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11 条记录 (耗时 0.082 秒)

    Compound having antimalarial activity
    1.
    发明授权
    Compound having antimalarial activity 失效
    具有抗疟活性的化合物

    公开(公告)号：US06710074B2

    公开(公告)日：2004-03-23

    申请号：US10220244

    申请日：2002-08-30

    申请人： Masataka Ihara ,  Kiyosei Takasu ,  Yusuke Wataya ,  Hye-Sook Kim

    发明人： Masataka Ihara ,  Kiyosei Takasu ,  Yusuke Wataya ,  Hye-Sook Kim

    IPC分类号： A61K3135

    CPC分类号： C07D493/10

    摘要： An object of the present invention is to provide a novel compound having antimalarial acitivity and an antimalarial agent containing the novel compound as an active component. An antimalarial agent containing 12-hidroxy-2-(1-methoxy-carbonylethyl)-5-oxo-10,11,13-trioxatricyclo[7.2.0.01,6]tridecane represented by a following formula (II) as an active agent is prepared.

    摘要翻译： 本发明的目的是提供具有抗疟活性的新化合物和含有新化合物作为活性成分的抗疟剂。 含有由下式（II）表示的12-羟基-2-（1-甲氧基 - 乙基乙基）-5-氧代-10,11,13-三氧杂三环[7.2.0.0 1,6]十一烷的抗疟剂作为 制备活性剂。

    Compound with antimalarial activity and antimalarial drug containing the same as active ingredient
    4.
    发明授权
    Compound with antimalarial activity and antimalarial drug containing the same as active ingredient 失效
    具有抗疟活性的化合物和含有与活性成分相同的抗疟药

    公开(公告)号：US07973027B2

    公开(公告)日：2011-07-05

    申请号：US12224387

    申请日：2007-02-26

    申请人： Tsunehiko Higuchi ,  Hirohisa Omiya ,  Naoki Umezawa ,  Hye-Sook Kim ,  Yusuke Wataya

    发明人： Tsunehiko Higuchi ,  Hirohisa Omiya ,  Naoki Umezawa ,  Hye-Sook Kim ,  Yusuke Wataya

    IPC分类号： A61K31/47 ,  C07D215/46

    CPC分类号： C07D401/12

    摘要： Compounds with high antimalarial activity; and antimalarial drugs containing the same as an active ingredient. There are provided compounds with antimalarial activity represented by the chemical formula: (wherein R1 is H, Cl or OCH3; R2 is H or CH3; R3 is CH, CH2, C(CH3), CH(CH3) or C(CH3)2; Ar is imidazole, triazole, pyridine, benzene, pyrrole, furan, thiophene or derivatives thereof; n is 1 to 5; and m is 1 to 5). Further, there are provided antimalarial drugs containing these compounds with antimalarial activity or pharmacologically acceptable salts thereof as active ingredients.

    摘要翻译： 抗疟活性高的化合物 和含有与活性成分相同的抗疟药。 提供具有化学式表示的抗疟活性化合物：其中R1为H，Cl或OCH3; R2为H或CH3; R3为CH，CH2，C（CH3），CH（CH3）或C（CH3）2 ; Ar为咪唑，三唑，吡啶，苯，吡咯，呋喃，噻吩或其衍生物; n为1至5; m为1至5）。 此外，提供了含有抗疟活性化合物的抗疟药物或其药理学上可接受的盐作为活性成分。

    Compound With Antimalarial Activity And Antimalarial Drug Containing The Same As Active Ingredient
    5.
    发明申请
    Compound With Antimalarial Activity And Antimalarial Drug Containing The Same As Active Ingredient 失效
    具有抗疟活性的化合物和含有作为活性成分的抗疟药

    公开(公告)号：US20090275612A1

    公开(公告)日：2009-11-05

    申请号：US12224387

    申请日：2007-02-26

    申请人： Tsunehiko Higuchi ,  Hirohisa Omiya ,  Naoki Umezawa ,  Hye-Sook Kim ,  Yusuke Wataya

    发明人： Tsunehiko Higuchi ,  Hirohisa Omiya ,  Naoki Umezawa ,  Hye-Sook Kim ,  Yusuke Wataya

    IPC分类号： A61K31/4709 ,  C07D215/38 ,  A61P33/06

    CPC分类号： C07D401/12

    摘要： Compounds with high antimalarial activity; and antimalarial drugs containing the same as an active ingredient. There are provided compounds with antimalarial activity represented by the chemical formula: (wherein R1 is H, Cl or OCH3; R2 is H or CH3; R3 is CH, CH2, C(CH3), CH(CH3) or C(CH3)2; Ar is imidazole, triazole, pyridine, benzene, pyrrole, furan, thiophene or derivatives thereof; n is 1 to 5; and m is 1 to 5). Further, there are provided antimalarial drugs containing these compounds with antimalarial activity or pharmacologically acceptable salts thereof as active ingredients.

