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公开(公告)号：US20170320039A1
公开(公告)日：2017-11-09
申请号：US15586246
申请日：2017-05-03
Applicant: Massachusetts Institute of Technology
Inventor： Ruixuan Gao , Ishan Gupta , Edward S. Boyden
Abstract: A method for synthesizing nanoparticles by sonofragmentation includes dispersing ultra-thin substrate units in a solvent chosen for suitability for sonofragmentation of the substrate, forming a suspension; ultrasonicating the suspension for a length of time sufficient to fragment the substrate into nanoparticles that are dispersed in the solvent; and evaporating the solvent. Solvent exchange with a second solvent may be performed. The synthesized nanoparticles are highly crystalline and monodispersed. The surface of the synthesized nanoparticles may be functionalized by choosing the solvents according to chemistry related to the intended surface functionalization of the synthesized nanoparticles, by adding surfactants to one or more of the solvents, and/or by performing ligand exchange or chemical modification to replace surface-bonded solvent or surfactant molecules with other functional groups to produce nanoparticles having the desired surface functionalization.
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公开(公告)号：US20210196856A1
公开(公告)日：2021-07-01
申请号：US17144551
申请日：2021-01-08
Applicant: Massachusetts Institute of Technology
Inventor： Edward Stuart Boyden , Nikita Obidin , Ruixuan Gao , Linyi Gao
IPC: A61L27/16 , G01N1/31 , C08F220/56 , C08L33/26 , A61L27/56
Abstract: The invention provides a method for preparing an expanded cell or tissue sample suitable for microscopic analysis. Expanding the sample can be achieved by binding, e.g., anchoring, key biomolecules to a DMAA-TF polymer network and swelling, or expanding, the polymer network, thereby moving the biomolecules apart as further described herein. As the biomolecules are anchored to the polymer network isotropic expansion of the polymer network retains the spatial orientation of the biomolecules resulting in an expanded, or enlarged, sample.
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公开(公告)号：US20190256633A1
公开(公告)日：2019-08-22
申请号：US16267849
申请日：2019-02-05
Applicant: Massachusetts Institute of Technology
Inventor： Ruixuan Gao , Linyi Gao , Chih-Chieh Yu , Edward Stuart Boyden
IPC: C08F220/30 , C12Q1/6834 , C12Q1/6841 , C08F220/34 , C08G65/26
Abstract: The invention encompasses hydrogels, monomer precursors of the hydrogels, methods for the preparation thereof, and methods of use therefor. The linking of monomers can take place using non-radical, bioorthogonal reactions such as copper-free click-chemistry.
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公开(公告)号：US20240174818A1
公开(公告)日：2024-05-30
申请号：US18523580
申请日：2023-11-29
Applicant: Massachusetts Institute of Technology
Inventor： Ruixuan Gao , Linyi Gao , Chih-Chieh Yu , Edward Stuart Boyden
IPC: C08J3/075 , C08F8/00 , C08F8/12 , C08F8/30 , C08F8/44 , C08F222/10 , C08G65/26 , C08G65/32 , C08G81/02 , C08J3/24 , C12Q1/68 , C12Q1/6834 , C12Q1/6841 , C12Q1/6869 , G01N1/30 , G01N33/545 , C08F220/04 , C08F220/30 , C08F220/34 , G01N1/36 , G01N15/0205
CPC classification number: C08J3/075 , C08F8/00 , C08F8/12 , C08F8/30 , C08F8/44 , C08F222/104 , C08G65/2624 , C08G65/32 , C08G81/025 , C08J3/246 , C12Q1/68 , C12Q1/6834 , C12Q1/6841 , C12Q1/6869 , G01N1/30 , G01N33/545 , C08F220/04 , C08F220/303 , C08F220/346 , C08F2438/01 , C08G2210/00 , C08J2300/206 , C08J2400/206 , C12Q2523/101 , G01N1/36 , G01N15/0205
Abstract: The invention encompasses hydrogels, monomer precursors of the hydrogels, methods for the preparation thereof, and methods of use therefor. The linking of monomers can take place using non-radical, bioorthogonal reactions such as copper-free click-chemistry.
