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公开(公告)号：US20070298425A1
公开(公告)日：2007-12-27
申请号：US11711561
申请日：2007-02-27
CPC分类号： C12Q1/6837 , C12Q1/6881 , C12Q2600/156
摘要： The present invention provides a portable system for real-time population-scale HLA genotyping and/or allelotyping in a field environment and methods of such population-scale HLA genotyping. The individual components of the system are portable to and operable within a field environment thereby providing high throughput with real-time geno- or allelotyping. Also provided are HLA gene-specific primers and HLA allele-specific or single nucleotide polymorphism-specific hybridization probes. In addition the present invention provides a microarray comprising the hybridization probes. Further provided is a kit comprising the HLA gene-specific primers and the microarray.
摘要翻译： 本发明提供了一种用于现场环境中实时种群规模HLA基因分型和/或等位基因的便携式系统以及这种群体规模HLA基因分型的方法。 系统的各个组件可以在现场环境中移植到并可操作，从而通过实时基因或等位基因提供高吞吐量。 还提供了HLA基因特异性引物和HLA等位基因特异性或单核苷酸多态性特异性杂交探针。 此外，本发明提供了包含杂交探针的微阵列。 还提供了包含HLA基因特异性引物和微阵列的试剂盒。
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2.发明授权Methods and devices based upon a novel form of nucleic acid duplex on a surface 有权基于表面上核酸双链体的新形式的方法和装置公开(公告)号：US07354710B2
公开(公告)日：2008-04-08
申请号：US10193938
申请日：2002-07-11
申请人： Michael Hogan , Sergy Lemeshko , Yuri Belosludtsev , Tom Powdrill , Rahul Mitra
发明人： Michael Hogan , Sergy Lemeshko , Yuri Belosludtsev , Tom Powdrill , Rahul Mitra
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00376 , B01J2219/00387 , B01J2219/00497 , B01J2219/005 , B01J2219/00529 , B01J2219/00576 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00691 , B01J2219/00722 , C40B60/14 , C12Q2523/308
摘要： The present invention relates to simple method to fabricate DNA hybridization devices based upon adsorptive attachment of oligonucleotides to a positively charged surface. Such adsorbed oligonucleotide probes form a densely packed monolayer, which retains capacity for base-pair specific hybridization with a solution state nucleic acid target strand to form the duplex. However, both strand dissociation kinetics and the rate of DNase digestion suggest on symmetry grounds that solution-state nucleic acid binds to such adsorbed oligonucleotides to form a highly asymmetric and unwound duplex, with structural details that are substantially different from that known for the Watson-Crick DNA duplex. This novel nucleic acid duplex form can serve as the basis for a new class of hybridization device and methods for their use. It is also disclosed that new methods of nucleic acid duplex detection can be developed which are based upon the interaction of enzymes and dye labels with the unique structural characteristics of the non-helical duplex described herein. Preferred implementations of the invention include DNA microarrays, bead-based nucleic acid analysis, microelectronic devices to detect nucleic acid hybridization and more traditional methods of laboratory analysis, including hybridization on membranous and other solid supports.
摘要翻译： 本发明涉及基于将寡核苷酸吸附到带正电的表面上的DNA杂交装置的简单方法。 这种吸附的寡核苷酸探针形成密集填充的单层，其保留与溶液状态核酸靶链的碱基对特异性杂交以形成双链体的能力。 然而，链分解动力学和DNA酶消化速率都表明溶液状态核酸与这些吸附的寡核苷酸结合以形成高度不对称和未解链双链体的对称性，结构细节与Watson- 克里克DNA双链体。 这种新的核酸双相形式可以作为新一类杂交装置及其使用方法的基础。 还公开了可以开发新的核酸双相检测方法，其基于酶和染料标记与本文所述的非螺旋双螺旋的独特结构特征的相互作用。 本发明的优选实施方案包括DNA微阵列，基于珠的核酸分析，用于检测核酸杂交的微电子装置和更传统的实验室分析方法，包括膜质和其它固体支持物上的杂交。
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公开(公告)号：US08926270B2
公开(公告)日：2015-01-06
申请号：US12971893
申请日：2010-12-17
CPC分类号： F01D9/02 , F01D11/08 , F01D25/246 , F05D2250/75 , F05D2260/38 , F05D2300/518 , F05D2300/6033
摘要： A turbine flowpath apparatus is provided for a gas turbine engine having a centerline axis. The apparatus includes: an annular flowpath member of low-ductility material, the flowpath member having a flowpath surface and an opposed back surface, and having a cross-sectional shape comprising a generally cylindrical forward section and an aft section that extends aft and radially outward at a non-perpendicular, non-parallel angle to the centerline axis; an annular stationary structure surrounding the flowpath member; and an annular centering spring disposed between the stationary structure and the flowpath member, the centering spring urging the flowpath member towards a centered position within the stationary structure.
