公开(公告)号：US20050123976A1

公开(公告)日：2005-06-09

申请号：US11003223

申请日：2004-12-02

申请人： Michael Mitas ,  David Cole ,  William Gillanders ,  Michael Wallace

发明人： Michael Mitas ,  David Cole ,  William Gillanders ,  Michael Wallace

IPC分类号： A61B20060101 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118

摘要： Provided is a method for detecting metastases of epithelial cancers, comprising detecting in non-primary tissue overexpression of a nucleic acid of KS1/4, or detecting in non-primary tissue overexpression of a combination of nucleic acids of KS1/4 and PIP, of nucleic acids of KS1/4 and mam, of nucleic acids of PIP and mam, of nucleic acids of KS1/4, PIP and mam, or of nucleic acids of KS1/4 and lunx, the overexpression of a nucleic acid of KS1/4, or the overexpression of a combination of nucleic acids of KS1/4 and PIP, of nucleic acids of KS1/4 and mam, of nucleic acids of PIP and mam, of nucleic acids of KS1/4, PIP and mam, or of nucleic acids of KS1/4 and lunx in non-primary tissue being correlated with metastases of epithelial cancers.

摘要翻译： 提供了一种用于检测上皮癌转移的方法，包括在非原代组织中检测KS1 / 4核酸的过表达，或检测非小细胞组织过表达KS1 / 4和PIP核酸的组合， KS1 / 4，PIP和mam核酸或KS1 / 4和lunx核酸的PIP和mam的核酸的KS1 / 4和mam的核酸，KS1 / 4的核酸的过表达 或KS1 / 4，PIP和mam核酸或核酸的核酸的PIP和mam的核酸的KS1 / 4和mam的核酸的KS1 / 4和PIP的核酸的组合的过表达或核酸 KS1 / 4的酸和非原发性组织中的lunx与上皮癌的转移相关。

公开(公告)号：US20130261140A1

公开(公告)日：2013-10-03

申请号：US13990948

申请日：2011-12-01

申请人： Duane A. Burnett ,  Zhiqiang Zhao ,  David Cole ,  Hubert Josien ,  Dmitri A. Pissarnitski ,  Thavalakulamgar Sasikumar ,  Wen-Lian Wu ,  Martin Domalski

发明人： Duane A. Burnett ,  Zhiqiang Zhao ,  David Cole ,  Hubert Josien ,  Dmitri A. Pissarnitski ,  Thavalakulamgar Sasikumar ,  Wen-Lian Wu ,  Martin Domalski

IPC分类号： A61K31/519 ,  C07D487/14

CPC分类号： A61K31/519 ,  C07D487/14

摘要： The present invention is directed to novel tricyclic heterocycles of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved. I

摘要翻译： 本发明涉及结构式I的新型三环杂环，其是二肽基肽酶-IV酶的抑制剂，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病，特别是 2型糖尿病 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。 一世

公开(公告)号：US07909222B2

公开(公告)日：2011-03-22

申请号：US12052997

申请日：2008-03-21

申请人： David Cole ,  Andrew Smith

发明人： David Cole ,  Andrew Smith

IPC分类号： A61B17/068

CPC分类号： A61B17/072 ,  A61B17/064 ,  A61B17/115 ,  A61B17/32053 ,  A61B2017/00539 ,  A61B2017/00818 ,  A61B2017/07271 ,  A61B2017/306 ,  A61F5/0013 ,  A61F5/0083

摘要： Described herein are endoscopic staplers used to apply one or more fasteners to body tissue. In one embodiment, a fastener-applying device, which is preferably a stapler, is passed transorally into the stomach and used to plicate stomach tissue by engaging tissue from inside of the stomach and drawing it inwardly. In the disclosed embodiments, the tissue is drawn inwardly into a vacuum chamber, causing sections of serosal tissue on the exterior of the stomach to be positioned facing one another. The disclosed staplers allow the opposed sections of tissue to be moved into contact with one another, and preferably deliver staples for maintaining contact between the tissue sections at least until serosal bonds form between them. Each of these steps may be performed wholly from the inside of the stomach and thus can eliminate the need for any surgical or laparoscopic intervention. After one or more plications are formed, medical devices may optionally be coupled to the plication(s) for retention within the stomach.

