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1.发明授权Method of assessing a lipid-related health risk based on ion mobility analysis of lipoproteins 有权基于脂蛋白离子迁移率分析评估与脂质相关的健康风险的方法公开(公告)号：US07851224B2
公开(公告)日：2010-12-14
申请号：US12775225
申请日：2010-05-06
CPC分类号： G01N15/0266 , G01N33/92 , G01N2800/52 , Y10T436/104165 , Y10T436/24
摘要： A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.
摘要翻译： 描述了用于分析非共价结合的附聚生物颗粒的医学诊断方法和仪器系统。 该方法和系统包括：一种制备生物颗粒的方法; 电喷发生器; α粒子辐射源; 差分迁移率分析仪; 粒子计数器 数据采集和分析手段。 通过脂蛋白部分密度的快速定量分析，医疗装置可用于评估人类疾病，如心脏病风险和高脂血症。 最初，描述了纯化程序以将初始血液样品减少到仪器的分析输入。 来自分析样品的测量尺寸与密度相关，导致脂蛋白密度谱。 然后可以将脂蛋白密度分布用于表征心脏和其他与脂质有关的健康风险。
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公开(公告)号：US20100213061A1
公开(公告)日：2010-08-26
申请号：US12775225
申请日：2010-05-06
CPC分类号： G01N15/0266 , G01N33/92 , G01N2800/52 , Y10T436/104165 , Y10T436/24
摘要： A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.
摘要翻译： 描述了用于分析非共价结合的附聚生物颗粒的医学诊断方法和仪器系统。 该方法和系统包括：一种制备生物颗粒的方法; 电喷发生器; α粒子辐射源; 差分迁移率分析仪; 粒子计数器 数据采集和分析手段。 通过脂蛋白部分密度的快速定量分析，医疗装置可用于评估人类疾病，如心脏病风险和高脂血症。 最初，描述了纯化程序以将初始血液样品减少到仪器的分析输入。 来自分析样品的测量尺寸与密度相关，导致脂蛋白密度谱。 然后可以将脂蛋白密度分布用于表征心脏和其他与脂质有关的健康风险。
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3.发明授权Determining the risk of cardiovascular disease using ion mobility of lipoproteins 有权使用脂蛋白的离子迁移率确定心血管疾病的风险公开(公告)号：US07713744B2
公开(公告)日：2010-05-11
申请号：US11771862
申请日：2007-06-29
IPC分类号： G01N33/92
CPC分类号： G01N15/0266 , G01N33/92 , G01N2800/52 , Y10T436/104165 , Y10T436/24
摘要： A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.
摘要翻译： 描述了用于分析非共价结合的附聚生物颗粒的医学诊断方法和仪器系统。 该方法和系统包括：一种制备生物颗粒的方法; 电喷发生器; α粒子辐射源; 差分迁移率分析仪; 粒子计数器 数据采集和分析手段。 通过脂蛋白部分密度的快速定量分析，医疗装置可用于评估人类疾病，如心脏病风险和高脂血症。 最初，描述了纯化程序以将初始血液样品减少到仪器的分析输入。 来自分析样品的测量尺寸与密度相关，导致脂蛋白密度谱。 然后可以将脂蛋白密度分布用于表征心脏和其他与脂质有关的健康风险。
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公开(公告)号：US20110089037A1
公开(公告)日：2011-04-21
申请号：US12966739
申请日：2010-12-13
IPC分类号： G01N27/447 , C07K14/775 , C07K14/005 , C07K16/00
CPC分类号： G01N15/0266 , G01N33/92 , G01N2800/52 , Y10T436/104165 , Y10T436/24
摘要： A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.
摘要翻译： 描述了用于分析非共价结合的附聚生物颗粒的医学诊断方法和仪器系统。 该方法和系统包括：一种制备生物颗粒的方法; 电喷发生器; α粒子辐射源; 差分迁移率分析仪; 粒子计数器 数据采集和分析手段。 通过脂蛋白部分密度的快速定量分析，医疗装置可用于评估人类疾病，如心脏病风险和高脂血症。 最初，描述了纯化程序以将初始血液样品减少到仪器的分析输入。 来自分析样品的测量尺寸与密度相关，导致脂蛋白密度谱。 然后可以将脂蛋白密度分布用于表征心脏和其他与脂质有关的健康风险。
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公开(公告)号：US07259018B2
公开(公告)日：2007-08-21
申请号：US10293610
申请日：2002-11-12
CPC分类号： G01N15/0266 , G01N33/92 , G01N2800/52 , Y10T436/104165 , Y10T436/24
摘要： A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.
