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1.发明申请Carrier Polymer Particle, Process for Producing the Same, Magnetic Particle for Specific Trapping, and Process for Producing the Same 审中-公开载体聚合物颗粒，其制备方法，用于特定捕集的磁性颗粒及其生产方法公开(公告)号：US20090014682A1
公开(公告)日：2009-01-15
申请号：US11914986
申请日：2006-05-17
申请人： Masayuki Takahashi , Tetsuo Fukuta , Kiyoshi Kasai , Toshihiro Ogawa , Satoshi Katayose , Kouji Tamori , Kinji Yamada
发明人： Masayuki Takahashi , Tetsuo Fukuta , Kiyoshi Kasai , Toshihiro Ogawa , Satoshi Katayose , Kouji Tamori , Kinji Yamada
CPC分类号： C08G63/91 , B32B5/16 , G01N33/53 , G01N33/5434 , G01N33/54353 , Y10T428/2982 , Y10T428/2998
摘要： Carrier polymer particles comprising organic polymer particles having a particle diameter of 0.1 to 20 micrometers and a saccharide with which the surface of the organic polymer particles is covered, the organic polymer particles and the saccharide being chemically bonded.
摘要翻译： 包含粒径为0.1-20微米的有机聚合物颗粒的载体聚合物颗粒和被覆盖有机聚合物颗粒的表面的糖类，有机聚合物颗粒和化学键合的糖类。
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2.发明申请CARRIER POLYMER PARTICLE, PROCESS FOR PRODUCING THE SAME, MAGNETIC PARTICLE FOR SPECIFIC TRAPPING, AND PROCESS FOR PRODUCING THE SAME 审中-公开载体聚合物颗粒，其制造方法，用于特定捕获的磁性颗粒及其生产方法公开(公告)号：US20110184155A1
公开(公告)日：2011-07-28
申请号：US13025273
申请日：2011-02-11
申请人： Masayuki TAKAHASHI , Tetsuo Fukuta , Kiyoshi Kasai , Toshihiro Ogawa , Satoshi Katayose , Kouji Tamori , Kinji Yamada
发明人： Masayuki TAKAHASHI , Tetsuo Fukuta , Kiyoshi Kasai , Toshihiro Ogawa , Satoshi Katayose , Kouji Tamori , Kinji Yamada
CPC分类号： C08G63/91 , B32B5/16 , G01N33/53 , G01N33/5434 , G01N33/54353 , Y10T428/2982 , Y10T428/2998
摘要： Carrier polymer particles comprising organic polymer particles having a particle diameter of 0.1 to 20 micrometers and a saccharide with which the surface of the organic polymer particles is covered, the organic polymer particles and the saccharide being chemically bonded.
摘要翻译： 包含粒径为0.1-20微米的有机聚合物颗粒的载体聚合物颗粒和被覆盖有机聚合物颗粒的表面的糖类，有机聚合物颗粒和化学键合的糖类。
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3.发明申请CARRIER POLYMER PARTICLE, PROCESS FOR PRODUCING THE SAME, MAGNETIC PARTICLE FOR SPECIFIC TRAPPING, AND PROCESS FOR PRODUCING THE SAME 审中-公开载体聚合物颗粒，其制造方法，用于特定捕获的磁性颗粒及其生产方法公开(公告)号：US20130164761A1
公开(公告)日：2013-06-27
申请号：US13740763
申请日：2013-01-14
申请人： Masayuki TAKAHASHI , Tetsuo Fukuda , Kiyoshi Kasai , Toshihiro Ogawa , Satoshi Katayose , Kouji Tamori , Kinji Yamada
发明人： Masayuki TAKAHASHI , Tetsuo Fukuda , Kiyoshi Kasai , Toshihiro Ogawa , Satoshi Katayose , Kouji Tamori , Kinji Yamada
IPC分类号： G01N33/53
CPC分类号： C08G63/91 , B32B5/16 , G01N33/53 , G01N33/5434 , G01N33/54353 , Y10T428/2982 , Y10T428/2998
摘要： Carrier polymer particles comprising organic polymer particles having a particle diameter of 0.1 to 20 micrometers and a saccharide with which the surface of the organic polymer particles is covered, the organic polymer particles and the saccharide being chemically bonded.
