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1.发明授权公开(公告)号：US10780410B2
公开(公告)日：2020-09-22
申请号：US15504049
申请日：2015-08-14
Applicant: Massachusetts Institute of Technology
Inventor： Klavs F. Jensen , Timothy F. Jamison , Allan S. Myerson , Jean-Christophe M. Monbaliu , Mohsen Behnam , Shin Yee Wong , Nopphon Weeranoppanant , Eve Marie Revalor , Torsten Stelzer , Jie Chen , Andrea Adamo , David R. Snead , Ping Zhang
IPC: B01J19/00 , B01J19/18 , A61K31/14 , A61K31/167
Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.
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Patent Agency Ranking
2.发明公开公开(公告)号：US20230201787A1
公开(公告)日：2023-06-29
申请号：US18086487
申请日：2022-12-21
Applicant: Massachusetts Institute of Technology
Inventor： Klavs F. Jensen , Timothy F. Jamison , Allan Stuart Myerson , Jean-Christophe M. Monbaliu , Mohsen Behnam , Shin Yee Wong , Nopphon Weeranoppanant , Eve Marie Revalor , Torsten Stelzer , Jie Chen , Andrea Adamo , David R. Snead , Ping Zhang
CPC classification number: B01J19/004 , B01J19/0093 , B01J19/18 , B01J2219/00799 , B01J2219/00011 , B01J2219/0004 , B01J2219/00795 , B01J2219/00806 , B01J2219/00813 , B01J2219/00907 , B01J2219/00909 , B01J2219/00918 , B01J2219/00831 , B01J2219/0081 , B01J2219/00833 , B01J2219/00873 , B01J2219/00817 , B01J2219/00822 , B01J2219/00986 , B01J2219/00835 , B01J2219/00889 , B01J2219/00871 , B01J2219/0002 , A61K31/14
Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.
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公开(公告)号：US20210256355A1
公开(公告)日：2021-08-19
申请号：US16790682
申请日：2020-02-13
Inventor： Jie Chen , Aldo Pareja , Giacomo Domeniconi , Tengfei Ma , Toyotaro Suzumura , Hiroki Kanezashi , Timothy Kaler , Tao B. Schardl , Charles E. Leiserson
Abstract: A system includes a plurality of graph convolutional networks corresponding to a plurality of time steps, each network modelling a graph including nodes and edges, and in turn including a plurality of graph convolution units; an evolving mechanism; and an output layer. Each of the units, for a given one of the time steps, takes as input a graph adjacency matrix, a node feature matrix, and a parameter matrix for a current layer, and outputs a new node feature matrix for a next highest layer. The mechanism takes as input a parameter matrix for a prior time step updates the input parameter matrix, and outputs the parameter matrix for the given time step. The output layer obtains, as input, output of each of the units for a final time step, and based on the output of each of the units for the final time step, outputs a graph solution.
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4.发明申请公开(公告)号：US20200368710A1
公开(公告)日：2020-11-26
申请号：US16988827
申请日：2020-08-10
Applicant: Massachusetts Institute of Technology
Inventor： Klavs F. Jensen , Timothy F. Jamison , Allan S. Myerson , Jean-Christophe M. Monbaliu , Mohsen Behnam , Shin Yee Wong , Nopphon Weeranoppanant , Eve Marie Revalor , Torsten Stelzer , Jie Chen , Andrea Adamo , David R. Snead , Ping Zhang
Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.
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5.发明授权公开(公告)号：US11565230B2
公开(公告)日：2023-01-31
申请号：US16988827
申请日：2020-08-10
Applicant: Massachusetts Institute of Technology
Inventor： Klavs F. Jensen , Timothy F. Jamison , Allan S. Myerson , Jean-Christophe M. Monbaliu , Mohsen Behnam , Shin Yee Wong , Nopphon Weeranoppanant , Eve Marie Revalor , Torsten Stelzer , Jie Chen , Andrea Adamo , David R. Snead , Ping Zhang
IPC: B01J19/00 , B01J19/18 , A61K31/14 , A61K31/167
Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.
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公开(公告)号：US11537852B2
公开(公告)日：2022-12-27
申请号：US16790682
申请日：2020-02-13
Inventor： Jie Chen , Aldo Pareja , Giacomo Domeniconi , Tengfei Ma , Toyotaro Suzumura , Timothy Kaler , Tao B. Schardl , Charles E. Leiserson
Abstract: A system includes a plurality of graph convolutional networks corresponding to a plurality of time steps, each network modelling a graph including nodes and edges, and in turn including a plurality of graph convolution units; an evolving mechanism; and an output layer. Each of the units, for a given one of the time steps, takes as input a graph adjacency matrix, a node feature matrix, and a parameter matrix for a current layer, and outputs a new node feature matrix for a next highest layer. The mechanism takes as input a parameter matrix for a prior time step updates the input parameter matrix, and outputs the parameter matrix for the given time step. The output layer obtains, as input, output of each of the units for a final time step, and based on the output of each of the units for the final time step, outputs a graph solution.
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