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    Nanoparticles of cerium oxide having superoxide dismutase activity
    2.
    发明授权
    Nanoparticles of cerium oxide having superoxide dismutase activity 有权
    具有超氧化物歧化酶活性的氧化铈纳米颗粒

    公开(公告)号：US07504356B1

    公开(公告)日：2009-03-17

    申请号：US11676579

    申请日：2007-02-20

    申请人： William T. Self ,  Sudipta Seal

    发明人： William T. Self ,  Sudipta Seal

    IPC分类号： B01J23/10 ,  B01J37/00 ,  C01B15/01 ,  C01F17/00

    CPC分类号： C01F17/0043 ,  B01J23/10 ,  B01J35/0013 ,  B82Y30/00 ,  C01B15/01 ,  C01P2002/60 ,  C01P2002/72 ,  C01P2004/04 ,  C01P2004/61 ,  C01P2004/64

    摘要： A synthetic catalyst providing superoxide dismutase activity consists essentially of monodispersed nanoparticles of cerium oxide having a crystal lattice containing cerium in mixed valence states of Ce3+ and Ce4+ wherein the Ce4+ valence state predominates and containing an enhanced Ce3+/Ce4+ ratio and an effective number of oxygen vacancies in the crystal lattice so as to increase catalytic efficiency. A method of making the synthetic catalyst includes dissolving hydrous Ce(NO3)3 in water so as to form a solution, stirring the solution, adding hydrogen peroxide, heating and stopping when the solution develops a light yellow color.

    摘要翻译： 提供超氧化物歧化酶活性的合成催化剂基本上由具有Ce 3+和Ce 4+的混合价态的具有铈的晶格的氧化铈的单分散纳米颗粒组成，其中Ce 4+价态占优势并且含有增强的Ce 3+ / Ce 4+比例和有效数量的氧空位 在晶格中提高催化效率。 制造合成催化剂的方法包括将水中的Ce（NO 3）3溶解在水中以形成溶液，搅拌溶液，加入过氧化氢，当溶液呈淡黄色时加热和停止。

    Functionalized nanoceria composition for ophthalmic treatment
    4.
    发明授权
    Functionalized nanoceria composition for ophthalmic treatment 有权
    用于眼科治疗的功能性纳米组合物

    公开(公告)号：US08795737B2

    公开(公告)日：2014-08-05

    申请号：US13724750

    申请日：2012-12-21

    申请人： Sudipta Seal ,  Swanand D. Patil ,  Manas K. Haldar ,  Sanku Malik

    发明人： Sudipta Seal ,  Swanand D. Patil ,  Manas K. Haldar ,  Sanku Malik

    IPC分类号： A61K33/34

    CPC分类号： C07F5/003 ,  A61K31/18 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

    摘要： The invention provides a composition comprising a plurality of nanoceria particles, a sufficient amount of at least one inhibitor of human carbonic anhydrase II associated with said plurality of nanoceria particles, and a pharmaceutically acceptable carrier containing said plurality of nanoceria particles with associated inhibitor. One preferred inhibitor of human carbonic anhydrase II comprises 4-carboxybenzene sulfonamide. The disclosed composition is useful in treatment of glaucoma.

    摘要翻译： 本发明提供一种组合物，其包含多个纳米颗粒，足量的至少一种与所述多个纳米颗粒相关联的人碳酸酐酶II抑制剂，以及含有所述多个具有相关抑制剂的纳米颗粒的药学上可接受的载体。 人碳酸酐酶II的一种优选抑制剂包括4-羧基苯磺酰胺。 所公开的组合物可用于治疗青光眼。

    Inhibition of neovascularization by cerium oxide nanoparticles
    5.
    发明授权
    Inhibition of neovascularization by cerium oxide nanoparticles 有权
    通过氧化铈纳米颗粒抑制新生血管形成

