公开(公告)号：US08274058B1

公开(公告)日：2012-09-25

申请号：US12488612

申请日：2009-06-22

申请人： Michael C. Wanke ,  Mark Lee ,  Christopher D. Nordquist ,  Michael J. Cich

发明人： Michael C. Wanke ,  Mark Lee ,  Christopher D. Nordquist ,  Michael J. Cich

IPC分类号： G01T1/24

CPC分类号： H01Q1/38 ,  B82Y20/00 ,  G01N21/3581 ,  G01N2021/1793 ,  H01S1/02 ,  H01S5/02248 ,  H01S5/0262 ,  H01S5/1046 ,  H01S5/3401 ,  H01S5/50 ,  H01S2301/145 ,  H01S2302/02

摘要： A heterodyne terahertz transceiver comprises a quantum cascade laser that is integrated on-chip with a Schottky diode mixer. A terahertz signal can be received by an antenna connected to the mixer, an end facet or sidewall of the laser, or through a separate active section that can amplify the incident signal. The quantum cascade laser couples terahertz local oscillator power to the Schottky diode to mix with the received terahertz signal to provide an intermediate frequency output signal. The fully integrated transceiver optimizes power efficiency, sensitivity, compactness, and reliability. The transceiver can be used in compact, fieldable systems covering a wide variety of deployable applications not possible with existing technology.

摘要翻译： 外差太赫兹收发器包括采用肖特基二极管混频器集成在芯片上的量子级联激光器。 太赫兹信号可以由连接到混频器的天线，激光器的端面或侧壁，或通过可以放大入射信号的单独的有源部分接收。 量子级联激光器将太赫兹本地振荡器功率耦合到肖特基二极管以与接收到的太赫兹信号混合以提供中频输出信号。 完全集成的收发器优化了电源效率，灵敏度，紧凑性和可靠性。 收发器可用于紧凑型现场系统，涵盖现有技术无法实现的各种部署应用。

公开(公告)号：US07376403B1

公开(公告)日：2008-05-20

申请号：US11113635

申请日：2005-04-25

申请人： Michael C. Wanke ,  S. James Allen ,  Mark Lee

发明人： Michael C. Wanke ,  S. James Allen ,  Mark Lee

IPC分类号： H04B1/18

CPC分类号： H03D7/125 ,  H01L29/205 ,  H01L29/7783

摘要： A terahertz radiation mixer comprises a heterodyned field-effect transistor (FET) having a high electron mobility heterostructure that provides a gatable two-dimensional electron gas in the channel region of the FET. The mixer can operate in either a broadband pinch-off mode or a narrowband resonant plasmon mode by changing a grating gate bias of the FET. The mixer can beat an RF signal frequency against a local oscillator frequency to generate an intermediate frequency difference signal in the microwave region. The mixer can have a low local oscillator power requirement and a large intermediate frequency bandwidth. The terahertz radiation mixer is particularly useful for terahertz applications requiring high resolution.

摘要翻译： 太赫兹辐射混合器包括具有高电子迁移率异质结构的外差场效应晶体管（FET），其在FET的沟道区域中提供可点缀的二维电子气。 混频器可以通过改变FET的栅极栅极偏置来工作在宽带夹断模式或窄带谐振等离子体激元模式。 混频器可以针对本地振荡器频率击败RF信号频率，以在微波区域中产生中频差信号。 混频器可以具有低本地振荡器功率要求和大的中频带宽。 太赫兹辐射混合器对于需要高分辨率的太赫兹应用特别有用。

公开(公告)号：US07550734B1

公开(公告)日：2009-06-23

申请号：US11698010

申请日：2007-01-25

申请人： Mark Lee ,  Michael C. Wanke

发明人： Mark Lee ,  Michael C. Wanke

IPC分类号： G01T1/24

CPC分类号： H01S5/3401 ,  B82Y20/00 ,  G01N21/3581 ,  G01N2021/1793 ,  H01Q1/38 ,  H01S1/02 ,  H01S5/026 ,  H01S5/0262 ,  H01S5/0604 ,  H01S5/1046 ,  H01S2301/145 ,  H01S2302/02

摘要： A heterodyne terahertz transceiver comprises a quantum cascade laser that is integrated on-chip with a Schottky diode mixer. An antenna connected to the Schottky diode receives a terahertz signal. The quantum cascade laser couples terahertz local oscillator power to the Schottky diode to mix with the received terahertz signal to provide an intermediate frequency output signal. The fully integrated transceiver optimizes power efficiency, sensitivity, compactness, and reliability. The transceiver can be used in compact, fieldable systems covering a wide variety of deployable applications not possible with existing technology.