摘要翻译： 包含粒径为0.1-20微米的有机聚合物颗粒的载体聚合物颗粒和被覆盖有机聚合物颗粒的表面的糖类，有机聚合物颗粒和化学键合的糖类。
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4.发明授权公开(公告)号：US08703289B2
公开(公告)日：2014-04-22
申请号：US11588388
申请日：2006-10-27
申请人： Kouji Tamori , Tetsuo Fukuta , Mitsuhiro Murata , Masaru Ueno , Satoshi Katayose , Eiji Takamoto , Kiyoshi Kasai
发明人： Kouji Tamori , Tetsuo Fukuta , Mitsuhiro Murata , Masaru Ueno , Satoshi Katayose , Eiji Takamoto , Kiyoshi Kasai
CPC分类号： G01N33/54326 , C08F8/36 , C08F8/42 , C08F8/44 , C08F220/26 , C08F220/32 , C08F222/1006 , C08F257/02 , C08F265/04 , C08F291/00 , C08F2810/20 , C08L25/04 , C08L33/066 , C08L51/003 , G01N33/5434 , H01F1/0054 , Y10T428/2991 , Y10T428/2998 , C08L2666/06 , C08L2666/02 , C08F8/12 , C08F2220/325 , C08F2220/1825 , C08F2222/1013 , C08F212/08 , C08F212/36 , C08F220/14 , C08F2222/1026 , C08F2220/281 , C08F2220/282
摘要： The organic polymer particles comprise a carboxyl group and 2,3-dihydroxypropyl group, and the magnetic particles for diagnostics comprise fine magnetic material particles and a polymer part containing a hydrophilic polymer part and a crosslinked polymer part, a dry coating film obtained from a water dispersion thereof having a contact angle with water of 5° to 60°. The process for producing the carboxyl group-containing particles comprises a step of producing an ester bond by reacting a hydroxyl group in organic polymer particles having the hydroxyl group with a carboxylic anhydride. The organic polymer particles comprise a hydroxyl group originating from a 2,3-dihydroxypropyl group and a polyoxyethylene group.
摘要翻译： 有机聚合物颗粒包含羧基和2,3-二羟基丙基，用于诊断的磁性颗粒包括细小的磁性材料颗粒和含有亲水性聚合物部分和交联聚合物部分的聚合物部分，从水中获得的干燥涂膜 其与水的接触角为5°至60°的分散体。 制备含羧基颗粒的方法包括通过使具有羟基的有机聚合物颗粒中的羟基与羧酸酐反应而产生酯键的步骤。 有机聚合物颗粒包含源自2,3-二羟基丙基和聚氧乙烯基团的羟基。
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5.发明申请公开(公告)号：US20070099814A1
公开(公告)日：2007-05-03
申请号：US11588388
申请日：2006-10-27
申请人： Kouji Tamori , Tetsuo Fukuta , Mitsuhiro Murata , Masaru Ueno , Satoshi Katayose , Eiji Takamoto , Kiyoshi Kasai
发明人： Kouji Tamori , Tetsuo Fukuta , Mitsuhiro Murata , Masaru Ueno , Satoshi Katayose , Eiji Takamoto , Kiyoshi Kasai
IPC分类号： C11D17/00
CPC分类号： G01N33/54326 , C08F8/36 , C08F8/42 , C08F8/44 , C08F220/26 , C08F220/32 , C08F222/1006 , C08F257/02 , C08F265/04 , C08F291/00 , C08F2810/20 , C08L25/04 , C08L33/066 , C08L51/003 , G01N33/5434 , H01F1/0054 , Y10T428/2991 , Y10T428/2998 , C08L2666/06 , C08L2666/02 , C08F8/12 , C08F2220/325 , C08F2220/1825 , C08F2222/1013 , C08F212/08 , C08F212/36 , C08F220/14 , C08F2222/1026 , C08F2220/281 , C08F2220/282
摘要： The organic polymer particles comprise a carboxyl group and 2,3-dihydroxypropyl group, and the magnetic particles for diagnostics comprise fine magnetic material particles and a polymer part containing a hydrophilic polymer part and a crosslinked polymer part, a dry coating film obtained from a water dispersion thereof having a contact angle with water of 5° to 60°. The process for producing the carboxyl group-containing particles comprises a step of producing an ester bond by reacting a hydroxyl group in organic polymer particles having the hydroxyl group with a carboxylic anhydride. The organic polymer particles comprise a hydroxyl group originating from a 2,3-dihydroxypropyl group and a polyoxyethylene group.
