公开(公告)号：US10017812B2

公开(公告)日：2018-07-10

申请号：US13300235

申请日：2011-11-18

Applicant: Matthew Rabinowitz ,  George Gemelos ,  Milena Banjevic ,  Allison Ryan ,  Zachary Demko ,  Matthew Hill ,  Bernhard Zimmermann ,  Johan Baner

Inventor： Matthew Rabinowitz ,  George Gemelos ,  Milena Banjevic ,  Allison Ryan ,  Zachary Demko ,  Matthew Hill ,  Bernhard Zimmermann ,  Johan Baner

IPC: G01N33/48 ,  G01N31/00 ,  G06G7/48 ,  G06G7/58 ,  C12Q1/6869 ,  C12Q1/6827 ,  G06F19/18 ,  C12Q1/6883 ,  C12Q1/6862 ,  G06F19/24

CPC classification number: C12Q1/6869 ,  C12Q1/6806 ,  C12Q1/6827 ,  C12Q1/686 ,  C12Q1/6862 ,  C12Q1/6874 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/16 ,  G06F19/34 ,  G16B20/00 ,  G16B40/00 ,  C12Q2537/161 ,  C12Q2537/165 ,  C12Q2537/143

Abstract: The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.

公开(公告)号：US20120185176A1

公开(公告)日：2012-07-19

申请号：US13499086

申请日：2010-09-30

Applicant: Matthew Rabinowitz ,  Allison Ryan ,  George Gemelos ,  Milena Banjevic ,  Zachary Demko

Inventor： Matthew Rabinowitz ,  Allison Ryan ,  George Gemelos ,  Milena Banjevic ,  Zachary Demko

IPC: G06F19/00

CPC classification number: G16B30/00 ,  C12Q1/6827 ,  C12Q1/6874 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/16 ,  G06N7/005 ,  G16B20/00 ,  C12Q2537/16 ,  C12Q2537/165

Abstract: Disclosed herein are methods for determining the copy number of a chromosome in a fetus in the context of non-invasive prenatal diagnosis. In an embodiment, the measured genetic data from a sample of genetic material that contains both fetal DNA and maternal DNA is analyzed, along with the genetic data from the biological parents of the fetus, and the copy number of the chromosome of interest is determined. In an embodiment, the maternal serum is measured using a single-nucleotide polymorphism (SNP) microarray, along with parental genomic data, and the determination of the chromosome copy number is used to make clinical decisions pertaining to the fetus.

Abstract translation: 本文公开了用于在非侵入性产前诊断的上下文中确定胎儿中染色体的拷贝数的方法。 在一个实施方案中，分析来自含有胎儿DNA和母体DNA的遗传物质的样品的测量的遗传数据以及来自胎儿的生物亲本的遗传数据，并确定感兴趣的染色体的拷贝数。 在一个实施方案中，使用单核苷酸多态性（SNP）微阵列以及亲本基因组数据测量母体血清，并且使用染色体拷贝数的确定来进行与胎儿有关的临床决定。

公开(公告)号：US08024128B2

公开(公告)日：2011-09-20

申请号：US11004274

申请日：2004-12-03

Applicant: Matthew Rabinowitz ,  Wayne Chambliss ,  John Croswell ,  Miro Sarbaev ,  Milena Banjevic

Inventor： Matthew Rabinowitz ,  Wayne Chambliss ,  John Croswell ,  Miro Sarbaev ,  Milena Banjevic

IPC: G01N33/50

CPC classification number: G06F19/24 ,  G06F19/18

Abstract: The information management system disclosed enables caregivers to make better decisions by using aggregated data. The system enables the integration, validation and analysis of genetic, phenotypic and clinical data from multiple subjects. A standardized data model stores a range of patient data in standardized data classes comprising patient profile, genetic, symptomatic, treatment and diagnostic information. Data is converted into standardized data classes using a data parser specifically tailored to the source system. Relationships exist between standardized data classes, based on expert rules and statistical models, and are used to validate new data and predict phenotypic outcomes. The prediction may comprise a clinical outcome in response to a proposed intervention. The statistical models and methods for training those models may be input according to a standardized template. Methods are described for selecting, creating and training the statistical models to operate on genetic, phenotypic, clinical and undetermined data sets.