公开(公告)号：US07708181B2

公开(公告)日：2010-05-04

申请号：US12052885

申请日：2008-03-21

申请人： David Cole ,  Andrew Smith ,  Samuel T. Crews ,  Bretton Swope ,  Daniel J. Balbierz

发明人： David Cole ,  Andrew Smith ,  Samuel T. Crews ,  Bretton Swope ,  Daniel J. Balbierz

IPC分类号： A61B17/068

CPC分类号： A61B17/072 ,  A61B17/064 ,  A61B17/115 ,  A61B17/32053 ,  A61B2017/00539 ,  A61B2017/00818 ,  A61B2017/07271 ,  A61B2017/306 ,  A61F5/0013 ,  A61F5/0083

摘要： Described herein are endoscopic staplers used to apply one or more fasteners to body tissue. In one embodiment, a fastener-applying device, which is preferably a stapler, is passed transorally into the stomach and used to plicate stomach tissue by engaging tissue from inside of the stomach and drawing it inwardly. In the disclosed embodiments, the tissue is drawn inwardly into a vacuum chamber, causing sections of serosal tissue on the exterior of the stomach to be positioned facing one another. The disclosed staplers allow the opposed sections of tissue to be moved into contact with one another, and preferably deliver staples for maintaining contact between the tissue sections at least until serosal bonds form between them. Each of these steps may be performed wholly from the inside of the stomach and thus can eliminate the need for any surgical or laparoscopic intervention. After one or more plications are formed, medical devices may optionally be coupled to the plication(s) for retention within the stomach.

公开(公告)号：US20080236147A1

公开(公告)日：2008-10-02

申请号：US12078252

申请日：2008-03-28

申请人： Willem Nicolaas Van Vuuren ,  Stephen Bugos ,  William Imoehl ,  Michael Hornby ,  Ray Wildeson ,  Olaf Graupner ,  David Cole

发明人： Willem Nicolaas Van Vuuren ,  Stephen Bugos ,  William Imoehl ,  Michael Hornby ,  Ray Wildeson ,  Olaf Graupner ,  David Cole

IPC分类号： F01N3/10 ,  F01N3/18

CPC分类号： F01N3/2066 ,  F01N2240/20 ,  F01N2570/14 ,  F01N2610/02 ,  F01N2610/10 ,  F01N2610/1453 ,  F01N2610/1486 ,  Y02A50/2325 ,  Y02T10/24 ,  Y10T137/0486 ,  Y10T137/6606 ,  Y10T137/7833 ,  Y10T137/7886

摘要： A reductant delivery unit (10) is provided for selective catalytic reduction (SCR) after-treatment for vehicles. The unit includes a solenoid fluid injector (10) constructed and arranged to be associated with an exhaust gas flow path (14) upstream of a SCR catalytic converter (17). The fluid injector has a fluid inlet (13) and a fluid outlet (15) with the fluid inlet being constructed and arranged to receive a source of urea solution and the fluid outlet being constructed and arranged to communicate directly with the exhaust flow path so as to control injection of urea solution into the exhaust gas flow path. An interface (24) is constructed and arranged to couple the fluid injector to the gas flow path. The interface defines a thermal barrier constructed and arranged to decoupled a body of the injector from exposure to heat in the exhaust gas flow path.

摘要翻译： 提供还原剂输送单元（10）用于车辆的选择性催化还原（SCR）后处理。 该单元包括构造和布置为与SCR催化转化器（17）上游的排气流动路径（14）相关联的电磁流体注射器（10）。 流体注射器具有流体入口（13）和流体出口（15），流体入口被构造和布置成接收尿素溶液源，流体出口构造和布置成直接与排气流动路径连通，以便 以控制将尿素溶液注入废气流路。 接口（24）被构造和布置成将流体喷射器耦合到气体流动路径。 界面限定了构造和布置成将喷射器的主体与废气流动路径中的热量相接合的热障。