摘要翻译： 有机聚合物颗粒包含羧基和2,3-二羟基丙基，用于诊断的磁性颗粒包括细小的磁性材料颗粒和含有亲水性聚合物部分和交联聚合物部分的聚合物部分，从水中获得的干燥涂膜 其与水的接触角为5°至60°的分散体。 制备含羧基颗粒的方法包括通过使具有羟基的有机聚合物颗粒中的羟基与羧酸酐反应而产生酯键的步骤。 有机聚合物颗粒包含源自2,3-二羟基丙基和聚氧乙烯基团的羟基。
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6.发明授权Magnetic particles comprising an organic polymer layer and method for producing the same 有权包含有机聚合物层的磁性颗粒及其制备方法公开(公告)号：US07713627B2
公开(公告)日：2010-05-11
申请号：US11688653
申请日：2007-03-20
申请人： Kouji Tamori , Tetsuo Fukuta , Satoshi Katayose , Masaru Ueno , Mitsuhiro Murata
发明人： Kouji Tamori , Tetsuo Fukuta , Satoshi Katayose , Masaru Ueno , Mitsuhiro Murata
IPC分类号： B32B5/16
CPC分类号： G01N33/5434 , G01N33/54393 , Y10S525/921 , Y10T428/2991 , Y10T428/2998
摘要： Magnetic particles comprising a group shown by the following formula (1): wherein R1 and R2 individually represent a hydroxyl group, a group shown by the following formula (2), or a group shown by the following formula (3), provided that R1 and R2 are not both hydrogen atoms, wherein R3 represents an a linear, branched, or cyclic alkylene group having 2 to 6 carbon atoms or an arylene group, and wherein R4 is a hydrogen atom or an alkyl group.
摘要翻译： 包含由下式（1）表示的基团的磁性颗粒：其中R1和R2各自表示羟基，下式（2）表示的基团或下式（3）所示的基团，条件是R1 并且R 2不是氢原子，其中R 3表示具有2至6个碳原子的直链，支链或环状亚烷基或亚芳基，并且其中R4是氢原子或烷基。
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7.发明授权Alkali-resistant variants of protein A and their use in affinity chromatography 有权蛋白A的抗碱性变体及其在亲和层析中的应用公开(公告)号：US09051375B2
公开(公告)日：2015-06-09
申请号：US13997015
申请日：2011-12-21
申请人： Shun-Cheng Li , Xing Li , Courtney Voss , Satoshi Nakamura , Tetsuo Fukuta , Yusuke Okano , Tomonori Shiotani , Kouji Tamori , Yu Otani
发明人： Shun-Cheng Li , Xing Li , Courtney Voss , Satoshi Nakamura , Tetsuo Fukuta , Yusuke Okano , Tomonori Shiotani , Kouji Tamori , Yu Otani
CPC分类号： C07K14/31 , B01D15/3809 , B01J20/28057 , B01J20/28078 , B01J20/3204 , B01J20/3208 , B01J20/3219 , B01J20/3274 , C07K1/22 , C07K17/06
摘要： The present invention relates to immunoglobulin (Ig)-binding proteins with alkali-resistance properties. In one embodiment, the present invention provides for a variant of an Ig-binding protein, the variant comprising the Ig-binding protein having at least one asparagine residue substituted with a histidine, a serine, an aspartic acid or a threonine residue. The at least one substitution may confer to the variant Ig-binding protein an increased stability in alkaline solutions when compared to the wild-type Ig-binding. The present invention relates also to matrices for affinity separation of immunoglobulins comprising the Ig-binding proteins of the present invention, and to methods of using the Ig-binding proteins of the present invention to separate immunoglobulins from mixture compositions.
摘要翻译： 本发明涉及具有耐碱特性的免疫球蛋白（Ig）结合蛋白。 在一个实施方案中，本发明提供Ig结合蛋白的变体，所述变体包含具有至少一个被组氨酸取代的天冬酰胺残基，丝氨酸，天冬氨酸或苏氨酸残基的Ig结合蛋白。 当与野生型Ig结合相比时，至少一种取代可赋予变体Ig结合蛋白在碱性溶液中增加的稳定性。 本发明还涉及用于亲和分离包含本发明的Ig结合蛋白的免疫球蛋白的基质，以及使用本发明的Ig结合蛋白质从混合物组合物中分离免疫球蛋白的方法。
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公开(公告)号：US20110262748A1
公开(公告)日：2011-10-27
申请号：US13121124
申请日：2009-09-24
申请人： Kouji Tamori , Tetsuo Fukuta , Masaaki Miyaji , Yong Wang , Takayoshi Abe , Yuusuke Okano , Masaki Momiyama , Takahiro Kawai
发明人： Kouji Tamori , Tetsuo Fukuta , Masaaki Miyaji , Yong Wang , Takayoshi Abe , Yuusuke Okano , Masaki Momiyama , Takahiro Kawai
CPC分类号： C07K1/22 , B01J20/286 , B01J20/321 , B01J20/3219 , B01J20/3274 , Y10T428/29
摘要： An affinity chromatography packing material includes porous mother particles that include a copolymer of a monomer mixture including a crosslinkable vinyl monomer and an epoxy group-containing vinyl monomer, a ligand being bound to the porous mother particles, and the porous mother particles including a ring-opening epoxy group produced by ring-opening of the epoxy group included in the porous mother particles.