Abstract translation: 公开的信息管理系统使护理人员能够通过使用聚合数据做出更好的决策。 该系统能够整合，验证和分析来自多个受试者的遗传，表型和临床数据。 标准化数据模型将患者数据范围存储在包括患者概况，遗传，症状，治疗和诊断信息的标准化数据类别中。 使用专门针对源系统定制的数据解析器将数据转换为标准化数据类。 基于专家规则和统计模型，标准化数据类之间存在关系，用于验证新数据并预测表型结果。 预测可以包括响应于所提出的干预的临床结果。 可以根据标准化模板输入训练这些模型的统计模型和方法。 描述了用于选择，创建和训练统计模型以操作遗传，表型，临床和未确定数据集的方法。

公开(公告)号：US20110092763A1

公开(公告)日：2011-04-21

申请号：US12994260

申请日：2009-05-27

Applicant: Matthew Rabinowitz ,  David S. Johnson ,  Nigam Shah ,  George Gemelos

Inventor： Matthew Rabinowitz ,  David S. Johnson ,  Nigam Shah ,  George Gemelos

IPC: A61B17/435 ,  G06F19/00

CPC classification number: C12Q1/6883 ,  C12Q2600/156

Abstract: Disclosed herein are methods for determining which embryos from a group of embryos are most likely to implant and develop as desired. In an embodiment of the present disclosure, one or more cells are biopsied from each of the embryos, and the genetic condition of those cells are determined. Within a group of embryos that each test positive for aneuploidy, the likelihood that each embryo contains euploid cells may be determined from the type of aneuploidy observed in the biopsied cells. This knowledge may be used to make a decision as to which embryos to transfer to a uterus. In an embodiment of the present disclosure, these determinations are made for the purpose of embryo selection in the context of in vitro fertilization.

Abstract translation: 本文公开了用于根据需要确定来自一组胚胎最可能植入和发育的胚胎的方法。 在本公开的一个实施方案中，从每个胚胎活检一个或多个细胞，并确定那些细胞的遗传条件。 在一组胚胎中，每个胚胎均检测到非整倍体阳性，每个胚胎含有整倍体细胞的可能性可以从活检细胞中观察到的非整倍体类型确定。 这些知识可能用于决定哪些胚胎转移到子宫。 在本公开的一个实施方案中，这些确定是为了在体外受精的背景下进行胚胎选择的目的。

公开(公告)号：US06839024B2

公开(公告)日：2005-01-04

申请号：US10356698

申请日：2003-01-31

Applicant: James J. Spilker, Jr. ,  Matthew Rabinowitz

Inventor： James J. Spilker, Jr. ,  Matthew Rabinowitz

IPC: G01S1/00 ,  G01S5/00 ,  G01S5/02 ,  G01S5/14 ,  G01S19/46 ,  H04N7/24 ,  G01S1/08

CPC classification number: H04N21/25841 ,  A63F2300/205 ,  G01S5/0036 ,  G01S5/0054 ,  G01S5/0081 ,  G01S5/02 ,  G01S5/0205 ,  G01S5/021 ,  G01S5/0215 ,  G01S5/0221 ,  G01S5/0226 ,  G01S5/0236 ,  G01S5/145 ,  G01S19/46 ,  H04N21/235 ,  H04N21/2662 ,  H04N21/2668 ,  H04N21/41422 ,  H04N21/435 ,  H04N21/615 ,  H04N21/8126

Abstract: An apparatus, method, and computer-readable media comprise a receiver adapted to receive a plurality of broadcast signals; a signal processor adapted to determine a position based on the received plurality of broadcast signals; a signal generator adapted to generate a ranging signal comprising a known component of a television signal; and a transmitter adapted to broadcast a signal comprising the ranging signal and a position signal comprising a description of the position.

