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36 条记录 (耗时 0.045 秒)

    NON-NUTRITIVE SWEETENED BEVERAGES WITH LHG JUICE CONCENTRATE
    4.
    发明申请
    NON-NUTRITIVE SWEETENED BEVERAGES WITH LHG JUICE CONCENTRATE 审中-公开
    不含营养浸泡饮料与LHG浓缩汁

    公开(公告)号：US20080226796A1

    公开(公告)日：2008-09-18

    申请号：US11686248

    申请日：2007-03-14

    申请人： Thomas Lee ,  Pei K. Chang ,  Hang Chen

    发明人： Thomas Lee ,  Pei K. Chang ,  Hang Chen

    IPC分类号： A23L2/38

    CPC分类号： A23L2/60 ,  A23L2/385 ,  A23L27/31 ,  A23L27/33 ,  A23L27/34 ,  A23L27/36 ,  A23V2002/00 ,  A23V2200/132 ,  A23V2200/15 ,  A23V2200/06 ,  A23V2250/258 ,  A23V2250/634 ,  A23V2250/254 ,  A23V2250/262 ,  A23V2250/6402

    摘要： Beverage compositions sweetened with at least one non-nutritive sweetener, such as a compound from the stevia plant, including steviol glycosides, e.g., rebaudiosides such as Rebaudioside A, stevioside, etc. Lo Han Guo (LHG) juice concentrate is present in an amount sufficient to enhance the mouthfeel of the beverage, yet not affect the taste. Non-nutritive sweetened beverage compositions, natural beverage compositions, and beverage concentrates incorporating steviosides and LHG juice concentrate are provided. In addition, a method for including LHG juice concentrate in a beverage formulation to enhance the mouthfeel of a beverage sweetened with a compound from the stevia plant is provided.

    摘要翻译： 用至少一种非营养甜味剂，例如来自甜叶菊植物的化合物，包括甜菊糖苷，例如莱鲍迪甙A，甜菊苷等的新蛇菊苷，甜味剂（LHG）果汁浓缩物以一定量存在， 足以增强饮料的口感，但不影响味道。 提供非营养甜味饮料组合物，天然饮料组合物和掺入甜菊苷和LHG浓缩汁的饮料浓缩物。 此外，提供了一种在饮料配方中包含LHG浓缩汁以增强用来自甜叶菊植物的化合物甜化的饮料的口感的方法。

    Fused quinazoline derivatives useful as tyrosine kinase inhibitors
    6.
    发明授权
    Fused quinazoline derivatives useful as tyrosine kinase inhibitors 有权

    公开(公告)号：US07078409B2

    公开(公告)日：2006-07-18

    申请号：US10397660

    申请日：2003-03-26

    申请人： Don Zhang ,  Guojian Xie ,  Charles Davis ,  Zhengzhuang Cheng ,  Hang Chen ,  Yinxiang Wang ,  Mehrnaz Kamal

    发明人： Don Zhang ,  Guojian Xie ,  Charles Davis ,  Zhengzhuang Cheng ,  Hang Chen ,  Yinxiang Wang ,  Mehrnaz Kamal

    IPC分类号： A61K31/519 ,  C07D239/70

    CPC分类号： C07D491/04 ,  C07D497/04

    摘要： The present invention is directed to a compound having the structure wherein A is a 7–18 membered ring that comprises 0 to 6 heteroatoms selected from O, S, and N; R1 is selected from the group consisting of hydrogen, halogen, substituted or unsubstituted C1-8alkyl, substituted or unsubstituted C2-8alkenyl, substituted or unsubstituted C2-8alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, and substituted or unsubstituted heterocyclyl; m is an integer from 0 to 3; X is selected from the group consisting of NR2, CHR3, O, or S; wherein R2 and R3 are each individually H or C1-8alkyl; R is selected from the group consisting of unsubstituted aryl, and substituted or unsubstituted heteroaryl, substituted or unsubstituted aryl-(C1-3)alkyl, substituted or unsubstituted aryl-(C3-7)cycloalkyl, substituted or unsubstituted heteroaryl-(C1-3)alkyl, and substituted or unsubstituted heteroaryl-(C3-7)cycloalkyl; and pharmaceutically acceptable salts thereof; with the proviso that if A is a 7 or 8 membered ring, then R1 is selected from the group consisting of other than H, C1–C4 alkyl, (C1–C4 alkoxy)C1–C4 alkyl, C1–C4 alkanoyl, C1–C4 alkoxy or —S(O)x(C1–C4 alkyl) wherein x is 0 to 2, and wherein said alkyl group and the alkyl moieties of said R1 groups are optionally substituted by 1 to 3 halogens. The present invention is also directed to pharmaceutical compositions comprising the above compound, and methods of treating patients suffering from tyrosine kinase-mediated disorders using the above compound.

    Anti-inflammatory and anti-thrombotic compounds and their compositions
    7.
    发明申请
    Anti-inflammatory and anti-thrombotic compounds and their compositions 审中-公开
    抗炎和抗血栓形成的化合物及其组成

    公开(公告)号：US20050148554A1

    公开(公告)日：2005-07-07

    申请号：US10986974

    申请日：2004-11-12

    申请人： Don Zhang ,  Guojian Xie ,  Zhengwei Huan ,  Hang Chen ,  Charles Davis

    发明人： Don Zhang ,  Guojian Xie ,  Zhengwei Huan ,  Hang Chen ,  Charles Davis

    IPC分类号： C07C203/04 ,  C07C203/10 ,  C07C381/00 ,  A61K31/60 ,  C07C23/02

    CPC分类号： C07C203/10 ,  C07C203/04 ,  C07C381/00

    摘要： The invention encompasses novel compounds of Formula I, which are anti-inflammatory and anti-thrombotic agents. The invention also encompasses certain pharmaceutical compositions and methods for treatment of cyclooxygenases (COX-1 and COX-2) mediated diseases comprising the use of compounds of Formula I. The above compounds may be used as a combination therapy with low-dose aspirin, NSAIDs, or selective COX-2 inhibitors to treat chronic cyclooxygenases mediated diseases or conditions while simultaneously reducing the risk of thrombotic cardiovascular events.

    摘要翻译： 本发明包括式I的新型化合物，其为抗炎和抗血栓形成剂。 本发明还包括用于治疗环氧合酶（COX-1和COX-2）介导的疾病的某些药物组合物和方法，其包括使用式I化合物。上述化合物可以用作与低剂量阿司匹林，NSAIDs的组合疗法 或选择性COX-2抑制剂来治疗慢性环氧合酶介导的疾病或病症，同时降低血栓性心血管事件的风险。