    摘要翻译： 抗疟活性高的化合物 和含有与活性成分相同的抗疟药。 提供具有化学式表示的抗疟活性化合物：其中R1为H，Cl或OCH3; R2为H或CH3; R3为CH，CH2，C（CH3），CH（CH3）或C（CH3）2 ; Ar为咪唑，三唑，吡啶，苯，吡咯，呋喃，噻吩或其衍生物; n为1至5; m为1至5）。 此外，提供了含有抗疟活性化合物的抗疟药物或其药理学上可接受的盐作为活性成分。

    Novel Antischistosomal Agent
    7.
    发明申请
    Novel Antischistosomal Agent 审中-公开
    新型抗血吸虫药

    公开(公告)号：US20110172445A1

    公开(公告)日：2011-07-14

    申请号：US13001676

    申请日：2009-06-26

    申请人： Yusuke Wataya ,  Hye-Sook Kim ,  Akiko Hiramoto ,  Akira Sato ,  Nobuo Ota ,  Takashi Kumagai ,  Rieko Shimogawara ,  Toshie Taniguchi

    发明人： Yusuke Wataya ,  Hye-Sook Kim ,  Akiko Hiramoto ,  Akira Sato ,  Nobuo Ota ,  Takashi Kumagai ,  Rieko Shimogawara ,  Toshie Taniguchi

    IPC分类号： C07D323/00

    CPC分类号： C07D323/00 ,  A61K31/357 ,  C07D325/00 ,  Y02A50/423

    摘要： An object of the present invention is to provide a novel antischistosomal agent, and more specifically, to provide a novel drug capable of inhibiting a growth of schistosomes in vivo to prevent development of liver dysfunction due to eggs of the schistosomes in the case of infection with the schistosomes. The novel antischistosomal agent includes as an active ingredient a peroxide derivative. Specifically, the novel antischistosomal agent includes as an active ingredient a peroxide derivative represented by the general formula (I): where C represents an alicyclic hydrocarbon ring group which may be substituted, and n represents an integer of 1 to 6.

    摘要翻译： 本发明的目的是提供一种新的抗血吸虫药，更具体地说，提供一种能够在体内抑制血吸虫生长的新型药物，以防止在感染情况下由于血吸虫卵产生的肝功能障碍的发展 血吸虫 新型抗血吸虫药包括作为活性成分的过氧化物衍生物。 具体地说，新型抗血吸虫药包括作为活性成分的通式（I）表示的过氧化物衍生物：其中C表示可被取代的脂环族烃环基，n表示1〜6的整数。

    Tetraoxaspriro anti-malarials
    8.
    发明授权
    Tetraoxaspriro anti-malarials 有权
    四恶草抗疟药

    公开(公告)号：US07407984B2

    公开(公告)日：2008-08-05

    申请号：US10507640

    申请日：2003-03-11

    申请人： Yusuke Wataya ,  Hye-Sook Kim ,  Masatomo Nojima

    发明人： Yusuke Wataya ,  Hye-Sook Kim ,  Masatomo Nojima

    IPC分类号： A61K31/357

    CPC分类号： A61K31/357 ,  C07D323/00 ,  Y02A50/411

    摘要： The present invention is to provide an antimalarial agent having excellent antimalarial activity with little side effects, in particular, having remarkable antimalarial activity against drug-resistant malaria parasites, and being capable of increasing solubility not only to organic solvent including olive oil, but also to water, and therefore, being usable not only as oral drugs but also as injectable solutions. The antimalarial agent of the present invention contains a compound represented by the following general formula (I) [wherein Z represents an unsubstituted or optionally substituted alicyclic hydrocarbon group, R0 represents a water-soluble functional group, m represents any one of integers of from 0 to 6, n represents any one of integers of from 0 to 10.].

    摘要翻译： 本发明提供具有优异的抗疟活性的抗疟药，其副作用小，特别是对耐药性疟疾寄生虫具有显着的抗疟活性，并且能够增加不仅对包括橄榄油在内的有机溶剂的溶解性， 水，因此不仅可用作口服药物，也可用作可注射溶液。 本发明的抗疟剂含有下述通式（I）表示的化合物[式中，Z表示未取代或任意取代的脂环族烃基，R 0表示水溶性官能团，m 表示0至6的整数中的任何一个，n表示0至10的整数中的任何一个。

    Novel compounds and antimalarials
    9.
    发明申请
    Novel compounds and antimalarials 有权
    新型化合物和抗疟药

    公开(公告)号：US20050131058A1

    公开(公告)日：2005-06-16

    申请号：US10507640

    申请日：2003-03-11

    申请人： Yusuke Wataya ,  Hye-Sook Kim ,  Masatomo Nojima

    发明人： Yusuke Wataya ,  Hye-Sook Kim ,  Masatomo Nojima

    IPC分类号： A61K31/357 ,  A61P33/06 ,  C07D323/00 ,  A61K31/335

    CPC分类号： A61K31/357 ,  C07D323/00 ,  Y02A50/411

    摘要： The present invention is to provide an antimalarial agent having excellent antimalarial activity with little side effects, in particular, having remarkable antimalarial activity against drug-resistant malaria parasites, and being capable of increasing solubility not only to organic solvent including olive oil, but also to water, and therefore, being usable not only as oral drugs but also as injectable solutions. The antimalarial agent of the present invention contains a compound represented by the following general formula (I) [wherein Z represents an unsubstituted or optionally substituted alicyclic hydrocarbon group, R0 represents a water-soluble functional group, m represents anyone of integers of from 0 to 6, n represents any one of integers of from 0 to 10.].

    摘要翻译： 本发明提供具有优异的抗疟活性的抗疟药，其副作用小，特别是对耐药性疟疾寄生虫具有显着的抗疟活性，并且能够增加不仅对包括橄榄油在内的有机溶剂的溶解性， 水，因此不仅可用作口服药物，也可用作可注射溶液。 本发明的抗疟剂含有下述通式（I）表示的化合物[式中，Z表示未取代或任意取代的脂环族烃基，R 0表示水溶性官能团，m 表示从0到6的整数的任何一个，n表示0至10的整数中的任何一个。