摘要翻译： 外差太赫兹收发器包括采用肖特基二极管混频器集成在芯片上的量子级联激光器。 连接到肖特基二极管的天线接收太赫兹信号。 量子级联激光器将太赫兹本地振荡器功率耦合到肖特基二极管以与接收到的太赫兹信号混合以提供中频输出信号。 完全集成的收发器优化了电源效率，灵敏度，紧凑性和可靠性。 收发器可用于紧凑型现场系统，涵盖现有技术无法实现的各种部署应用。

公开(公告)号：US07420225B1

公开(公告)日：2008-09-02

申请号：US11290090

申请日：2005-11-30

申请人： Michael C. Wanke ,  Mark Lee ,  Eric A. Shaner ,  S. James Allen

发明人： Michael C. Wanke ,  Mark Lee ,  Eric A. Shaner ,  S. James Allen

IPC分类号： H01L31/0328 ,  H01L31/0336 ,  H01L31/072 ,  H01L31/109 ,  H01L29/06

CPC分类号： H01L31/119 ,  B82Y10/00 ,  H01L23/647 ,  H01L23/66 ,  H01L29/775 ,  H01L2924/0002 ,  H01L2924/19104 ,  H01L2924/00

摘要： A direct detector for terahertz radiation comprises a grating-gated field-effect transistor with one or more quantum wells that provide a two-dimensional electron gas in the channel region. The grating gate can be a split-grating gate having at least one finger that can be individually biased. Biasing an individual finger of the split-grating gate to near pinch-off greatly increases the detector's resonant response magnitude over prior QW FET detectors while maintaining frequency selectivity. The split-grating-gated QW FET shows a tunable resonant plasmon response to FIR radiation that makes possible an electrically sweepable spectrometer-on-a-chip with no moving mechanical optical parts. Further, the narrow spectral response and signal-to-noise are adequate for use of the split-grating-gated QW FET in a passive, multispectral terahertz imaging system. The detector can be operated in a photoconductive or a photovoltaic mode. Other embodiments include uniform front and back gates to independently vary the carrier densities in the channel region, a thinned substrate to increase bolometric responsivity, and a resistive shunt to connect the fingers of the grating gate in parallel and provide a uniform gate-channel voltage along the length of the channel to increase the responsivity and improve the spectral resolution.

摘要翻译： 用于太赫兹辐射的直接检测器包括具有一个或多个在通道区域中提供二维电子气的量子阱的光栅门控场效应晶体管。 光栅可以是具有至少一个可以单独偏置的手指的分割光栅门。 将分光栅门的单根手指偏压到接近夹点，大大增加了检测器的谐振响应幅度，超过了现有的QW FET检测器，同时保持了频率选择性。 分光栅门控QW FET显示对FIR辐射的可调谐共振等离子体响应，这使得可以在无可移动的机械光学部件上实现电扫描光谱仪。 此外，窄频谱响应和信噪比足以在无源多光谱太赫兹成像系统中使用分光栅门控QW FET。 检测器可以在光电导或光伏模式下工作。 其他实施例包括均匀的前门和后门，以独立地改变沟道区域中的载流子密度，减薄的衬底以增加测温响应性，以及电阻分流器，以并行连接光栅门的指状物，并沿着栅极通道电压提供均匀的栅极通道电压 通道的长度增加了响应度并提高了光谱分辨率。

公开(公告)号：US20120028264A1

公开(公告)日：2012-02-02

申请号：US13190391

申请日：2011-07-25

申请人： Steven Shak ,  Frederick L. Baehner ,  Tara Maddala ,  Mark Lee ,  Robert J. Pelham ,  Wayne Cowens ,  Diana Cherbavaz ,  Michael C. Kiefer ,  Michael Crager ,  Audrey Goddard ,  Joffre B. Baker

发明人： Steven Shak ,  Frederick L. Baehner ,  Tara Maddala ,  Mark Lee ,  Robert J. Pelham ,  Wayne Cowens ,  Diana Cherbavaz ,  Michael C. Kiefer ,  Michael Crager ,  Audrey Goddard ,  Joffre B. Baker

IPC分类号： C12Q1/68

摘要： Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.