摘要翻译： 描述了用于分析非共价结合的附聚生物颗粒的医学诊断方法和仪器系统。 该方法和系统包括：一种制备生物颗粒的方法; 电喷发生器; α粒子辐射源; 差分迁移率分析仪; 粒子计数器 数据采集和分析手段。 通过脂蛋白部分密度的快速定量分析，医疗装置可用于评估人类疾病，如心脏病风险和高脂血症。 最初，描述了纯化程序以将初始血液样品减少到仪器的分析输入。 来自分析样品的测量尺寸与密度相关，导致脂蛋白密度谱。 然后可以将脂蛋白密度分布用于表征心脏和其他与脂质有关的健康风险。
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公开(公告)号：US5925229A
公开(公告)日：1999-07-20
申请号：US642296
申请日：1996-05-03
IPC分类号： G01N27/447 , G01N27/26
CPC分类号： G01N27/44773 , G01N27/44747
摘要： A variable rate density gradient electrophoric gel is described which separate LDL subfractions with the precision of ultracentrifugation techniques. Also, an innovative bottom inlet mixing chamber particularly useful for producing these gels is described.
摘要翻译： 描述了可变速率密度梯度电泳凝胶，其以超速离心技术的精度分离LDL亚级分。 此外，描述了特别可用于制造这些凝胶的创新的底部入口混合室。
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公开(公告)号：US20100152295A1
公开(公告)日：2010-06-17
申请号：US12579996
申请日：2009-10-15
IPC分类号： A61K31/192 , A61P3/06
CPC分类号： A61K31/192 , A61K31/09 , A61K31/4015
摘要： The present invention provides methods for increasing LDL particle size.
摘要翻译： 本发明提供了增加LDL粒径的方法。
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公开(公告)号：US09322833B2
公开(公告)日：2016-04-26
申请号：US14123927
申请日：2012-06-14
CPC分类号： G01N33/92 , B82Y5/00 , B82Y15/00 , C07K14/4741 , C07K14/775 , G01N33/6887 , G01N33/6893 , G01N2333/4742 , G01N2333/775 , G01N2800/32 , G01N2800/52 , Y10T428/2982
摘要： The present disclosure provides an isolated particle comprising very high density, ultra small, lipid depleted apo B containing particles, and may also contain cytokeratin 8. The isolated particle is useful in diagnostic assays, which are also provided.
摘要翻译： 本公开提供了包含非常高密度，超小脂质耗尽的含载脂蛋白B的颗粒的分离的颗粒，并且还可以含有细胞角蛋白8.分离的颗粒可用于诊断测定，其也被提供。
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9.发明授权Lipidomic approaches to determining drug response phenotypes in cardiovascular disease 有权确定心血管疾病药物反应表型的脂质体方法公开(公告)号：US08137977B2
公开(公告)日：2012-03-20
申请号：US12257957
申请日：2008-10-24
申请人： Rima F. Kaddurah-Daouk , Michelle M. Wiest , Steven M. Watkins , Rebecca Ann Baillie , Madhumita Patnaik , K. Ranga Rama Krishnan , Richard M. Weinshilboum , Ronald M. Krauss
发明人： Rima F. Kaddurah-Daouk , Michelle M. Wiest , Steven M. Watkins , Rebecca Ann Baillie , Madhumita Patnaik , K. Ranga Rama Krishnan , Richard M. Weinshilboum , Ronald M. Krauss
CPC分类号： G01N33/92 , G01N2800/32 , G01N2800/52
摘要： The present invention concerns the application of lipidomics to statin treatment for disorders such as cardiovascular disorders. Hence, the invention provides, among other things, a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject following commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen. The invention further provides a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject before commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen.
摘要翻译： 本发明涉及脂质组学对于诸如心血管疾病之类的病症的他汀类药物治疗的应用。 因此，本发明尤其提供了一种通过在开始治疗方案之后从哺乳动物受试者获得样品的脂质谱，将脂质谱与对他汀类药物治疗方案的阳性或阴性反应相关的方法; 并将样品中的脂质谱与对治疗方案的阳性或阴性反应相关联。 本发明还提供了一种通过在开始治疗方案之前从哺乳动物受试者获得样品的脂质分布来将脂质谱与对他汀类药物治疗方案的阳性或阴性反应相关的方法; 并将样品中的脂质谱与对治疗方案的阳性或阴性反应相关联。
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10.发明授权HMGCR isoforms in prediction of efficacy and identification of cholesterol-modulating compounds 有权HMGCR同种型预测胆固醇调节化合物的功效和鉴定公开(公告)号：US08084209B2
公开(公告)日：2011-12-27
申请号：US11994495
申请日：2006-07-21
CPC分类号： A61K31/22 , A61K31/401 , G01N33/573
摘要： The present invention provides methods for assessing a subject's responsiveness to a HMGCR inhibitor therapy, and selection of a HMGCR inhibitor therapy based upon such methods. The invention further provides methods for identifying agents that modulate HMGCR activity, e.g., through modulating HMGCR mRNA splicing, while avoiding elevation of the statin-resistant isoform of HMGCR.
摘要翻译： 本发明提供了评估受试者对HMGCR抑制剂治疗的反应性以及基于这些方法选择HMGCR抑制剂治疗的方法。 本发明还提供用于鉴定调节HMGCR活性的试剂的方法，例如通过调节HMGCR mRNA剪接，同时避免HMGCR的他汀类抗性同种型的升高。
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