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公开(公告)号：US11873374B2
公开(公告)日：2024-01-16
申请号：US16267849
申请日：2019-02-05
Applicant: Massachusetts Institute of Technology
Inventor： Ruixuan Gao , Linyi Gao , Chih-Chieh Yu , Edward Stuart Boyden
IPC: C08J3/075 , C08G65/26 , C12Q1/6834 , C12Q1/6841 , G01N33/545 , C08G81/02 , C08F8/12 , G01N1/30 , C08J3/24 , C12Q1/68 , C08F8/30 , C08G65/32 , C12Q1/6869 , C08F8/44 , C08F8/00 , C08F222/10 , C08F220/04 , G01N15/02 , G01N1/36 , C08F220/30 , C08F220/34
CPC classification number: C08J3/075 , C08F8/00 , C08F8/12 , C08F8/30 , C08F8/44 , C08F222/104 , C08G65/2624 , C08G65/32 , C08G81/025 , C08J3/246 , C12Q1/68 , C12Q1/6834 , C12Q1/6841 , C12Q1/6869 , G01N1/30 , G01N33/545 , C08F220/04 , C08F220/303 , C08F220/346 , C08F2438/01 , C08G2210/00 , C08J2300/206 , C08J2400/206 , C12Q2523/101 , G01N1/36 , G01N15/0205 , C08F8/12 , C08F8/30 , C08F20/18 , C08F8/12 , C08F8/00 , C08F8/04 , C08F8/30 , C08F20/18 , C08F8/44 , C08F8/30 , C08F20/18 , C08F8/44 , C08F8/00 , C08F8/04 , C08F8/30 , C08F20/18 , C12Q1/6869 , C12Q2521/107 , C12Q2525/191 , C12Q2527/125 , C12Q2543/101
Abstract: The invention encompasses hydrogels, monomer precursors of the hydrogels, methods for the preparation thereof, and methods of use therefor. The linking of monomers can take place using non-radical, bioorthogonal reactions such as copper-free click-chemistry.
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Patent Agency Ranking
公开(公告)号：US20170081489A1
公开(公告)日：2017-03-23
申请号：US15261163
申请日：2016-09-09
Applicant: Massachusetts Institute of Technology
Inventor： Samuel G. Rodriques , Daniel Oran , Ruixuan Gao , Shoh Asano , Mark A. Skylar-Scott , Fei Chen , Paul W. Tillberg , Adam H. Marblestone , Edward S. Boyden
CPC classification number: C08J7/123 , B29C35/0805 , B29C2035/0838 , B29K2105/0061 , B33Y80/00 , C08J3/075 , C08J3/28 , C08J7/02 , C08J7/12 , C08J2333/26
Abstract: The present invention enables three-dimensional nanofabrication by isotropic shrinking of patterned hydrogels. A hydrogel is first expanded, the rate of expansion being controlled by the concentration of the crosslinker. The hydrogel is then infused with a reactive group and patterned in three dimensions using a photon beam through a limited-diffraction microscope. Functional particles or materials are then deposited on the pattern. The hydrogel is then shrunk and cleaved from the pattern.
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公开(公告)号：US12258454B2
公开(公告)日：2025-03-25
申请号：US18523580
申请日：2023-11-29
Applicant: Massachusetts Institute of Technology
Inventor： Ruixuan Gao , Linyi Gao , Chih-Chieh Yu , Edward Stuart Boyden
IPC: C08J3/075 , C08F8/00 , C08F8/12 , C08F8/30 , C08F8/44 , C08F220/04 , C08F220/30 , C08F222/10 , C08G65/26 , C08G65/32 , C08G81/02 , C08J3/24 , C12Q1/68 , C12Q1/6834 , C12Q1/6841 , C12Q1/6869 , G01N1/30 , G01N1/36 , G01N15/0205 , G01N33/545 , C08F220/34
Abstract: The invention encompasses hydrogels, monomer precursors of the hydrogels, methods for the preparation thereof, and methods of use therefor. The linking of monomers can take place using non-radical, bioorthogonal reactions such as copper-free click-chemistry.
