公开(公告)号：US20050028978A1

公开(公告)日：2005-02-10

申请号：US10644429

申请日：2003-08-20

申请人： Mehmet Parlar ,  Liz Morris ,  Yiyan Chen ,  Paul Price

发明人： Mehmet Parlar ,  Liz Morris ,  Yiyan Chen ,  Paul Price

IPC分类号： C09K8/36 ,  E21B43/04

CPC分类号： C09K8/36 ,  C09K2208/30 ,  E21B43/04

摘要： A method is disclosed for using aqueous VES-based gravel carrier fluids in gravel packing operations using screens and shunt tubes that have been run into a well completed with an oil-based mud. With this method, the previously necessary but undesirable steps of first running in a perforated liner and then displacing the oil-based mud with an aqueous-based fluid in the region to be gravel packed are both avoided while the advantages of gravel packing with an aqueous-based fluid are retained.

摘要翻译： 公开了一种在使用已经用油基泥浆完成的筛网和分流管的砾石包装操作中使用水性VES基砾石载体流体的方法。 使用这种方法，首先在穿孔衬里中运行，然后在要砾石填充的区域中用含水基流体移动油基泥浆的先前必要但不期望的步骤都是避免的，而具有水性的砾石填充的优点 的流体被保留。

公开(公告)号：US4300423A

公开(公告)日：1981-11-17

申请号：US91196

申请日：1979-11-07

申请人： Paul Price

发明人： Paul Price

IPC分类号： B01L99/00 ,  B26D1/547 ,  B26D3/00 ,  B01L11/00

CPC分类号： B01L99/00 ,  B26D1/547 ,  Y10T83/2216 ,  Y10T83/222 ,  Y10T83/6544 ,  Y10T83/6614 ,  Y10T83/7587

摘要： For the purposes of severing and separating a plurality of cup-shaped object supports (2) of plastic material, which are interconnectedly arranged on a support plate (1), use is made of a method wherein the support plate (1) is first put into a gripping device (4) and secured therein. Subsequently a severing device (5) which is displaceable in the plane of the support plate (1) is set in motion to sever the cup-shaped object supports by means of a saw blade (14). The object supports (2) fall into the respectively associated glass reagent vessels (20) by way of distributor passages (18) which lead downwardly in a truncated pyramid configuration, which reagent vessels can be pushed into position below the distributor block (17) in a container carrier (19). The method according to the invention replaces the conventional operations of severing and separating the object supports (2) by a shears.

摘要翻译： 为了切断和分离互连地布置在支撑板（1）上的多个塑料材料的杯形物体支撑件（2）的目的，使用其中首先放置支撑板（1）的方法 进入夹紧装置（4）并固定在其中。 随后，在支撑板（1）的平面中可移位的切断装置（5）被运动以通过锯片（14）切断杯形物体支撑件。 物体支撑件（2）通过分配器通道（18）落入分别关联的玻璃试剂容器（20）中，分配器通道（18）以截锥形结构向下引导，该试剂容器可以被推入分配器块（17）下方的位置 容器托架（19）。 根据本发明的方法取代了用剪切机切断和分离物体支撑件（2）的常规操作。

公开(公告)号：US08455246B2

公开(公告)日：2013-06-04

申请号：US12463351

申请日：2009-05-08

申请人： Stephen Gorfien ,  Richard Fike ,  Glenn Godwin ,  Joyce Dzimian ,  David A. Epstein ,  Dale Gruber ,  Paul Price

发明人： Stephen Gorfien ,  Richard Fike ,  Glenn Godwin ,  Joyce Dzimian ,  David A. Epstein ,  Dale Gruber ,  Paul Price

IPC分类号： A61K33/32 ,  A61K33/34 ,  A01N59/16 ,  C12N5/00 ,  C12N5/02 ,  C12N5/07 ,  C12N5/10 ,  C12N11/00 ,  C12N11/16

CPC分类号： C12N5/0682 ,  C07K14/61 ,  C12N5/0037 ,  C12N5/0043 ,  C12N5/005 ,  C12N5/0603 ,  C12N7/00 ,  C12N9/2402 ,  C12N9/2471 ,  C12N15/85 ,  C12N2500/14 ,  C12N2500/16 ,  C12N2500/22 ,  C12N2500/24 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/35 ,  C12N2500/38 ,  C12N2500/74 ,  C12N2500/76 ,  C12N2500/90 ,  C12N2500/95 ,  C12N2501/90 ,  C12N2501/91 ,  C12N2710/10051 ,  C12Y302/01023

摘要： The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.

