health food and drink products, pharmaceutical products, and feeds and blended with D-psicose, and/or a derivative thereof as the active component, for use in preventing and therapeutically treating diseases requiring the saving of insufficient insulin, the amelioration of insulin sensitivity and the amelioration of hyperglycemia, and/or diseases of which the symptoms can be ameliorated via the suppression of the abnormal intra-day increase of plasma glucose concentration or of which the onset can be prevented via the suppression thereof, such as diabetes mellitus, occult diabetic states, obesity, hyperglycemia, and/or arteriosclerosis. A method for using D-psicose in suppressing the abnormal intra-day increase of plasma glucose concentration, comprising giving D-psicose at given times to suppress the abnormal increase of plasma glucose concentration throughout the day.

摘要翻译： 提供了一种新的D-psicose的用途（用于抑制日内异常增加血糖水平）。 作为活性成分含有D-灵芝蛋白的组合物，用于抑制日内异常增加血浆葡萄糖浓度。 组合物是与D-灵芝蛋白和/或其衍生物共混的组合物。 该组合物为选自甜味剂，调味料，食品添加剂，食品材料，食品和饮料产品，保健食品和饮料产品，药品和饲料中的形式，并且与D-灵芝蛋白和/或其衍生物作为活性成分 组分，用于预防和治疗需要节省胰岛素不足的疾病，改善胰岛素敏感性和改善高血糖症，和/或通过抑制日内异常升高可以改善症状的疾病 血浆葡萄糖浓度或通过其抑制如糖尿病，隐匿性糖尿病状态，肥胖症，高血糖症和/或动脉硬化可以预防发作。 一种用于抑制血浆葡萄糖浓度异常日增加的方法，包括在给定时间给予D-psicose以抑制全天血浆葡萄糖浓度的异常增加。

公开(公告)号：US20090062215A1

公开(公告)日：2009-03-05

申请号：US11909493

申请日：2006-03-22

申请人： Masaaki Tokuda ,  Ken Izumori ,  Tatsuhiro Matsuo ,  Kenji Morimoto ,  Kaoru Takekawa

发明人： Masaaki Tokuda ,  Ken Izumori ,  Tatsuhiro Matsuo ,  Kenji Morimoto ,  Kaoru Takekawa

IPC分类号： A61K31/7004 ,  C07H1/00 ,  A61P3/08

CPC分类号： A23K50/40 ,  A23K20/163 ,  A23L27/30 ,  A23L33/10 ,  A61K31/7004

摘要： A novel use of D-psicose (for suppressing the abnormal intra-day increase of blood glucose level) is provided. A composition containing D-psicose as the active component and for use in suppressing the abnormal intra-day increase of plasma glucose concentration. The composition is a composition in blend with D-psicose and/or a derivative thereof. The composition is in a form selected from sweeteners, seasonings, food additives, food materials, food and drink products, health food and drink products, pharmaceutical products, and feeds and blended with D-psicose, and/or a derivative thereof as the active component, for use in preventing and therapeutically treating diseases requiring the saving of insufficient insulin, the amelioration of insulin sensitivity and the amelioration of hyperglycemia, and/or diseases of which the symptoms can be ameliorated via the suppression of the abnormal intra-day increase of plasma glucose concentration or of which the onset can be prevented via the suppression thereof, such as diabetes mellitus, occult diabetic states, obesity, hyperglycemia, and/or arteriosclerosis. A method for using D-psicose in suppressing the abnormal intra-day increase of plasma glucose concentration, comprising giving D-psicose at given times to suppress the abnormal increase of plasma glucose concentration throughout the day.

摘要翻译： 提供了一种新的D-psicose的用途（用于抑制日内异常增加血糖水平）。 作为活性成分含有D-灵芝蛋白的组合物，用于抑制日内异常增加血浆葡萄糖浓度。 组合物是与D-灵芝蛋白和/或其衍生物共混的组合物。 该组合物为选自甜味剂，调味料，食品添加剂，食品材料，食品和饮料产品，保健食品和饮料产品，药品和饲料中的形式，并且与D-灵芝蛋白和/或其衍生物作为活性成分 组分，用于预防和治疗需要节省胰岛素不足的疾病，改善胰岛素敏感性和改善高血糖症，和/或通过抑制日内异常升高可以改善症状的疾病 血浆葡萄糖浓度或通过其抑制如糖尿病，隐匿性糖尿病状态，肥胖症，高血糖症和/或动脉硬化可预防发作。 一种用于抑制血浆葡萄糖浓度异常日增加的方法，包括在给定时间给予D-psicose以抑制全天血浆葡萄糖浓度的异常增加。