    公开(公告)号：US08703200B2

    公开(公告)日：2014-04-22

    申请号：US12429650

    申请日：2009-04-24

    申请人： James F. McGinnis ,  Xiaohong Zhou ,  Lily L. Wong ,  Sudipta Seal

    发明人： James F. McGinnis ,  Xiaohong Zhou ,  Lily L. Wong ,  Sudipta Seal

    IPC分类号： A61K9/14 ,  A01N59/16 ,  A61K33/24

    CPC分类号： A61K9/14 ,  A61K33/24

    摘要： The present invention provides methods for reducing, reversing or inhibiting neovascularization in a tissue of a mammalian subject having a pathological condition involving neovascularization by administration in vivo of nanoceria particles (cerium oxide nanoparticles) to the subject. The method of the invention is useful, for example, for reducing, treating, reversing or inhibiting neovascularization in ocular tissue such as the retina, macula or cornea; in skin; in synovial tissue; in intestinal tissue; or in bone. In addition, the method of the invention is useful for reducing or inhibiting neovascularization in a neoplasm (tumors), which can be benign or malignant and, where malignant, can be a metastatic neoplasm. As such, the invention provides compositions, which contain nanoceria particles and are useful for reducing, treating, reversing or inhibiting angiogenesis in a mammalian subject.

    摘要翻译： 本发明提供了通过在受试者体内施用纳米颗粒（氧化铈纳米颗粒）的体内，减少，逆转或抑制具有涉及新血管形成的病理状况的哺乳动物受试者的组织中的新生血管形成的方法。 本发明的方法例如用于减少，治疗，逆转或抑制眼组织如视网膜，黄斑或角膜中的新生血管形成; 在皮肤上 在滑膜组织中 在肠组织中 或在骨头。 此外，本发明的方法可用于减少或抑制肿瘤（肿瘤）中的新生血管形成，其可以是良性或恶性的，并且恶性肿瘤可以是转移性肿瘤。 因此，本发明提供了含有纳米颗粒并且可用于在哺乳动物受试者中减少，治疗，逆转或抑制血管生成的组合物。

    Functionalized nanoceria composition for ophthalmic treatment
    6.
    发明授权
    Functionalized nanoceria composition for ophthalmic treatment 有权
    用于眼科治疗的功能性纳米组合物

    公开(公告)号：US08337898B2

    公开(公告)日：2012-12-25

    申请号：US13154849

    申请日：2011-06-07

    申请人： Sudipta Seal ,  Swanand D. Patil ,  Manas K. Haldar ,  Sanku Malik

    发明人： Sudipta Seal ,  Swanand D. Patil ,  Manas K. Haldar ,  Sanku Malik

    IPC分类号： A61K9/14 ,  A01N59/16

    CPC分类号： C07F5/003 ,  A61K31/18 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

    摘要： The invention provides a composition comprising a plurality of nanoceria particles, a sufficient amount of at least one inhibitor of human carbonic anhydrase II associated with said plurality of nanoceria particles, and a pharmaceutically acceptable carrier containing said plurality of nanoceria particles with associated inhibitor. One preferred inhibitor of human carbonic anhydrase II comprises 4-carboxybenzene sulfonamide. The disclosed composition is useful in treatment of glaucoma.

    摘要翻译： 本发明提供一种组合物，其包含多个纳米颗粒，足量的至少一种与所述多个纳米颗粒相关联的人碳酸酐酶II抑制剂，以及含有所述多个具有相关抑制剂的纳米颗粒的药学上可接受的载体。 人碳酸酐酶II的一种优选抑制剂包括4-羧基苯磺酰胺。 所公开的组合物可用于治疗青光眼。

    Sol-gel coating methods and thin film coated substrates therefrom
    7.
    发明授权
    Sol-gel coating methods and thin film coated substrates therefrom 有权
    溶胶 - 凝胶涂布方法和薄膜涂布的基材

    公开(公告)号：US08329299B2

    公开(公告)日：2012-12-11

    申请号：US12059948

    申请日：2008-03-31

    申请人： Sudipta Seal ,  Erik R. Brinley ,  Suresh Babu Krishna Moorthy ,  Abhilash Vincent ,  David Reid ,  Clara Rivero

    发明人： Sudipta Seal ,  Erik R. Brinley ,  Suresh Babu Krishna Moorthy ,  Abhilash Vincent ,  David Reid ,  Clara Rivero

