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    Vascular Occlusion Devices
    3.
    发明申请
    Vascular Occlusion Devices 有权
    血管闭塞装置

    公开(公告)号：US20120046687A1

    公开(公告)日：2012-02-23

    申请号：US13262546

    申请日：2010-04-02

    申请人： Julie Marie Trommeter ,  Michael B. Lyons ,  Jeffrey Paul Castleberry ,  Robin Shandas ,  James Fogelberg ,  Stephen Johnson

    发明人： Julie Marie Trommeter ,  Michael B. Lyons ,  Jeffrey Paul Castleberry ,  Robin Shandas ,  James Fogelberg ,  Stephen Johnson

    IPC分类号： A61F2/01

    CPC分类号： A61B17/12022 ,  A61B17/12109 ,  A61B17/12113 ,  A61B17/12145 ,  A61B17/1215 ,  A61B2017/00477 ,  A61B2017/00778 ,  A61B2017/00871 ,  A61B2017/00898 ,  A61B2017/12054 ,  A61L31/04 ,  A61L31/14 ,  A61L2400/16 ,  A61L2430/36

    摘要： Shape memory materials (SMM) are formed as coil-shaped vascular occlusion devices upon deployment. Shape memory polymer (SMP) materials are tailored through formulation for specific mechanical behavior of the coils. Concurrent coil diameter changes enhance the relative change in stiffness along the length of the coil. Interconnecting structures (104a/b) are formed on ends of elongated members (102a) in the pre-deployment shape for multiple coil insertion capability within an introducer. Channels (206) are formed in pre-deployment shape, elongate members (202) that allow access for injection of imaging contrast agent or concurrent placement of instruments. A single SMM occlusive device (300) transforms into multiple, smaller diameter coils (302b) in the deployed state to generate a complex occlusive structure. A SMM occlusive device (400) has a collapsed fabric (404) component attached to and extending along a sidewall during storage and insertion, and then deploys as a coil (402b) to form a single- or multiple-layer occlusive fabric surface within a center of the coil (402b).

    摘要翻译： 形状记忆材料（SMM）在部署时形成为线圈状血管闭塞装置。 形状记忆聚合物（SMP）材料通过配方为线圈的特定机械性能而定制。 并联线圈直径变化增强沿着线圈长度的刚度的相对变化。 互连结构（104a / b）形成在细长构件（102a）的端部中，用于在引导器内用于多个线圈插入能力的预展开形状。 通道（206）以预先展开形状形成，细长构件（202）允许进入成像造影剂的注入或仪器的同时放置。 单个SMM闭塞装置（300）在展开状态下变换成多个较小直径的线圈（302b），以产生复杂的闭塞结构。 SMM闭塞装置（400）具有在储存和插入期间附着并沿侧壁延伸的塌陷织物（404）部件，然后作为线圈（402b）展开以形成单层或多层闭塞织物表面 线圈（402b）的中心。

    Shape Memory Polymer Medical Devices
    10.
    发明申请
    Shape Memory Polymer Medical Devices 审中-公开
    形状记忆聚合物医疗器械

    公开(公告)号：US20090248141A1

    公开(公告)日：2009-10-01

    申请号：US12295594

    申请日：2007-03-30

    申请人： Robin Shandas ,  Christopher M. Yakacki ,  Kenneth Gall ,  Alex E. Eckstein ,  Michael Lyons ,  Devatha P. Nair

    发明人： Robin Shandas ,  Christopher M. Yakacki ,  Kenneth Gall ,  Alex E. Eckstein ,  Michael Lyons ,  Devatha P. Nair

    IPC分类号： A61F2/92 ,  A61M29/00 ,  A61M29/04 ,  B29C35/02

    CPC分类号： A61B17/12022 ,  A61B17/12099 ,  A61B17/12159 ,  A61B17/12163 ,  A61B17/1219 ,  A61B2017/00526 ,  A61B2017/00867 ,  A61F2/844 ,  A61F2/88 ,  A61F2/91 ,  A61F2/92 ,  A61F2220/0016 ,  A61L31/048 ,  A61L31/14 ,  A61L2400/16 ,  C08L33/04

    摘要： Medical devices for in vivo medical applications are disclosed. The medical devices are constructed of shape memory polymer (SMP) materials capable of assuming a memory shape at physiological temperatures. These medical devices may be used in surgical procedures and in both vascular and non-vascular applications. These SMP medical devices have a post-implantation memory shape that is substantially identical to or slightly larger than the insertion site to adapt to vessel growth or size changes. SMP medical devices may be formed as stents or occlusion devices (i.e., plugs) having a number of different structural features. The SMP medical devices may be formed from a first monomer and a second cross-linking monomer, wherein the weight percentages of the first and second monomers are selected by performing an iterative function to reach a predetermined glass transition temperature (Tg) and a predetermined rubbery modulus to optimize post-implantation memory shape properties of the devices.

    摘要翻译： 公开了用于体内医疗应用的医疗装置。 医疗器械由能够在生理温度下呈现记忆形状的形状记忆聚合物（SMP）材料构成。 这些医疗装置可用于外科手术和血管和非血管应用。 这些SMP医疗装置具有植入后记忆形状，其基本上与插入位点相同或略大，以适应血管生长或尺寸变化。 SMP医疗装置可以形成为具有多个不同结构特征的支架或闭塞装置（即插头）。 SMP医疗装置可以由第一单体和第二交联单体形成，其中第一和第二单体的重量百分比通过执行迭代函数来选择以达到预定的玻璃化转变温度（Tg）和预定的橡胶状 模数以优化植入后记忆形状特性的器件。