公开(公告)号：US20070283441A1

公开(公告)日：2007-12-06

申请号：US11748439

申请日：2007-05-14

申请人： David Cole ,  Dennis Hanzlik ,  Erik Caso

发明人： David Cole ,  Dennis Hanzlik ,  Erik Caso

IPC分类号： G06F11/00

CPC分类号： G02B5/3083 ,  G02B6/105 ,  G02B6/12011 ,  G02B6/12023 ,  G02B2006/12097 ,  G02B2006/12116 ,  H04L41/12 ,  H04L41/22 ,  H04L63/0218 ,  H04L63/1408 ,  H04L63/1416 ,  H04L63/1433 ,  H04L63/145

摘要： A system and method provide comprehensive and highly automated testing of vulnerabilities to intrusion on a target network, including identification of operating system, identification of target network topology and target computers, identification of open target ports, assessment of vulnerabilities on target ports, active assessment of vulnerabilities based on information acquired from target computers, quantitative assessment of target network security and vulnerability, and hierarchical graphical representation of the target network, target computers, and vulnerabilities in a test report. The system and method employ minimally obtrusive techniques to avoid interference with or damage to the target network during or after testing.

摘要翻译： 系统和方法提供对目标网络入侵的漏洞的全面和高度自动化测试，包括操作系统的识别，目标网络拓扑和目标计算机的识别，目标端口的识别，目标端口的漏洞评估，主动评估 基于从目标计算机获取的信息的漏洞，目标网络安全性和漏洞的定量评估，以及目标网络，目标计算机和测试报告中的漏洞的分层图形表示。 该系统和方法采用最低限度的突出技术，以避免在测试期间或之后对目标网络的干扰或损坏。

公开(公告)号：US20070252387A1

公开(公告)日：2007-11-01

申请号：US11414315

申请日：2006-04-28

申请人： Michael Beard ,  David Cole ,  Christopher Caldwell ,  Michael Foley

发明人： Michael Beard ,  David Cole ,  Christopher Caldwell ,  Michael Foley

IPC分类号： F16L21/06

CPC分类号： E21B17/085 ,  F16L37/138

摘要： A marine riser assembly having a first tubular member having an external surface with a plurality of first axially spaced formations, a second tubular member having an external surface with a plurality of second axially spaced formations thereon, a segmented ring in surrounding relationship to the first and second tubular members, the segmented ring having an inner surface with a plurality of formations engageable with the formations on the first and second tubular members, the engageable formations serving to urge the first and second tubular members toward each other when the segmented ring is subjected to radially inwardly directed compressive forces, a sleeve in surrounding relationship to force the engageable formations together and a seal assembly for sealing against external and internal pressure.

摘要翻译： 一种具有第一管状构件的海洋提升管组件，该第一管状构件具有多个第一轴向间隔的结构的外表面，第二管状构件，具有在其上具有多个第二轴向间隔的结构的外表面，与第一和第 第二管状构件，分段环具有内表面，其具有可与第一和第二管状构件上的结构接合的多个结构，所述可接合构造用于在分段环经受第一和第二管状构件时将第一和第二管状构件朝向彼此推动 径向向内的压缩力，围绕关系的套筒，以将可接合的结构压在一起，以及用于密封抵抗外部和内部压力的密封组件。

公开(公告)号：US20070251288A1

公开(公告)日：2007-11-01

申请号：US11411374

申请日：2006-04-26

申请人： David Cole

发明人： David Cole

IPC分类号： B21C23/00

CPC分类号： B21C23/22

摘要： A method of forming an elongate composite product wherein a composite body formed of an internal billet and an external sleeve is assembled, the interior periphery of the sleeve being complimentary to the exterior periphery of the billet, the composite body then being formed as by extruding into an elongate product having an inner core and an outer sheath.

摘要翻译： 一种形成细长复合产品的方法，其中组装由内部坯料和外部套筒形成的复合体，套筒的内周与坯料的外部周边互补，然后通过挤压形成复合体 具有内芯和外护套的细长产品。

公开(公告)号：US20070250084A1

公开(公告)日：2007-10-25

申请号：US11818360

申请日：2007-06-14

申请人： A. Sharkawy ,  J. Stine ,  David Cole ,  Samuel Crews ,  Darin Gittings ,  Adam Kessler ,  Mark Foley

发明人： A. Sharkawy ,  J. Stine ,  David Cole ,  Samuel Crews ,  Darin Gittings ,  Adam Kessler ,  Mark Foley