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公开(公告)号：US12233184B2
公开(公告)日：2025-02-25
申请号：US17144551
申请日：2021-01-08
Applicant: Massachusetts Institute of Technology
Inventor： Edward Stuart Boyden , Nikita Obidin , Ruixuan Gao , Linyi Gao
IPC: B01L3/00 , A61L27/16 , A61L27/56 , B01F23/00 , B01F23/41 , B01F101/23 , B01L9/00 , B23Q17/24 , C07K14/705 , C08F220/56 , C08L33/26 , C12M1/34 , C12Q1/04 , C12Q1/18 , C12Q1/686 , G01N1/31 , G01N21/17 , G01N21/3577 , G01N21/359 , G01N21/39 , G01N21/45 , G01N21/64 , G01N21/77 , G01N21/78 , G01N27/414 , G01N30/12 , G01N30/68 , G01N30/70 , G01N30/72 , G01N30/88 , G01N33/00 , G01N33/18 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/68 , G01N33/74 , G01N35/00 , G01N35/10 , G06T7/00 , G06T7/90 , H10K10/46 , H10K85/00 , H10K85/20
Abstract: The invention provides a method for preparing an expanded cell or tissue sample suitable for microscopic analysis. Expanding the sample can be achieved by binding, e.g., anchoring, key biomolecules to a DMAA-TF polymer network and swelling, or expanding, the polymer network, thereby moving the biomolecules apart as further described herein. As the biomolecules are anchored to the polymer network isotropic expansion of the polymer network retains the spatial orientation of the biomolecules resulting in an expanded, or enlarged, sample.
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公开(公告)号：US20220126257A1
公开(公告)日：2022-04-28
申请号：US17464651
申请日：2021-09-01
Applicant: Massachusetts Institute of Technology
Inventor： Ruixuan Gao , Ishan Gupta , Edward S. Boyden
Abstract: A method for synthesizing nanoparticles by sonofragmentation includes dispersing ultra-thin substrate units in a solvent chosen for suitability for sonofragmentation of the substrate, forming a suspension; ultrasonicating the suspension for a length of time sufficient to fragment the substrate into nanoparticles that are dispersed in the solvent; and evaporating the solvent. Solvent exchange with a second solvent may be performed. The synthesized nanoparticles are highly crystalline and monodispersed. The surface of the synthesized nanoparticles may be functionalized by choosing the solvents according to chemistry related to the intended surface functionalization of the synthesized nanoparticles, by adding surfactants to one or more of the solvents, and/or by performing ligand exchange or chemical modification to replace surface-bonded solvent or surfactant molecules with other functional groups to produce nanoparticles having the desired surface functionalization.
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公开(公告)号：US11214661B2
公开(公告)日：2022-01-04
申请号：US15261163
申请日：2016-09-09
Applicant: Massachusetts Institute of Technology
Inventor： Samuel G. Rodriques , Daniel Oran , Ruixuan Gao , Shoh Asano , Mark A. Skylar-Scott , Fei Chen , Paul W. Tillberg , Adam H. Marblestone , Edward S. Boyden
Abstract: The present invention enables three-dimensional nanofabrication by isotropic shrinking of patterned hydrogels. A hydrogel is first expanded, the rate of expansion being controlled by the concentration of the crosslinker. The hydrogel is then infused with a reactive group and patterned in three dimensions using a photon beam through a limited-diffraction microscope. Functional particles or materials are then deposited on the pattern. The hydrogel is then shrunk and cleaved from the pattern.
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