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    Graft materials containing bioactive substances, and methods for their manufacture
    1.
    发明授权
    Graft materials containing bioactive substances, and methods for their manufacture 有权
    含有生物活性物质的接枝材料及其制造方法

    公开(公告)号：US08021692B2

    公开(公告)日：2011-09-20

    申请号：US10569218

    申请日：2004-08-25

    申请人： Michael C. Hiles ,  Jason P. Hodde ,  David M. J. Ernst ,  Lal Ninan

    发明人： Michael C. Hiles ,  Jason P. Hodde ,  David M. J. Ernst ,  Lal Ninan

    IPC分类号： A61K38/18 ,  A61K35/37

    CPC分类号： A61L27/54 ,  A61K35/38 ,  A61K38/1825 ,  A61L27/227 ,  A61L27/24 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/3687 ,  A61L27/50 ,  A61L2300/414 ,  A61L2400/06

    摘要： Described are packaged, sterile medical graft products containing controlled levels of a growth factor such as Fibrob-last Growth Factor-2 (FGF-2). Also described are methods of manufacturing medical graft products wherein processing, including sterilization, is controlled and monitored to provide medical graft products having modulated, known levels of a extracellular matrix factor, such as a growth factor, e.g. FGF-2. Preferred graft materials are extracellular matrix materials isolated from human or animal donors, particularly submucosa containing extracellular matrix materials. Further described are ECM compositions that are or are useful for preparing gels, and related methods for preparation and use.

    摘要翻译： 描述了含有受控水平的生长因子如Fibrob-last Growth Factor-2（FGF-2）的包装的无菌医用移植物产品。 还描述了制造医疗移植产品的方法，其中控制和监测包括灭菌在内的处理以提供具有调节的已知水平的细胞外基质因子例如生长因子的医疗移植物产品，例如生长因子。 FGF-2。 优选的移植材料是从人或动物供体分离的细胞外基质材料，特别是含有细胞外基质材料的粘膜下层。 进一步描述的是用于制备凝胶或可用于制备凝胶的ECM组合物，以及相关的制备和使用方法。

    GRAFT MATERIALS CONTAINING BIOACTIVE EXTRACELLULAR MATRICES AND CELLS
    2.
    发明申请
    GRAFT MATERIALS CONTAINING BIOACTIVE EXTRACELLULAR MATRICES AND CELLS 审中-公开
    含有生物活性细胞基质和细胞的GRAFT材料

    公开(公告)号：US20100196480A1

    公开(公告)日：2010-08-05

    申请号：US12762058

    申请日：2010-04-16

    申请人： Michael C. Hiles ,  Jason P. Hodde ,  David M. J. Ernst ,  Lal Ninan

    发明人： Michael C. Hiles ,  Jason P. Hodde ,  David M. J. Ernst ,  Lal Ninan

    IPC分类号： A61K9/00 ,  A61K35/12 ,  C12N5/02

    CPC分类号： A61L27/54 ,  A61K35/38 ,  A61K38/1825 ,  A61L27/227 ,  A61L27/24 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/3687 ,  A61L27/50 ,  A61L2300/414 ,  A61L2400/06

    摘要： Described are packaged, sterile medical graft products containing controlled levels of a growth factor such as Fibroblast Growth Factor-2 (FGF-2). Also described are methods of manufacturing medical graft products wherein processing, including sterilization, is controlled and monitored to provide medical graft products having modulated, known levels of a extracellular matrix factor, such as a growth factor, e.g. FGF-2. Preferred graft materials are extracellular matrix materials isolated from human or animal donors, particularly submucosa-containing extracellular matrix materials. Further described are ECM compositions that are or are useful for preparing gels, and related methods for preparation and use.

    摘要翻译： 描述了含有受控水平的生长因子如成纤维细胞生长因子-2（FGF-2）的包装的无菌医用移植物产品。 还描述了制造医疗移植产品的方法，其中控制和监测包括灭菌在内的处理以提供具有调节的已知水平的细胞外基质因子例如生长因子的医疗移植物产品，例如生长因子。 FGF-2。 优选的移植材料是从人或动物供体分离的细胞外基质材料，特别是含粘膜下层的细胞外基质材料。 进一步描述的是用于制备凝胶或可用于制备凝胶的ECM组合物，以及相关的制备和使用方法。

    Graft materials containing bioactive substances, and methods for their manufacture
    3.
    发明授权
    Graft materials containing bioactive substances, and methods for their manufacture 有权
    含有生物活性物质的接枝材料及其制造方法

    公开(公告)号：US09504769B2

    公开(公告)日：2016-11-29

    申请号：US13225585

    申请日：2011-09-06

    申请人： Michael C. Hiles ,  Jason P. Hodde ,  David M. J. Ernst ,  Lal Ninan

    发明人： Michael C. Hiles ,  Jason P. Hodde ,  David M. J. Ernst ,  Lal Ninan

    IPC分类号： A61K9/14 ,  A61L27/36 ,  A61K35/38 ,  A61K38/18 ,  A61L27/22

    CPC分类号： A61L27/54 ,  A61K35/38 ,  A61K38/1825 ,  A61L27/227 ,  A61L27/24 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/3687 ,  A61L27/50 ,  A61L2300/414 ,  A61L2400/06