Abstract translation: 一种装置，方法和计算机可读介质包括适于接收多个广播信号的接收机; 信号处理器，其适于基于所接收的多个广播信号来确定位置; 信号发生器，适于生成包括电视信号的已知分量的测距信号; 以及发射机，其适于广播包括所述测距信号的信号和包括所述位置的描述的位置信号。

公开(公告)号：US06351740B1

公开(公告)日：2002-02-26

申请号：US09201927

申请日：1998-12-01

Applicant: Matthew Rabinowitz

Inventor： Matthew Rabinowitz

IPC: G06F1518

CPC classification number: G06N99/005 ,  H03H21/0016 ,  H03H2222/04

Abstract: Described herein is a method and system for training nonlinear adaptive filters (or neural networks) which have embedded memory. Such memory can arise in a multi-layer finite impulse response (FIR) architecture, or an infinite impulse response (IIR) architecture. We focus on filter architectures with separate linear dynamic components and static nonlinear components. Such filters can be structured so as to restrict their degrees of computational freedom based on a priori knowledge about the dynamic operation to be emulated. The method is detailed for an FIR architecture which consists of linear FIR filters together with nonlinear generalized single layer subnets. For the IIR case, we extend the methodology to a general nonlinear architecture which uses feedback. For these dynamic architectures, we describe how one can apply optimization techniques which make updates closer to the Newton direction than those of a steepest descent method, such as backpropagation. We detail a novel adaptive modified Gauss-Newton optimization technique, which uses an adaptive learning rate to determine both the magnitude and direction of update steps. For a wide range of adaptive filtering applications, the new training algorithm converges faster and to a smaller value of cost than both steepest-descent methods such as backpropagation-through-time, and standard quasi-Newton methods. We apply the algorithm to modeling the inverse of a nonlinear dynamic tracking system 5, as well as a nonlinear amplifier 6.

Abstract translation: 这里描述了一种用于训练具有嵌入式存储器的非线性自适应滤波器（或神经网络）的方法和系统。 这种存储器可以出现在多层有限脉冲响应（FIR）架构或无限脉冲响应（IIR）架构中。 我们专注于具有单独的线性动态组件和静态非线性组件的滤波器架构。 这样的滤波器可以被构造成基于关于待仿真的动态操作的先验知识来限制它们的计算自由度。 该方法对于由线性FIR滤波器和非线性广义单层子网组成的FIR架构是详细的。 对于IIR案例，我们将方法扩展到使用反馈的一般非线性架构。 对于这些动态架构，我们描述了如何应用优化技术，使更新更接近牛顿方向，而不是最速下降方法，如反向传播。 我们详细介绍了一种新颖的自适应修正高斯牛顿优化技术，它利用自适应学习速率来确定更新步长的幅度和方向。 对于广泛的自适应滤波应用，新的训练算法比最快下降方法（如反向传播通过时间和标准准牛顿法）收敛速度更快，成本更低。 我们应用算法建模非线性动态跟踪系统5的逆，以及非线性放大器6。

公开(公告)号：US20130252824A1

公开(公告)日：2013-09-26

申请号：US13793186

申请日：2013-03-11

Applicant: Matthew Rabinowitz ,  Milena Banjevic ,  Zachary Demko ,  David Johnson

Inventor： Matthew Rabinowitz ,  Milena Banjevic ,  Zachary Demko ,  David Johnson

IPC: G06F19/20

CPC classification number: G06F19/20 ,  G06F19/18

Abstract: A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available, are disclosed. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related subjects. In accordance with one embodiment of the invention, incomplete genetic data is acquired from embryonic cells, fetal cells, or cell-free fetal DNA isolated from the mother's blood, and the incomplete genetic data is reconstructed using the more complete genetic data from a larger sample diploid cells from one or both parents, with or without genetic data from haploid cells from one or both parents, and/or genetic data taken from other related individuals.

Abstract translation: 公开了一种用于确定一个或一小组细胞遗传数据的系统和方法，或从有限数量的遗传数据获得的片段DNA。 使用已知方法获取和扩增目标个体的遗传数据，并且使用目标基因组与基因相关受试者的基因组之间的预期相似性重建差测量的碱基对，缺失的等位基因和缺失区域。 根据本发明的一个实施方案，从母体血液中分离的胚胎细胞，胎儿细胞或无细胞胎儿DNA获得不完整的遗传数据，并且使用更大的样本的更完整的遗传数据来重建不完整的遗传数据 来自一个或两个父母的二倍体细胞，具有或不具有来自一个或两个亲本的单倍体细胞的遗传数据和/或从其他相关个体获取的遗传数据。

公开(公告)号：US08102317B2

公开(公告)日：2012-01-24

申请号：US11284800

申请日：2005-11-22

Applicant: Andy Lee ,  James J. Spilker, Jr. ,  Matthew Rabinowitz ,  Jimmy K. Omura

Inventor： Andy Lee ,  James J. Spilker, Jr. ,  Matthew Rabinowitz ,  Jimmy K. Omura

IPC: G01S3/02

CPC classification number: G01S5/0252 ,  H04H60/51 ,  H04W64/00

Abstract: An apparatus comprises a receiver to receive a plurality of wireless television signals each representing a television channel, and a measurement circuit to identify the television channels based on the wireless television signals. One or more of a plurality of possible locations of the apparatus are selected based on identities of the television channels identified by the measurement circuit and a plurality of associations each associating one of the possible locations with identities of the television channels expected at one of the possible locations.

