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    Mass biosensor method with quantified sensor renewal
    2.
    发明授权
    Mass biosensor method with quantified sensor renewal 失效
    大量生物传感器方法与定量传感器更新

    公开(公告)号：US5229301A

    公开(公告)日：1993-07-20

    申请号：US711786

    申请日：1991-06-07

    Applicant: Darlene J. Spira-Solomon ,  May Tom-Moy ,  Carl A. Myerholtz

    Inventor： Darlene J. Spira-Solomon ,  May Tom-Moy ,  Carl A. Myerholtz

    IPC: G01N21/64 ,  G01N21/76 ,  G01N33/543

    CPC classification number: G01N33/54373 ,  Y10S436/80 ,  Y10S436/805

    Abstract: A mass biosensor method provides enhanced quantification of analyte concentrations in a sample. In a direct approach, an analyte is derivatized to form an analyte chelate and then specifically bound to a sensor. In an indirect approach, a complement of the analyte is derivatized to form a complement chelate which is then bound to a sensor. In a direct/indirect hybrid approach, an analog of the analyte is derivatized to form an analog chelate that is bound to a sensor in competition with the sample analyte. In all three approaches, mass measurements taken as the ligand chelate attaches to the sensor permit the concentration of the analyte in the sample to be calculated. Once measurement is completed, a dissociation treatment is applied to dissociate the derivatized species from the sensor so that the sensor can be reused. The effects of the dissociation treatment can be monitored using phosphorescence detection. The results obtained during monitoring can be compared with a predetermined threshold to ensure complete dissociation while avoiding alteration of the sensor surface. This procedure permits precision renewal of a sensor to maximize the number of times a sensor can be used. Moreover, this method allows quantification to be performed using the same sensor and coating in place during calibration, minimizing systematic errors and enhancing quantification accuracy.

    Power-modulated inductively coupled plasma spectrometry
    3.
    发明授权
    Power-modulated inductively coupled plasma spectrometry 失效
    功率调制电感耦合等离子体光谱法

    公开(公告)号：US06222186B1

    公开(公告)日：2001-04-24

    申请号：US09104754

    申请日：1998-06-25

    Applicant: Gangqiang Li ,  Thomas P. Doherty ,  Carl A. Myerholtz

    Inventor： Gangqiang Li ,  Thomas P. Doherty ,  Carl A. Myerholtz

    IPC: H01J4900

    CPC classification number: H01J49/105

    Abstract: A technique that modulates the power of a inductively coupled plasma (ICP) according to the operative modes of a spectrometer. An analytical apparatus of the present invention contains an inductively coupled plasma generator (ICPG) and a spectrometer. The ICPG generates a plasma for forming ionic and excited molecular species from a sample. The spectrometer analyzes the ionic and excited molecular species formed. The spectrometer operates in an analysis mode wherein the ionic and excited molecular species are identified according to physical characteristics of the species to provide data on the species and further has a washout mode wherein the spectrometer flushes out interfering ions and molecules and provides no significant data on the sample. The controller modulates the ICPG to operate in power cycles, at each cycle the ICPG operates in an analysis period and a stand-by period. By modulating the plasma power, the power consumption and heat dissipation can be reduced. When such a power modulated plasma source is coupled to, for example, a time-of-flight mass spectrometer (TOFMS), high analytical performance can be achieved with simultaneous multi-element detection capability.

    Abstract translation: 根据光谱仪的操作模式调制感应耦合等离子体（ICP）的功率的技术。 本发明的分析装置包含电感耦合等离子体发生器（ICPG）和光谱仪。 ICPG产生用于从样品形成离子和激发的分子物质的等离子体。 光谱仪分析形成的离子和激发的分子物质。 光谱仪以分析模式工作，其中根据物种的物理特性鉴定离子和激发的分子种类，以提供物种数据，并且还具有洗脱模式，其中光谱仪冲洗干扰离子和分子，并且不提供关于 例子。 控制员调控ICPG在动力循环中运行，ICPG在分析周期和待机期间运行的每个周期。 通过调制等离子体功率，可以降低功耗和散热。 当这种功率调制等离子体源耦合到例如飞行时间质谱仪（TOFMS）时，可以通过同时多元素检测能力实现高分析性能。

    Capsule Injection System for Gas Chromatography
    4.
    发明申请
    Capsule Injection System for Gas Chromatography 有权
    胶囊注射系统用于气相色谱

    公开(公告)号：US20110146380A1

    公开(公告)日：2011-06-23

    申请号：US12642843

    申请日：2009-12-20

    Applicant: Arthur Schleifer ,  Carl A. Myerholtz

    Inventor： Arthur Schleifer ,  Carl A. Myerholtz

    IPC: G01N30/16 ,  B01L3/00

    CPC classification number: G01N30/16 ,  G01N2030/025

    Abstract: The present invention includes a heat sealable capsule adapted for use in analysis devices such as GCs, and methods for using the capsules to perform analysis in such devices. The capsules include a tube having an end that is heat-sealed to contain a sample that is to be analyzed at an injection temperature. The tube includes a heat sealable medium having a heat seal that closes the end, the tube having an inner and outer surface, both of the surfaces being substantially chemically inert with respect to the sample. The tube is substantially free of any material that outgases at the injection temperature. The tube is openable without breaking into pieces, and remains intact at the injection temperature. The capsule can include a programmable tag that stores information related to the sample contained therein.