公开(公告)号：US20120094940A1

公开(公告)日：2012-04-19

申请号：US13262558

申请日：2010-03-26

申请人： Satoshi Takamine ,  Tetsuo Iida ,  Kazuhiro Okuma ,  Tsuyoshi Shimonishi ,  Ken Izumori ,  Tatsuhiro Matsuo

发明人： Satoshi Takamine ,  Tetsuo Iida ,  Kazuhiro Okuma ,  Tsuyoshi Shimonishi ,  Ken Izumori ,  Tatsuhiro Matsuo

IPC分类号： C07H3/02 ,  A61K8/60 ,  A61K31/7004 ,  A23L1/22 ,  A61P3/10 ,  C13B20/14 ,  A23L1/09 ,  A61K47/26 ,  A61P3/04

CPC分类号： C13K13/007 ,  A23L2/60 ,  A23L27/33 ,  A61K8/60 ,  A61K31/7004 ,  A61K47/26 ,  A61Q19/00 ,  C07H3/02

摘要： ProblemsDevelopment of a process of producing inexpensive and safe hexose and compositions of the same.Means for ResolutionA process of producing a sugar composition comprising a definite amount of an target hexose, comprising treating a starting liquid sugar material comprising a starting sugar material hexose or a mixture comprising hexose in a system in the presence of one or more types selected from the group consisting of basic ion exchange resins, alkalis and calcium salts to initiate an isomerization reaction as an equilibrium reaction to transform the starting sugar material hexose to the target hexose to prepare a sugar mixture comprising a definite amount of the target hexose and having a sugar constitution different from that of the starting sugar material, and hexose compositions containing D-allose and D-psicose and the use of the hexose compositions.

摘要翻译： 问题开发生产廉价且安全的己糖及其组合物的方法。 解决方法一种制备包含一定量目标己糖的糖组合物的方法，包括在一种或多种选自以下的一种或多种的存在下，在系统中处理包含起始糖料己糖或包含己糖的混合物的起始液体糖料 由碱性离子交换树脂，碱和钙盐组成的组，以引发异构化反应作为平衡反应，以将起始糖料己糖转化为目标己糖，以制备包含一定量目标己糖并具有糖的糖混合物 不同于起始糖料的结构，以及含有D-丙氨酸和D-灵芝蛋白的己糖组合物以及己糖组合物的用途。

公开(公告)号：US09109266B2

公开(公告)日：2015-08-18

申请号：US13262558

申请日：2010-03-26

申请人： Satoshi Takamine ,  Tetsuo Iida ,  Kazuhiro Okuma ,  Tsuyoshi Shimonishi ,  Ken Izumori ,  Tatsuhiro Matsuo

发明人： Satoshi Takamine ,  Tetsuo Iida ,  Kazuhiro Okuma ,  Tsuyoshi Shimonishi ,  Ken Izumori ,  Tatsuhiro Matsuo

IPC分类号： C13K13/00 ,  A23L1/236 ,  A23L2/60 ,  A61K8/60 ,  A61K31/7004 ,  A61K47/26 ,  A61Q19/00 ,  C07H3/02

CPC分类号： C13K13/007 ,  A23L2/60 ,  A23L27/33 ,  A61K8/60 ,  A61K31/7004 ,  A61K47/26 ,  A61Q19/00 ,  C07H3/02

摘要： ProblemsDevelopment of a process of producing inexpensive and safe hexose and compositions of the same.Means for ResolutionA process of producing a sugar composition comprising a definite amount of an target hexose, comprising treating a starting liquid sugar material comprising a starting sugar material hexose or a mixture comprising hexose in a system in the presence of one or more types selected from the group consisting of basic ion exchange resins, alkalis and calcium salts to initiate an isomerization reaction as an equilibrium reaction to transform the starting sugar material hexose to the target hexose to prepare a sugar mixture comprising a definite amount of the target hexose and having a sugar constitution different from that of the starting sugar material, and hexose compositions containing D-allose and D-psicose and the use of the hexose compositions.

摘要翻译： 问题开发生产廉价且安全的己糖及其组合物的方法。 解决方法一种制备包含一定量目标己糖的糖组合物的方法，包括在一种或多种选自以下的一种或多种的存在下，在系统中处理包含起始糖料己糖或包含己糖的混合物的起始液体糖料 由碱性离子交换树脂，碱和钙盐组成的组，以引发异构化反应作为平衡反应，以将起始糖料己糖转化为目标己糖，以制备包含一定量目标己糖并具有糖的糖混合物 不同于起始糖料的结构，以及含有D-丙氨酸和D-灵芝蛋白的己糖组合物以及己糖组合物的用途。