Methods for treating inflammatory conditions and states, and cancers by antagonizing NF-κB activation
    4.
    发明授权
    Methods for treating inflammatory conditions and states, and cancers by antagonizing NF-κB activation 有权
    通过拮抗NF-κB活化来治疗炎症状态和状态以及癌症的方法

    公开(公告)号:US09301945B2

    公开(公告)日:2016-04-05

    申请号:US14234033

    申请日:2012-07-19

    摘要: The disclosure is directed to methods for treating inflammatory conditions and cancers that have misregulated NF-κB. In some embodiments, the disclosure is directed to methods for treating inflammatory conditions, inflammatory states associated with treating HIV and AIDS infections, and cancers that include administering strontium ranelate to a subject diagnosed with or at risk of inflammatory conditions, inflammatory states, and cancers, respectively.

    摘要翻译: 本公开涉及用于治疗炎症性疾病和已经失调NF-κB的癌症的方法。 在一些实施方案中,本公开涉及用于治疗炎性病症,与治疗HIV和AIDS感染相关的炎症状态的癌症,以及包括向被诊断患有或处于炎症状态,炎性状态和癌症风险的受试者施用雷奈酸锶的癌症的方法, 分别。

    METHODS FOR TREATING INFLAMATORY CONDITIONS AND STATES, AND CANCERS BY ANTAGONIZING NF-kB ACTIVATION
    6.
    发明申请
    METHODS FOR TREATING INFLAMATORY CONDITIONS AND STATES, AND CANCERS BY ANTAGONIZING NF-kB ACTIVATION 审中-公开
    通过拮抗NF-kB激活治疗炎症病症和状况的方法和癌症

    公开(公告)号:US20140163093A1

    公开(公告)日:2014-06-12

    申请号:US14234033

    申请日:2012-07-19

    IPC分类号: A61K31/381 A61K45/06

    摘要: The disclosure is directed to methods for treating inflammatory conditions and cancers that have misregulated NF-κB. In some embodiments, the disclosure is directed to methods for treating inflammatory conditions, inflammatory states associated with treating HIV and AIDS infections, and cancers that include administering strontium ranelate to a subject diagnosed with or at risk of inflammatory conditions, inflammatory states, and cancers, respectively.

    摘要翻译: 本公开涉及用于治疗炎症性疾病和已经失调NF-κB的癌症的方法。 在一些实施方案中,本公开涉及用于治疗炎性病症,与治疗HIV和AIDS感染相关的炎症状态的癌症,以及包括向被诊断患有或处于炎症状态,炎性状态和癌症风险的受试者施用雷奈酸锶的癌症的方法, 分别。

    Osteogenesis promoter containing β-cryptoxanthin as the active ingredient
    8.
    发明授权
    Osteogenesis promoter containing β-cryptoxanthin as the active ingredient 有权
    含骨质疏松促进剂含有黄曲霉毒素作为活性成分

    公开(公告)号:US08148431B2

    公开(公告)日:2012-04-03

    申请号:US10532775

    申请日:2003-10-03

    IPC分类号: A61K31/07

    摘要: It is intended to provide an osteogenesis promoter having a remarkable effect of positively promoting osteogenesis and thus preventing/treating bone diseases; a preventive/a remedy for bone diseases such as osteoporosis having both of an osteogenesis-promoting effect and a bone resorption-inhibiting effect; and a method of screening an active ingredient for preventing/treating bone diseases by using a compound having both of an osteogenesis-promoting effect and a bone resorption-inhibiting effect as a lead compound. It is confirmed that beta-cryptoxanthin, which occurs in a large amount in peel and sarcocarp of satsuma orange, has an osteogenesis-promoting effect and a therapeutic effect on bone disease. Thus, beta-cryptoxanthin or its composition is used as an osteogenesis promoter, a preventive/a remedy for bone diseases, a functional food or a food material for preventing/treating bone diseases and a feed composition.

