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1.发明授权Certain glycine derivatives as factor Xa inhibitors for use in the treatment of thrombotic disorders 失效某些甘氨酸衍生物作为用于治疗血栓形成障碍的因子Xa抑制剂公开(公告)号：US07297706B2
公开(公告)日：2007-11-20
申请号：US11456589
申请日：2006-07-11
申请人： Michael Robert Wiley , Daniel Jon Sall , Christopher William Murray , Stephen Clinton Young , Jolie Anne Bastian
发明人： Michael Robert Wiley , Daniel Jon Sall , Christopher William Murray , Stephen Clinton Young , Jolie Anne Bastian
IPC分类号： A61K31/4375 , A61K31/435 , C07D211/10
CPC分类号： C07D401/14 , C07D211/26 , C07D211/58 , C07D401/04 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Compounds of formula (I) in which R, R1, R2, n and X1 have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders.
摘要翻译： 其中R，R 1，R 2，n和X 1具有本说明书中给出的含义的式（I）化合物是因子 可用于治疗血栓形成障碍的Xa抑制剂。
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2.发明授权Certain glycine derivatives as factor Xa inhibitors for use in the treatment of thrombotic disorders 失效某些甘氨酸衍生物作为用于治疗血栓形成障碍的因子Xa抑制剂公开(公告)号：US07078415B2
公开(公告)日：2006-07-18
申请号：US10496020
申请日：2002-12-09
申请人： Michael Robert Wiley , Daniel Jon Sall , Christopher William Murray , Stephen Clinton Young , Jolie Anne Bastian
发明人： Michael Robert Wiley , Daniel Jon Sall , Christopher William Murray , Stephen Clinton Young , Jolie Anne Bastian
IPC分类号： A61K31/4375 , A61K31/435 , C07D211/10
CPC分类号： C07D401/14 , C07D211/26 , C07D211/58 , C07D401/04 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Compounds of formula (I) in which R, R1, R2, n and X1 have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders.
摘要翻译： 其中R，R 1，R 2，n和X 1具有本说明书中给出的含义的式（I）化合物是因子 可用于治疗血栓形成障碍的Xa抑制剂。
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公开(公告)号：US07294627B2
公开(公告)日：2007-11-13
申请号：US10496018
申请日：2002-12-09
申请人： Steven Douglas Hiscock , Stuart Donald Jones , Daniel Jon Sall , Stephen Clinton Young , Michael Robert Wiley
发明人： Steven Douglas Hiscock , Stuart Donald Jones , Daniel Jon Sall , Stephen Clinton Young , Michael Robert Wiley
IPC分类号： A61K31/501 , A61K31/506 , A61K31/4545 , C07D401/14 , C07D401/12
CPC分类号： C07D401/12 , C07D401/14
摘要： Compounds of formula (I) in which R1, R2, R3 and R4, have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders.
摘要翻译： 其中R 1，R 2，R 3和R 4的式（I）化合物具有 说明书中给出的含义是可用于治疗血栓形成障碍的因子Xa抑制剂。
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公开(公告)号：US06946467B2
公开(公告)日：2005-09-20
申请号：US10030187
申请日：2001-12-06
申请人： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson , Peter Robert Guzzo , Michael John Mayer
发明人： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson , Peter Robert Guzzo , Michael John Mayer
IPC分类号： C07D295/16 , A61K31/395 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/501 , A61P1/16 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/02 , A61P19/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D207/12 , C07D207/14 , C07D211/26 , C07D211/46 , C07D211/58 , C07D213/36 , C07D213/38 , C07D213/56 , C07D213/74 , C07D231/56 , C07D277/64 , C07D295/18 , C07D295/185 , C07D309/14 , C07D309/32 , C07D309/34 , C07D335/02 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D417/12 , C07D417/14 , C07D521/00
CPC分类号： C07D295/185 , C07D207/12 , C07D207/14 , C07D211/26 , C07D211/46 , C07D213/36 , C07D213/56 , C07D231/12 , C07D233/56 , C07D249/08 , C07D309/34 , C07D335/02 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D417/12 , C07D417/14
摘要： The compound 1-(indole-6-carbonyl-D-phenylglycinyl)-4-(1-methylpiperidin-4-yl)piperazine and physiologically-tolerable salts thereof are factor Xa inhibitors useful for the treatment of thrombotic disorders.
摘要翻译： 化合物1-（吲哚-6-羰基-D-苯基甘氨酰基）-4-（1-甲基哌啶-4-基）哌嗪及其生理上可耐受的盐是可用于治疗血栓形成障碍的因子Xa抑制剂。
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公开(公告)号：US06855715B1
公开(公告)日：2005-02-15
申请号：US09926712
申请日：2000-06-13
申请人： John Walter Liebeschuetz , Amanda Jane Lyons , Christopher William Murray , Andrew David Rimmer , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , Phillip John Morgan , Simon James Richards , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley
发明人： John Walter Liebeschuetz , Amanda Jane Lyons , Christopher William Murray , Andrew David Rimmer , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , Phillip John Morgan , Simon James Richards , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley
IPC分类号： C07D295/16 , A61K31/166 , A61K31/40 , A61K31/4025 , A61K31/433 , A61K31/4439 , A61K31/445 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/497 , A61P1/16 , A61P7/00 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P19/02 , A61P35/00 , A61P43/00 , C07C237/22 , C07C237/36 , C07C255/60 , C07D207/12 , C07D209/08 , C07D209/30 , C07D209/34 , C07D209/42 , C07D211/00 , C07D211/26 , C07D211/30 , C07D211/34 , C07D211/46 , C07D211/60 , C07D213/53 , C07D213/72 , C07D213/74 , C07D213/82 , C07D215/38 , C07D217/02 , C07D217/04 , C07D217/06 , C07D231/56 , C07D235/06 , C07D235/08 , C07D241/24 , C07D277/28 , C07D277/46 , C07D277/64 , C07D277/82 , C07D295/135 , C07D295/185 , C07D317/68 , C07D333/24 , C07D333/38 , C07D333/68 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D487/04 , C07D241/04
CPC分类号： C07D401/14 , C07C237/36 , C07C255/60 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07D209/08 , C07D209/30 , C07D209/34 , C07D209/42 , C07D211/26 , C07D211/34 , C07D211/46 , C07D211/60 , C07D213/53 , C07D213/74 , C07D213/82 , C07D215/38 , C07D217/04 , C07D217/06 , C07D231/56 , C07D235/06 , C07D241/24 , C07D277/28 , C07D277/46 , C07D277/64 , C07D277/82 , C07D295/135 , C07D295/185 , C07D317/68 , C07D333/38 , C07D333/68 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/14 , C07D413/14 , C07D417/06 , C07D487/04
摘要： Compounds of formula (I) where R2, each X, L, Y, Cy, Lp, D and n are as defined in the specification, are serine protease inhibitors useful as antithrombotic agents.
