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    Fluidic module permanent stack assemblies and methods
    3.
    发明授权
    Fluidic module permanent stack assemblies and methods 有权
    流体模块永久堆栈组件和方法

    公开(公告)号：US09446378B2

    公开(公告)日：2016-09-20

    申请号：US14361842

    申请日：2012-11-30

    Applicant: Corning Incorporated

    Inventor： Thierry Luc Alain Dannoux ,  Sylvain Maxime F. Gremetz ,  Olivier Lobet ,  Ronan Tanguy

    IPC: B01J19/32 ,  B23P19/10 ,  B01J19/00 ,  C03B23/24 ,  B81C3/00 ,  C03C3/091 ,  C03C27/00

    CPC classification number: B01J19/32 ,  B01J19/0093 ,  B01J2219/00786 ,  B01J2219/00806 ,  B01J2219/00808 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/32213 ,  B01J2219/32275 ,  B01J2219/32425 ,  B01J2219/32441 ,  B01J2219/328 ,  B23P19/10 ,  B81B2201/058 ,  B81C3/001 ,  B81C2201/019 ,  C03B23/245 ,  C03C3/091 ,  C03C27/00 ,  Y10T29/49904

    Abstract: The present disclosure provides an assembled stack of fluidic modules comprising at least first and second fluidic modules assembled in a stacked configuration. The first fluidic module has first and second major planar surfaces and encloses a first fluidic passage extending therethrough from a first passage entrance to a first passage exit with the first passage exit located on the second major planar surface of the first fluidic module. The second fluidic module also has first and second major planar surfaces and encloses a second fluidic passage extending therethrough from a second passage entrance to a second passage exit, with the second passage entrance located on the first major planar surface of the second fluidic module. The second major planar surface of the first fluidic module and the first major planar surface of the second fluidic module are spaced apart and physically joined together by at least three separate glass or glass-ceramic pads fused therebetween, and the at least three pads include at least one pad having no through-hole and at least one pad having a through-hole, with the through-hole forming a sealed fluidic interconnection between the first fluidic passage and the second fluidic passage. A method of forming the assembled stack is also disclosed.

    Abstract translation: 本公开提供了一组流体模块，其包括以堆叠结构组装的至少第一和第二流体模块。 第一流体模块具有第一和第二主平面表面，并且包围第一流体通道，其从第一通道入口延伸到第一通道出口，第一通道出口位于第一流体模块的第二主平面上。 第二流体模块还具有第一和第二主平面表面，并且包围从第二通道入口延伸穿过第二通道出口的第二流体通道，第二通道入口位于第二流体模块的第一主平面上。 第一流体模块的第二主平面表面和第二流体模块的第一主平面表面间隔开并通过至少三个分开的玻璃或玻璃 - 陶瓷垫在其间融合并物理地连接在一起，并且至少三个垫包括在 至少一个不具有通孔的垫和至少一个具有通孔的垫，所述通孔在所述第一流体通道和所述第二流体通道之间形成密封的流体互连。 还公开了一种形成组装堆叠的方法。

    METHOD AND DEVICE FOR MANUFACTURING OF RADIOPHARMACEUTICALS
    6.
    发明申请
    METHOD AND DEVICE FOR MANUFACTURING OF RADIOPHARMACEUTICALS 审中-公开
    用于制造放射线照相的方法和装置

    公开(公告)号：US20120108858A1

    公开(公告)日：2012-05-03

    申请号：US12982499

    申请日：2010-12-30

    Applicant: MAXIM KISELEV

    Inventor： MAXIM KISELEV

    IPC: C07C25/00

    CPC classification number: C07B59/005 ,  A61K51/0491 ,  B01J19/004 ,  B01J19/0093 ,  B01J2219/00799 ,  B01J2219/00806 ,  B01J2219/00808 ,  B01J2219/00817 ,  B01J2219/00822 ,  B01J2219/00862 ,  B01J2219/00873 ,  B01J2219/00889

    Abstract: The invention relates to a device for processing radioisotopes and production of radiopharmaceuticals, for example, 18F-2 Deoxy-2-Fluoro-D-Glucose (FDG), for Positron Emission Tomography (PET). Use of a tilting and rotating reactor with optimized geometry allows for decreased processing time and increased efficiency. Reagent vials are separated from the reactor module and placed in a separate enclosure allowing safe reloading of the system and production of multiple batches with minimal operator exposure to radiation. Reagent vials enclosure is protected from the environment and filled with purified air to reduce risk of contamination. Product and reagents pathways are sealed from the environment and are sterilized.

    Abstract translation: 本发明涉及用于正电子发射断层扫描（PET）的放射性同位素和放射性药物的制备装置，例如18F-2脱氧-2-氟-D-葡萄糖（FDG）。 使用具有优化几何形状的倾斜和旋转反应器可减少加工时间并提高效率。 将试剂瓶与反应器模块分离，并放置在单独的外壳中，允许系统的安全重新装载，并且以最小的操作者暴露于辐射来生产多个批次。 试剂盒外壳受环境保护，并充满净化空气，以减少污染的风险。 产品和试剂通道与环境密封并进行灭菌。

    A GLASS LINED METAL MICRO-REACTOR
    9.
    发明申请
    A GLASS LINED METAL MICRO-REACTOR 有权
    玻璃线金属微反应器

    公开(公告)号：US20160317996A1

    公开(公告)日：2016-11-03

    申请号：US15103623

    申请日：2014-12-12

    Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

    Inventor： Amol A. Kulkarni ,  Vivek V. Ranade

    IPC: B01J19/00

    CPC classification number: B01J19/0093 ,  B01J19/02 ,  B01J2219/00783 ,  B01J2219/00804 ,  B01J2219/00806 ,  B01J2219/00822 ,  B01J2219/00831 ,  B01J2219/0084 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00873 ,  B01J2219/0099 ,  B01J2219/0209

    Abstract: The invention discloses a glass lined metal micro-reactor with enhanced heat transfer efficiency in continuous flow operation. More particularly, the invention discloses a glass lined micro-reactor that can be reassembled. The invention provides a novel glass lined metal micro-reactor with micro fluidic channels that provide a better mixing, better heat exchange, and better temperature control. The micro fluidic channels machined in the glass lined metal reactor/mixer may be straight, curved, lamellar, flower shaped, or spiral such that the cross sectional area of the micro fluidic channel is configured to suit the cross sectional area of the micro-reactor.

    Abstract translation: 本发明公开了一种在连续流动操作中具有增强的传热效率的玻璃衬里金属微反应器。 更具体地说，本发明公开了一种可重新组装的玻璃衬里微反应器。 本发明提供了一种具有微流体通道的新型玻璃衬里金属微反应器，其提供更好的混合，更好的热交换和更好的温度控制。 在玻璃衬里金属反应器/混合器中加工的微流体通道可以是直的，弯曲的，层状的，花形的或螺旋形的，使得微流体通道的横截面积被配置成适合微反应器的横截面积 。

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