摘要翻译： 为具有中心线轴线的燃气涡轮发动机提供涡轮流路装置。 该装置包括：低延性材料的环形流路构件，流路构件具有流路表面和相对的后表面，并且具有横截面形状，该横截面形状包括大致圆柱形的前部和在尾部和径向向外延伸的后部 与中心线轴线成非垂直非平行角; 围绕流路构件的环形固定结构; 以及设置在所述固定结构和所述流路构件之间的环形定心弹簧，所述定心弹簧将所述流路构件推向所述固定结构内的居中位置。
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公开(公告)号：US08226644B2
公开(公告)日：2012-07-24
申请号：US12503738
申请日：2009-07-15
IPC分类号： A61B18/14
CPC分类号： A61B18/042
摘要： A gas-enhanced electrosurgical instrument includes a hand-held applicator and a portable actuator assembly. The hand-held applicator has a gas delivery member adapted to deliver pressurized ionizable gas to the proximity of an electrode located adjacent a distal end of the applicator. The portable actuator assembly is capable of holding a source of pressurized ionizable gas, such as a cylinder or cartridge, and includes at least one controller to control the delivery of the gas from the source to the hand-held applicator and to control the delivery of electrosurgical energy to the hand-held applicator.
摘要翻译： 气体增强型电外科器械包括手持式敷贴器和便携式致动器组件。 手持施加器具有适于将加压的可离子化气体输送到位于邻近施用器的远端的电极附近的气体输送构件。 便携式致动器组件能够保持加压的可电离气体源，例如气缸或筒，并且包括至少一个控制器，用于控制气体从源到手持式施放器的输送，并且控制输送 电手术能量到手持式敷贴器。
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公开(公告)号：US08051404B2
公开(公告)日：2011-11-01
申请号：US10415466
申请日：2001-10-26
申请人： Fergal McGovern , Martin Chapman , Garrett Conaty , Philip Head , Michael Hogan
发明人： Fergal McGovern , Martin Chapman , Garrett Conaty , Philip Head , Michael Hogan
IPC分类号： G06F9/44
CPC分类号： G06F8/10
摘要： A method of developing software capable of performing a task, the task comprising at least one task step required to perform the task. The task step has a resultant effect. The method comprises recording a use case comprising one or more scenarios, that comprise one of more further steps; recording the scenario or one of the scenarios as a main success scenarios such that the resultant effect of the main success scenario is the same as the resultant effect of the task step. Use cases which have been stripped of context-specific information may be re-used. Such information may be included in a reference to the re-used use case.
摘要翻译： 一种开发能够执行任务的软件的方法，所述任务包括执行任务所需的至少一个任务步骤。 任务步骤具有结果效果。 该方法包括记录包括一个或多个情景的用例，其包括更进一步的步骤之一; 将场景或场景之一记录为主要成功场景，使得主要成功场景的最终效果与任务步骤的最终效果相同。 可能会重新使用已被剥离上下文相关信息的用例。 这样的信息可以被包括在对重用的用例的引用中。
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公开(公告)号：US20110256530A1
公开(公告)日：2011-10-20
申请号：US13085302
申请日：2011-04-12
申请人： Michael Hogan
发明人： Michael Hogan
CPC分类号： G01N1/30
摘要： The present application relates to methods for increasing stability of formalin fixed, optionally paraffin embedded biological material. In one example, DNAse inhibitors and/or RNAse inhibitors are combined with the biological material or formalin at the time of fixation or shortly prior.
摘要翻译： 本申请涉及增加福尔马林固定，任选石蜡包埋的生物材料的稳定性的方法。 在一个实例中，DNAse抑制剂和/或RNA酶抑制剂在固定时或不久之前与生物材料或福尔马林组合。
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7.发明授权System and method for batch process control with diverse distributed control system protocols 有权用多种分布式控制系统协议进行批处理控制的系统和方法公开(公告)号：US07747416B2
公开(公告)日：2010-06-29
申请号：US11755212
申请日：2007-05-30
申请人： Thomas A. Deininger , Michael Hogan , Yingnian Xu
发明人： Thomas A. Deininger , Michael Hogan , Yingnian Xu
IPC分类号： G06F19/00
CPC分类号： G05B19/41865 , H04L67/12 , H04L69/08
摘要： A system and method for batch process control with diverse distributed control system (DCS) protocols is disclosed. A run-time extension acts as an adaptation layer that allows a single batch manager to supervise controllers utilizing diverse DCS protocols. The run-time extension receives commands transmitted from the batch supervisor in a first DCS protocol, translates the commands to a second DCS protocol utilized by a controller, and transmits the translated command to the controller to control various equipment associated with the controller. A database automation object (DBA) inputs configuration information from controllers utilizing diverse DCS protocols, extracts equipment information from the configuration information, generates protocol translation logic based on the configuration information, and translates recipe and formula information included in the configuration information into a common format.
