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公开(公告)号：US08709818B2
公开(公告)日：2014-04-29
申请号：US13589404
申请日：2012-08-20
申请人： Michael P. Caulfield , Richard E. Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
发明人： Michael P. Caulfield , Richard E. Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
CPC分类号： G01N33/92 , C07K1/14 , G01N15/0266 , G06F19/00 , G06F19/10 , G16H50/30 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
摘要翻译： 本发明提供了利用差示带电粒子迁移率分析方法从生物样品制备脂蛋白的方法，包括HDL，LDL，Lp（a），IDL和VLDL，用于诊断目的。 还提供了通过差示带电粒子迁移率分析脂蛋白的大小分布的方法，该脂蛋白通过本发明的方法制备。 还提供了评估脂质相关健康风险，心血管疾病，心血管疾病风险以及对治疗性干预的反应性的方法，该方法利用通过本发明方法测定的脂蛋白大小分布。
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公开(公告)号：US20120315706A1
公开(公告)日：2012-12-13
申请号：US13589404
申请日：2012-08-20
申请人： Michael P. Caulfield , Richard E. Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
发明人： Michael P. Caulfield , Richard E. Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
CPC分类号： G01N33/92 , C07K1/14 , G01N15/0266 , G06F19/00 , G06F19/10 , G16H50/30 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
摘要翻译： 本发明提供了利用差示带电粒子迁移率分析方法从生物样品制备脂蛋白的方法，包括HDL，LDL，Lp（a），IDL和VLDL，用于诊断目的。 还提供了通过差示带电粒子迁移率分析脂蛋白的大小分布的方法，该脂蛋白通过本发明的方法制备。 还提供了评估脂质相关健康风险，心血管疾病，心血管疾病风险以及对治疗性干预的反应性的方法，该方法利用通过本发明方法测定的脂蛋白大小分布。
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公开(公告)号：US08247235B2
公开(公告)日：2012-08-21
申请号：US11760672
申请日：2007-06-08
申请人： Michael P. Caulfield , Richard E. Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
发明人： Michael P. Caulfield , Richard E. Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
CPC分类号： G01N33/92 , C07K1/14 , G01N15/0266 , G06F19/00 , G06F19/10 , G16H50/30 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
摘要翻译： 本发明提供了利用差示带电粒子迁移率分析方法从生物样品制备脂蛋白的方法，包括HDL，LDL，Lp（a），IDL和VLDL，用于诊断目的。 还提供了通过差示带电粒子迁移率分析脂蛋白的大小分布的方法，该脂蛋白通过本发明的方法制备。 还提供了评估脂质相关健康风险，心血管疾病，心血管疾病风险以及对治疗性干预的反应性的方法，该方法利用通过本发明方法测定的脂蛋白大小分布。
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公开(公告)号：US20080305549A1
公开(公告)日：2008-12-11
申请号：US11760672
申请日：2007-06-08
申请人： Michael P. Caulfield , Richard E. Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
发明人： Michael P. Caulfield , Richard E. Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
CPC分类号： G01N33/92 , C07K1/14 , G01N15/0266 , G06F19/00 , G06F19/10 , G16H50/30 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
摘要翻译： 本发明提供了利用差示带电粒子迁移率分析方法从生物样品制备脂蛋白的方法，包括HDL，LDL，Lp（a），IDL和VLDL，用于诊断目的。 还提供了通过差示带电粒子迁移率分析脂蛋白的大小分布的方法，该脂蛋白通过本发明的方法制备。 还提供了评估脂质相关健康风险，心血管疾病，心血管疾病风险以及对治疗性干预的反应性的方法，该方法利用通过本发明方法测定的脂蛋白大小分布。
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5.发明授权Method of assessing a lipid-related health risk based on ion mobility analysis of lipoproteins 有权基于脂蛋白离子迁移率分析评估与脂质相关的健康风险的方法公开(公告)号：US07851224B2
公开(公告)日：2010-12-14
申请号：US12775225
申请日：2010-05-06
CPC分类号： G01N15/0266 , G01N33/92 , G01N2800/52 , Y10T436/104165 , Y10T436/24
摘要： A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.
摘要翻译： 描述了用于分析非共价结合的附聚生物颗粒的医学诊断方法和仪器系统。 该方法和系统包括：一种制备生物颗粒的方法; 电喷发生器; α粒子辐射源; 差分迁移率分析仪; 粒子计数器 数据采集和分析手段。 通过脂蛋白部分密度的快速定量分析，医疗装置可用于评估人类疾病，如心脏病风险和高脂血症。 最初，描述了纯化程序以将初始血液样品减少到仪器的分析输入。 来自分析样品的测量尺寸与密度相关，导致脂蛋白密度谱。 然后可以将脂蛋白密度分布用于表征心脏和其他与脂质有关的健康风险。
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公开(公告)号：US20110089037A1
公开(公告)日：2011-04-21
申请号：US12966739
申请日：2010-12-13
IPC分类号： G01N27/447 , C07K14/775 , C07K14/005 , C07K16/00
CPC分类号： G01N15/0266 , G01N33/92 , G01N2800/52 , Y10T436/104165 , Y10T436/24
摘要： A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.