    摘要翻译: 本发明提供一种成骨促进剂,其具有积极促进成骨,从而预防/治疗骨病的显着效果; 骨质疏松症等骨疾病的预防/补救措施,具有成骨促进作用和骨吸收抑制作用; 以及通过使用具有成骨促进作用和骨吸收抑制作用两者的化合物作为前导化合物来筛选用于预防/治疗骨疾病的活性成分的方法。 可以确认,在沙粒的果皮和果肉中大量发生的β-隐黄质具有成骨促进作用和对骨病的治疗作用。 因此,β-隐黄质或其组合物用作成骨促进剂,用于骨疾病的预防/治疗,功能性食品或用于预防/治疗骨疾病的食物材料和饲料组合物。

    CROSSLINKED MATERIAL OF PROPYLENE RESIN COMPOSITION, A PROCESS FOR PRODUCING THE CROSSLINKED MATERIAL AND CROSSLINKED MOLDED ARTICLE FORMED FROM THE CROSSLINKED MATERIAL
    9.
    发明申请
    CROSSLINKED MATERIAL OF PROPYLENE RESIN COMPOSITION, A PROCESS FOR PRODUCING THE CROSSLINKED MATERIAL AND CROSSLINKED MOLDED ARTICLE FORMED FROM THE CROSSLINKED MATERIAL 有权
    丙烯类树脂组合物的交联材料,生产从交联材料形成的交联材料和交联成型品的方法

    公开(公告)号:US20100130662A1

    公开(公告)日:2010-05-27

    申请号:US12451242

    申请日:2008-04-23

    IPC分类号: C08K3/26 C08L23/12 C08F110/06

    摘要: The crosslinked material of the present invention is obtainable by crosslinking a propylene resin composition through irradiation with an ionizing radiation wherein the propylene resin composition comprises 100 parts by mass of a propylene resin comprising 15 to 99% by mass of a propylene polymer (A) having a melting point, as measured by a differential scanning calorimeter (DSC), of 120 to 170° C., and 1 to 85% by mass of propylene polymer (B) having a melting point, as measured by a differential scanning calorimeter (DSC), of below 120° C. or not observed (provided that the total of the components (A) and (B) is 100% by mass), and 0.1 to 5 parts by mass of a crosslinking assistant (C). The production process of the crosslinked material of the present invention comprises a step of molding the propylene resin composition into a molded form, and a step of crosslinking the molded form through irradiation with an ionizing radiation. The crosslinked molded article of the present invention is formed from the crosslinked material.

    摘要翻译: 本发明的交联材料可以通过用电离辐射照射使丙烯树脂组合物交联而获得,其中丙烯树脂组合物包含100质量份含有15至99质量%的丙烯聚合物(A)的丙烯树脂,其具有 通过差示扫描量热计(DSC)测定的熔点为120〜170℃,1〜85质量%的通过差示扫描量热计(DSC)测定的熔点的丙烯聚合物(B) ),低于120℃或未观察到(组分(A)和(B)的总量为100质量%)和0.1〜5质量份交联助剂(C)。 本发明的交联材料的制造方法包括将丙烯类树脂组合物成型为成型体的工序,以及通过电离辐射照射使成型体交联的工序。 本发明的交联成型体由交联材料形成。

    Database management program, database management apparatus and database management method
    10.
    发明申请
    Database management program, database management apparatus and database management method 有权
    数据库管理程序,数据库管理装置和数据库管理方法

    公开(公告)号:US20080056581A1

    公开(公告)日:2008-03-06

    申请号:US11892650

    申请日:2007-08-24

    IPC分类号: G06K9/46 G06F17/30

    CPC分类号: G06F17/30259 G06K9/6211

    摘要: A database management program, a database management apparatus and a database management method can determine the sameness of shape data at high speed. The program causes a computer to execute a first edge line acquisition step that acquires the edge lines of the first shape data, an information registration step that generates information showing the characteristics of the edge lines acquired by the first edge line acquisition step as first edge line characteristic information, associates the first edge line characteristic information with the first shape data and registers them in a database, a second edge line acquisition step that acquires the edge lines of the second shape data showing the requirements of retrieval, an information generation step that generates edge line characteristic information of the edge lines acquired by the second edge line acquisition step as second edge line characteristic information and a retrieval step that retrieves the third shape data that is the part of the first shape data that agrees with the second shape data according to the first edge line characteristic information and the second edge line characteristic information.

    摘要翻译: 数据库管理程序,数据库管理装置和数据库管理方法可以高速确定形状数据的同一性。 该程序使计算机执行获取第一形状数据的边缘线的第一边缘线获取步骤,产生表示通过第一边缘线获取步骤获取的边缘线的特性的信息作为第一边缘线的信息登记步骤 特征信息,将第一边缘线特征信息与第一形状数据相关联并将它们登记在数据库中;第二边缘线获取步骤,获取表示检索要求的第二形状数据的边缘线;信息生成步骤,生成 由第二边缘线获取步骤获取的边缘线的边缘线特性信息作为第二边缘线特征信息;以及检索步骤,检索作为与第二形状数据相符合的第一形状数据的第三形状数据,根据 第一边缘线特征信息和第二边缘线c 特征信息。