    IPC分类号： B32B27/32 ,  B32B17/10 ,  B32B17/06 ,  B05D3/00 ,  B29C71/02

    CPC分类号： C03C17/02 ,  C03C1/008 ,  C03C2203/26 ,  C03C2218/113 ,  G02B2207/109 ,  Y10T428/26 ,  Y10T428/265 ,  Y10T428/269 ,  Y10T428/31504

    摘要： A method for depositing sol-gel derived coatings on substrates to form coated substrates includes the steps of providing a first solution including at least one sol precursor and at least one solvent. A water comprising solution is added to the first solution to form a sol-gel. The sol-gel is deposited on a substrate. The sol-gel layer on the substrate is dried/cured at a temperature ≦100° C. for at least 10 minutes to form a solid layer, wherein the solid layer has a thickness from 50 nm to 110 nm. The depositing and curing steps are repeated at least once until combined thickness of the solid layers forms a coating of a predetermined thickness. The resulting solid layers are low water content layers that can be evidenced by transmission measurements. The coated substrate can be an IR transmissive substrate having a recrystallization temperature

    摘要翻译： 用于在基底上沉积溶胶凝胶衍生的涂层以形成涂覆的基底的方法包括提供包括至少一种溶胶前体和至少一种溶剂的第一溶液的步骤。 向第一溶液中加入包含水的溶液以形成溶胶 - 凝胶。 溶胶 - 凝胶沉积在基底上。 将衬底上的溶胶 - 凝胶层在温度为100℃，100℃下干燥/固化至少10分钟以形成固体层，其中固体层具有50nm至110nm的厚度。 沉积和固化步骤重复至少一次，直到固体层的组合厚度形成预定厚度的涂层。 所得固体层是低含水层，可以通过透射测量来证明。 涂覆的基板可以是具有重结晶温度<130℃的IR透射基板，并且每个固体层在λ= 2950nm处提供透射，如果放置在≥99％的IR透射基底上则为法向入射和1mW功率， 的传输直接通过IR透射基板。

    Surfactant incorporated nanostructure for pressure drop reduction in oil and gas lines
    8.
    发明授权
    Surfactant incorporated nanostructure for pressure drop reduction in oil and gas lines 失效
    表面活性剂纳入了油气管线压降降低的纳米结构

    公开(公告)号：US08252259B2

    公开(公告)日：2012-08-28

    申请号：US12290501

    申请日：2008-10-31

    申请人： Sudipta Seal ,  William P. Jepson ,  Sameer Deshpande ,  Suresh C. Kuiry ,  Swanand D. Patil

    发明人： Sudipta Seal ,  William P. Jepson ,  Sameer Deshpande ,  Suresh C. Kuiry ,  Swanand D. Patil

    IPC分类号： C01F17/00

    CPC分类号： F17D1/16 ,  Y10T137/0391

    摘要： Nano-sized rare earth metal oxide particles are prepared from aqueous reverse micelles. The engineered nanoparticles have large surface area to volume ratios, and uniformly incorporate a surfactant in each particle, so that when applied to the inner surface of a pipeline or sprayed onto a fluid stream in a pipeline, the particles reduce the roughness of the inside surface of pipe being used to transport fluid. The application of a nanolayer of this novel nanoceria mixture causes a significant reduction in pressure drops, friction, and better recovery and yield of fluid flowing through a pipeline.

    摘要翻译： 由水性反胶束制备纳米级稀土金属氧化物颗粒。 工程纳米颗粒具有大的表面积与体积比，并且在每个颗粒中均匀地加入表面活性剂，使得当施用到管道的内表面或喷射到管道中的流体流时，颗粒减小了内表面的粗糙度 的管道用于运输流体。 这种新型纳米碳混合物的纳米层的应用导致压降，摩擦力以及流过管道的流体的更好的回收率和产量的显着降低。

    Advanced catalyst system prepared from a whiskered aluminum-containing metallic alloy substrate
    9.
    发明授权
    Advanced catalyst system prepared from a whiskered aluminum-containing metallic alloy substrate 失效
    先进的催化剂体系由含铝的金属合金基材制成