摘要翻译： 描述了用于分析非共价结合的附聚生物颗粒的医学诊断方法和仪器系统。 该方法和系统包括：一种制备生物颗粒的方法; 电喷发生器; α粒子辐射源; 差分迁移率分析仪; 粒子计数器 数据采集和分析手段。 通过脂蛋白部分密度的快速定量分析，医疗装置可用于评估人类疾病，如心脏病风险和高脂血症。 最初，描述了纯化程序以将初始血液样品减少到仪器的分析输入。 来自分析样品的测量尺寸与密度相关，导致脂蛋白密度谱。 然后可以将脂蛋白密度分布用于表征心脏和其他与脂质有关的健康风险。
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公开(公告)号：US07259018B2
公开(公告)日：2007-08-21
申请号：US10293610
申请日：2002-11-12
CPC分类号： G01N15/0266 , G01N33/92 , G01N2800/52 , Y10T436/104165 , Y10T436/24
摘要： A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.
摘要翻译： 描述了用于分析非共价结合的附聚生物颗粒的医学诊断方法和仪器系统。 该方法和系统包括：一种制备生物颗粒的方法; 电喷发生器; α粒子辐射源; 差分迁移率分析仪; 粒子计数器 数据采集和分析手段。 通过脂蛋白部分密度的快速定量分析，医疗装置可用于评估人类疾病，如心脏病风险和高脂血症。 最初，描述了纯化程序以将初始血液样品减少到仪器的分析输入。 来自分析样品的测量尺寸与密度相关，导致脂蛋白密度谱。 然后可以将脂蛋白密度分布用于表征心脏和其他与脂质有关的健康风险。
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公开(公告)号：US20100213061A1
公开(公告)日：2010-08-26
申请号：US12775225
申请日：2010-05-06
CPC分类号： G01N15/0266 , G01N33/92 , G01N2800/52 , Y10T436/104165 , Y10T436/24
摘要： A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.
摘要翻译： 描述了用于分析非共价结合的附聚生物颗粒的医学诊断方法和仪器系统。 该方法和系统包括：一种制备生物颗粒的方法; 电喷发生器; α粒子辐射源; 差分迁移率分析仪; 粒子计数器 数据采集和分析手段。 通过脂蛋白部分密度的快速定量分析，医疗装置可用于评估人类疾病，如心脏病风险和高脂血症。 最初，描述了纯化程序以将初始血液样品减少到仪器的分析输入。 来自分析样品的测量尺寸与密度相关，导致脂蛋白密度谱。 然后可以将脂蛋白密度分布用于表征心脏和其他与脂质有关的健康风险。
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9.发明授权Determining the risk of cardiovascular disease using ion mobility of lipoproteins 有权使用脂蛋白的离子迁移率确定心血管疾病的风险公开(公告)号：US07713744B2
公开(公告)日：2010-05-11
申请号：US11771862
申请日：2007-06-29
IPC分类号： G01N33/92
CPC分类号： G01N15/0266 , G01N33/92 , G01N2800/52 , Y10T436/104165 , Y10T436/24
摘要： A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.
摘要翻译： 描述了用于分析非共价结合的附聚生物颗粒的医学诊断方法和仪器系统。 该方法和系统包括：一种制备生物颗粒的方法; 电喷发生器; α粒子辐射源; 差分迁移率分析仪; 粒子计数器 数据采集和分析手段。 通过脂蛋白部分密度的快速定量分析，医疗装置可用于评估人类疾病，如心脏病风险和高脂血症。 最初，描述了纯化程序以将初始血液样品减少到仪器的分析输入。 来自分析样品的测量尺寸与密度相关，导致脂蛋白密度谱。 然后可以将脂蛋白密度分布用于表征心脏和其他与脂质有关的健康风险。
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公开(公告)号：US5925229A
公开(公告)日：1999-07-20
申请号：US642296
申请日：1996-05-03
IPC分类号： G01N27/447 , G01N27/26
CPC分类号： G01N27/44773 , G01N27/44747
摘要： A variable rate density gradient electrophoric gel is described which separate LDL subfractions with the precision of ultracentrifugation techniques. Also, an innovative bottom inlet mixing chamber particularly useful for producing these gels is described.
摘要翻译： 描述了可变速率密度梯度电泳凝胶，其以超速离心技术的精度分离LDL亚级分。 此外，描述了特别可用于制造这些凝胶的创新的底部入口混合室。
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