    Abstract translation: 本发明包括适用于诸如GC之类的分析装置的可热封胶囊，以及使用该胶囊在这些装置中进行分析的方法。 胶囊包括具有热封端以容纳在注射温度下待分析的样品的管。 管包括具有封闭端部的热封的热封介质，管具有内表面和外表面，两个表面相对于样品基本上是化学惰性的。 该管基本上不含任何在注射温度下会出现的物质。 管可打开而不会碎片，并且在注射温度下保持完好。 胶囊可以包括可编程标签，其存储与其中包含的样品有关的信息。

    Sequencing ion packets for ion time-of-flight mass spectrometry
    6.
    发明授权
    Sequencing ion packets for ion time-of-flight mass spectrometry 失效
    用于离子飞行时间质谱的测序离子包

    公开(公告)号：US5396065A

    公开(公告)日：1995-03-07

    申请号：US171076

    申请日：1993-12-21

    Applicant: Carl A. Myerholtz ,  Richard L. Baer ,  Christian A. Le Cocq

    Inventor： Carl A. Myerholtz ,  Richard L. Baer ,  Christian A. Le Cocq

    IPC: G01N27/62 ,  H01J49/40

    CPC classification number: H01J49/0031 ,  H01J49/40

    Abstract: A method and apparatus for analyzing ions by determining times of flight include establishing an encoded sequence for launching packets of ions from a source region toward a detector. The encoded sequence is one in which the high-mass ions of a leading packet will be passed by the low-mass ions of a trailing packet. Thus, a high efficiency time-of-flight mass spectrometer is formed. The ions of each packet are acted upon to bunch the ions of the packet, thereby compensating for initial space and/or velocity distributions of ions in the launching of the packet. The times of arrival of the ions are determined at the detector to obtain a signal of overlapping spectra corresponding to the overlapping launched packets. A correlation between the overlapping spectra and the encoded launch sequence is employed to derive a single non-overlapped spectrum.

    Abstract translation: 通过确定飞行时间来分析离子的方法和装置包括建立用于从源区域向检测器发射离子包的编码序列。 编码的序列是其中前导分组的高质量离子将由尾部分组的低质量离子通过的序列。 因此，形成了高效率的飞行时间质谱仪。 每个分组的离子被作用于束化分组的离子，从而补偿分组发射中离子的初始空间和/或速度分布。 在检测器处确定离子的到达时间，以获得与重叠发射的分组相对应的重叠光谱的信号。 使用重叠光谱和编码的发射序列之间的相关性来导出单个非重叠光谱。

    Capsule injection system for gas chromatography
    9.
    发明授权
    Capsule injection system for gas chromatography 有权
    胶囊注射系统用于气相色谱

    公开(公告)号：US08490466B2

    公开(公告)日：2013-07-23

    申请号：US12642843

    申请日：2009-12-20

    Applicant: Arthur Schleifer ,  Carl A. Myerholtz

    Inventor： Arthur Schleifer ,  Carl A. Myerholtz

    IPC: G01N1/22 ,  G01N1/28 ,  G01N30/06

    CPC classification number: G01N30/16 ,  G01N2030/025

    Abstract: The present invention includes a heat sealable capsule adapted for use in analysis devices such as GCs, and methods for using the capsules to perform analysis in such devices. The capsules include a tube having an end that is heat-sealed to contain a sample that is to be analyzed at an injection temperature. The tube includes a heat sealable medium having a heat seal that closes the end, the tube having an inner and outer surface, both of the surfaces being substantially chemically inert with respect to the sample. The tube is substantially free of any material that outgases at the injection temperature. The tube is openable without breaking into pieces, and remains intact at the injection temperature. The capsule can include a programmable tag that stores information related to the sample contained therein.

    Abstract translation: 本发明包括适用于诸如GC之类的分析装置的可热封胶囊，以及使用该胶囊在这些装置中进行分析的方法。 胶囊包括具有热封端以容纳在注射温度下待分析的样品的管。 管包括具有封闭端部的热封的热封介质，管具有内表面和外表面，两个表面相对于样品基本上是化学惰性的。 该管基本上不含任何在注射温度下会出现的物质。 管可打开而不会碎片，并且在注射温度下保持完好。 胶囊可以包括可编程标签，其存储与其中包含的样品有关的信息。

    Multilayered gas chromatograph
    10.
    发明授权
    Multilayered gas chromatograph 失效
    多层气相色谱仪

    公开(公告)号：US06497138B1

    公开(公告)日：2002-12-24

    申请号：US09691601

    申请日：2000-10-18

    Applicant: Mahmoud Farid Abdel-Rahman ,  Carl A. Myerholtz

    Inventor： Mahmoud Farid Abdel-Rahman ,  Carl A. Myerholtz

    IPC: G01N3004

    CPC classification number: G01N30/466 ,  G01N30/6095 ,  G01N30/88 ,  G01N2030/085

    Abstract: The present disclosure relates to a gas chromatograph having a plurality of layers or channels. The chromatograph typically comprises an inlet that receives a sample to be analyzed, a column disposed in each of the plurality of chromatograph layers, each column being in fluid communication with and downstream from the inlet and having a stationary phase coating its inner surfaces, and a detector in fluid communication with and downstream from at least one of the columns. In a preferred arrangement, the chromatograph includes a pre-column disposed in each of the chromatograph layers upstream of the columns, each pre-column being in fluid communication with the inlet and having a stationary phase coating its inner surfaces.

    Abstract translation: 本公开涉及具有多个层或通道的气相色谱仪。 色谱仪通常包括接收待分析样品的入口，设置在多个色谱层中的每一层中的色谱柱，每个色谱柱与入口流体连通和下游，并具有涂覆其内表面的固定相，和 检测器与至少一个柱流体连通和下游。 在优选的布置中，色谱仪包括设置在每个色谱层在色谱柱上游的预柱，每个预柱与入口流体连通并具有涂覆其内表面的固定相。

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