    公开(公告)号：US08247034B2

    公开(公告)日：2012-08-21

    申请号：US13224848

    申请日：2011-09-02

    申请人： Weifeng Fei ,  Suresh C. Kuiry ,  Sudipta Seal

    发明人： Weifeng Fei ,  Suresh C. Kuiry ,  Sudipta Seal

    IPC分类号： B05D3/02

    CPC分类号： C30B29/62 ,  B22F2998/00 ,  C30B1/02 ,  B22F1/004 ,  B22F1/02

    摘要： A method for whisker formation on the surface of aluminum-containing metallic alloy fibers and substrates provides a support structure for many technical, medical and pharmaceutical applications. The novel surface modification of metallic alloy fibers and other metallic substrates involves heating the fiber or substrate in air at temperatures ranging from approximately 800° C. to approximately 1000° C. for a period of time ranging from approximately 10 hours to approximately 100 hours to form whiskers. The use of a metal oxide coating with large ions, such as zirconium oxide, allows the formation of alumina whiskers while preserving the structural integrity of the metallic alloy substrate. Uses of the present invention include, but are not limited to an advanced catalyst support, a highly efficient filter medium, a support for implants and the like.

    摘要翻译： 在含铝金属合金纤维和基材的表面上形成晶须的方法为许多技术，医疗和制药应用提供了支撑结构。 金属合金纤维和其它金属基底的新型表面改性涉及将空气中的纤维或基底在约800℃至约1000℃的温度范围内加热约10小时至约100小时的时间， 形成晶须 使用具有大离子的金属氧化物涂层，例如氧化锆，允许形成氧化铝晶须，同时保持金属合金基底的结构完整性。 本发明的用途包括但不限于高级催化剂载体，高效过滤介质，用于植入物的载体等。

    FUNCTIONALIZED FLY ASH AND OIL SCAVENGING USING THE SAME
    10.
    发明申请
    FUNCTIONALIZED FLY ASH AND OIL SCAVENGING USING THE SAME 有权
    功能化飞行和使用相同的油

    公开(公告)号：US20120006753A1

    公开(公告)日：2012-01-12

    申请号：US13180161

    申请日：2011-07-11

    申请人： Sudipta Seal ,  David L. Reid ,  Larry L. Hench

    发明人： Sudipta Seal ,  David L. Reid ,  Larry L. Hench

    IPC分类号： C02F1/28 ,  C02F1/40 ,  B01J20/22 ,  B01J20/30 ,  B01J20/16 ,  B01J20/18

    CPC分类号： C02F1/283 ,  B01J20/3204 ,  B01J20/3217 ,  B01J20/3238 ,  B01J20/3244 ,  B01J20/3248 ,  B01J20/3289 ,  B01J2220/4887 ,  C02F1/288 ,  C02F1/681 ,  C02F2101/32

    摘要： A method of scavenging oil from an oil-water mixture includes providing a plurality of functionalized fly ash particles having functionalized surfaces including reactive groups or reactive materials having hydrophobic groups covalently bound to the reactive groups or reactive materials. The oil-water mixture is contacted with the plurality of functionalized fly ash particles. The plurality of functionalized fly ash particles absorb oil from the oil-water mixture to form oil-laden fly ash particles. The oil-laden fly ash particles can be fed into a combustion process to generate heat from oil absorbed thereon, or absorbed oil from the oil-laden fly ash particles can be separated using a desorption process, and the oil recovered after separating.

    摘要翻译： 从油 - 水混合物中清除油的方法包括提供多个具有功能化表面的官能化飞灰颗粒，其包括反应性基团或具有与反应性基团共价结合的疏水基团的反应性物质或反应性物质。 油水混合物与多个功能化的飞灰颗粒接触。 多个功能化飞灰颗粒从油 - 水混合物中吸收油以形成含油飞灰颗粒。 可以将含油粉煤灰颗粒进料到燃烧过程中以从其上吸收的油产生热量，或者可以使用解吸过程从含油载粉煤灰颗粒中吸收的油分离，并在分离后回收油。