    摘要： Described are packaged, sterile medical graft products containing controlled levels of a growth factor such as Fibroblast Growth Factor-2 (FGF-2). Also described are methods of manufacturing medical graft products wherein processing, including sterilization, is controlled and monitored to provide medical graft products having modulated, known levels of a extracellular matrix factor, such as a growth factor, e.g. FGF-2. Preferred graft materials are extracellular matrix materials isolated from human or animal donors, particularly submucosa-containing extracellular matrix materials. Further described are ECM compositions that are or are useful for preparing gels, and related methods for preparation and use.

    摘要翻译： 描述了含有受控水平的生长因子如成纤维细胞生长因子-2（FGF-2）的包装的无菌医用移植物产品。 还描述了制造医疗移植产品的方法，其中控制和监测包括灭菌在内的处理以提供具有调节的已知水平的细胞外基质因子例如生长因子的医疗移植物产品，例如生长因子。 FGF-2。 优选的移植材料是从人或动物供体分离的细胞外基质材料，特别是含粘膜下层的细胞外基质材料。 进一步描述的是用于制备凝胶或可用于制备凝胶的ECM组合物，以及相关的制备和使用方法。

    GRAFT MATERIALS CONTAINING BIOACTIVE SUBSTANCES, AND METHODS FOR THEIR MANUFACTURE
    4.
    发明申请
    GRAFT MATERIALS CONTAINING BIOACTIVE SUBSTANCES, AND METHODS FOR THEIR MANUFACTURE 有权
    含有生物活性物质的材料及其制造方法

    公开(公告)号：US20110318419A1

    公开(公告)日：2011-12-29

    申请号：US13225585

    申请日：2011-09-06

    申请人： Michael C. Hiles ,  Jason P. Hodde ,  David M.J. Ernst ,  Lal Ninan

    发明人： Michael C. Hiles ,  Jason P. Hodde ,  David M.J. Ernst ,  Lal Ninan

    IPC分类号： A61K9/14 ,  A61K38/02 ,  A61P43/00 ,  A61K38/18

    CPC分类号： A61L27/54 ,  A61K35/38 ,  A61K38/1825 ,  A61L27/227 ,  A61L27/24 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/3687 ,  A61L27/50 ,  A61L2300/414 ,  A61L2400/06

    摘要： Described are packaged, sterile medical graft products containing controlled levels of a growth factor such as Fibroblast Growth Factor-2 (FGF-2). Also described are methods of manufacturing medical graft products wherein processing, including sterilization, is controlled and monitored to provide medical graft products having modulated, known levels of a extracellular matrix factor, such as a growth factor, e.g. FGF-2. Preferred graft materials are extracellular matrix materials isolated from human or animal donors, particularly submucosa-containing extracellular matrix materials. Further described are ECM compositions that are or are useful for preparing gels, and related methods for preparation and use.

    摘要翻译： 描述了含有受控水平的生长因子如成纤维细胞生长因子-2（FGF-2）的包装的无菌医用移植物产品。 还描述了制造医疗移植产品的方法，其中控制和监测包括灭菌在内的处理以提供具有调节的已知水平的细胞外基质因子例如生长因子的医疗移植物产品，例如生长因子。 FGF-2。 优选的移植材料是从人或动物供体分离的细胞外基质材料，特别是含粘膜下层的细胞外基质材料。 进一步描述的是用于制备凝胶或可用于制备凝胶的ECM组合物，以及相关的制备和使用方法。

    Graft materials containing ECM components, and methods for their manufacture
    5.
    发明授权
    Graft materials containing ECM components, and methods for their manufacture 有权
    包含ECM组分的接枝材料及其制造方法

    公开(公告)号：US08741352B2

    公开(公告)日：2014-06-03

    申请号：US11851923

    申请日：2007-09-07

    申请人： Jason P. Hodde ,  David M. J. Ernst ,  Lal Ninan ,  Sherry Voytik-Harbin ,  Nathan Hammond

    发明人： Jason P. Hodde ,  David M. J. Ernst ,  Lal Ninan ,  Sherry Voytik-Harbin ,  Nathan Hammond

    IPC分类号： A61K35/12 ,  A61L27/36 ,  A61L27/22 ,  A61K35/38 ,  A61K38/18 ,  A61K35/37

    CPC分类号： A61K35/37 ,  A61K35/38 ,  A61K38/1825 ,  A61L27/227 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/3687 ,  A61K2300/00

    摘要： Described are packaged, sterile medical graft products containing controlled levels of a growth factor such as Fibroblast Growth Factor-2 (FGF-2). Also described are methods of manufacturing medical graft products wherein processing, including sterilization, is controlled and monitored to provide medical graft products having modulated, known levels of a extracellular matrix factor, such as a growth factor, e.g. FGF-2. Preferred graft materials are extracellular matrix materials isolated from human or animal donors, particularly submucosa-containing extracellular matrix materials. Further described are ECM compositions that are or are useful for preparing gels, and related methods for preparation and use.