IPC分类号： A61B17/08

CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B17/0469 ,  A61B17/064 ,  A61B17/0643 ,  A61B17/0644 ,  A61B17/068 ,  A61B17/11 ,  A61B2017/00252 ,  A61B2017/00876 ,  A61B2017/044 ,  A61B2017/0648 ,  A61B2017/1107 ,  A61B2017/1132 ,  A61B2017/1135 ,  A61B2017/1139 ,  A61F2/064 ,  A61F2/07 ,  A61F2/89 ,  A61F2/90 ,  A61F2002/061 ,  A61F2002/067 ,  A61F2002/075 ,  A61F2002/30079 ,  A61F2002/821 ,  A61F2210/009 ,  A61F2230/005 ,  A61F2230/0067 ,  H01F41/026

摘要： Anastomotic components may be attached to hollow bodies or vessels by magnetic or mechanical force to create an anastomosis, form a port in a vessel, or repair a diseased vessel lumen. Anastomoses are created by coupling a first connection to an end of a vessel and then attracting it to a second connector secured to the side wall of another vessel. The connection between the first and second connectors may be solidly magnetic, solely mechanical, or a combination thereof. Also disclosed are methods and devices for treating diseased vessel lumens, for example abdominal aortic aneurysm. A plurality of docking members is attached to the vessel at solicited positions, and then one or more grafts is secured to the docking members in any suitable manner.

摘要翻译： 吻合组件可以通过磁力或机械力连接到中空体或血管，以产生吻合，在血管中形成端口或修复患病血管腔。 通过将第一连接件连接到容器的端部，然后将其吸引到固定到另一个容器的侧壁的第二连接器来产生吻合。 第一和第二连接器之间的连接可以是固体磁性的，机械的或它们的组合。 还公开了用于治疗患病血管腔的方法和装置，例如腹主动脉瘤。 多个对接构件在被请求的位置附接到容器，然后以任何合适的方式将一个或多个移植物固定到对接构件。

公开(公告)号：US20060247110A1

公开(公告)日：2006-11-02

申请号：US11120235

申请日：2005-05-02

申请人： Robert Brinkman ,  Paul Allart ,  David Cole ,  Liberato Pietrantoni

发明人： Robert Brinkman ,  Paul Allart ,  David Cole ,  Liberato Pietrantoni

IPC分类号： B23Q3/155

CPC分类号： B23B31/36 ,  B23B31/1107 ,  B23B31/1122 ,  Y10T82/2589 ,  Y10T279/17931 ,  Y10T408/957 ,  Y10T409/309408 ,  Y10T483/1702

摘要： The present invention provides an improvement (20) in a Davenport® automatic screw machine having a stationary spindle. The improvement broadly includes a quick-change mechanism (26) associated with the stationary spindle (22). The mechanism includes mating frusto-conical first and second surfaces (28, 31) on the spindle and tool holder, and a multi-lead threaded connection (32) between the tool holder and stationary spindle such that the tool holder may be quickly locked into mating engagement with the stationary spindle by relative rotation therebetween through a short angular distance. The invention may also include an adjustment mechanism (33) that allows the axis (x2-x2) of the tool to be aligned with the axis (x1-x1) of a spaced rotatable spindle. This adjustment mechanism includes a base member (34), an adjustment member (35), and a locking mechanism (37) for selectively holding the adjustment member in the desired position relative to the base member.

摘要翻译： 本发明提供了具有静止心轴的Davenport自动螺旋机器的改进（20）。 该改进广泛地包括与静止心轴（22）相关联的快速切换机构（26）。 该机构包括在主轴和工具夹具上配合截头圆锥形的第一和第二表面（28,31），以及在工具架和固定主轴之间的多引线螺纹连接（32），使得工具夹可以快速地锁定 通过相对旋转通过短的角距离与固定的主轴配合。 本发明还可以包括调整机构（33），其允许工具的轴线（x 2 -x 2-x 2）与轴线对准（x < 间隔开的可旋转主轴的1/1×1/1）。 该调节机构包括基座部件（34），调节部件（35）和用于将调节部件相对于基部部件选择性地保持在所需位置的锁定机构（37）。