摘要翻译： 涉及从前列腺癌患者获得的生物样品中测量预后生物标志物或共表达生物标志物的表达水平的分子测定，以及测量的表达水平的分析以提供关于所述患者的可能预后的信息，以及可能性 所述患者将具有前列腺癌的复发，或通过临床结果或TMPRSS2融合状态的可能性来分类肿瘤。

公开(公告)号：US20110081543A1

公开(公告)日：2011-04-07

申请号：US12894647

申请日：2010-09-30

申请人： Mark Lee ,  Keunsuk P. Chang ,  Nao Yokota

发明人： Mark Lee ,  Keunsuk P. Chang ,  Nao Yokota

IPC分类号： B32B7/02 ,  B32B27/28 ,  B32B27/36 ,  B32B15/09 ,  B32B27/06

CPC分类号： B65D65/466 ,  B32B27/08 ,  B32B27/18 ,  B32B27/28 ,  B32B27/32 ,  B32B27/36 ,  B32B2250/02 ,  B32B2250/03 ,  B32B2250/244 ,  B32B2255/10 ,  B32B2255/20 ,  B32B2255/205 ,  B32B2270/00 ,  B32B2307/31 ,  B32B2307/514 ,  B32B2307/702 ,  B32B2307/7163 ,  B32B2307/7246 ,  B32B2439/70 ,  Y10T428/12014 ,  Y10T428/1352 ,  Y10T428/1355 ,  Y10T428/1379 ,  Y10T428/273 ,  Y10T428/2813 ,  Y10T428/2817 ,  Y10T428/2826 ,  Y10T428/31678 ,  Y10T428/31681 ,  Y10T428/31786

摘要： The present invention is directed to a multilayer film having, as its main component, a hydroxy acid polymer with improved gas barrier and optional heat sealability. The oriented film of predominately hydroxy acid polymer having controlled shrink can be produced by melting and coextruding a hydroxy acid polymer with a much thinner layer of an amorphous aromatic copolyester to form a multilayer film that is quench cooled, then biaxially stretched at a process temperature above the glass transition and below the cold crystallization temperature of the hydroxy acid polymer. A heat-setting treatment with a controlled relaxation of the film above the hydroxy acid polymer glass transition temperature and below its melt temperature may be used to control shrinkage. The films thus obtained are vacuum metallized on the aromatic copolyester surface to produce environmentally friendly packaging from predominately renewable resources having improved gas barrier properties.

摘要翻译： 本发明涉及一种具有改进的阻气性和任选的热封性的羟基酸聚合物作为其主要成分的多层膜。 具有受控收缩的主要羟基酸聚合物的定向膜可以通过用非常薄的无定形芳族共聚酯层的熔融和共挤出羟基酸聚合物来形成多层膜，所述多层膜被淬火冷却，然后在上述过程温度下双轴拉伸 玻璃化转变并低于羟基酸聚合物的冷结晶温度。 可以使用在羟基酸聚合物玻璃化转变温度以上且低于其熔融温度下控制松弛膜的热定型处理来控制收缩。 由此获得的薄膜在芳族共聚酯表面上真空金属化，以产生具有改进的气体阻隔性能的主要可再生资源的环境友好的包装。

公开(公告)号：US07803783B2

公开(公告)日：2010-09-28

申请号：US11707386

申请日：2007-02-16

申请人： Mark Lee ,  Calvin Jay Kuo ,  Tannishtha Reya ,  Irving L. Weissman

发明人： Mark Lee ,  Calvin Jay Kuo ,  Tannishtha Reya ,  Irving L. Weissman

IPC分类号： A61K31/713

CPC分类号： A61K38/17 ,  C07K2319/30

摘要： Methods and compositions are provided for the protection of normal cells from cytoreductive therapy that target proliferating cells, by administering an inhibitor of Wnt signaling pathways. Wnt signaling is critically important for homeostasis of the epithelial lining of the adult intestine and other proliferating normal adult tissues.