摘要翻译： 本发明提供了支持哺乳动物细胞，特别是上皮细胞和成纤维细胞的体外培养，特别是悬浮液的细胞培养基制剂，以及使用这些培养基在体外悬浮培养哺乳动物细胞的方法。 培养基包含基础培养基和聚阴离子或聚阴离子化合物，优选多磺化或多硫酸化合物，更优选硫酸葡聚糖。 本发明还提供化学上定义的，无蛋白质的真核细胞培养基，其包含铁螯合物和锌，其能够支持悬浮培养物中的生长（特别是哺乳动物细胞的高密度生长），从而增加表达水平 的培养细胞中的重组蛋白，和/或增加培养细胞中的病毒产生。

公开(公告)号：US08048637B2

公开(公告)日：2011-11-01

申请号：US12666027

申请日：2007-06-29

申请人： Patrik Buholzer ,  Alex Raber ,  Paul Price ,  Daniel Zwald ,  Weldy Bonilla Pinschewer ,  Roger Marti ,  Jurg Weidmann ,  Christoph Stamm

发明人： Patrik Buholzer ,  Alex Raber ,  Paul Price ,  Daniel Zwald ,  Weldy Bonilla Pinschewer ,  Roger Marti ,  Jurg Weidmann ,  Christoph Stamm

IPC分类号： G01N33/53 ,  G01N33/532 ,  G01N33/531 ,  G01N33/533 ,  A61K38/00

CPC分类号： G01N33/5308 ,  C07K14/4354 ,  G01N33/569 ,  G01N33/6854 ,  G01N2333/4353

摘要： A diagnostic composition to detect antibodies in a sample obtained from an animal or human being infected by Trichinella, comprising at least one peptide containing a series of amino acids that form a continuous or discontinuous epitope recognized by sera from pigs infected with Trichinella.

摘要翻译： 一种用于检测从被旋毛虫感染的动物或人获得的样品中的抗体的诊断组合物，其包含至少一种含有一系列氨基酸的肽，所述氨基酸形成由感染旋毛虫的猪的血清识别的连续或不连续表位。

公开(公告)号：US20100190182A1

公开(公告)日：2010-07-29

申请号：US12666027

申请日：2007-06-29

申请人： Patrik Buholzer ,  Alex Raber ,  Paul Price ,  Daniel Zwald ,  Weldy Bonilla Pinschewer ,  Roger Marti ,  Jurg Weidmann ,  Christoph Stamm

发明人： Patrik Buholzer ,  Alex Raber ,  Paul Price ,  Daniel Zwald ,  Weldy Bonilla Pinschewer ,  Roger Marti ,  Jurg Weidmann ,  Christoph Stamm

IPC分类号： G01N33/53 ,  C07K2/00

CPC分类号： G01N33/5308 ,  C07K14/4354 ,  G01N33/569 ,  G01N33/6854 ,  G01N2333/4353

摘要： A diagnostic composition to detect antibodies in a sample obtained from an animal or human being infected by Trichinella, comprising at least one peptide containing a series of amino acids that form a continuous or discontinuous epitope recognized by sera from pigs infected with Trichinella.

摘要翻译： 一种用于检测从被旋毛虫感染的动物或人获得的样品中的抗体的诊断组合物，其包含至少一种含有一系列氨基酸的肽，所述氨基酸形成由感染旋毛虫的猪的血清识别的连续或不连续表位。

公开(公告)号：US07103860B2

公开(公告)日：2006-09-05

申请号：US10349452

申请日：2003-01-23

申请人： Paul Price ,  Jean-François Côté ,  Ajit Kumar Verma

发明人： Paul Price ,  Jean-François Côté ,  Ajit Kumar Verma

IPC分类号： G06F17/50

CPC分类号： G01R31/318314 ,  G01R31/318307 ,  G01R31/318357 ,  G06F17/5022

摘要： A program product for use in generating test benches for verifying test structures embedded in a circuit, comprises a verification specification processor for parsing a verification specification containing test specifications for selected test structures and a test bench generator for each of one or more types of embedded test structures, each test bench generator being operable to process a test structure specification of a test structure of a corresponding test structure type and generate a test bench using data contained in said test specifications of said verification specification, data contained in said test structure specification and data contained in a test connection specification.

公开(公告)号：US20060148074A1

公开(公告)日：2006-07-06

申请号：US11151647

申请日：2005-06-14

申请人： Stephen Gorfien ,  Richard Fike ,  Glenn Godwin ,  Joyce Dzimian ,  David Epstein ,  Dale Gruber ,  Don McClure ,  Paul Price

发明人： Stephen Gorfien ,  Richard Fike ,  Glenn Godwin ,  Joyce Dzimian ,  David Epstein ,  Dale Gruber ,  Don McClure ,  Paul Price

IPC分类号： C12N5/06

CPC分类号： C12N5/0682 ,  C07K14/61 ,  C12N5/0037 ,  C12N5/0043 ,  C12N5/005 ,  C12N5/0603 ,  C12N7/00 ,  C12N9/2402 ,  C12N9/2471 ,  C12N15/85 ,  C12N2500/14 ,  C12N2500/16 ,  C12N2500/22 ,  C12N2500/24 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/35 ,  C12N2500/38 ,  C12N2500/74 ,  C12N2500/76 ,  C12N2500/90 ,  C12N2500/95 ,  C12N2501/90 ,  C12N2501/91 ,  C12N2710/10051 ,  C12Y302/01023

摘要： The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.

