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    Immunostimulating agents
    1.
    发明授权
    Immunostimulating agents 有权
    免疫刺激剂

    公开(公告)号：US07790189B2

    公开(公告)日：2010-09-07

    申请号：US10557108

    申请日：2004-05-13

    申请人： Masami Mizu ,  Seiji Shinkai ,  Kazuo Sakurai ,  Kazuya Koumoto ,  Munenori Numata ,  Takahiro Matsumoto

    发明人： Masami Mizu ,  Seiji Shinkai ,  Kazuo Sakurai ,  Kazuya Koumoto ,  Munenori Numata ,  Takahiro Matsumoto

    IPC分类号： A61K45/00 ,  A61K38/16 ,  A61K31/70 ,  A61K31/715 ,  A01N43/04

    CPC分类号： A61K9/0019 ,  A61K31/7125 ,  A61K47/36 ,  A61K2039/55561 ,  C08B37/0024

    摘要： Disclosed is a new type of immunostimulating agent including an immunostimulating oligonucleotide complexed with a carrier which is safe and has a high transfection effect. The carrier complexed with the immunostimulating oligonucleotide to form the immunostimulating agent is a polysaccharide having β-1,3-bonds (preferably β-1,3-glucan such as schizophyllan). A preferred example of the immunostimulating oligonucleotide is one containing an unmethylated CpG motif. The polysaccharide for use is preferably modified with nucleic acid-binding functional group and/or cell membrane-affinitive functional group.

    摘要翻译： 公开了一种新型的免疫刺激剂，其包括与载体复合的免疫刺激寡核苷酸，其是安全的并且具有高的转染效果。 与免疫刺激寡核苷酸复合以形成免疫刺激剂的载体是具有＆bgr; -1,3键的多糖（优选的是诸如分枝杆菌分子-1,3-β-葡聚糖）。 免疫刺激寡核苷酸的优选实例是含有未甲基化CpG基序的寡核苷酸。 所用的多糖优选用核酸结合官能团和/或细胞膜亲和官能团修饰。

    Immunostimulating Agents
    2.
    发明申请
    Immunostimulating Agents 有权
    免疫刺激剂

    公开(公告)号：US20080262210A1

    公开(公告)日：2008-10-23

    申请号：US10557108

    申请日：2004-05-13

    申请人： Masami Mizu ,  Seiji Shinkai ,  Kazuo Sakurai ,  Kazuya Koumoto ,  Munenori Numata ,  Takahiro Matsumoto

    发明人： Masami Mizu ,  Seiji Shinkai ,  Kazuo Sakurai ,  Kazuya Koumoto ,  Munenori Numata ,  Takahiro Matsumoto

    IPC分类号： C07H21/00

    CPC分类号： A61K9/0019 ,  A61K31/7125 ,  A61K47/36 ,  A61K2039/55561 ,  C08B37/0024

    摘要： Disclosed is a new type of immunostimulating agent including an immunostimulating oligonucleotide complexed with a carrier which is safe and has a high transfection effect. The carrier complexed with the immunostimulating oligonucleotide to form the immunostimulating agent is a polysaccharide having β-1,3-bonds (preferably β-1,3-glucan such as schizophyllan). A preferred example of the immunostimulating oligonucleotide is one containing an unmethylated CpG motif. The polysaccharide for use is preferably modified with nucleic acid-binding functional group and/or cell membrane-affinitive functional group.

    摘要翻译： 公开了一种新型的免疫刺激剂，其包括与载体复合的免疫刺激寡核苷酸，其是安全的并且具有高的转染效果。 与免疫刺激寡核苷酸复合以形成免疫刺激剂的载体是具有β-1,3-键的多糖（优选β-1,3-葡聚糖如分枝孢子菌素）。 免疫刺激寡核苷酸的优选实例是含有未甲基化CpG基序的寡核苷酸。 所用的多糖优选用核酸结合官能团和/或细胞膜亲和官能团修饰。

    Gene carriers with the use of polysaccharide and process for producing the same
    4.
    发明授权
    Gene carriers with the use of polysaccharide and process for producing the same 有权
    使用多糖的基因载体及其生产方法

    公开(公告)号：US07521433B2

    公开(公告)日：2009-04-21

    申请号：US10471366

    申请日：2002-03-11

    申请人： Taro Kimura ,  Masami Mizu ,  Kazuo Sakurai ,  Seiji Shinkai ,  Kazuya Koumoto

    发明人： Taro Kimura ,  Masami Mizu ,  Kazuo Sakurai ,  Seiji Shinkai ,  Kazuya Koumoto

    IPC分类号： A61K31/716 ,  C07H15/04

    CPC分类号： A61K9/0019 ,  A61K31/711 ,  A61K31/716 ,  A61K47/36 ,  A61K48/0041 ,  C12N15/87

    摘要： Disclosed are gene carriers utilizing β-1,3-glucan and methods of preparing the same. The β-1,3-glucan has at least one 1,6-glucopyranoside branch and is chemically modified through periodate oxidation and reductive amination so as to impart nucleic acid-binding functional groups (for example, cationic functional groups) to at least some of the 1,6-glucopyranoside branches thereof. Triple helix β-1,3-glucan is dissolved in a polar organic solvent to form single-stranded β-1,3-glucan. By replacing, in the presence of a nucleic acid, the polar organic solvent for the solution containing the chemically modified single-stranded β-1,3-glucan by water, a complex (gene carrier) is formed in which the nucleic acid is bound to double-stranded β-1,3-glucan.

