摘要:
A method is provided for non-invasively detecting mechanical wear of a prosthetic device implanted in a patient, the method comprises using a non-invasive imaging technique to image the prosthetic device that includes a wear indicating composition; and detecting whether the wear indicating composition has been released from the prosthetic device, and, if so, the location, type, and/or amount thereof. The implant device includes a prosthetic device body having at least one outer surface area; at least one reservoir (e.g., a plurality of discretely spaced micro-reservoirs) in the device body; a wear indicator composition disposed in said at least one reservoir, wherein mechanical wear of the at least one outer surface area of the device body in vivo causes release of at least part of the wear indicator composition. The prosthetic device body may be one for replacement of a hip, a knee, a shoulder, an elbow, or a vertebra.
摘要:
A pump patch device is provided for drug delivery. The device may include a substrate having a plurality of discrete reservoirs, each reservoir having a reservoir opening; a drug disposed in the reservoirs; a pump for delivering a carrier fluid through or adjacent to the reservoir openings; a flow channel for receiving and combining the carrier fluid from the pump with the drug from the reservoirs to form a fluidized drug; and a needle for delivering the fluidized drug into the skin or another biological tissue of a patient. A device is provided for use in dialysis that includes a non-disposable module including a pump or pressure generator; and a disposable cassette operably connected to the pump or pressure generator and including a plurality of discrete reservoirs containing drug and sensors. A fluidics connection device is provided that includes a compression cold weld seal for a microfluidic via.
摘要:
Methods and devices are provided for enhancing mass transport through any fibrous tissue capsule that may form around an implanted medical device following implantation. Methods and devices are also provided to enhance vascularization around the implanted device, which also will aid in mass transport to/from the device. The device preferably comprises multiple reservoirs containing (i) a drug formulation for short- or long-term, controlled drug delivery, (ii) sensors for sensing an analyte in the patient, or (iii) a combination thereof.
摘要:
Golf club heads are releasably engaged with shafts so that the club heads and shafts can be readily interchanged and/or so that the shaft position with respect to the club head can be readily changed. Assemblies for connecting the club head and shaft may include: (a) a shaft engaging member including a rotation-inhibiting structure; (b) a club head engaging member including a shaft-receiving chamber and a retaining structure for engaging the rotation-inhibiting structure; and (c) a securing system for releasably securing the shaft engaging member with respect to the club head engaging member. The club head and shaft may be changed by releasing the securing system and exchanging the original parts with different parts. Furthermore, the shaft may be bent or otherwise extend at an angle from the shaft engaging member so as to allow adjustment of the shaft position with respect to the club head.
摘要:
The present optical image viewing fiberoptic otoscope electromagnetically passive. A body portion is connectable to a light source and has mounted to it a fiberoptic cable and an optical viewer. The fiberoptic cable is thin and flexible, and contains separate light and image transmission paths. Its distal end is adapted for emitting and receiving light. The body includes a light source connection for interfacing an external light source. An optical-type image viewer attached to the body is in light communication with the image path for displaying a received image for viewing by a user. One or more tools are mountable to the otoscope body or fiberoptic cable for performing an operation at the distal end of the fiberoptic cable, e.g., removal of a material from the site. Optionally, the otoscope body may be mounted to a headband via an articulated support arm.
摘要:
A minimally-shearing feeder mechanism supplies a desired flow of particulate solids mixture, with minimal to no sifting segregation, to a desired location. The feeder mechanism maintains a uniform concentration of each size of particle within the mixture.
摘要:
A bed of particulate solids is fluidized in a test chamber to yield multiple test samples for subsequent evaluation of segregation effects. A controlled stream of gas enters the chamber in a series of flow rate cycles each progressively increasing to a maximum rate of gas flow and then decreasing, the maximum rate increasing for successive cycles. An indicating function is formed from measurements of corresponding rates of gas flow and pressure across the bed. Upon termination of the fluidization, multiple samples are sequentially extracted from a single space at the bottom of the test chamber.
摘要:
Methods, formulations, and devices are provided for enhancing drug delivery from a medical device. The method is provided for increasing the rate or quantity of a drug formulation released from an implantable drug delivery device, which method comprises the step of providing a release-modifying agent within or proximate to the implantable drug delivery device, in a manner effective to inhibit gelation, aggregation, or precipitation of the drug formulation being released from the device. The drug formulation and the release-modifying agent may be stored together in at least one reservoir in the implantable drug deliver device. Alternatively, the release-modifying agent may be stored in one or more reservoirs separate from the drug formulation.
摘要:
An Internet-based purchasing system and associated method, including: (i) a remote terminal for use by a consumer; (ii) an on-line purchasing system, wherein the system further includes a system database in communication with the remote terminal for storing both consumer information and ticket and merchandise information; (iii) a user interface between the remote terminal and the on-line purchasing system for allowing the exchange of information and commands between the remote terminal and the on-line purchasing system; (iv) at least one source system in communication with the on-line purchasing system for allowing vendors of tickets or merchandise to sell items on-line, wherein the source system further includes a source database for storing current ticket and merchandise information; (v) a communication interface between the on-line purchasing system and the source system for allowing data exchange between the systems; (vi) software means for allowing the on-line purchasing system to monitor the source system for current ticket or merchandise information and communicate the information back to the on-line purchasing system; (vii) software means for allowing the on-line purchasing system to execute the purchase of tickets or merchandise from the source system based on the current information; and (viii) software means for allowing the source system to communicate with the remote terminal to indicate the completion of the purchase to the consumer.
摘要:
Golf club heads are releasably engaged with shafts so that the club heads and shafts can be readily interchanged and/or so that the shaft position with respect to the club head can be readily changed. Assemblies for connecting the club head and shaft may include: (a) a shaft engaging member including a rotation-inhibiting structure; (b) a club head engaging member including a shaft-receiving chamber and a retaining structure for engaging the rotation-inhibiting structure; and (c) a securing system for releasably securing the shaft engaging member with respect to the club head engaging member. The club head and shaft may be changed by releasing the securing system and exchanging the original parts with different parts. Furthermore, the shaft may be bent or otherwise extend at an angle from the shaft engaging member so as to allow adjustment of the shaft position with respect to the club head.