公开(公告)号：US06725435B2

公开(公告)日：2004-04-20

申请号：US10323815

申请日：2002-12-20

申请人： Jean-François Côté ,  Paul Price

发明人： Jean-François Côté ,  Paul Price

IPC分类号： G06F1750

CPC分类号： G06F17/5022

摘要： A sign-off method for use in verifying of embedded test structures in a circuit design extracts a description of all embedded test structures from a circuit description to create a test connection map file, and verifies the connections of the test structures to circuit pins or nets, creates verification configuration files for use, in performing a sign-off verification of the circuit, for a circuit containing logic test structures, verifies that each logic test structure complies with logic test design rules and creates logic test vectors and a reference signature, performs a formal verification and a static timing analysis of the circuit, generates a sign-off simulation test bench for each test structure using the verification configuration files and the test connection map file, executes the test benches to simulate all test structures in the circuit; and creates manufacturing test patterns.

摘要翻译： 用于验证电路设计中嵌入式测试结构的签名方法从电路描述中提取所有嵌入式测试结构的描述，以创建测试连接映射文件，并验证测试结构与电路引脚或网络的连接 ，创建验证配置文件以供使用，在对包含逻辑测试结构的电路执行电路的签发验证时，验证每个逻辑测试结构符合逻辑测试设计规则并创建逻辑测试向量和参考签名，执行 电路的正式验证和静态时序分析，使用验证配置文件和测试连接图文件为每个测试结构生成一个注销仿真测试台，执行测试台以模拟电路中的所有测试结构; 并创建制造测试模式。

公开(公告)号：US08673301B2

公开(公告)日：2014-03-18

申请号：US13290803

申请日：2011-12-02

申请人： Richard Bonnichsen ,  Paul Price

发明人： Richard Bonnichsen ,  Paul Price

IPC分类号： A61K39/395

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/73

摘要： The present invention relates to monoclonal anti-human YKL-antibodies which are capable to modulate biological processes in which YKL-40 plays a prominent role, e.g. inhibit the growth and/or inducing apoptosis of cells, in particular cancer cells. The invention also relates to pharmaceutical compositions comprising said antibodies and uses said antibodies and/or pharmaceutical compositions for treatment of a disease wherein inhibition of cell growth, cell differentiation, remodelling of extracellular matrix, metastasis and/or induction of cell death due to apoptosis is a prerequisite for successful curing. An antibody of the invention is capable of inhibiting biological function of YKL-40 in the above mentioned processes by binding to a specific epitope on YKL-40.

摘要翻译： 本发明涉及能够调节其中YKL-40起突出作用的生物学过程的单克隆抗人YKL-抗体。 抑制细胞，特别是癌细胞的生长和/或诱导细胞凋亡。 本发明还涉及包含所述抗体的药物组合物，并且使用所述抗体和/或药物组合物来治疗疾病，其中抑制细胞生长，细胞分裂，细胞外基质的重塑，转移和/或由细胞凋亡引起的细胞死亡的诱导是 成功治愈的先决条件。 本发明的抗体能够通过与YKL-40上的特异性表位结合而在上述方法中抑制YKL-40的生物学功能。

公开(公告)号：US20120149882A1

公开(公告)日：2012-06-14

申请号：US13290803

申请日：2011-12-02

申请人： Richard Bonnichsen ,  Paul Price

发明人： Richard Bonnichsen ,  Paul Price

IPC分类号： C07K16/40

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/73

摘要： The present invention relates to monoclonal anti-human YKL-antibodies which are capable to modulate biological processes in which YKL-40 plays a prominent role, e.g. inhibit the growth and/or inducing apoptosis of cells, in particular cancer cells. The invention also relates to pharmaceutical compositions comprising said antibodies and uses said antibodies and/or pharmaceutical compositions for treatment of a disease wherein inhibition of cell growth, cell differentiation, remodelling of extracellular matrix, metastasis and/or induction of cell death due to apoptosis is a prerequisite for successful curing. An antibody of the invention is capable of inhibiting biological function of YKL-40 in the above mentioned processes by binding to a specific epitope on YKL-40.

摘要翻译： 本发明涉及能够调节其中YKL-40起突出作用的生物学过程的单克隆抗人YKL-抗体。 抑制细胞，特别是癌细胞的生长和/或诱导细胞凋亡。 本发明还涉及包含所述抗体的药物组合物，并且使用所述抗体和/或药物组合物来治疗疾病，其中抑制细胞生长，细胞分裂，细胞外基质的重塑，转移和/或由细胞凋亡引起的细胞死亡的诱导是 成功治愈的先决条件。 本发明的抗体能够通过与YKL-40上的特异性表位结合而在上述方法中抑制YKL-40的生物学功能。