Abstract translation: 一种装置包括接收多个代表电视频道的无线电视信号的接收机，以及基于无线电视信号识别电视频道的测量电路。 基于由测量电路识别的电视频道的身份，选择多个可能的位置中的一个或多个，每个关联可以将可能位置中的一个与预期的电视频道中的一个相关联， 位置。

公开(公告)号：US20110288780A1

公开(公告)日：2011-11-24

申请号：US13110685

申请日：2011-05-18

Applicant: Matthew Rabinowitz ,  George Gemelos ,  Milena Banjevic ,  Allison Ryan ,  Zachary Demko ,  Matthew Hill ,  Bernhard Zimmermann ,  Johan Baner

Inventor： Matthew Rabinowitz ,  George Gemelos ,  Milena Banjevic ,  Allison Ryan ,  Zachary Demko ,  Matthew Hill ,  Bernhard Zimmermann ,  Johan Baner

IPC: G06F19/00 ,  C07H21/04

CPC classification number: C12Q1/6883 ,  C12Q1/6827 ,  C12Q1/6869 ,  C12Q2537/161 ,  C12Q2537/165 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2600/172 ,  G06F19/00 ,  G06F19/12 ,  G06F19/18 ,  G06F19/22 ,  G06F19/34 ,  G16H50/30

Abstract: Methods for non-invasive prenatal ploidy calling are disclosed herein. Methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a sample of DNA from the mother of the fetus and from the fetus, and from genotypic data from the mother and optionally also from the father are disclosed herein. The ploidy state is determined by using a joint distribution model to create a set of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. In an embodiment, the mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias.

Abstract translation: 本文公开了非侵入性产前倍性呼叫的方法。 本文公开了从胎儿母体和胎儿的DNA样本以及来自母亲和任选也来自父亲的基因型数据测量的基因型数据中确定妊娠胎儿染色体倍性状态的方法。 通过使用联合分布模型来确定给定父母基因型数据的不同可能胎儿倍性状态的一组预期等位基因分布，并将预期等位基因分布与在混合样品中测量的测量等位基因分布的模式进行比较来确定倍性状态， 并选择其预期等位基因分布模式与观察到的等位基因分布模式最接近的倍性状态。 在一个实施方案中，DNA的混合样品可以以使等位基因偏倚最小化的方式优先富集在多个多态位点。

公开(公告)号：US20110263269A1

公开(公告)日：2011-10-27

申请号：US12741346

申请日：2009-06-02

Applicant: Ju-Yong Do ,  Guttorm Opshaug ,  James J. ER ,  Matthew Rabinowitz

Inventor： Ju-Yong Do ,  Guttorm Opshaug ,  James J. ER ,  Matthew Rabinowitz

IPC: H04W24/00

CPC classification number: H04W64/00 ,  H04W64/003 ,  H04W84/045

Abstract: Apparatus having corresponding methods and tangible computer-readable media comprise: a measurement module adapted to generate measurements of a wireless television signal received by the apparatus and measurements of a wireless satellite positioning signal received by the apparatus; a location module adapted to determine a location of the apparatus based on the measurements of the wireless television signal and the measurements of the wireless satellite positioning signal; and a time module adapted to provide a clock control signal for the apparatus based on at least one of the measurements of the wireless television signal, and the measurements of the wireless satellite positioning signal.

Abstract translation: 具有相应方法和有形计算机可读介质的装置包括：测量模块，其适于产生由所述装置接收的无线电视信号的测量值和由所述装置接收的无线卫星定位信号的测量值; 位置模块，其适于基于所述无线电视信号的测量结果和所述无线卫星定位信号的测量来确定所述设备的位置; 以及时间模块，其适于基于所述无线电视信号的所述测量中的至少一个以及所述无线卫星定位信号的测量来为所述装置提供时钟控制信号。