摘要翻译： 公开了一种用于具有多种分布式控制系统（DCS）协议的批处理控制的系统和方法。 运行时扩展充当适配层，允许单个批处理管理器使用多种DCS协议来监督控制器。 运行时间扩展接收在第一DCS协议中从批量监督器发送的命令，将命令转换成由控制器使用的第二DCS协议，并将转换的命令发送到控制器以控制与控制器相关联的各种设备。 数据库自动化对象（DBA）使用多种DCS协议从控制器输入配置信息，从配置信息中提取设备信息，基于配置信息生成协议转换逻辑，并将配置信息中包含的配方和公式信息转换为通用格式 。
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8.发明授权公开(公告)号：US07589184B2
公开(公告)日：2009-09-15
申请号：US11137806
申请日：2005-05-24
申请人： Michael Hogan , James C. Davis
发明人： Michael Hogan , James C. Davis
CPC分类号： A01N1/0263 , A61K38/02 , C07K1/042 , C07K1/047 , C07K17/00 , C07K17/08 , C12N15/1006 , G01N33/543 , G01N33/68 , G01N33/6842 , Y10T436/2525
摘要： The invention provides compositions and methods for storage of biomolecules. The biomolecules are stored via absorption to a substrate. Absorbed biomolecules can be eluted or recovered from the substrate at a future time, and optionally be subjected to a subsequent analysis or application. Biomolecules absorbed to a substrate for storage may also optionally be preserved, i.e., the absorbed biomolecule is resistant to or resists degradation.
摘要翻译： 本发明提供用于储存生物分子的组合物和方法。 通过吸收将生物分子储存到底物中。 吸收的生物分子可以在将来的时间从底物洗脱或回收，并且任选地进行随后的分析或应用。 吸收到用于储存的底物的生物分子也可以任选地被保留，即，所吸收的生物分子对抗或抵抗降解。
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公开(公告)号：US20080098245A1
公开(公告)日：2008-04-24
申请号：US11638998
申请日：2006-12-13
申请人： Michael Hogan , Thomas McDermott
发明人： Michael Hogan , Thomas McDermott
IPC分类号： G06F1/00
CPC分类号： G06F1/3203 , G06F1/3287 , Y02D10/171 , Y02D50/20
摘要： Power management for a computing device is described based on idle thread code execution and other conditions. In one example, a controller is operated at a first power state. Then the controller is transitioned from the first power state to a second lower power state after it starts executing idle thread code. As an additional optional feature it may be determined whether any one or more of a plurality of conditions is true and the controller may be transitioned from the first power state to the second power state if one or more of the plurality of conditions is true.
摘要翻译： 基于空闲线程代码执行和其他条件来描述计算设备的电源管理。 在一个示例中，控制器在第一功率状态下操作。 然后在开始执行空闲线程代码之后，控制器从第一个电源状态转换到第二个较低功率状态。 作为附加可选特征，可以确定多个条件中的任何一个或多个是否为真，并且如果多个条件中的一个或多个为真，则控制器可以从第一功率状态转换到第二功率状态。
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公开(公告)号：US20080072472A1
公开(公告)日：2008-03-27
申请号：US11938536
申请日：2007-11-12
申请人： Michael Hogan
发明人： Michael Hogan
摘要： An improved soft flexible fishing lure and a method of rigging same are provided by the present invention. More in particular, the invention provides a soft flexible fishing lure having an elongate lure body having a longitudinal axis, a top longitudinal surface, a bottom longitudinal surface, a left wall surface, a right wall surface, a head region forming the distal end, and a tail region forming the proximal end and a channel positioned along the longitudinal axis of the lure at the bottom longitudinal surface. The fishing lure of the invention is further provided with a tandem hook assembly that resides in part in the channel of the soft flexible lure body.
摘要翻译： 本发明提供了一种改进的软柔性钓鱼诱饵及其搭载方法。 更具体地，本发明提供了一种软柔性钓鱼诱饵，其具有具有纵向轴线的细长诱饵体，顶部纵向表面，底部纵向表面，左壁表面，右壁表面，形成远端的头部区域， 以及形成近端的尾部区域和在底部纵向表面沿着诱饵的纵向轴线定位的通道。 本发明的钓鱼诱饵还设置有一部分在柔软柔性诱饵体的通道中的串联钩组件。
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