    摘要翻译： 描述了含有受控水平的生长因子如成纤维细胞生长因子-2（FGF-2）的包装的无菌医用移植物产品。 还描述了制造医疗移植产品的方法，其中控制和监测包括灭菌在内的处理以提供具有调节的已知水平的细胞外基质因子例如生长因子的医疗移植物产品，例如生长因子。 FGF-2。 优选的移植材料是从人或动物供体分离的细胞外基质材料，特别是含粘膜下层的细胞外基质材料。 进一步描述的是用于制备凝胶或可用于制备凝胶的ECM组合物，以及相关的制备和使用方法。

    GRAFT MATERIALS CONTAINING ECM COMPONENTS, AND METHODS FOR THEIR MANUFACTURE
    7.
    发明申请
    GRAFT MATERIALS CONTAINING ECM COMPONENTS, AND METHODS FOR THEIR MANUFACTURE 有权
    包含ECM组件的GRAFT材料及其制造方法

    公开(公告)号：US20080107750A1

    公开(公告)日：2008-05-08

    申请号：US11851923

    申请日：2007-09-07

    申请人： Jason Hodde ,  David Ernst ,  Lal Ninan ,  Sherry Voytik-Harbin ,  Nathan Hammond

    发明人： Jason Hodde ,  David Ernst ,  Lal Ninan ,  Sherry Voytik-Harbin ,  Nathan Hammond

    IPC分类号： A61K35/12 ,  A61P43/00 ,  A61L2/00 ,  A61L2/16

    CPC分类号： A61K35/37 ,  A61K35/38 ,  A61K38/1825 ,  A61L27/227 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/3687 ,  A61K2300/00

    摘要： Described are packaged, sterile medical graft products containing controlled levels of a growth factor such as Fibroblast Growth Factor-2 (FGF-2). Also described are methods of manufacturing medical graft products wherein processing, including sterilization, is controlled and monitored to provide medical graft products having modulated, known levels of a extracellular matrix factor, such as a growth factor, e.g. FGF-2. Preferred graft materials are extracellular matrix materials isolated from human or animal donors, particularly submucosa-containing extracellular matrix materials. Further described are ECM compositions that are or are useful for preparing gels, and related methods for preparation and use.

    摘要翻译： 描述了含有受控水平的生长因子如成纤维细胞生长因子-2（FGF-2）的包装的无菌医用移植物产品。 还描述了制造医疗移植产品的方法，其中控制和监测包括灭菌在内的处理以提供具有调节的已知水平的细胞外基质因子例如生长因子的医疗移植物产品，例如生长因子。 FGF-2。 优选的移植材料是从人或动物供体分离的细胞外基质材料，特别是含粘膜下层的细胞外基质材料。 进一步描述的是用于制备凝胶或可用于制备凝胶的ECM组合物，以及相关的制备和使用方法。

    Coated embolization device
    9.
    发明授权
    Coated embolization device 有权
    涂层栓塞装置

    公开(公告)号：US08956378B2

    公开(公告)日：2015-02-17

    申请号：US12394823

    申请日：2009-02-27

    申请人： Joel A. Virkler ,  Lal Ninan

    发明人： Joel A. Virkler ,  Lal Ninan

    IPC分类号： A61M29/00 ,  A61L31/16 ,  A61L31/10

    CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/45 ,  A61L2430/36 ,  C08L89/06

    摘要： Described are embolization devices having unique bioactive coatings, as well as methods for their manufacture and use. An illustrative embolization device of the invention comprises an embolic body and a coating material comprising biotropic extracellular matrix material immobilized on a surface of the embolic body. The biotropic extracellular matrix material comprises a network of self-assembled collagen fibrils, and comprises at least one bioactive agent retained in the extracellular matrix material, wherein the bioactive agent is selected from the group consisting of a proteoglycan, a growth factor, a glycoprotein, and a glycosaminoglycan. In certain forms, such an extracellular matrix material comprises a remodelable, angiogenic extracellular matrix material, for example, a submucosa material such as but not limited to porcine small intestinal submucosa.

    摘要翻译： 描述了具有独特生物活性涂层的栓塞装置，以及其制造和使用的方法。 本发明的说明性栓塞装置包括栓塞体和包含固定在栓塞体表面上的生物型细胞外基质材料的涂层材料。 该生物活性剂选自蛋白多糖，生长因子，糖蛋白，蛋白多糖，蛋白多糖，糖蛋白， 和糖胺聚糖。 在某些形式中，这种细胞外基质材料包括可重塑的血管生成细胞外基质材料，例如粘膜下层材料，例如但不限于猪小肠粘膜下层。