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    Mass biosensor method with quantified sensor renewal
    3.
    发明授权
    Mass biosensor method with quantified sensor renewal 失效
    大量生物传感器方法与定量传感器更新

    公开(公告)号：US5229301A

    公开(公告)日：1993-07-20

    申请号：US711786

    申请日：1991-06-07

    申请人： Darlene J. Spira-Solomon ,  May Tom-Moy ,  Carl A. Myerholtz

    发明人： Darlene J. Spira-Solomon ,  May Tom-Moy ,  Carl A. Myerholtz

    IPC分类号： G01N21/64 ,  G01N21/76 ,  G01N33/543

    CPC分类号： G01N33/54373 ,  Y10S436/80 ,  Y10S436/805

    摘要： A mass biosensor method provides enhanced quantification of analyte concentrations in a sample. In a direct approach, an analyte is derivatized to form an analyte chelate and then specifically bound to a sensor. In an indirect approach, a complement of the analyte is derivatized to form a complement chelate which is then bound to a sensor. In a direct/indirect hybrid approach, an analog of the analyte is derivatized to form an analog chelate that is bound to a sensor in competition with the sample analyte. In all three approaches, mass measurements taken as the ligand chelate attaches to the sensor permit the concentration of the analyte in the sample to be calculated. Once measurement is completed, a dissociation treatment is applied to dissociate the derivatized species from the sensor so that the sensor can be reused. The effects of the dissociation treatment can be monitored using phosphorescence detection. The results obtained during monitoring can be compared with a predetermined threshold to ensure complete dissociation while avoiding alteration of the sensor surface. This procedure permits precision renewal of a sensor to maximize the number of times a sensor can be used. Moreover, this method allows quantification to be performed using the same sensor and coating in place during calibration, minimizing systematic errors and enhancing quantification accuracy.

    Chemically sensitive, dimensionally-stable organosilicon material composition and techniques
    5.
    发明授权
    Chemically sensitive, dimensionally-stable organosilicon material composition and techniques 失效
    化学敏感，尺寸稳定的有机硅材料组成和技术

    公开(公告)号：US5194391A

    公开(公告)日：1993-03-16

    申请号：US720983

    申请日：1991-06-25

    申请人： Ganapati R. Nauze ,  Robert R. Holloway ,  Darlene J. Spira-Solomon

    发明人： Ganapati R. Nauze ,  Robert R. Holloway ,  Darlene J. Spira-Solomon

    IPC分类号： C08K13/02 ,  G01N31/22

    CPC分类号： G01N31/22 ,  C08K13/02 ,  Y10T436/207497

    摘要： A dimensionally-stable organosilicon material composition and method for producing the material composition including non-crosslinkable, continuous phase silicone with silica filler material dispersed therethrough, and having dissolved therein a variably-radiative material (e.g., ruthenium dye) responsive to the concentration of a selected analyte (e.g., oxygen), and the products of a reaction between water and a modifier material selected for establishing the sensitivity of said variably-radiative material to the selected analyte.

    摘要翻译： 一种尺寸稳定的有机硅材料组合物和用于制备材料组合物的方法，所述组合物包括分散在其中的二氧化硅填料的不可交联连续相硅氧烷，并且其中溶解有可变辐射材料（例如钌染料） 选择的分析物（例如氧气）以及水和选择用于确定所述可变辐射材料对所选择的分析物的灵敏度的改性剂材料之间的反应产物。

    Preparing a dye-containing polymer
    6.
    发明授权
    Preparing a dye-containing polymer 失效
    制备含染料的聚合物

    公开(公告)号：US5286777A

    公开(公告)日：1994-02-15

    申请号：US912063

    申请日：1992-07-07

    申请人： Ulrich Schoeler ,  Peter Ast ,  Eugene W. Reynolds, deceased ,  Darlene J. Spira-Solomon

    发明人： Ulrich Schoeler ,  Peter Ast ,  Eugene W. Reynolds, deceased ,  Darlene J. Spira-Solomon

    IPC分类号： C08F2/02 ,  C08F2/44 ,  C08F20/56 ,  C08G63/78 ,  C08L39/00

    CPC分类号： C08F2/44

    摘要： In a process for producing a dye-containing polymer to be used for spectroscopic sample analysis, monomers are polymerized in the presence of a dye to form a block of bulk polymer. The bulk polymer or slices thereof can be easily measured in a spectrometer in order to determine the spectroscopic properties of the dye containing polymer. The bulk polymer is subsequently ground to particles which can be used to fill a fiber optical sensor. Since the particles have the same optical properties as the bulk polymer, the properties of the particles of dye-containing polymer of the sensor can be accurately determined from the bulk polymer.

    摘要翻译： 在制备用于光谱样品分析的含染料的聚合物的方法中，单体在染料存在下聚合以形成本体聚合物的嵌段。 为了确定含染料的聚合物的光谱性质，可以在光谱仪中容易地测量本体聚合物或其片。 随后将本体聚合物研磨成可用于填充纤维光学传感器的颗粒。 由于颗粒具有与本体聚合物相同的光学性能，所以传感器的含染料聚合物的颗粒的性质可以从本体聚合物精确地确定。