摘要翻译： 亲和层析填充材料包括多孔母体颗粒，其包括包含可交联乙烯基单体和含环氧基的乙烯基单体的单体混合物的共聚物，与多孔母体颗粒结合的配体，以及多孔母体颗粒， 开环环氧基，其由包含在多孔母体颗粒中的环氧基开环制得。
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公开(公告)号：US08846877B2
公开(公告)日：2014-09-30
申请号：US13121124
申请日：2009-09-24
申请人： Kouji Tamori , Tetsuo Fukuta , Masaaki Miyaji , Yong Wang , Takayoshi Abe , Yuusuke Okano , Masaki Momiyama , Takahiro Kawai
发明人： Kouji Tamori , Tetsuo Fukuta , Masaaki Miyaji , Yong Wang , Takayoshi Abe , Yuusuke Okano , Masaki Momiyama , Takahiro Kawai
IPC分类号： C07K1/14 , G01N33/544 , G01N33/547 , B01J20/32 , C07K1/22 , B01J20/286
CPC分类号： C07K1/22 , B01J20/286 , B01J20/321 , B01J20/3219 , B01J20/3274 , Y10T428/29
摘要： An affinity chromatography packing material includes porous mother particles that include a copolymer of a monomer mixture including a crosslinkable vinyl monomer and an epoxy group-containing vinyl monomer, a ligand being bound to the porous mother particles, and the porous mother particles including a ring-opening epoxy group produced by ring-opening of the epoxy group included in the porous mother particles.
摘要翻译： 亲和层析填充材料包括多孔母体颗粒，其包括包含可交联乙烯基单体和含环氧基的乙烯基单体的单体混合物的共聚物，与多孔母体颗粒结合的配体，以及多孔母体颗粒， 开环环氧基，其由包含在多孔母体颗粒中的环氧基开环制得。
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10.发明授权公开(公告)号：US09051355B2
公开(公告)日：2015-06-09
申请号：US13636410
申请日：2011-03-23
申请人： Kouji Tamori , Tetsuo Fukuta , Masaaki Miyaji , Yong Wang , Takayoshi Abe , Yusuke Okano , Masaki Momiyama , Takahiro Kawai
发明人： Kouji Tamori , Tetsuo Fukuta , Masaaki Miyaji , Yong Wang , Takayoshi Abe , Yusuke Okano , Masaki Momiyama , Takahiro Kawai
IPC分类号： A61K38/00 , C07K1/22 , B01D15/38 , B01J20/286 , B01J20/288 , B01J20/32
CPC分类号： C07K1/22 , B01D15/3804 , B01J20/286 , B01J20/288 , B01J20/3219 , B01J20/3274 , C07K2317/10
摘要： Provided are a filler for affinity chromatography which has excellent alkali resistance, and a method for isolating immunoglobulin. The filler for affinity chromatography is a filler in which a protein represented by the following formula (1) is immobilized on a carrier. R—R2 (1) wherein R represents an amino acid sequence consisting of 4 to 300 amino acid residues containing a region consisting of 4 to 20 contiguous histidine residues; and R2 represents an amino acid sequence capable of binding to immunoglobulin, the amino acid sequence consisting of 50 to 500 amino acid residues containing Z domain of Protein A or a fragment thereof, or a variant thereof, provided that the R binds to C-terminus or N-terminus of the R2.
摘要翻译： 提供了具有优异的耐碱性的亲和色谱法的填充剂和分离免疫球蛋白的方法。 用于亲和层析的填料是其中由下式（1）表示的蛋白质固定在载体上的填料。 R-R2（1）其中R表示由4至300个氨基酸残基组成的氨基酸序列，其含有由4至20个连续组氨酸残基组成的区域; 并且R 2表示能够结合免疫球蛋白的氨基酸序列，所述氨基酸序列由含有蛋白A的Z结构域或其片段的50至500个氨基酸残基或其变体组成，条件是R与C-末端结合 或R2的N-末端。
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