    摘要翻译： 公开了利用β-1,3-葡聚糖的基因载体及其制备方法。 β-1,3-葡聚糖具有至少一个1,6-吡喃葡萄糖苷分支，并通过高碘酸氧化和还原胺化进行化学修饰，从而将核酸结合官能团（例如阳离子官能团）赋予至少一些 的1,6-吡喃葡萄糖苷分枝。 将三螺旋β-1,3-葡聚糖溶于极性有机溶剂中以形成单链β-1,3-葡聚糖。 通过在核酸存在下用水代替含有化学修饰的单链β-1,3-葡聚糖的溶液的极性有机溶剂，形成核酸结合的复合物（基因载体） 到双链β-1,3-葡聚糖。

    Gene carrier
    7.
    发明授权
    Gene carrier 有权
    基因载体

    公开(公告)号：US08017742B2

    公开(公告)日：2011-09-13

    申请号：US10465402

    申请日：2003-06-19

    申请人： Kazuo Sakurai ,  Seiji Shinkai ,  Taro Kimura ,  Kengo Tabata ,  Kazuya Koumoto ,  Oliver Gronwald

    发明人： Kazuo Sakurai ,  Seiji Shinkai ,  Taro Kimura ,  Kengo Tabata ,  Kazuya Koumoto ,  Oliver Gronwald

    IPC分类号： C07H1/00 ,  C07H21/44

    CPC分类号： C07H15/04 ,  A61K47/61 ,  A61K47/645 ,  A61K48/00 ,  C07B2200/11 ,  C07H21/00 ,  C08B37/0024 ,  C12N15/87

    摘要： Disclosed is a gene carrier composed of a hydrogen-bonding polymer having a polymer chain with hydrogen-bonding sites formed on the polymer chain, in which the polymer chain has a conformation similar to the conformation of a nucleic acid, and particularly, the polymer chain has helix parameters similar to the helix parameters of a nucleic acid of a helix structure. In a preferred embodiment, the hydrogen-bonding polymer is composed of β-1,3-glucan such as schizophyllan. The carrier can be expected to be applied as a vector and a separator for nucleic acids because it is capable of interacting with a nucleic acid to form a complex with the nucleic acid and thus carrying the nucleic acid.

    摘要翻译： 公开了一种基因载体，其由具有在聚合物链上形成的氢键位置的聚合物链的氢键聚合物组成，其中聚合物链具有与核酸构象相似的构象，特别是聚合物链 具有类似于螺旋结构的核酸的螺旋参数的螺旋参数。 在一个优选的实施方案中，氢键聚合物由诸如裂枝菌碱等的β-葡聚糖组成。 可以期望载体作为核酸的载体和分离子应用，因为它能够与核酸相互作用以与核酸形成复合物，从而携带核酸。

    Lubricant supply system of a scroll fluid machine
    10.
    发明授权
    Lubricant supply system of a scroll fluid machine 失效
    滚动流体机械的润滑剂供应系统

    公开(公告)号：US5110268A

    公开(公告)日：1992-05-05

    申请号：US620613

    申请日：1990-12-03

    申请人： Kazuo Sakurai ,  Takahiro Tamura

    发明人： Kazuo Sakurai ,  Takahiro Tamura

    IPC分类号： F01C1/02 ,  F04C18/02 ,  F04C29/02

    CPC分类号： F01C1/0215 ,  F04C18/0215 ,  F04C29/02

    摘要： A scroll compressor has a scroll mechanism disposed in a closed container and driven by a motor through a crank shaft rotatably supported at two points by first and second bearings disposed adjacent the opposite ends of the motor. The bearing which is remote from the scroll mechanism comprises a sliding bearing. The first end of the crank shaft remote from the scroll mechanism has a peripheral surface disposed in sliding engagement with the sliding bearing and formed therein with a lubricant supply groove communicated with an axial lubricant supply hole formed in the crank shaft and having a closed end adjacent the first end of the crank shaft and opened in an end face of a crank pin section thereof. The sliding bearing is communicated with a lubricant reservoir formed by a lower part of the container. The lubricant in the reservoir is subjected to the pressure of a compressed fluid discharged from the scroll mechanism and is forcibly fed into the lubricant supply groove through the sliding bearing.

    摘要翻译： 涡旋压缩机具有设置在密闭容器中的涡旋机构，并且由电动机驱动，所述曲轴通过与所述马达的相对端相邻设置的第一和第二轴承可旋转地支撑在两点上。 远离涡旋机构的轴承包括滑动轴承。 曲柄轴远离涡旋机构的第一端具有与滑动轴承滑动接合的周面，并在其中形成有与形成在曲轴中的轴向润滑剂供给孔连通并具有相邻的封闭端的润滑剂供给槽 曲柄轴的第一端并在其曲柄销部分的端面中敞开。 滑动轴承与由容器的下部形成的润滑剂储存器连通。 储存器中的润滑剂受到从涡旋机构排出的压缩流体的压力，并通过滑动轴承强制地进入润滑剂供给槽。