摘要翻译： 其中R2，X，L，Y，Cy，Lp，D和n如说明书中所定义的式（I）化合物是用作抗血栓形成剂的丝氨酸蛋白酶抑制剂。
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公开(公告)号：US07351822B2
公开(公告)日：2008-04-01
申请号：US10803157
申请日：2004-03-18
申请人： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson , Peter Robert Guzzo , Michael John Mayer
发明人： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson , Peter Robert Guzzo , Michael John Mayer
IPC分类号： C07D401/12 , C07D401/14 , A61K31/496
CPC分类号： C07D295/185 , C07D207/12 , C07D207/14 , C07D211/26 , C07D211/46 , C07D213/36 , C07D213/56 , C07D231/12 , C07D233/56 , C07D249/08 , C07D309/34 , C07D335/02 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D417/12 , C07D417/14
摘要： Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardiovascular disorders.
摘要翻译： 其中R 2，X，Y，Cy，L和Lp（D）n N具有本说明书中给出的含义的式（I）化合物是 丝氨酸蛋白酶，因子Xa，可用于治疗心血管疾病。
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公开(公告)号：US07053078B2
公开(公告)日：2006-05-30
申请号：US10030188
申请日：2001-06-12
申请人： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson
发明人： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson
IPC分类号： A61K31/33 , A61K31/445 , C07D211/00 , C07D401/00 , C07D209/04
CPC分类号： C07D401/04 , C07D207/12 , C07D211/26 , C07D211/46 , C07D211/58 , C07D211/62 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D417/14
摘要： Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardiovascular disorders.
摘要翻译： 其中R 2，X，Y，Cy，L和Lp（D）n N具有本说明书中给出的含义的式（I）化合物是 丝氨酸蛋白酶，因子Xa，可用于治疗心血管疾病。
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公开(公告)号：US06936611B2
公开(公告)日：2005-08-30
申请号：US10754923
申请日：2004-01-12
申请人： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson , Peter Robert Guzzo , Michael John Mayer
发明人： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson , Peter Robert Guzzo , Michael John Mayer
IPC分类号： C07D295/16 , A61K31/395 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/501 , A61P1/16 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/02 , A61P19/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D207/12 , C07D207/14 , C07D211/26 , C07D211/46 , C07D211/58 , C07D213/36 , C07D213/38 , C07D213/56 , C07D213/74 , C07D231/56 , C07D277/64 , C07D295/18 , C07D295/185 , C07D309/14 , C07D309/32 , C07D309/34 , C07D335/02 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D417/12 , C07D417/14 , C07D521/00
CPC分类号： C07D295/185 , C07D207/12 , C07D207/14 , C07D211/26 , C07D211/46 , C07D213/36 , C07D213/56 , C07D231/12 , C07D233/56 , C07D249/08 , C07D309/34 , C07D335/02 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D417/12 , C07D417/14
摘要： Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardiovascular disorders.
摘要翻译： 其中R 2，X，Y，Cy，L和Lp（D）n N具有本说明书中给出的含义的式（I）化合物是 丝氨酸蛋白酶，因子Xa，可用于治疗心血管疾病。
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公开(公告)号：US06900196B2
公开(公告)日：2005-05-31
申请号：US10883715
申请日：2004-07-06
申请人： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson
发明人： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson
IPC分类号： C07D207/12 , C07D211/26 , C07D211/46 , C07D211/58 , C07D211/62 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D417/14 , A61K31/33 , A61K31/445 , C07D209/04 , C07D211/00 , C07D401/00
CPC分类号： C07D401/04 , C07D207/12 , C07D211/26 , C07D211/46 , C07D211/58 , C07D211/62 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D417/14
摘要： Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardiovascular disorders.
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公开(公告)号：US06878725B2
公开(公告)日：2005-04-12
申请号：US10030189
申请日：2001-06-12
申请人： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson
发明人： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson
IPC分类号： A61K31/40 , A61K31/4439 , A61K31/445 , A61K31/4545 , A61K31/4709 , A61P1/16 , A61P7/02 , A61P9/02 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/00 , A61P17/02 , A61P19/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D207/12 , C07D211/46 , C07D401/12 , C07D401/14 , C07D417/14
CPC分类号： C07D401/14 , C07D207/12 , C07D211/46 , C07D401/12 , C07D417/14
摘要： Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardiovascular disorders.
摘要翻译： 其中R2，X，Y，Cy，L和Lp（D）n具有本说明书中给出的含义的式（I）化合物是丝氨酸蛋白酶因子Xa的抑制剂，可用于治疗心血管疾病。
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