摘要翻译： 提供了通过施用Wnt信号通路抑制剂来保护正常细胞免受靶向增殖细胞的细胞减灭治疗的方法和组合物。 Wnt信号对成年肠和其他增殖正常成人组织的上皮内皮的稳态至关重要。

公开(公告)号：US20080012937A1

公开(公告)日：2008-01-17

申请号：US11485998

申请日：2006-07-14

申请人： Mark Lee ,  Jung-Chang Wu ,  Wei-Yu Wu

发明人： Mark Lee ,  Jung-Chang Wu ,  Wei-Yu Wu

IPC分类号： H04N7/18

CPC分类号： H04N5/64

摘要： An audio/video (A/V) display device capable of swapping digital/Analog A/V output modules mainly comprises a socket set up for inserting a digital/Analog A/V output module. By swapping different digital/Analog A/V output modules, said A/V display device can let users watch digital TV and DVD discs, browse photos stored in a memory card, organize data in said memory card, or play video games, etc.

摘要翻译： 能够交换数字/模拟A / V输出模块的音频/视频（A / V）显示设备主要包括一个用于插入数字/模拟A / V输出模块的插座。 通过交换不同的数字/模拟A / V输出模块，所述A / V显示设备可以让用户观看数字电视和DVD光盘，浏览存储在存储卡中的照片，组织所述存储卡中的数据或播放视频游戏等。

公开(公告)号：US07202589B2

公开(公告)日：2007-04-10

申请号：US10492724

申请日：2002-10-16

申请人： Victor Alexandrovich Kalinin ,  Mark Lee

发明人： Victor Alexandrovich Kalinin ,  Mark Lee

IPC分类号： H03H9/25

CPC分类号： H03H9/02834 ,  G01D5/485 ,  G01L1/165 ,  G01L3/106

摘要： A surface acoustic wave (SAW) sensor includes a transducer (240 provided on a substrate (23), wherein the transducer (24) is oriented on the substrate (23) so that the direction of acoustic wave propagation is such that the variation of sensor output with temperature, associated with the variation of the substrate third-elastic constants with temperature, substantially equal but opposite to the sum total of the variation of sensor output with temperature associated with the substrate linear temperature coefficient of expansion and with the variations with temperature of the substrate non-zero third order elastic constants, the substrate first-order elastic constants and the substrate density. The effect of temperature variation on sensor output is thereby minimized. This is achieved with a 35-degree arrangement or with reflective gratings inclined at an angle of 3.1 degrees to normal. Additionally, a robust package with a dish is given. Particular applications include the measurement of torque.

摘要翻译： 表面声波（SAW）传感器包括换能器（240），其设置在基板（23）上，其中换能器（24）定向在基板（23）上，使得声波传播的方向使得传感器 与温度的输出相关联的第三弹性常数与温度的变化相关，基本上等于但与传感器输出的变化与基板线性温度系数膨胀的温度的变化总和相反， 衬底非零三阶弹性常数，衬底一级弹性常数和衬底密度，因此温度变化对传感器输出的影响最小化，这是通过35度布置或反射光栅倾斜于 角度为3.1度至正常值，另外，还提供了带有盘的强力包装，具体应用包括测量 扭矩。

公开(公告)号：US20070039390A1

公开(公告)日：2007-02-22

申请号：US11205964

申请日：2005-08-17

申请人： Michael Duncan ,  Mark Lee ,  Fred Young

发明人： Michael Duncan ,  Mark Lee ,  Fred Young

IPC分类号： G01N29/04

CPC分类号： G01N29/226 ,  G01N29/265 ,  G01N2291/2694

摘要： A system and method for inspecting a structure are provided. The system includes at least one non-destructive inspection (“NDI”) sensor capable of acquiring data indicative of at least a portion of the structure, and at least one positional sensor for acquiring positional data of the NDI sensor. The system also includes a mechanism operable to trigger the NDI sensor and/or the positional sensor to acquire data such that data indicative of the structure and the positional data are acquired at approximately the same time. The system further includes a movable arm carrying the sensors and movably attached to a base. The system includes a data acquisition system capable of communicating with the sensors such that the data acquisition system generates information indicative of at least a portion of the structure based on the data acquired by the sensors.

摘要翻译： 提供了一种用于检查结构的系统和方法。 该系统包括能够获取表示该结构的至少一部分的数据的至少一个非破坏性检查（“NDI”）传感器，以及用于获取NDI传感器的位置数据的至少一个位置传感器。 该系统还包括可操作以触发NDI传感器和/或位置传感器以获取数据的机构，使得在大约相同的时间获取指示结构和位置数据的数据。 所述系统还包括携带所述传感器并可移动地附接到基座的可移动臂。 该系统包括能够与传感器通信的数据采集系统，使得数据采集系统基于由传感器获取的数据生成指示结构的至少一部分的信息。